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The map label for this gene is gor [H]

Identifier: 85058046

GI number: 85058046

Start: 104605

End: 105957

Strand: Reverse

Name: gor [H]

Synonym: SG0068

Alternate gene names: 85058046

Gene position: 105957-104605 (Counterclockwise)

Preceding gene: 85058047

Following gene: 85058045

Centisome position: 2.54

GC content: 55.58

Gene sequence:

>1353_bases
ATGACCCGACATTACGATTACCTCGCCATTGGCGGCGGCAGCGGTGGCATTGCGTCAATTAATCGCGCTGCACAATACGG
CCGTAAATGTGCGCTGATTGAAGTCAAATACCTTGGCGGCACCTGTGTCAACGTGGGTTGCGTTCCGAAGAAAGTGATGT
GGCACGCCGCGCAAATTGCCGAGGCGGTAAAGCTGTATGCGCCCGATTACGGATTTAGCACGACCGTTGAAAAATTTGAC
TGGCGCACCTTGATCGAGAGCCGCAACGCCTATATCAATCGCATCCATCAATCCTACGAACAGGTGCTGGGCAATAATCA
TGTCGATATCATTCACGGCTTCGCTCGTTTTGTTGATGCGCATACCGTGGAGGTGAACGGCGAGCACATCACCGCCGATC
ACATATTAATAGCGACCGGCGGCCGTCCCAGCAAAGTGGCTATTCCGGGCGCGGAATATGGCATTGATTCCGACGGCTTC
TTCGCGTTGGACGCCATGCCGGAACGCGTCGCGGTAGTAGGCGCTGGTTATATCGCGGTGGAAATCGCGGGTGTGCTCAA
CGGCCTGGGCACCGATACCCATCTGTTTGTTCGCAAACACGCGACGCTGCGCAGCTTTGATCCGCTCATTGTCGAGACGT
TGGTCGAGGTCATGCAGGCAGAAGGGCCTGCGCTACATACCGGCTCGGTGCCGCGATCGGTGGCGAAAAACCCGGACGGC
AGCCTGACGCTGACGCTGCAAAATGAAGAGCAATTTACCGTTGACGCGTTGATTTGGGCTATTGGGCGCGAGCCGGCCAC
CGATAATCTCAATCTGGTGGCGGCGGGCGTAAAAACCGACGATACCGGCCACATTCAGGTGGATAAATACCAAAACACTA
ACGTGTCGGGTATTTACGCCGTTGGCGATAATACCGGCGCCGTCGAGTTAACGCCGGTAGCGGTCGCCGCCGGTCGCAGG
CTGTCGGAGCGCTTGTTCAACAACAAGCCGGAAGAGCATCTGAACTATGATCTCATCCCGACGGTGGTCTTCAGCCATCC
CCCTATCGGCGCCATTGGTCTGACTGAGCCCGAAGCCAAGGAAAAATACGGTGAAACCGAGGTCAAAGTCTACAAGACGT
CTTTTACTTCCATGTACACCGCGGTCACCCGGCATCGTCAACTGTGCCGTATGAAACTGGTTTGCGTCGGGCTGCAAGAG
AAAATTGTCGGTCTGCACGGCATTGGTTTCGGTATGGATGAAATGTTGCAGGGTTTCGCCGTCGCCATCAAAATGGGCGC
CACCAAGCAGGATTTTGACAATACCGTGGCAATCCACCCGACCGCAGCGGAAGAGCTGGTGACAATGCGTTAA

Upstream 100 bases:

>100_bases
AACGGCGCCTCACCTATCATAGGGATTGACGCAATCTTTGCGACAACGGGCGTTTGCACGTTACACTTGTGCCAACGATT
TTGCTGAAGGAAACGCCCGA

Downstream 100 bases:

>100_bases
GCTCATTGTCCCTGTCACCCGGGCCTGCGAAATTGCCCTTTTTGCCCTTTTATTTCCTTTAAATTCCAATTTTAGCCGGT
TTTTAATCTTATCGCACCGT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTRHYDYLAIGGGSGGIASINRAAQYGRKCALIEVKYLGGTCVNVGCVPKKVMWHAAQIAEAVKLYAPDYGFSTTVEKFD
WRTLIESRNAYINRIHQSYEQVLGNNHVDIIHGFARFVDAHTVEVNGEHITADHILIATGGRPSKVAIPGAEYGIDSDGF
FALDAMPERVAVVGAGYIAVEIAGVLNGLGTDTHLFVRKHATLRSFDPLIVETLVEVMQAEGPALHTGSVPRSVAKNPDG
SLTLTLQNEEQFTVDALIWAIGREPATDNLNLVAAGVKTDDTGHIQVDKYQNTNVSGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPEEHLNYDLIPTVVFSHPPIGAIGLTEPEAKEKYGETEVKVYKTSFTSMYTAVTRHRQLCRMKLVCVGLQE
KIVGLHGIGFGMDEMLQGFAVAIKMGATKQDFDNTVAIHPTAAEELVTMR

Sequences:

