Click here to switch to the map view.

The map label for this gene is mdtE [H]

Identifier: 84624301

GI number: 84624301

Start: 2960607

End: 2961911

Strand: Direct

Name: mdtE [H]

Synonym: XOO_2644

Alternate gene names: 84624301

Gene position: 2960607-2961911 (Clockwise)

Preceding gene: 84624300

Following gene: 84624302

Centisome position: 59.93

GC content: 68.74

Gene sequence:

>1305_bases
ATGATTGCCCTGCTCCGCTCATTCGGCCTGGCCTGTGCCATCACCGTGGCGCTCGCTGCCTGCAGCAAGCCCGAACAACA
GCAGGCACCGCCGCCGGAAGTGTCGGTGCTGGAAATGAAGCCGCAGACGCTGCCGCTGGAACGCGACCTGGTCGGCCGCC
TATCGGCATACCGCTCGGCCGATGTGCGCGCACGCGTGGACGGCGTGGTGCTCAAGCGCCTGTACACCGAAGGCGCCAAC
GTCAAAGAGGGCCAACCGCTGTTCCAGATCGACCCGTCGCAGCTGAAGGCCACGCTGCTGCAGGCGCAGGGCCAGCTGGC
CGCCGCCGAAGCGACCTATACCAACGCCAAGATCGCCGCGACGCGTGCGCGCAGCCTGGCGCCGCAGCAGTACGTCTCGC
GCGCCGACATCGACACCGCCGAAGCCAACGAGCGTTCGTCCGGCGCCAGCGTGCAACAGGCGCGCGGCGCGGTCGAAGCC
GCGCGCATCCACCTCAGCTTCGCCACCGTCACCTCGCCGATCACCGGTCGCGCCGGTATCCAGCGCGTCACCGAAGGCGC
ACTGGTCGGTGCCGGTGAAGCCACCCTGCTCACCACCGTCGACCAGATAGACCCGCTGTACGTGAACTTCGCCATGAACA
GCGAAGAACTGGCTGCCCTGCGTCAGGCGCAGAGCAGCGGCAACGTGCAGCTCAGCGGCGACGGCAAGTCCTCCATCAAC
GTGGAGCTGGGCAACGGCACGCAGTACCAGCACCCCGGCACGCTGGACGTCTCTGCGGTGACGGTAAACCCGAGTACCGG
TGCGGTGTCGCTGCGCGCCACCTTGCCCAACCCCGAACAATCGCTGCTGCCGGGCGCGTTCGTGACGTTCAAGGCCAGCC
TGGGCCAGCGCAACAATGCCTACCTGCTGCCGCAGCAGGCGTTGCAGCGCGATGCCACCGGACCCTACGTCCTGGTGCTG
GACAAGGACGGCAAGGTGGCCCGCAAGAACCTTACCGTCGACGGCCAGCAGAAGGGCCAGTGGATCGTCACCGGCGGCAT
GACCCAGGGCGACCAGGTCATCGTCGATGGCGTGCAAAAGGCCAAGCAAGGGCAGCCGGCCAAGGGCGTGCCGTGGGATC
CGAACAAGCCGGCACAAGGCGGCCAGCCCGGCTCACCGGGCGCGGCGCCTGCCGCGGCCCAGAGTGGCGATGCGCAAGCC
GCACCGTCCGCCGACAAGGCCGATGCAGCGGCGCCGGCCGCTCAGCAACAGCCCAAGCAGGATGCGGCCGCGCAACCGGC
CGACTCCCAGTCCACGCAGCAGTGA

Upstream 100 bases:

>100_bases
CCGTGGACGCCTTCTTGCGTGCGTTCGCTACGGCACCTGCCGCGCCGACGCTGGCACCACCATCTCTTCTCACTTCAAGA
CCCTAACGGAGTTCCTCCTC

Downstream 100 bases:

>100_bases
CGGAACCCGGACATGCCTAAGTTTTTTATCGAACACCCGGTCTTTGCGTGGGTGGTGGCGATCCTGATCTCGCTTGCGGG
CGTGATCTCGATCCTGAATC

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MIALLRSFGLACAITVALAACSKPEQQQAPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGAN
VKEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGASVQQARGAVEA
ARIHLSFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMNSEELAALRQAQSSGNVQLSGDGKSSIN
VELGNGTQYQHPGTLDVSAVTVNPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQALQRDATGPYVLVL
DKDGKVARKNLTVDGQQKGQWIVTGGMTQGDQVIVDGVQKAKQGQPAKGVPWDPNKPAQGGQPGSPGAAPAAAQSGDAQA
APSADKADAAAPAAQQQPKQDAAAQPADSQSTQQ

