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The map label for this gene is relA [H]

Identifier: 84623294

GI number: 84623294

Start: 1781194

End: 1783377

Strand: Direct

Name: relA [H]

Synonym: XOO_1637

Alternate gene names: 84623294

Gene position: 1781194-1783377 (Clockwise)

Preceding gene: 84623288

Following gene: 84623295

Centisome position: 36.05

GC content: 67.12

Gene sequence:

>2184_bases
GTGCCCGCCACCGTGTCCACTGTTGTGACCAGTTCCTCATTCGATCGCCTGCAGGCTTTGTTGCAGCGCCCGGCCGTGGC
CTCCATTTCCCCGGCATTGCGCGAAGCGTTGGCGCGGGCCTGGCAGGAGCTGCCGCCCGCGCAGACCGATAACGTGCCGT
GGGCCCTGCTTGGCGACACCCTGGACGCACTGGCGCTGCTGGCGGCCGACGAGGCCACATTGATTGCAGCATTGCTGTTC
GATCTGCCCGCGCTGCGCGGCGCGGTGACCGACCTGCCGTGGCAGCCGGCGGAGCGGCGGGTGGCAGTGGAAGGATTGCT
GGATGGCCTGGATGCAGCCGATCAGGTCTGGGCGCTGCATGCCGGGCGCGAGGCCGGGCGCAACAGCGAAGGGTTGCGGC
GACTGCTGCTTTCCATCATCCACGACCTGCGCGTGGTGCCGATCCTGTTGGCGCGGCAGCTGTCGCGCATGCGTGTGGCC
GACCGTCTCAGTAAAGAACAGCGCCATGCACTGGCCCAACTCACGCGCGACATCCACGCGCCGCTGGCGAACCGGCTGGG
CATCTGGCAGGTGAAGTGGGAGCTGGAAGATCTGGCGTTCCGGCATCTGGAGCCTGACACCTATCGCCGCATCGCCCGCG
AAGTGGACGAAACCCGCGTGGCGCGCGAGCGCTATCTGGAAGCGGTCAAGCGCACCTTGTCGGCGGCGCTCGCCCAGCAG
GGCCTGCGCGCAGACGTCAGCGGGCGGCCCAAACACATCTACAGCATCTGGCGGAAGATGCAGAAGAAGCGGCTGTCGTT
CGATCAGCTATACGACATCCGCGCGGTGCGGGTGATGGTCGACGATGTGGCGGCCTGTTACGCCGCGCTGGGCGCTGTGC
ATTCATTGTGGGCGCCGGTGCCGAGCGAGTTCGACGATTACATCGCCCGGCCCAAGGCCAACGATTATCGCTCGCTGCAT
ACCGCGGTGGTCGGCCAGGAAGGGCGCACGATCGAAATCCAGATCCGCACCCATGAGATGCACGCCCAGGCCGAACTCGG
CGTGGCTGCGCACTGGAAATACAAGGAAGGCGGCAAGGGCGGCGAAAAGGCCTTCGACCGCAAGATTCTGTGGATGCGCC
AGCTGCTGGAACAGGTGCAGGAAGGCGAGCACGGCGAACTGGCCGGCGCGCTGGATGCCGAGCTGATCGAAGACCGCGTG
TATGCGCTGACCCCCAAGGGCGAGGTGATCGATCTGCCGCAAGGCGCAACGCCGCTGGATTTTGCGTACCACGTCCACAC
CATGGTCGGGCATCGCTGCCGCGGCGCGCGCGTCAACGACCGCATCGTGCCGCTGACCTACCGGCTGCGCAGCGGCGACC
GTGTGGAGATCATGACCGCCAAGGAAGCGGACCCGCGCCGCGACTGGTTGCTGGCCTCCAACGGTTTTCTGGCCAGCGGG
CGTTCGCGCGACAAGGTGCGTGCGTGGTTCCACAAGCTGGACCGCGCGCGCAACGTGCAGGCCGGCAAGGATTTGCTCGA
TCGCGAGCTCAAACGCCTGGGCCTCCAGCATGCGGATCTGAGCGTGGCCACGCGCAAATTCCACGCCGACACCATCGACG
ATTTGTATATCCAGGTGGCATTGGGCGATACCGGGCCGAATCAGGTCAGCCGCGCATTACTGGAAGCCGAGCGTGCCGCC
TCGCAGCCGGCGGTACCGGCGCCCCCGCGGCCGACTGCGCGTCGCGAGGGGCTGGGCAAATCCAAATTCACCGTGGAGGG
CGTGGGCAACCTGCTGGTGCAGCTGGCGCGGTGTTGCCAACCCGTGGCGGGCGAGCCGATTGCCGGCTACCTCACCCGCG
GCCGCGGCATCACCGTGCATCGCACCGATTGCGCGGCATTGGCGCGCTTGGCCGCCGCCCATACGCAGCGGGTCTTGCCG
GTGGAGTGGGGCAAGGCCGGCACCGGCTACGAGGTCGATGTGCAGGTGCGCGCGGTGGACCGCCGCTGGCTGCTCAAGGA
CATCACCAACCTGATCGCCCAGGAAGACGCGCACGTGCTGGAAATCAATAGCGACAACGTGCGCGACACGGGCAGGGCGC
AGCTGCGCTTGCGCCTGAAGGTAAGCGATTACGACCAGCTGTCCGGACTGCTTGGCAAGCTGGACGCGCTGCCCGGCGTG
AGCGAGGTACGGCGGCTGGGCTGA

