Click here to switch to the map view.

The map label for this gene is aroP [H]

Identifier: 85058443

GI number: 85058443

Start: 802630

End: 804000

Strand: Reverse

Name: aroP [H]

Synonym: SG0465

Alternate gene names: 85058443

Gene position: 804000-802630 (Counterclockwise)

Preceding gene: 85058449

Following gene: 85058442

Centisome position: 19.28

GC content: 57.11

Gene sequence:

>1371_bases
ATGATGGAAGGTCAACAGCGCGACGAGACGCTGAAACGCGGGCTAAAAAACCGCCATATACAGCTCATTGCTTTGGGCGG
CGCGATTGGAACCGGCCTGTTTCTAGGGATTGCACAAACCATACAAATGGCCGGCCCTTCGGTTATTCTGGGCTATGCCA
TCGGCGGTTTTATCGCTTTCCTTATCATGCGCCAGCTGGGCGAGATGGTGGTGGAAGAGCCGGTAGCGGGCTCGTTTAGC
CACTTCGCCTATAAATACTGGGGTAATTTCGCCGGTTTCGCCTCCGGCTGGAACTATTGGGTGCTCTATGTCCTGGTGGC
GATGGCGGAATTGTCCGCGGTCGGCATCTATATGCAATATTGGTGGCCCGGGCTGCCGACCTGGGTATCGGCGGCGGTGT
TTTTCCTGCTGATTAATGCCATCAATCTGGCCAACGTGAAGCTTTATGGTGAAATGGAATTCTGGTTCGCCATTATCAAG
GTGATCGCCATCGTCGCGATGATCGTGTTTGGCGCCTGGCTCCTGCTCAGCGGTCGTGGCGGCCCGGAAGCCAGCGTCAC
CAACTTATGGGCGCAGGGAGGCTTCTTCCCGCACGGCGGCAAAGGTTTGCTGATGGCCATGGCGGTTATCATGTTTTCCT
TCGGTGGTCTGGAGCTGGTGGGTATTACCGCCGCCGAGGCCGACGACCCGACGCGCAGTATTCCTAAAGCCACCAATCAG
GTCATTTACCGCATCCTGATATTCTATATCGGCGCGCTGGCGATCCTGCTTTCGCTCTACCCCTGGGCCAAAGTGGTAGA
GGGCGGTAGCCCATTTGTCCTGATTTTCCAGGCCATTAACAGCTACTGGGTGGCTAATATCCTCAATCTGGTGGTCCTGA
CCGCCGCGTTGTCGGTCTACAACAGCTGCGTTTACAGTAATAGCCGCATGCTGTACGGTCTGGCCCGTCAAGGCAATGGC
CCGCAATCGCTGGCGAAAGTAGACCGGCGCGGCGTGCCGGTGGCTGCGCTCGGCGTCTCGGCGGTCGCGACCGCGATTTG
TGTGCTGCTCAACTACCTGATGCCCGGTCAGGCTTTTGGTGTGCTGATGGCGTTGGTGGTGTCAGCGCTGGTAATCAATT
GGAGCATGATCAGTCTGGCGCATTGGAAATTTCGCCGCAAAAAAGCGCAACAGGGCGTCATTCCGCGTTTTCCGGCGCTG
TGGTACCCGATAGGCAACTGTCTTTGCCTGCTCTTCATGGCGGGTATTCTGGCGATTATGCTGCTCACCCAGGGCATGGC
GATTTCGGTGTATTTGATTCCGGTTTGGCTGGTGGTGCTGGGTGTCGGCTTCGCGCTGAAAACTTCCGGCCAGAGCGCTG
ACGCACGCTGA

Upstream 100 bases:

>100_bases
CCGGGCCGCGTAAATTAAAACGTACAATAACCGTAACCGTGGACAGACACAGCGCAGGCCGGCATCCAGGTACTTGCCCG
CCTTAACGACAGAGGATTCG

Downstream 100 bases:

>100_bases
TCCCCGGTTTCCGCACCGGCCGATTTTACCGTGCCGGCGACAGGCGGACAGCCTAGACCAGCGCGCCGTAAATGGTCAAC
AGCGCCACCACCACAATCAC

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MMEGQQRDETLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELSAVGIYMQYWWPGLPTWVSAAVFFLLINAINLANVKLYGEMEFWFAIIK
VIAIVAMIVFGAWLLLSGRGGPEASVTNLWAQGGFFPHGGKGLLMAMAVIMFSFGGLELVGITAAEADDPTRSIPKATNQ
VIYRILIFYIGALAILLSLYPWAKVVEGGSPFVLIFQAINSYWVANILNLVVLTAALSVYNSCVYSNSRMLYGLARQGNG
PQSLAKVDRRGVPVAALGVSAVATAICVLLNYLMPGQAFGVLMALVVSALVINWSMISLAHWKFRRKKAQQGVIPRFPAL
WYPIGNCLCLLFMAGILAIMLLTQGMAISVYLIPVWLVVLGVGFALKTSGQSADAR

Sequences:

