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The map label for this gene is fucK [H]

Identifier: 85058158

GI number: 85058158

Start: 340761

End: 342224

Strand: Reverse

Name: fucK [H]

Synonym: SG0180

Alternate gene names: 85058158

Gene position: 342224-340761 (Counterclockwise)

Preceding gene: 85058159

Following gene: 85058157

Centisome position: 8.2

GC content: 58.54

Gene sequence:

>1464_bases
ATGAATCGTGATGTTGTCATCGTGCTGGATTGCGGCGCTACAAGTATCCGCGCCATCGCGGTAGACGCCGAAGGCCGGCT
TGTCGCCCAGGCTACCACCCCCAATGCCACCGCGCCGGCGGCAGAAAACCCTCAATGGCATATCTGGCCGCTGGAACCTT
TAATGCAGCGCTTCGCCTATTGCTGCCAGCAGATTATGCCGCAGCTCAGACAGGACCATATACACGCCCTCACCGTGACG
GCCTTTGGCGTCGACGGCGCGCCAGTGGACCAGCAGGGGGAACTACTGTATCCCGTCATCAGTTGGAAATGTCCGCGCAC
CGCGACGGTTATGGAGCAAATTGACCGCTTTATCAGCCCCACCGAGCTACAAGTGCTATCAGGCATTGGCCAATTCAGCT
TCAATACGCTTTATAAGTTACTGTGGTTGAAACAGAATCATCCGCGTCTAATGGAACAGGCGCACTGCTGGCTGTTTCTT
TCGTCACTGATTAACTATCGCCTGACGGGGGAATTTACCACTGACCGCACCATGGCGGGCACCAGCCAATTGCTCGACGT
GCGCCAGGAAAAATTCAGCGATACCATTTTACAGCGTACCGGCCTGTCGTCCGATCTTTTTCCTCGCCTGGTGGCCGCGG
GCGAAGTCATCGGCACGCTGCGTGCGTCAATGGCGGCACGGCTCGGTTTACCCGTGGGATTACCGGTTATCGCCACCGGG
CACGACACGCAGTTTGCGCTGTTTGGTTCGGGAGCGGCGCTCGATCAGGCCGTCCTCAGCTCCGGCACCTGGGAGATCCT
GATGGTACGTACACCCCAGGTAGATACCAGCCTGCTGCCGCGCTATGAAGGTTCCACCTGCGAGCTGGACAGCTGTCGCG
GTCTGTTTAACCCCGGTTTGCAGTGGCTGGCGTCGGGCACGCTGGAATGGGTACGCCAGCTTTACTGGCCCGACGATCCA
TTACCTGCCGCCTATGATCTTATGATTTCCGAGGGCCGGACCATCCCGCCGGGCTGTCAGGGCGTCCGTTTACAGGGCCA
ATTGCTGGACTGCAGGCGCCAGACCAGCTGGACCGGTTTATCGCTGTATTCCAGCCGCGGTCATTTTTACCGCGCCGCGC
TGGAGAATCTCGCCTGGCGTCTGCGTCATCATCTAAGCGTACTGCAAAATATCGGCGGCTTCCGCGCCACCGGTTTGTTG
CTAGTCGGCGGCGGCAGCCGCAATCCCTTGTGGAATCAAATCAAGGCTGACGTCCTTAACATGCCGATCAACGTGCTGAA
GGACGCCGAAACCACCGTACTCGGCGCCGCCATGTTCGCCTGGAGCGGCGCCGGTTTCTATGATTCGCCGGAAACCGCGC
GCCAGCAGGTCAACTATCGTTACTACCGCTACTATCCCGGCGAACAGTGCGCCAATTATCAACAAATGGTGGAACAACTC
GACGCAATGACGGAAGGAGAGTGA

Upstream 100 bases:

>100_bases
GATGGATTTGGAAGGACAAGATTACCGCGCCTGCCGCAATTATGGCCCGCTTTATCGGAACTGAATGCATTACGCGGCGC
CCCCGCAGACAGGAGAAATT

Downstream 100 bases:

>100_bases
TATGTTGAAAATCCTTTCTCCCCTGATCAGTCCCGATCTGCTCAAGACGCTGTCAGAGATGGGGCACGGTGATGAAATTA
TCTTTGCCGATGCCCATTTT

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNRDVVIVLDCGATSIRAIAVDAEGRLVAQATTPNATAPAAENPQWHIWPLEPLMQRFAYCCQQIMPQLRQDHIHALTVT
AFGVDGAPVDQQGELLYPVISWKCPRTATVMEQIDRFISPTELQVLSGIGQFSFNTLYKLLWLKQNHPRLMEQAHCWLFL
SSLINYRLTGEFTTDRTMAGTSQLLDVRQEKFSDTILQRTGLSSDLFPRLVAAGEVIGTLRASMAARLGLPVGLPVIATG
HDTQFALFGSGAALDQAVLSSGTWEILMVRTPQVDTSLLPRYEGSTCELDSCRGLFNPGLQWLASGTLEWVRQLYWPDDP
LPAAYDLMISEGRTIPPGCQGVRLQGQLLDCRRQTSWTGLSLYSSRGHFYRAALENLAWRLRHHLSVLQNIGGFRATGLL
LVGGGSRNPLWNQIKADVLNMPINVLKDAETTVLGAAMFAWSGAGFYDSPETARQQVNYRYYRYYPGEQCANYQQMVEQL
DAMTEGE

Sequences:

