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The map label for this gene is czcR [H]

Identifier: 84625209

GI number: 84625209

Start: 4012977

End: 4013723

Strand: Reverse

Name: czcR [H]

Synonym: XOO_3552

Alternate gene names: 84625209

Gene position: 4013723-4012977 (Counterclockwise)

Preceding gene: 84625210

Following gene: 84625208

Centisome position: 81.25

GC content: 63.99

Gene sequence:

>747_bases
ATGTTTCACAAAGCTGAAGACCGAGGAAAGTCCATGCGTCAGACCAAGGAAACGTCCGGCCTCGTGCTGGTCGTCGAAGA
CAATCGCAATATCTCCGAAATGATCGGCGAATACCTGGAAGGCCGTGGCTTCGAGGTCGACTACGCGCAGGACGGCCTGG
ATGGTTACCGTCTGGCCGCCGAGAACAGCTACGACGTGGTCGTACTGGATCTCATGCTGCCACGGCTGGACGGCATCGAA
GTGTGTCGCCGCCTGCGTAACGACGCACGCAAGTCCACGCCGGTGTTGATGTTGACCGCCCGCGACACGCTGGACGACAA
GCTCACCGGCCTGGGCTTCGGCGCCGATGACTACCTGACCAAGCCGTTTGCGATTCAGGAGCTGGAAGCGCGCCTGCGTG
CCCTGATCCGTCGCGAGCGTCGCCAGGTGGGCTCGGAAGTGCTCAAGGTCGCCGACCTGGTGCTCGACCCGGTGAGCATG
CGCGCCACCCGTGCCGGCACCGAGCTGCAGCTCTCGCCGATCGGCCTGCGCCTGCTGACCATCCTGATGCGCGAATCGCC
GCGCGTGGTGACGCGCCAGGAAATCGAGCGCGAGATCTGGGGCAACGGGTTGCCGGATTCGGACACCCTGCGCAGCCATC
TGTACAACCTGCGCAAGATCATCGACAAGCCGTTCGACCGCCCGCTGCTGCACACCGTGCAGAGCGCCGGCTATCGCATC
GCCGACATCGCCCAACCGATGGCCTGA

Upstream 100 bases:

>100_bases
GAGACGGTGTGGCCAGCGTTGCGCCCGCTGCTCGGGTCCTAATCGCCGAGCAGGGCGAAACGTTGTCCGGTCTTCACGTT
ATTTCTACTGTCAATCCGGC

Downstream 100 bases:

>100_bases
TGTCCTCGGCCGGCCGTCGTTCTGGCGGCCGGCTGCGGTGTAGGCGCCCACGCGCCGATCGCTTTCCTGTGCTGCCGGCT
GGTTGCACGACGGACTCACG

Product: two-component system regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MFHKAEDRGKSMRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAAENSYDVVVLDLMLPRLDGIE
VCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSM
RATRAGTELQLSPIGLRLLTILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRI
ADIAQPMA

Sequences:

>Translated_248_residues
MFHKAEDRGKSMRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAAENSYDVVVLDLMLPRLDGIE
VCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSM
RATRAGTELQLSPIGLRLLTILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRI
ADIAQPMA
>Mature_248_residues
MFHKAEDRGKSMRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAAENSYDVVVLDLMLPRLDGIE
VCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLTKPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSM
RATRAGTELQLSPIGLRLLTILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRI
ADIAQPMA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=39.5454545454545, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=35.5555555555556, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.0134529147982, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=35.5855855855856, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=36.4864864864865, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=39.2070484581498, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.6106194690265, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790860, Length=199, Percent_Identity=34.1708542713568, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.4821428571429, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=29.5652173913043, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=41.5254237288136, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.004329004329, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=24.3362831858407, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=31.3559322033898, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=141, Percent_Identity=30.4964539007092, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28137; Mature: 28137

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHKAEDRGKSMRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAA
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCEECHHHCCCCCEEEEC
ENSYDVVVLDLMLPRLDGIEVCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLT
CCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCHHHCC
KPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSMRATRAGTELQLSPIGLRLLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECHHHHHHHH
ILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRI
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCH
ADIAQPMA
HHHHCCCC
>Mature Secondary Structure
MFHKAEDRGKSMRQTKETSGLVLVVEDNRNISEMIGEYLEGRGFEVDYAQDGLDGYRLAA
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCEECHHHCCCCCEEEEC
ENSYDVVVLDLMLPRLDGIEVCRRLRNDARKSTPVLMLTARDTLDDKLTGLGFGADDYLT
CCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCHHHCC
KPFAIQELEARLRALIRRERRQVGSEVLKVADLVLDPVSMRATRAGTELQLSPIGLRLLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECHHHHHHHH
ILMRESPRVVTRQEIEREIWGNGLPDSDTLRSHLYNLRKIIDKPFDRPLLHTVQSAGYRI
HHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCH
ADIAQPMA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]