>Translated_456_residues
MMEGQQRDETLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELSAVGIYMQYWWPGLPTWVSAAVFFLLINAINLANVKLYGEMEFWFAIIK
VIAIVAMIVFGAWLLLSGRGGPEASVTNLWAQGGFFPHGGKGLLMAMAVIMFSFGGLELVGITAAEADDPTRSIPKATNQ
VIYRILIFYIGALAILLSLYPWAKVVEGGSPFVLIFQAINSYWVANILNLVVLTAALSVYNSCVYSNSRMLYGLARQGNG
PQSLAKVDRRGVPVAALGVSAVATAICVLLNYLMPGQAFGVLMALVVSALVINWSMISLAHWKFRRKKAQQGVIPRFPAL
WYPIGNCLCLLFMAGILAIMLLTQGMAISVYLIPVWLVVLGVGFALKTSGQSADAR
>Mature_456_residues
MMEGQQRDETLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFS
HFAYKYWGNFAGFASGWNYWVLYVLVAMAELSAVGIYMQYWWPGLPTWVSAAVFFLLINAINLANVKLYGEMEFWFAIIK
VIAIVAMIVFGAWLLLSGRGGPEASVTNLWAQGGFFPHGGKGLLMAMAVIMFSFGGLELVGITAAEADDPTRSIPKATNQ
VIYRILIFYIGALAILLSLYPWAKVVEGGSPFVLIFQAINSYWVANILNLVVLTAALSVYNSCVYSNSRMLYGLARQGNG
PQSLAKVDRRGVPVAALGVSAVATAICVLLNYLMPGQAFGVLMALVVSALVINWSMISLAHWKFRRKKAQQGVIPRFPAL
WYPIGNCLCLLFMAGILAIMLLTQGMAISVYLIPVWLVVLGVGFALKTSGQSADAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=24.8603351955307, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI258645169, Length=438, Percent_Identity=23.5159817351598, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI181337167, Length=346, Percent_Identity=25.1445086705202, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614005, Length=439, Percent_Identity=23.0068337129841, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI258614003, Length=439, Percent_Identity=23.0068337129841, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=76.8211920529801, Blast_Score=711, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=440, Percent_Identity=64.0909090909091, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=45.5555555555556, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=38.7308533916849, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=41.5313225058005, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI87081915, Length=384, Percent_Identity=38.8020833333333, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI87081708, Length=427, Percent_Identity=36.5339578454333, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=35.4988399071926, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1788480, Length=453, Percent_Identity=35.3200883002208, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=27.1676300578035, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=34.7629796839729, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6320772, Length=411, Percent_Identity=33.8199513381995, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324924, Length=456, Percent_Identity=32.2368421052632, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=398, Percent_Identity=33.9195979899498, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=31.0945273631841, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=31.9095477386935, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=30.2955665024631, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=405, Percent_Identity=32.0987654320988, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=420, Percent_Identity=30.7142857142857, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=412, Percent_Identity=33.7378640776699, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=29.3827160493827, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=30.5970149253731, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319608, Length=414, Percent_Identity=28.5024154589372, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=415, Percent_Identity=27.9518072289157, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=400, Percent_Identity=28.75, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=28.3251231527094, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.5353535353535, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=472, Percent_Identity=26.271186440678, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667468, Length=391, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24668806, Length=399, Percent_Identity=22.5563909774436, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356285, Length=399, Percent_Identity=22.5563909774436, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668802, Length=399, Percent_Identity=22.5563909774436, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221512776, Length=309, Percent_Identity=22.9773462783171, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666159, Length=309, Percent_Identity=22.9773462783171, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49477; Mature: 49477

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEGQQRDETLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQMAGPSVILGYAIGGFIAF
CCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGNFAGFASGWNYWVLYVLVAMAELSAVGIYMQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WWPGLPTWVSAAVFFLLINAINLANVKLYGEMEFWFAIIKVIAIVAMIVFGAWLLLSGRG
HCCCCCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPEASVTNLWAQGGFFPHGGKGLLMAMAVIMFSFGGLELVGITAAEADDPTRSIPKATNQ
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHCHHHHHH
VIYRILIFYIGALAILLSLYPWAKVVEGGSPFVLIFQAINSYWVANILNLVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSCVYSNSRMLYGLARQGNGPQSLAKVDRRGVPVAALGVSAVATAICVLLNYLMPGQAFG
HHHHHCCCHHEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
VLMALVVSALVINWSMISLAHWKFRRKKAQQGVIPRFPALWYPIGNCLCLLFMAGILAIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLTQGMAISVYLIPVWLVVLGVGFALKTSGQSADAR
HHHCCCHHHHHHHHHHHHHHHCCHHEECCCCCCCCC
>Mature Secondary Structure
MMEGQQRDETLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIQMAGPSVILGYAIGGFIAF
CCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LIMRQLGEMVVEEPVAGSFSHFAYKYWGNFAGFASGWNYWVLYVLVAMAELSAVGIYMQY
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WWPGLPTWVSAAVFFLLINAINLANVKLYGEMEFWFAIIKVIAIVAMIVFGAWLLLSGRG
HCCCCCHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GPEASVTNLWAQGGFFPHGGKGLLMAMAVIMFSFGGLELVGITAAEADDPTRSIPKATNQ
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHCHHHHHH
VIYRILIFYIGALAILLSLYPWAKVVEGGSPFVLIFQAINSYWVANILNLVVLTAALSVY
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSCVYSNSRMLYGLARQGNGPQSLAKVDRRGVPVAALGVSAVATAICVLLNYLMPGQAFG
HHHHHCCCHHEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
VLMALVVSALVINWSMISLAHWKFRRKKAQQGVIPRFPALWYPIGNCLCLLFMAGILAIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLTQGMAISVYLIPVWLVVLGVGFALKTSGQSADAR
HHHCCCHHHHHHHHHHHHHHHCCHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]