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The map label for this gene is argD [H]

Identifier: 84624012

GI number: 84624012

Start: 2616675

End: 2618171

Strand: Direct

Name: argD [H]

Synonym: XOO_2355

Alternate gene names: 84624012

Gene position: 2616675-2618171 (Clockwise)

Preceding gene: 84624005

Following gene: 84624016

Centisome position: 52.97

GC content: 66.2

Gene sequence:

>1497_bases
ATGTCCGTCCTTGCCCCGCTCGCCCCGCTGCGCGCCCATGCCGGCCGCCGCCTGACCGAAGGCCTGGACGACGCGACCAT
CGCGCGCCTGGCCGCAAACCACCCGGATCTGCAACAGGCCATCGCTGCGGCGGCAGCGGAATACGCACTGGTGCGCGATG
ACGTCGCCGACCTGCTGGATCTGGACGAAGACGGCCAGATCAGCGCAGTGCAGGAAGGTTTCATCAACTTCTACGCCGAC
GATGCAGTGACGCCCTACGTGGCGCTGGCCGCACGCGGGCCGTGGGTGGTCACGCTCAAAGGTGCGGTGCTGTACGACGC
CGGCGGCTACGGCATGCTCGGCTTCGGCCACACGCCGGCGGCGGTGCTTGACGCCATGGCGCGCCCGCAGGTGATGGCCA
ACGTGATGACGCCCAGCCTGGCGCAGCGCCGGTTTGATCGCGCCCTGCGCGCCGAGATCGGCCACAGCCGCGGCAGCTGC
CCGTTCGTCCGCTTCATGTGTCTCAACTCCGGCTCCGAAGCGGTGGGCTTGGCCGCGCGTATCGTCGATACCAATGCCAA
GCTGCACACCGACCCGGGCGCACGGCATGCCGGCGCCACCATCAAGCGCCTGGTGGTCAAGGGCAGTTTCCATGGCCGCA
CCGATCGCCCGGGCCTGTATTCGGATTCAAGCCGCAAGACCTACACCAAGTACCTGGCCAGCTATCGCGACGAGGACTCC
GTCATCGCGATTGCGCCGTATGACGTGGCCGCGTTGCAACGCGCCTTCGACGAGGCCACGCGCAATCACTGGTTTATCGA
AGCGGTATTCCTGGAGCCGGTGATGGGCGAAGGCGACCCTGGACGTGCGTTGCCGGCCGAGTTCTATGCCGCCGCGCGCG
TGCTCACCCGTACCCATGGCAGCCTGCTGCTGGTCGATTCCATCCAGGCCGGGCTGCGCGCGCATGGCGTGCTGTCGGTG
GTGGACTACCCGGGCTTCGAGCAGCTCGACCCGCCGGATCTGGAAACCTATTCCAAGGCACTGAACGCTGCGCAGTACCC
GCTGTCGGTGCTGGCAGTGAACGAGCACGCCGCGCAGGTGTATCGCAAGGGCACCTACGGCAACACCATGACCACCAACC
CGCGCGCGCTCGATGTGGCCTGCGCCACGCTGGCATTGTTTACGCCGCAAGTGCGCGACAACATCCGTCTCCGCGGTGCG
CAGGCGATTGCCAAACTGGAAGCGCTGCAATCCGAACTCGGCGGCTTGATCACCAAGGTGCAAGGCACCGGCCTGCTGTT
CTCCTGCGAGCTGGCATCGCAATTCAAGTGCTACGGCGCCGGTTCGACCGAAGAGTGGTTGCGCCATCGTGGCGTCAACG
TGATCCACGGCGGCGAGAATTCGCTGCGCTTCACCCCGCATTTCGCAATGGATGAAGACGAGCTCGATCTACTGGTCGGC
TTGATCGCGCGTGCGCTCAAGGAAGGCCCACGTCAGGTGCAGGCCGAAGCGGCGTGA

Upstream 100 bases:

>100_bases
TCGATGAAAATAGCGTACTTCCTGCCCAGATTCACGCTGCCAAACGCCGATCTTCTGCCGATAATAGTAAAGGGAATGCC
ACTATTGAAGGAGATGCGCC

Downstream 100 bases:

>100_bases
TCCAGTCCAGATGGCACACCGGCGCGCGTACGCCGTCTGTGTGCAGCCTGGGCAGATGATGAATCTGCCACGAGCCACAT
GCTGTGTGGCTCGGCATTTT

Product: L-lysine 6-aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSVLAPLAPLRAHAGRRLTEGLDDATIARLAANHPDLQQAIAAAAAEYALVRDDVADLLDLDEDGQISAVQEGFINFYAD
DAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLDAMARPQVMANVMTPSLAQRRFDRALRAEIGHSRGSC
PFVRFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
VIAIAPYDVAALQRAFDEATRNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARVLTRTHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVNEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRLRGA
QAIAKLEALQSELGGLITKVQGTGLLFSCELASQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
LIARALKEGPRQVQAEAA

Sequences:

>Translated_498_residues
MSVLAPLAPLRAHAGRRLTEGLDDATIARLAANHPDLQQAIAAAAAEYALVRDDVADLLDLDEDGQISAVQEGFINFYAD
DAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLDAMARPQVMANVMTPSLAQRRFDRALRAEIGHSRGSC
PFVRFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
VIAIAPYDVAALQRAFDEATRNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARVLTRTHGSLLLVDSIQAGLRAHGVLSV
VDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVNEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRLRGA
QAIAKLEALQSELGGLITKVQGTGLLFSCELASQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
LIARALKEGPRQVQAEAA
>Mature_497_residues
SVLAPLAPLRAHAGRRLTEGLDDATIARLAANHPDLQQAIAAAAAEYALVRDDVADLLDLDEDGQISAVQEGFINFYADD
AVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPAAVLDAMARPQVMANVMTPSLAQRRFDRALRAEIGHSRGSCP
FVRFMCLNSGSEAVGLAARIVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDSV
IAIAPYDVAALQRAFDEATRNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARVLTRTHGSLLLVDSIQAGLRAHGVLSVV
DYPGFEQLDPPDLETYSKALNAAQYPLSVLAVNEHAAQVYRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRLRGAQ
AIAKLEALQSELGGLITKVQGTGLLFSCELASQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVGL
IARALKEGPRQVQAEAA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=401, Percent_Identity=26.1845386533666, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI284507298, Length=336, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789759, Length=401, Percent_Identity=25.9351620947631, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788044, Length=321, Percent_Identity=29.595015576324, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=24.2053789731051, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25144274, Length=241, Percent_Identity=23.6514522821577, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=21.1302211302211, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=25.2403846153846, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=338, Percent_Identity=24.5562130177515, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 53653; Mature: 53522

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAPLAPLRAHAGRRLTEGLDDATIARLAANHPDLQQAIAAAAAEYALVRDDVADLLD
CCCCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LDEDGQISAVQEGFINFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPA
CCCCCCCHHHHHHHHHEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCCCCCCCCCHH
AVLDAMARPQVMANVMTPSLAQRRFDRALRAEIGHSRGSCPFVRFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDVAALQRAFDEATRNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARVLTRTHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVNEHAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRLRGAQAIAKLEALQSELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEHHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELASQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
CCCCEEEEECCCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHH
LIARALKEGPRQVQAEAA
HHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
SVLAPLAPLRAHAGRRLTEGLDDATIARLAANHPDLQQAIAAAAAEYALVRDDVADLLD
CCCCCCHHHHHHCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LDEDGQISAVQEGFINFYADDAVTPYVALAARGPWVVTLKGAVLYDAGGYGMLGFGHTPA
CCCCCCCHHHHHHHHHEEECCCCCCCEEEECCCCEEEEEECEEEEECCCCCCCCCCCCHH
AVLDAMARPQVMANVMTPSLAQRRFDRALRAEIGHSRGSCPFVRFMCLNSGSEAVGLAAR
HHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHEEEEE
IVDTNAKLHTDPGARHAGATIKRLVVKGSFHGRTDRPGLYSDSSRKTYTKYLASYRDEDS
EEECCCEEECCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VIAIAPYDVAALQRAFDEATRNHWFIEAVFLEPVMGEGDPGRALPAEFYAAARVLTRTHG
EEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SLLLVDSIQAGLRAHGVLSVVDYPGFEQLDPPDLETYSKALNAAQYPLSVLAVNEHAAQV
CEEEEECHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHH
YRKGTYGNTMTTNPRALDVACATLALFTPQVRDNIRLRGAQAIAKLEALQSELGGLITKV
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEEEHHHHHHHHHHHHHHHHCHHEEEE
QGTGLLFSCELASQFKCYGAGSTEEWLRHRGVNVIHGGENSLRFTPHFAMDEDELDLLVG
CCCCEEEEECCCCCEEEECCCCHHHHHHHCCCEEEECCCCCEEECCCCCCCCHHHHHHHH
LIARALKEGPRQVQAEAA
HHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]