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The map label for this gene is hisS

Identifier: 84623771

GI number: 84623771

Start: 2341105

End: 2342547

Strand: Direct

Name: hisS

Synonym: XOO_2114

Alternate gene names: 84623771

Gene position: 2341105-2342547 (Clockwise)

Preceding gene: 84623769

Following gene: 84623774

Centisome position: 47.39

GC content: 64.86

Gene sequence:

>1443_bases
GTGATCAAGCCCCGTACGCCGCCCGGCATCATGGAATTGCTGCCGCGCGAGCAGATCGCGTTCCAGCGCATGCTGGACGT
CATTCGCCGCAACTACGAGCGGTTCGGGTTCCTTCCGATCGAAACCCCGGTGTTCGAGCTGTCCGATGTGCTGCTGACCA
AGTCCGGCGGCGAGACCGAGCGCCAAGTGTATTTCGTACAGTCCACCGGCGCGCTGGCCAATGCCGCAGCGGCCGCCGAC
GAGGGTGCCGAGAACGGTGGGCTGCCCGAGCTTGCATTGCGCTTCGACCTGACCGTGCCGCTGGCGCGCTATGTCGCCGA
GCACGAGCACGACTTGAGCTTTCCATTCCGTCGTTATCAGATGCAGCGCGTGTACCGCGGCGAGCGTGCGCAACGCGGGC
GCTTCCGTGAGTTCTACCAGTGCGATATCGACGTGATCGGCAAGGATGCGCTGAGCATCCGTTACGACGCCGAAGTCCTG
GCGGTGATCCATGCGGTGTTCGCCGAGCTGGGCATCGGCGACTTCAAGGTGCAGTTGAACAACCGTAAGTTGCTGCGCGG
CTTCTTCGAAAGCCTGGGCGTGGCTGAGGGCGAGTTGCAGCTTGCTGTACTGCGCGAGGTCGACAAGATCGACAAGCGCG
GTGCCGACTATGTGCGCGACACATTGGTGGGCGAAGGCTTCGGCATCGCTGCCGAGCAGGTGGCCAGGATTCTCGCTTTC
GTGGCGTTGCGCTCTGAAGGGCATGCCGATGCGCTGGCGCAGTTGCAGGCGCTGGAAGCGTCGGTCGGCGCCAGTGCGAC
GCTGGGCGAGGGCATTGCCGAGTTGCGCGAAGTGCTCGAGCTGGTCAAGGCGCTGGGCGTGCCCGAGCGCGCGTACTGCC
TGAATTTCTCCATCGCGCGCGGGCTGGATTACTACACCGGCACCGTCTACGAGACCACGCTGACCGACCACCCGCAGATC
GGCTCGATCTGCTCGGGCGGCCGTTACGAAAGCCTGGCCAGCCACTACACCAAGTCCAGATTGCCCGGCGTGGGCATCTC
GATCGGCCTGACCCGCCTGTTCTGGCAGCTGCGCGAGGCCGGCCTGATCCAGGGCATCGCCGAAAGCAGCGTGCAGGCGA
TGGTGGCGCTGATGGACGAGACCCGCCTGGACGACGTGCTGGATATCGCACGTCGGCTGCGCATCGCTGGTATCAATACC
GAGGTGCAGATGGAGCCGAAGAAGGTCGGCAAGCAGTTCCAGTACGCCGCACGCGCGGGCATCCGCTTCGTGGTGCTGGC
CGGCGACGACGAGCTGGCGCGCGGCGTGGTGGCGGTGAAGGACCTGGTGCGCGAGCAGCAATTCGATGTCGCCCGCGACG
AGCTGGCCAGCACTTTGCTGGTTGAGCTGGAACAGGCCAAGGGCGATGCCGTAAGGCGAAGCTGGTCGTTTCTGCTTGCC
TGA

Upstream 100 bases:

>100_bases
CGCTGCTGGGACGCATCGCATGCTACGCCATGCGGTCAGCGCGGCCGCCCAGCCGGTAGAATTGTGCGTTCGCCACATTT
GTCCTGCAGGAGTTTCGCTC

Downstream 100 bases:

>100_bases
TTTCAAGGGTGCTGCAGCTGTCTGCCGTGCGAGTCCGGTGGGCATCCTGTTTTAAGAGAGGCGGGCGCAGTGGTTTGTGC
CGAAATGGTGAGCATCGTGC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPIETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIAAEQVARILAF
VALRSEGHADALAQLQALEASVGASATLGEGIAELREVLELVKALGVPERAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYESLASHYTKSRLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDVLDIARRLRIAGINT
EVQMEPKKVGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLLVELEQAKGDAVRRSWSFLLA