>Translated_450_residues
MTRHYDYLAIGGGSGGIASINRAAQYGRKCALIEVKYLGGTCVNVGCVPKKVMWHAAQIAEAVKLYAPDYGFSTTVEKFD
WRTLIESRNAYINRIHQSYEQVLGNNHVDIIHGFARFVDAHTVEVNGEHITADHILIATGGRPSKVAIPGAEYGIDSDGF
FALDAMPERVAVVGAGYIAVEIAGVLNGLGTDTHLFVRKHATLRSFDPLIVETLVEVMQAEGPALHTGSVPRSVAKNPDG
SLTLTLQNEEQFTVDALIWAIGREPATDNLNLVAAGVKTDDTGHIQVDKYQNTNVSGIYAVGDNTGAVELTPVAVAAGRR
LSERLFNNKPEEHLNYDLIPTVVFSHPPIGAIGLTEPEAKEKYGETEVKVYKTSFTSMYTAVTRHRQLCRMKLVCVGLQE
KIVGLHGIGFGMDEMLQGFAVAIKMGATKQDFDNTVAIHPTAAEELVTMR
>Mature_449_residues
TRHYDYLAIGGGSGGIASINRAAQYGRKCALIEVKYLGGTCVNVGCVPKKVMWHAAQIAEAVKLYAPDYGFSTTVEKFDW
RTLIESRNAYINRIHQSYEQVLGNNHVDIIHGFARFVDAHTVEVNGEHITADHILIATGGRPSKVAIPGAEYGIDSDGFF
ALDAMPERVAVVGAGYIAVEIAGVLNGLGTDTHLFVRKHATLRSFDPLIVETLVEVMQAEGPALHTGSVPRSVAKNPDGS
LTLTLQNEEQFTVDALIWAIGREPATDNLNLVAAGVKTDDTGHIQVDKYQNTNVSGIYAVGDNTGAVELTPVAVAAGRRL
SERLFNNKPEEHLNYDLIPTVVFSHPPIGAIGLTEPEAKEKYGETEVKVYKTSFTSMYTAVTRHRQLCRMKLVCVGLQEK
IVGLHGIGFGMDEMLQGFAVAIKMGATKQDFDNTVAIHPTAAEELVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=54.0305010893246, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=40.9282700421941, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=36.7032967032967, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=36.5426695842451, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=36.5426695842451, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=36.5426695842451, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=36.5426695842451, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=33.8747099767981, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=31.322505800464, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=27.7292576419214, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=80, Blast_Score=732, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=29.490022172949, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=26.9315673289183, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=24.945295404814, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=56.2222222222222, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=56, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=34.6723044397463, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=35.1351351351351, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=26.4642082429501, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=49.0486257928118, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=25.4817987152034, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=464, Percent_Identity=24.3534482758621, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=39.2324093816631, Blast_Score=274, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=39.2324093816631, Blast_Score=274, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=39.2324093816631, Blast_Score=274, Evalue=8e-74,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=37.7637130801688, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=28.6937901498929, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48833; Mature: 48702

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHYDYLAIGGGSGGIASINRAAQYGRKCALIEVKYLGGTCVNVGCVPKKVMWHAAQIA
CCCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCEEEECCCCCHHHHHHHHHHH
EAVKLYAPDYGFSTTVEKFDWRTLIESRNAYINRIHQSYEQVLGNNHVDIIHGFARFVDA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
HTVEVNGEHITADHILIATGGRPSKVAIPGAEYGIDSDGFFALDAMPERVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCEEEECCHHCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVLNGLGTDTHLFVRKHATLRSFDPLIVETLVEVMQAEGPALHTGSVPRSVAKNPDG
EHHHHHHCCCCCEEEEEEECCCHHCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLTLQNEEQFTVDALIWAIGREPATDNLNLVAAGVKTDDTGHIQVDKYQNTNVSGIYA
CEEEEEECCCCEEHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPEEHLNYDLIPTVVFSHPPIGAIGLTEPEAK
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEECCCCCCEECCCCCHHH
EKYGETEVKVYKTSFTSMYTAVTRHRQLCRMKLVCVGLQEKIVGLHGIGFGMDEMLQGFA
HHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHEECHHHHHEEEECCCCCHHHHHHHHE
VAIKMGATKQDFDNTVAIHPTAAEELVTMR
EEEEECCCCCCCCCEEEECCCCHHHHHCCC
>Mature Secondary Structure 
TRHYDYLAIGGGSGGIASINRAAQYGRKCALIEVKYLGGTCVNVGCVPKKVMWHAAQIA
CCEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCEEEECCCCCHHHHHHHHHHH
EAVKLYAPDYGFSTTVEKFDWRTLIESRNAYINRIHQSYEQVLGNNHVDIIHGFARFVDA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
HTVEVNGEHITADHILIATGGRPSKVAIPGAEYGIDSDGFFALDAMPERVAVVGAGYIAV
EEEEECCCEEEECEEEEEECCCCCEEEECCHHCCCCCCCEEEECCCCCEEEEEECCHHEE
EIAGVLNGLGTDTHLFVRKHATLRSFDPLIVETLVEVMQAEGPALHTGSVPRSVAKNPDG
EHHHHHHCCCCCEEEEEEECCCHHCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLTLQNEEQFTVDALIWAIGREPATDNLNLVAAGVKTDDTGHIQVDKYQNTNVSGIYA
CEEEEEECCCCEEHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCEEEE
VGDNTGAVELTPVAVAAGRRLSERLFNNKPEEHLNYDLIPTVVFSHPPIGAIGLTEPEAK
ECCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEECCCCCCEECCCCCHHH
EKYGETEVKVYKTSFTSMYTAVTRHRQLCRMKLVCVGLQEKIVGLHGIGFGMDEMLQGFA
HHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHEECHHHHHEEEECCCCCHHHHHHHHE
VAIKMGATKQDFDNTVAIHPTAAEELVTMR
EEEEECCCCCCCCCEEEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]