>Translated_487_residues
MNRDVVIVLDCGATSIRAIAVDAEGRLVAQATTPNATAPAAENPQWHIWPLEPLMQRFAYCCQQIMPQLRQDHIHALTVT
AFGVDGAPVDQQGELLYPVISWKCPRTATVMEQIDRFISPTELQVLSGIGQFSFNTLYKLLWLKQNHPRLMEQAHCWLFL
SSLINYRLTGEFTTDRTMAGTSQLLDVRQEKFSDTILQRTGLSSDLFPRLVAAGEVIGTLRASMAARLGLPVGLPVIATG
HDTQFALFGSGAALDQAVLSSGTWEILMVRTPQVDTSLLPRYEGSTCELDSCRGLFNPGLQWLASGTLEWVRQLYWPDDP
LPAAYDLMISEGRTIPPGCQGVRLQGQLLDCRRQTSWTGLSLYSSRGHFYRAALENLAWRLRHHLSVLQNIGGFRATGLL
LVGGGSRNPLWNQIKADVLNMPINVLKDAETTVLGAAMFAWSGAGFYDSPETARQQVNYRYYRYYPGEQCANYQQMVEQL
DAMTEGE
>Mature_487_residues
MNRDVVIVLDCGATSIRAIAVDAEGRLVAQATTPNATAPAAENPQWHIWPLEPLMQRFAYCCQQIMPQLRQDHIHALTVT
AFGVDGAPVDQQGELLYPVISWKCPRTATVMEQIDRFISPTELQVLSGIGQFSFNTLYKLLWLKQNHPRLMEQAHCWLFL
SSLINYRLTGEFTTDRTMAGTSQLLDVRQEKFSDTILQRTGLSSDLFPRLVAAGEVIGTLRASMAARLGLPVGLPVIATG
HDTQFALFGSGAALDQAVLSSGTWEILMVRTPQVDTSLLPRYEGSTCELDSCRGLFNPGLQWLASGTLEWVRQLYWPDDP
LPAAYDLMISEGRTIPPGCQGVRLQGQLLDCRRQTSWTGLSLYSSRGHFYRAALENLAWRLRHHLSVLQNIGGFRATGLL
LVGGGSRNPLWNQIKADVLNMPINVLKDAETTVLGAAMFAWSGAGFYDSPETARQQVNYRYYRYYPGEQCANYQQMVEQL
DAMTEGE

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=366, Percent_Identity=24.8633879781421, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789168, Length=466, Percent_Identity=62.2317596566524, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1787789, Length=517, Percent_Identity=25.1450676982592, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1790338, Length=373, Percent_Identity=27.0777479892761, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1789987, Length=494, Percent_Identity=24.4939271255061, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789138, Length=514, Percent_Identity=22.7626459143969, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790361, Length=488, Percent_Identity=21.7213114754098, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.51 [H]

Molecular weight: Translated: 54222; Mature: 54222

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDVVIVLDCGATSIRAIAVDAEGRLVAQATTPNATAPAAENPQWHIWPLEPLMQRFAY
CCCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHH
CCQQIMPQLRQDHIHALTVTAFGVDGAPVDQQGELLYPVISWKCPRTATVMEQIDRFISP
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
TELQVLSGIGQFSFNTLYKLLWLKQNHPRLMEQAHCWLFLSSLINYRLTGEFTTDRTMAG
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHH
TSQLLDVRQEKFSDTILQRTGLSSDLFPRLVAAGEVIGTLRASMAARLGLPVGLPVIATG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
HDTQFALFGSGAALDQAVLSSGTWEILMVRTPQVDTSLLPRYEGSTCELDSCRGLFNPGL
CCCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCCHHHHCCHHHHHH
QWLASGTLEWVRQLYWPDDPLPAAYDLMISEGRTIPPGCQGVRLQGQLLDCRRQTSWTGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHCCCCCCE
SLYSSRGHFYRAALENLAWRLRHHLSVLQNIGGFRATGLLLVGGGSRNPLWNQIKADVLN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHH
MPINVLKDAETTVLGAAMFAWSGAGFYDSPETARQQVNYRYYRYYPGEQCANYQQMVEQL
CCHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCHHHCCHHHHHHHH
DAMTEGE
HHHCCCC
>Mature Secondary Structure
MNRDVVIVLDCGATSIRAIAVDAEGRLVAQATTPNATAPAAENPQWHIWPLEPLMQRFAY
CCCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHH
CCQQIMPQLRQDHIHALTVTAFGVDGAPVDQQGELLYPVISWKCPRTATVMEQIDRFISP
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
TELQVLSGIGQFSFNTLYKLLWLKQNHPRLMEQAHCWLFLSSLINYRLTGEFTTDRTMAG
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHH
TSQLLDVRQEKFSDTILQRTGLSSDLFPRLVAAGEVIGTLRASMAARLGLPVGLPVIATG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
HDTQFALFGSGAALDQAVLSSGTWEILMVRTPQVDTSLLPRYEGSTCELDSCRGLFNPGL
CCCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCCCCCCHHHHCCHHHHHH
QWLASGTLEWVRQLYWPDDPLPAAYDLMISEGRTIPPGCQGVRLQGQLLDCRRQTSWTGL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHCCCCCCE
SLYSSRGHFYRAALENLAWRLRHHLSVLQNIGGFRATGLLLVGGGSRNPLWNQIKADVLN
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHH
MPINVLKDAETTVLGAAMFAWSGAGFYDSPETARQQVNYRYYRYYPGEQCANYQQMVEQL
CCHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCHHHCCHHHHHHHH
DAMTEGE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]