Sequences:

>Translated_434_residues
MIALLRSFGLACAITVALAACSKPEQQQAPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGAN
VKEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGASVQQARGAVEA
ARIHLSFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMNSEELAALRQAQSSGNVQLSGDGKSSIN
VELGNGTQYQHPGTLDVSAVTVNPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQALQRDATGPYVLVL
DKDGKVARKNLTVDGQQKGQWIVTGGMTQGDQVIVDGVQKAKQGQPAKGVPWDPNKPAQGGQPGSPGAAPAAAQSGDAQA
APSADKADAAAPAAQQQPKQDAAAQPADSQSTQQ
>Mature_434_residues
MIALLRSFGLACAITVALAACSKPEQQQAPPPEVSVLEMKPQTLPLERDLVGRLSAYRSADVRARVDGVVLKRLYTEGAN
VKEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAATRARSLAPQQYVSRADIDTAEANERSSGASVQQARGAVEA
ARIHLSFATVTSPITGRAGIQRVTEGALVGAGEATLLTTVDQIDPLYVNFAMNSEELAALRQAQSSGNVQLSGDGKSSIN
VELGNGTQYQHPGTLDVSAVTVNPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNAYLLPQQALQRDATGPYVLVL
DKDGKVARKNLTVDGQQKGQWIVTGGMTQGDQVIVDGVQKAKQGQPAKGVPWDPNKPAQGGQPGSPGAAPAAAQSGDAQA
APSADKADAAAPAAQQQPKQDAAAQPADSQSTQQ

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=356, Percent_Identity=39.6067415730337, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1789665, Length=375, Percent_Identity=38.9333333333333, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1786668, Length=380, Percent_Identity=39.2105263157895, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082036, Length=314, Percent_Identity=29.6178343949045, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45091; Mature: 45091

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALLRSFGLACAITVALAACSKPEQQQAPPPEVSVLEMKPQTLPLERDLVGRLSAYRSA
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCC
DVRARVDGVVLKRLYTEGANVKEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAA
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHCCCEEEEHEECCCCEEEH
TRARSLAPQQYVSRADIDTAEANERSSGASVQQARGAVEAARIHLSFATVTSPITGRAGI
HHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCHHEEEEEEEEEHHHCCCCCCHHHH
QRVTEGALVGAGEATLLTTVDQIDPLYVNFAMNSEELAALRQAQSSGNVQLSGDGKSSIN
HHHHCCCEECCCCCEEEEEHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEEE
VELGNGTQYQHPGTLDVSAVTVNPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNA
EEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHCCCEEEEEEECCCCCCCE
YLLPQQALQRDATGPYVLVLDKDGKVARKNLTVDGQQKGQWIVTGGMTQGDQVIVDGVQK
EECCHHHHHCCCCCCEEEEECCCCCEEECCCEECCCCCCCEEEECCCCCCCCHHHHHHHH
AKQGQPAKGVPWDPNKPAQGGQPGSPGAAPAAAQSGDAQAAPSADKADAAAPAAQQQPKQ
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCCH
DAAAQPADSQSTQQ
HHCCCCCCCCCCCC
>Mature Secondary Structure
MIALLRSFGLACAITVALAACSKPEQQQAPPPEVSVLEMKPQTLPLERDLVGRLSAYRSA
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCC
DVRARVDGVVLKRLYTEGANVKEGQPLFQIDPSQLKATLLQAQGQLAAAEATYTNAKIAA
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHCCCEEEEHEECCCCEEEH
TRARSLAPQQYVSRADIDTAEANERSSGASVQQARGAVEAARIHLSFATVTSPITGRAGI
HHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCHHEEEEEEEEEHHHCCCCCCHHHH
QRVTEGALVGAGEATLLTTVDQIDPLYVNFAMNSEELAALRQAQSSGNVQLSGDGKSSIN
HHHHCCCEECCCCCEEEEEHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCCCCEEE
VELGNGTQYQHPGTLDVSAVTVNPSTGAVSLRATLPNPEQSLLPGAFVTFKASLGQRNNA
EEECCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCHHHHCCCEEEEEEECCCCCCCE
YLLPQQALQRDATGPYVLVLDKDGKVARKNLTVDGQQKGQWIVTGGMTQGDQVIVDGVQK
EECCHHHHHCCCCCCEEEEECCCCCEEECCCEECCCCCCCEEEECCCCCCCCHHHHHHHH
AKQGQPAKGVPWDPNKPAQGGQPGSPGAAPAAAQSGDAQAAPSADKADAAAPAAQQQPKQ
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCCCH
DAAAQPADSQSTQQ
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]