Sequences:

>Translated_480_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPIETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIAAEQVARILAF
VALRSEGHADALAQLQALEASVGASATLGEGIAELREVLELVKALGVPERAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYESLASHYTKSRLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDVLDIARRLRIAGINT
EVQMEPKKVGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLLVELEQAKGDAVRRSWSFLLA
>Mature_480_residues
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPIETPVFELSDVLLTKSGGETERQVYFVQSTGALANAAAAAD
EGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQMQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVL
AVIHAVFAELGIGDFKVQLNNRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIAAEQVARILAF
VALRSEGHADALAQLQALEASVGASATLGEGIAELREVLELVKALGVPERAYCLNFSIARGLDYYTGTVYETTLTDHPQI
GSICSGGRYESLASHYTKSRLPGVGISIGLTRLFWQLREAGLIQGIAESSVQAMVALMDETRLDDVLDIARRLRIAGINT
EVQMEPKKVGKQFQYAARAGIRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLLVELEQAKGDAVRRSWSFLLA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=471, Percent_Identity=33.1210191082803, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI15029520, Length=479, Percent_Identity=29.6450939457203, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI65287717, Length=469, Percent_Identity=21.3219616204691, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788861, Length=478, Percent_Identity=25.3138075313808, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71993686, Length=480, Percent_Identity=31.875, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71993693, Length=480, Percent_Identity=31.875, Blast_Score=204, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6325290, Length=478, Percent_Identity=29.0794979079498, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24643061, Length=484, Percent_Identity=31.198347107438, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24643059, Length=489, Percent_Identity=30.2658486707566, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_XANOM (Q2P3K8)

Other databases:

- EMBL:   AP008229
- RefSeq:   YP_451143.1
- ProteinModelPortal:   Q2P3K8
- SMR:   Q2P3K8
- STRING:   Q2P3K8
- GeneID:   3859248
- GenomeReviews:   AP008229_GR
- KEGG:   xom:XOO_2114
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   YVAEHEH
- PhylomeDB:   Q2P3K8
- ProtClustDB:   PRK00037
- BioCyc:   XORY342109:XOO2114-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 53189; Mature: 53189

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPIETPVFELSDVLLTKSGGETE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCC
RQVYFVQSTGALANAAAAADEGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQ
EEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHH
MQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVLAVIHAVFAELGIGDFKVQLN
HHHHHCCCHHHCCHHHHHHHCCHHEECCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
NRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIAAEQVARILAF
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHH
VALRSEGHADALAQLQALEASVGASATLGEGIAELREVLELVKALGVPERAYCLNFSIAR
HHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHH
GLDYYTGTVYETTLTDHPQIGSICSGGRYESLASHYTKSRLPGVGISIGLTRLFWQLREA
CCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLIQGIAESSVQAMVALMDETRLDDVLDIARRLRIAGINTEVQMEPKKVGKQFQYAARAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCC
IRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLLVELEQAKGDAVRRSWSFLLA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MIKPRTPPGIMELLPREQIAFQRMLDVIRRNYERFGFLPIETPVFELSDVLLTKSGGETE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCC
RQVYFVQSTGALANAAAAADEGAENGGLPELALRFDLTVPLARYVAEHEHDLSFPFRRYQ
EEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHH
MQRVYRGERAQRGRFREFYQCDIDVIGKDALSIRYDAEVLAVIHAVFAELGIGDFKVQLN
HHHHHCCCHHHCCHHHHHHHCCHHEECCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEC
NRKLLRGFFESLGVAEGELQLAVLREVDKIDKRGADYVRDTLVGEGFGIAAEQVARILAF
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHH
VALRSEGHADALAQLQALEASVGASATLGEGIAELREVLELVKALGVPERAYCLNFSIAR
HHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHH
GLDYYTGTVYETTLTDHPQIGSICSGGRYESLASHYTKSRLPGVGISIGLTRLFWQLREA
CCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GLIQGIAESSVQAMVALMDETRLDDVLDIARRLRIAGINTEVQMEPKKVGKQFQYAARAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCC
IRFVVLAGDDELARGVVAVKDLVREQQFDVARDELASTLLVELEQAKGDAVRRSWSFLLA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA