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The map label for this gene is acrA [C]

Identifier: 84624853

GI number: 84624853

Start: 3620281

End: 3621351

Strand: Reverse

Name: acrA [C]

Synonym: XOO_3196

Alternate gene names: 84624853

Gene position: 3621351-3620281 (Counterclockwise)

Preceding gene: 84624854

Following gene: 84624852

Centisome position: 73.3

GC content: 65.55

Gene sequence:

>1071_bases
ATGCTTGTTCTGCCCAGCGCGCGCGTCTGCGCCGCGCTCTTGTTGGCCGCTGTCCTGGCCGGTTGTAGCCGTCAGGCCAG
CACGCCAGCCGCTGCCAAACCCATTCCGGTCTCTATGCAGGCGGTGACCACCCAACCCTGGAACTCGACCGTGCAGTCGA
TCGCCACGGTGCGTGCGCGCGAATCGGTGGCGCTCACCGCTGCGGTCAGCGATGTGGTGGAGCAGGTGTATTTCGACAGC
GGCGACGAGGTCAAGGCCGGGCAATTGCTGCTGCGTTTGCGCGGCAATTCGCAACAGGCGGCACTGACCGCCGCACAGGC
CACCTTCGAAGAAACCGACCAGTTGTATCGCCGGCAGTCGAGTCTGGTTGGCCAGCAACTGGTGGCCAAATCCACCGTGG
ATACGCAGCGTGCGCTACGCGATGCCGCGCAGGCGCGTGTGCAGCAGATGCGCGCGGAAATCACCGACCGCGAGGTGCGC
GCCCCGTTTTCCGGCGTACTCGGCATTCGCCAGATCAGTCCTGGCGCGTTGATCACCTCCAGCACGGTGATCGCCACATT
GGACGATGTGGCGCGCATGTACGTGGATTTCCAGGTGCCAGAATCGCAATTCGGCCTAGTGCAGGTCGGCAATTCGGTCA
GCGGCAGCGCAGCGGCCTATCCCGGCGCGCAGTTCGAAGGCGAAGTGGTGACCATCGATTCGCGGATCGACGAGACCACG
CGCTCGGTGACGGTACGCGCGGATTTCCCCAACGACGATCGCCGGCTGCGGCCAGGCATGCTGCTGGATGTGCGGCTGTT
CCAGCCGGCGCGGCAGGCGGTGGTGATCCCGGAAATTGCGGTGGTGCAGGTGGGGCGCGAGTCGTATGTGTTCCGGGTCA
AGCCCGATAGCAGCGTGGAGCGCGCCGATGTGCGCGTGGGCGAGCGGCGCGATGGCAAGGTGGAAATTCTCGAAGGCGTC
AAAGCCGGTGAGCGTATCGTGGTGGATGGCACCGGCAAGCTGCGTGTGGGCTTGAAGGTCGTGGACCAGGCACCGCCTGC
GTCGACCCGCCCGCAGGCGGCAGCACAATGA

Upstream 100 bases:

>100_bases
GGCGGCAAGGGTCTTTGGTCATGGTGCAAAGCGCGTCCTTTCTGTCAATTCATGGCGGCTAGGTCGGTAAACTTTCGACG
TACCCCGCCAGGATGTTCTG

Downstream 100 bases:

>100_bases
AACTCTCCGACCTGTCGATCACCCGCCCGGTGATGGCGGTGGTGATGAGTTTGCTGCTGATCGTGCTGGGGGTGATGTCG
TTCACCCGCCTCACCCTGCG

Product: RND efflux membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLVLPSARVCAALLLAAVLAGCSRQASTPAAAKPIPVSMQAVTTQPWNSTVQSIATVRARESVALTAAVSDVVEQVYFDS
GDEVKAGQLLLRLRGNSQQAALTAAQATFEETDQLYRRQSSLVGQQLVAKSTVDTQRALRDAAQARVQQMRAEITDREVR
APFSGVLGIRQISPGALITSSTVIATLDDVARMYVDFQVPESQFGLVQVGNSVSGSAAAYPGAQFEGEVVTIDSRIDETT
RSVTVRADFPNDDRRLRPGMLLDVRLFQPARQAVVIPEIAVVQVGRESYVFRVKPDSSVERADVRVGERRDGKVEILEGV
KAGERIVVDGTGKLRVGLKVVDQAPPASTRPQAAAQ

