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The map label for this gene is gcvT [H]

Identifier: 84623354

GI number: 84623354

Start: 1865946

End: 1867055

Strand: Direct

Name: gcvT [H]

Synonym: XOO_1697

Alternate gene names: 84623354

Gene position: 1865946-1867055 (Clockwise)

Preceding gene: 84623353

Following gene: 84623355

Centisome position: 37.77

GC content: 63.78

Gene sequence:

>1110_bases
ATGACCCAGAAGACCATCCTCAACGACACCCATCGTGCGCTCGGCGCCAAAATGGTCGACTTCGGCGGTTGGGACATGCC
GATCCACTATGGCTCGCAGTTGGACGAGCACCACCAAGTGCGCCGCGACGCCGGCATGTTCGACGTCAGCCACATGACCG
TGGTCGACCTGCACGGTGCGCGCGTACGCGCGTTTCTGCGCGACCTGCTCGCCAACTCGGTGGACAAGCTCAAGGTCTGC
GGCAAGGCGCTGTACACCTGCATGCTCAATCCGCAGGGTGGGGTGATCGACGACCTCATCGTCTATTACATGAGCGAAGA
CTTCTTCCGGTTGGTGGTCAATGCCGCCACCCGCGAAAAAGATCTGCAGTGGATCGGCGAGCAGGCCGTACGCTTCGATG
TGCGCGTGGAAGAGCGCAGCGACTTCGCGATGATCGCCGTGCAAGGCCCCAACGCACGCGCCAATGTCATCGACCTGCTG
GACCCGGCCGACACCGCAGCGGCGAGCAAGCTCGGCCGTTTCGCTGCACTGCAAACGCGTTCGCGCGATGGCATCGAATT
GTTTCTTGCGCGCACCGGCTACACCGGCGAAGACGGTTTCGAAATCGTGTTGCCGCAGGAGGCCGCCGTCGCGTTCTGGA
ATGCATTGCTCGCGCAGGGCGTCAAGCCAGCAGGTCTGGGCGCACGCGACACCTTGCGTCTGGAAGCGGGAATGCATCTT
TACGGGCAGGACATGGACGATGCGGTCACCCCCTACGAAGCCGCGCTGGCCTGGACGATTGCCCTGGACGAAGGACGCGA
CTTCATCGGTCGCCGTGTGCTCGAGTCGCAAAAGGCGCAGGGTGCACCGCGTCAGTTGATCGGTGTGGTGATGGACGACA
AGGGCGTGCTGCGACATGGCCAGGCGGTGTTCACCGCCAGTGGCGAAGGCGAGATTTTGTCCGGCACGTTCTCGCCGACG
CTCGGCAAGGCGATCGCCTTCGCGCGCGTGCCGGCCGGCAGCATCGATCAGCTACGCGTGGACATCCGTGGCAAGCAGGT
GCCGTTGCGCGCGGTGAAATTTCCGTTCGTTCGCGATGGCCAGGCACAGCCCGGCGTGCTCGGCGACTGA

Upstream 100 bases:

>100_bases
TCACTGTTCTCCAATCAGCGTAATCGCGCTGCTGCGCGCACGCCGTTCCCCAGGCGCGGCAGGACGGGGATAATGAGCGT
CTTTCCTTGGACCGGCGCTC

Downstream 100 bases:

>100_bases
AGCGTGCGACGCCGTGCATCCTGCGCACGGTGCCGCGTCCGCATCACCCGCCACCACACTGCCGCGTGCACCTGTCTCGT
CGCGCGGTCTAAACTAACCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVRAFLRDLLANSVDKLKVC
GKALYTCMLNPQGGVIDDLIVYYMSEDFFRLVVNAATREKDLQWIGEQAVRFDVRVEERSDFAMIAVQGPNARANVIDLL
DPADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMHL
YGQDMDDAVTPYEAALAWTIALDEGRDFIGRRVLESQKAQGAPRQLIGVVMDDKGVLRHGQAVFTASGEGEILSGTFSPT
LGKAIAFARVPAGSIDQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Sequences:

>Translated_369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVRAFLRDLLANSVDKLKVC
GKALYTCMLNPQGGVIDDLIVYYMSEDFFRLVVNAATREKDLQWIGEQAVRFDVRVEERSDFAMIAVQGPNARANVIDLL
DPADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMHL
YGQDMDDAVTPYEAALAWTIALDEGRDFIGRRVLESQKAQGAPRQLIGVVMDDKGVLRHGQAVFTASGEGEILSGTFSPT
LGKAIAFARVPAGSIDQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD
>Mature_368_residues
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVRAFLRDLLANSVDKLKVCG
KALYTCMLNPQGGVIDDLIVYYMSEDFFRLVVNAATREKDLQWIGEQAVRFDVRVEERSDFAMIAVQGPNARANVIDLLD
PADTAAASKLGRFAALQTRSRDGIELFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMHLY
GQDMDDAVTPYEAALAWTIALDEGRDFIGRRVLESQKAQGAPRQLIGVVMDDKGVLRHGQAVFTASGEGEILSGTFSPTL
GKAIAFARVPAGSIDQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=34.6666666666667, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI257796258, Length=345, Percent_Identity=34.7826086956522, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796254, Length=370, Percent_Identity=31.6216216216216, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI24797151, Length=337, Percent_Identity=29.9703264094956, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI257796256, Length=287, Percent_Identity=35.8885017421603, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI197927446, Length=345, Percent_Identity=28.695652173913, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI21361378, Length=345, Percent_Identity=28.695652173913, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194306651, Length=350, Percent_Identity=23.4285714285714, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=57.6086956521739, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=35.4666666666667, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32563613, Length=344, Percent_Identity=23.8372093023256, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994052, Length=353, Percent_Identity=24.0793201133144, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994045, Length=353, Percent_Identity=24.0793201133144, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=36.1256544502618, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=34.9333333333333, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI28571104, Length=268, Percent_Identity=27.6119402985075, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI20130091, Length=386, Percent_Identity=25.9067357512953, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40339; Mature: 40207

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVRAFLRDLLANSVDKLKVCGKALYTCMLNPQGGVIDDLIVYYMSEDFFRLVVNAATREK
HHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAVRFDVRVEERSDFAMIAVQGPNARANVIDLLDPADTAAASKLGRFAALQTR
HHHHHCCHHEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIELFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMHL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEE
YGQDMDDAVTPYEAALAWTIALDEGRDFIGRRVLESQKAQGAPRQLIGVVMDDKGVLRHG
ECCCCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCC
QAVFTASGEGEILSGTFSPTLGKAIAFARVPAGSIDQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHHEECCCCCCCEEEEEECCCCCCHHHEECCCEECC
QAQPGVLGD
CCCCCCCCC
>Mature Secondary Structure 
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVRAFLRDLLANSVDKLKVCGKALYTCMLNPQGGVIDDLIVYYMSEDFFRLVVNAATREK
HHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAVRFDVRVEERSDFAMIAVQGPNARANVIDLLDPADTAAASKLGRFAALQTR
HHHHHCCHHEEEEEEEECCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIELFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMHL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEE
YGQDMDDAVTPYEAALAWTIALDEGRDFIGRRVLESQKAQGAPRQLIGVVMDDKGVLRHG
ECCCCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCC
QAVFTASGEGEILSGTFSPTLGKAIAFARVPAGSIDQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHHEECCCCCCCEEEEEECCCCCCHHHEECCCEECC
QAQPGVLGD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]