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The map label for this gene is purH

Identifier: 85058121

GI number: 85058121

Start: 235058

End: 236647

Strand: Reverse

Name: purH

Synonym: SG0143

Alternate gene names: 85058121

Gene position: 236647-235058 (Counterclockwise)

Preceding gene: 85058125

Following gene: 85058120

Centisome position: 5.67

GC content: 59.06

Gene sequence:

>1590_bases
ATGCAACCACCACGTCCTGTCCGTCGCGCGCTGCTCAGCGTTTCCGATAAAACCGGTATTTTGGCGTTCGCCCGGTCGCT
GTCCGAGCGAGGCGTTGAGCTGCTTTCCACCGGCGGCACCGCCCGCCTGCTGGCCGAAGCGGGTCTACCGGTCACCGAAG
TGTCCGACTATACGGGCTTTCCCGAAATGATGGACGGGCGGGTTAAAACGCTGCATCCCAAAGTGCATGGCGGGATCCTG
GGCCGGCGCGATATCGATGACGCCATTATGCGCGAGCATGACATTGCCCCAATCGACATGGTGGTCGTCAACCTGTACCC
CTTTGCAGCCACAGTGGCGCGCGCGGAGTGTACCCGTGAAGAGGCGGTGGAAAATATCGATATCGGTGGCCCGACAATGG
TGCGCTCCGCCGCCAAGAACCATAAAGATGTCGCCATTGTGGTCAATAGCGCCAACTATCCCGCGGTTGTGGCGGAAATG
GATCAGCACAGCGGCTCGCTCACCCTGGAGACCCGTTTCGACCTCGCTATCAAGGCGTTTGAACACACCGCTGCCTATGA
CAGTATGATTGCCAACTATTTCGGCAGCCAGGTGCCGGCCTATCACGGCGATGCAAAGCAACCTTCCGGCCGCTTCCCGC
GCACCCTCAATCTTAACTTTATCAAGAAACAGGATATGCGCTACGGCGAGAACAGCCACCAGATGGCGGCGTTTTATACC
GATCCCGAGACGCCGGAAGCGTCGGTGGCCACCGCGCAGCAGCTACAGGGGAAGGCGCTTTCCTATAATAATATCGCCGA
TACCGATGCGGCGCTCGAATGCGTAAAAACCTTTACCGAGGCGGCTTGCGTTATTGTCAAGCATGCCAACCCGTGCGGCG
TGGCTACCAGCGATACCCTGTTGGCGGCCTATAATCGCGCCTACCAGACCGATCCGACGTCTGCGTTTGGCGGGATTATT
GCTTTCAACCGGCCGCTGGACGCCGATACTGCCAAAGCGATTGTGAGTCGCCAATTTGTTGAGGTTATCATCGCACCTGC
GGTCGACGACGACGCTCTGGGCGTGCTGGCCGGCAAGCAGAACGTGCGGGTACTGGCCTGCGGCAATTTGCAGCAGCCGT
CGCCGGGATTGGATTTCAAACGGGTTAACGGCGGCCTGCTGGTGCAGGAGCGCGACGTCGGCATGGTGGACCTGCAGGAT
TTGAGTGTGGTCACCGAGCGCCAGCCGACAGAAGAGGAAATGCGCGATGCGCTTTTCTGCTGGAAAGTGGCCAAGTTCGT
GAAATCCAACGCCATCGTTTATGCCCGCTACCAGCGCACCATCGGTATCGGCGCCGGGCAAATGAGCCGCGTTTATTCGG
CAAAAATCGCCGGCATCAAGGCGGCGGACGAAGGTCTGGACGTCAAGGGATCGGCGATGGCCTCAGACGCTTTCTTCCCC
TTCCGCGACGGTATTGATGCCGCGGCGGCGGTGGGCGTGCGTTGCGTCATTCAGCCAGGCGGATCGATTCACGATAATGA
AATCATCGCCGCCGCCAATGAGCATGGCATTGCCATGATCTTCACCCATATGCGTCATTTCCGCCATTAA

Upstream 100 bases:

>100_bases
TTCCCGTCCGGGTCGAGTGACCGCGCGGGCGAAATGCCATTTCGGCATTGCCAATCAATACAAGTAACATCATTGCTATT
CATATCAAGGGTCATTTGCC

Downstream 100 bases:

>100_bases
GCCCAGGAGTTAGCTCGCCATGAATATTTTAATTATCGGCAACGGTGGACGTGAACACTCCTTGGCCTGGAAAGCTGCTC
AGTCGACGCTTGCCGACAAC

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MQPPRPVRRALLSVSDKTGILAFARSLSERGVELLSTGGTARLLAEAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGIL
GRRDIDDAIMREHDIAPIDMVVVNLYPFAATVARAECTREEAVENIDIGGPTMVRSAAKNHKDVAIVVNSANYPAVVAEM
DQHSGSLTLETRFDLAIKAFEHTAAYDSMIANYFGSQVPAYHGDAKQPSGRFPRTLNLNFIKKQDMRYGENSHQMAAFYT
DPETPEASVATAQQLQGKALSYNNIADTDAALECVKTFTEAACVIVKHANPCGVATSDTLLAAYNRAYQTDPTSAFGGII
AFNRPLDADTAKAIVSRQFVEVIIAPAVDDDALGVLAGKQNVRVLACGNLQQPSPGLDFKRVNGGLLVQERDVGMVDLQD
LSVVTERQPTEEEMRDALFCWKVAKFVKSNAIVYARYQRTIGIGAGQMSRVYSAKIAGIKAADEGLDVKGSAMASDAFFP
FRDGIDAAAAVGVRCVIQPGGSIHDNEIIAAANEHGIAMIFTHMRHFRH

Sequences:

>Translated_529_residues
MQPPRPVRRALLSVSDKTGILAFARSLSERGVELLSTGGTARLLAEAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGIL
GRRDIDDAIMREHDIAPIDMVVVNLYPFAATVARAECTREEAVENIDIGGPTMVRSAAKNHKDVAIVVNSANYPAVVAEM
DQHSGSLTLETRFDLAIKAFEHTAAYDSMIANYFGSQVPAYHGDAKQPSGRFPRTLNLNFIKKQDMRYGENSHQMAAFYT
DPETPEASVATAQQLQGKALSYNNIADTDAALECVKTFTEAACVIVKHANPCGVATSDTLLAAYNRAYQTDPTSAFGGII
AFNRPLDADTAKAIVSRQFVEVIIAPAVDDDALGVLAGKQNVRVLACGNLQQPSPGLDFKRVNGGLLVQERDVGMVDLQD
LSVVTERQPTEEEMRDALFCWKVAKFVKSNAIVYARYQRTIGIGAGQMSRVYSAKIAGIKAADEGLDVKGSAMASDAFFP
FRDGIDAAAAVGVRCVIQPGGSIHDNEIIAAANEHGIAMIFTHMRHFRH
>Mature_529_residues
MQPPRPVRRALLSVSDKTGILAFARSLSERGVELLSTGGTARLLAEAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGIL
GRRDIDDAIMREHDIAPIDMVVVNLYPFAATVARAECTREEAVENIDIGGPTMVRSAAKNHKDVAIVVNSANYPAVVAEM
DQHSGSLTLETRFDLAIKAFEHTAAYDSMIANYFGSQVPAYHGDAKQPSGRFPRTLNLNFIKKQDMRYGENSHQMAAFYT
DPETPEASVATAQQLQGKALSYNNIADTDAALECVKTFTEAACVIVKHANPCGVATSDTLLAAYNRAYQTDPTSAFGGII
AFNRPLDADTAKAIVSRQFVEVIIAPAVDDDALGVLAGKQNVRVLACGNLQQPSPGLDFKRVNGGLLVQERDVGMVDLQD
LSVVTERQPTEEEMRDALFCWKVAKFVKSNAIVYARYQRTIGIGAGQMSRVYSAKIAGIKAADEGLDVKGSAMASDAFFP
FRDGIDAAAAVGVRCVIQPGGSIHDNEIIAAANEHGIAMIFTHMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=487, Percent_Identity=40.2464065708419, Blast_Score=277, Evalue=2e-74,
Organism=Escherichia coli, GI1790439, Length=529, Percent_Identity=80.5293005671078, Blast_Score=881, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=616, Percent_Identity=34.0909090909091, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71985574, Length=354, Percent_Identity=28.8135593220339, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985556, Length=60, Percent_Identity=51.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323768, Length=486, Percent_Identity=36.2139917695473, Blast_Score=255, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6323056, Length=490, Percent_Identity=34.8979591836735, Blast_Score=252, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24649832, Length=612, Percent_Identity=35.9477124183007, Blast_Score=301, Evalue=7e-82,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_SODGM (Q2NWQ7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_453823.1
- ProteinModelPortal:   Q2NWQ7
- SMR:   Q2NWQ7
- STRING:   Q2NWQ7
- GeneID:   3868509
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0143
- NMPDR:   fig|343509.6.peg.285
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q2NWQ7
- BioCyc:   SGLO343509:SG0143-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 57157; Mature: 57157

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPRPVRRALLSVSDKTGILAFARSLSERGVELLSTGGTARLLAEAGLPVTEVSDYTGF
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEECCCCHHHHHHHCCCCCEECCCCCCC
PEMMDGRVKTLHPKVHGGILGRRDIDDAIMREHDIAPIDMVVVNLYPFAATVARAECTRE
HHHHCCCEEEECCHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
EAVENIDIGGPTMVRSAAKNHKDVAIVVNSANYPAVVAEMDQHSGSLTLETRFDLAIKAF
HHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHCCCCCEEEEEECCCHHHHH
EHTAAYDSMIANYFGSQVPAYHGDAKQPSGRFPRTLNLNFIKKQDMRYGENSHQMAAFYT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEC
DPETPEASVATAQQLQGKALSYNNIADTDAALECVKTFTEAACVIVKHANPCGVATSDTL
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHH
LAAYNRAYQTDPTSAFGGIIAFNRPLDADTAKAIVSRQFVEVIIAPAVDDDALGVLAGKQ
HHHHHHHCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCC
NVRVLACGNLQQPSPGLDFKRVNGGLLVQERDVGMVDLQDLSVVTERQPTEEEMRDALFC
CEEEEEECCCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
WKVAKFVKSNAIVYARYQRTIGIGAGQMSRVYSAKIAGIKAADEGLDVKGSAMASDAFFP
HHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
FRDGIDAAAAVGVRCVIQPGGSIHDNEIIAAANEHGIAMIFTHMRHFRH
CCCCCCHHHHCCEEEEECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC
>Mature Secondary Structure
MQPPRPVRRALLSVSDKTGILAFARSLSERGVELLSTGGTARLLAEAGLPVTEVSDYTGF
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEECCCCHHHHHHHCCCCCEECCCCCCC
PEMMDGRVKTLHPKVHGGILGRRDIDDAIMREHDIAPIDMVVVNLYPFAATVARAECTRE
HHHHCCCEEEECCHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
EAVENIDIGGPTMVRSAAKNHKDVAIVVNSANYPAVVAEMDQHSGSLTLETRFDLAIKAF
HHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEHHCCCCCEEEEEECCCHHHHH
EHTAAYDSMIANYFGSQVPAYHGDAKQPSGRFPRTLNLNFIKKQDMRYGENSHQMAAFYT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEC
DPETPEASVATAQQLQGKALSYNNIADTDAALECVKTFTEAACVIVKHANPCGVATSDTL
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHH
LAAYNRAYQTDPTSAFGGIIAFNRPLDADTAKAIVSRQFVEVIIAPAVDDDALGVLAGKQ
HHHHHHHCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCC
NVRVLACGNLQQPSPGLDFKRVNGGLLVQERDVGMVDLQDLSVVTERQPTEEEMRDALFC
CEEEEEECCCCCCCCCCCEEECCCCEEEEECCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
WKVAKFVKSNAIVYARYQRTIGIGAGQMSRVYSAKIAGIKAADEGLDVKGSAMASDAFFP
HHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCC
FRDGIDAAAAVGVRCVIQPGGSIHDNEIIAAANEHGIAMIFTHMRHFRH
CCCCCCHHHHCCEEEEECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA