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The map label for this gene is lexA1 [H]

Identifier: 84624899

GI number: 84624899

Start: 3684946

End: 3685551

Strand: Reverse

Name: lexA1 [H]

Synonym: XOO_3242

Alternate gene names: 84624899

Gene position: 3685551-3684946 (Counterclockwise)

Preceding gene: 84624904

Following gene: 84624898

Centisome position: 74.6

GC content: 66.34

Gene sequence:

>606_bases
ATGCCACCACTGACCCCCCAACGTGCCGCCGTGTTGGCGTTCCTGCAAGAGCAGGCCCAGGCGGGTGTGTCACCCAGTCT
GGCCGAGATCGCGCAGGCCTTCGGGTTTGCCTCGCGCAATGCCGCACAAAAGCACGTGCAGGCGCTGGCCGAGGCTGGGT
TGATCGAGCTGCTGCCCAATCAGAAACGCGGCATCCGTGTGCCCGGTTGCGCCGGGCGCGATGCGCTGTTGAATTTGCCG
GTGCTGGGGCGTGTCGCGGCGGGTGTGCCGATCGGGGCGGATATCGGCCTGGAGCGTCAACTCTGGCTGGACCGTGCGCT
GTTTTCGCTGCGCCCGGATTACCTGTTGCAGGTGCAGGGGGATTCGATGATCGATGACGGCATTCTGGATGGCGACCTGG
TGGGCGTCCATCGCAGCAAGGAGGCGCGCGACGGGCAAATCGTGGTGGCGCGGGTGGATGGCGAAATCACCATCAAGCGC
CTGGAGCGCGGCACCGAACGGATCCGCCTGCTGCCGCGCAATCGCGCGCATGCACCGATTGTGGTGGCAGCCGATGCCGA
CTTCGCGATCGAAGGGCTGTACTGCGGCCTGATCCGGCAGGGCTGA

Upstream 100 bases:

>100_bases
CGCAAGCGCCCTGCTGAAGTGGCTCAGCAAGCCAGTCTCGCCTGCTGCGATCGATTAGTGTACAAATGTACACCTTGTTC
CGTCTCGCTGCCGCGCCCCG

Downstream 100 bases:

>100_bases
GATGAGCGAGCCGGTACAGTTGCGACAGCACGGCAATGCAGCAGTGGCCATGCCGCTGGACGCCCTGCTGGCCGCGCGCA
CGGTCTGGCGTGCAGGCCAG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MPPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPNQKRGIRVPGCAGRDALLNLP
VLGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKR
LERGTERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG

Sequences:

>Translated_201_residues
MPPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPNQKRGIRVPGCAGRDALLNLP
VLGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKR
LERGTERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG
>Mature_200_residues
PPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPNQKRGIRVPGCAGRDALLNLPV
LGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKRL
ERGTERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=203, Percent_Identity=43.8423645320197, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1787431, Length=128, Percent_Identity=34.375, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 21575; Mature: 21444

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPN
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCC
QKRGIRVPGCAGRDALLNLPVLGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQG
CCCCEECCCCCCCHHEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
DSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKRLERGTERIRLLPRNRAHAPI
CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEHHHHHCCHHHEEECCCCCCCCCE
VVAADADFAIEGLYCGLIRQG
EEEECCCEEHHHHEEEEECCC
>Mature Secondary Structure 
PPLTPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALAEAGLIELLPN
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCC
QKRGIRVPGCAGRDALLNLPVLGRVAAGVPIGADIGLERQLWLDRALFSLRPDYLLQVQG
CCCCEECCCCCCCHHEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
DSMIDDGILDGDLVGVHRSKEARDGQIVVARVDGEITIKRLERGTERIRLLPRNRAHAPI
CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEHHHHHCCHHHEEECCCCCCCCCE
VVAADADFAIEGLYCGLIRQG
EEEECCCEEHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]