Sequences:

>Translated_356_residues
MLVLPSARVCAALLLAAVLAGCSRQASTPAAAKPIPVSMQAVTTQPWNSTVQSIATVRARESVALTAAVSDVVEQVYFDS
GDEVKAGQLLLRLRGNSQQAALTAAQATFEETDQLYRRQSSLVGQQLVAKSTVDTQRALRDAAQARVQQMRAEITDREVR
APFSGVLGIRQISPGALITSSTVIATLDDVARMYVDFQVPESQFGLVQVGNSVSGSAAAYPGAQFEGEVVTIDSRIDETT
RSVTVRADFPNDDRRLRPGMLLDVRLFQPARQAVVIPEIAVVQVGRESYVFRVKPDSSVERADVRVGERRDGKVEILEGV
KAGERIVVDGTGKLRVGLKVVDQAPPASTRPQAAAQ
>Mature_356_residues
MLVLPSARVCAALLLAAVLAGCSRQASTPAAAKPIPVSMQAVTTQPWNSTVQSIATVRARESVALTAAVSDVVEQVYFDS
GDEVKAGQLLLRLRGNSQQAALTAAQATFEETDQLYRRQSSLVGQQLVAKSTVDTQRALRDAAQARVQQMRAEITDREVR
APFSGVLGIRQISPGALITSSTVIATLDDVARMYVDFQVPESQFGLVQVGNSVSGSAAAYPGAQFEGEVVTIDSRIDETT
RSVTVRADFPNDDRRLRPGMLLDVRLFQPARQAVVIPEIAVVQVGRESYVFRVKPDSSVERADVRVGERRDGKVEILEGV
KAGERIVVDGTGKLRVGLKVVDQAPPASTRPQAAAQ

Specific function: Acrab Is A Drug Efflux Protein With A Broad Substrate Specificity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786668, Length=381, Percent_Identity=27.2965879265092, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1789665, Length=377, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082036, Length=326, Percent_Identity=27.6073619631902, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789929, Length=359, Percent_Identity=26.1838440111421, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38178; Mature: 38178

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLPSARVCAALLLAAVLAGCSRQASTPAAAKPIPVSMQAVTTQPWNSTVQSIATVRAR
CEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
ESVALTAAVSDVVEQVYFDSGDEVKAGQLLLRLRGNSQQAALTAAQATFEETDQLYRRQS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SLVGQQLVAKSTVDTQRALRDAAQARVQQMRAEITDREVRAPFSGVLGIRQISPGALITS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCEEEECCCCCEEEC
STVIATLDDVARMYVDFQVPESQFGLVQVGNSVSGSAAAYPGAQFEGEVVTIDSRIDETT
CHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
RSVTVRADFPNDDRRLRPGMLLDVRLFQPARQAVVIPEIAVVQVGRESYVFRVKPDSSVE
EEEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEECCCEEEEEECCCCEEEEECCCCCCC
RADVRVGERRDGKVEILEGVKAGERIVVDGTGKLRVGLKVVDQAPPASTRPQAAAQ
HHHHCCCCCCCCCCCEECCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLVLPSARVCAALLLAAVLAGCSRQASTPAAAKPIPVSMQAVTTQPWNSTVQSIATVRAR
CEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
ESVALTAAVSDVVEQVYFDSGDEVKAGQLLLRLRGNSQQAALTAAQATFEETDQLYRRQS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SLVGQQLVAKSTVDTQRALRDAAQARVQQMRAEITDREVRAPFSGVLGIRQISPGALITS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCEEEECCCCCEEEC
STVIATLDDVARMYVDFQVPESQFGLVQVGNSVSGSAAAYPGAQFEGEVVTIDSRIDETT
CHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
RSVTVRADFPNDDRRLRPGMLLDVRLFQPARQAVVIPEIAVVQVGRESYVFRVKPDSSVE
EEEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEECCCEEEEEECCCCEEEEECCCCCCC
RADVRVGERRDGKVEILEGVKAGERIVVDGTGKLRVGLKVVDQAPPASTRPQAAAQ
HHHHCCCCCCCCCCCEECCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]