Upstream 100 bases:

>100_bases
TGGCATAAGCACCAGACCCTTCTCGCATTGCGAACGCGGTACCACCACGCGTTGTGGAGAAGGTGACGCGCACGTTACCG
TAGTCATCAGCCATCTGTTG

Downstream 100 bases:

>100_bases
GCGCGCCGAAAATTTTGCTGGCGCCCATCGATTGGAAACAAACAGCACGCAAGGGACGCGGGTTGTGCTTGCCTGCCGAA
TCCCGAATCCCGAATCCCGA

Product: ATP:GTP 3'-pyrophosphotranferase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MPATVSTVVTSSSFDRLQALLQRPAVASISPALREALARAWQELPPAQTDNVPWALLGDTLDALALLAADEATLIAALLF
DLPALRGAVTDLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLSRMRVA
DRLSKEQRHALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPDTYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
GLRADVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLH
TAVVGQEGRTIEIQIRTHEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRV
YALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVATRKFHADTIDDLYIQVALGDTGPNQVSRALLEAERAA
SQPAVPAPPRPTARREGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHTQRVLP
VEWGKAGTGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGV
SEVRRLG

Sequences:

>Translated_727_residues
MPATVSTVVTSSSFDRLQALLQRPAVASISPALREALARAWQELPPAQTDNVPWALLGDTLDALALLAADEATLIAALLF
DLPALRGAVTDLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLSRMRVA
DRLSKEQRHALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPDTYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
GLRADVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLH
TAVVGQEGRTIEIQIRTHEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRV
YALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVATRKFHADTIDDLYIQVALGDTGPNQVSRALLEAERAA
SQPAVPAPPRPTARREGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHTQRVLP
VEWGKAGTGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGV
SEVRRLG
>Mature_726_residues
PATVSTVVTSSSFDRLQALLQRPAVASISPALREALARAWQELPPAQTDNVPWALLGDTLDALALLAADEATLIAALLFD
LPALRGAVTDLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLSRMRVAD
RLSKEQRHALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPDTYRRIAREVDETRVARERYLEAVKRTLSAALAQQG
LRADVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLHT
AVVGQEGRTIEIQIRTHEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVY
ALTPKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGR
SRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVATRKFHADTIDDLYIQVALGDTGPNQVSRALLEAERAAS
QPAVPAPPRPTARREGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHTQRVLPV
EWGKAGTGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVS
EVRRLG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=714, Percent_Identity=42.0168067226891, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1790082, Length=672, Percent_Identity=34.077380952381, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 80907; Mature: 80775

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATVSTVVTSSSFDRLQALLQRPAVASISPALREALARAWQELPPAQTDNVPWALLGDT
CCCCHHHHHCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
LDALALLAADEATLIAALLFDLPALRGAVTDLPWQPAERRVAVEGLLDGLDAADQVWALH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLSRMRVADRLSKEQRHALAQLTRDIHA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLANRLGIWQVKWELEDLAFRHLEPDTYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
HHHHCCCEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRADVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSEFDDYIARPKANDYRSLHTAVVGQEGRTIEIQIRTHEMHAQAELGVAAHWKYKEGGKG
CCCHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHCCEEEEECCCCCCCC
GEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLD
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHH
FAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECC
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVATRKFHADTIDDLYIQVA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
LGDTGPNQVSRALLEAERAASQPAVPAPPRPTARREGLGKSKFTVEGVGNLLVQLARCCQ
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHHHHHHHHHHCC
PVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHTQRVLPVEWGKAGTGYEVDVQVRAVD
CCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEEHH
RRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGV
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCH
SEVRRLG
HHHHHCC
>Mature Secondary Structure 
PATVSTVVTSSSFDRLQALLQRPAVASISPALREALARAWQELPPAQTDNVPWALLGDT
CCCHHHHHCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
LDALALLAADEATLIAALLFDLPALRGAVTDLPWQPAERRVAVEGLLDGLDAADQVWALH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLSRMRVADRLSKEQRHALAQLTRDIHA
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLANRLGIWQVKWELEDLAFRHLEPDTYRRIAREVDETRVARERYLEAVKRTLSAALAQQ
HHHHCCCEEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLRADVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVDDVAACYAALGAVHSLWAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSEFDDYIARPKANDYRSLHTAVVGQEGRTIEIQIRTHEMHAQAELGVAAHWKYKEGGKG
CCCHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHCCEEEEECCCCCCCC
GEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLD
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHH
FAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECC
RSRDKVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVATRKFHADTIDDLYIQVA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
LGDTGPNQVSRALLEAERAASQPAVPAPPRPTARREGLGKSKFTVEGVGNLLVQLARCCQ
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEHHHHHHHHHHHHHHCC
PVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHTQRVLPVEWGKAGTGYEVDVQVRAVD
CCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEEHH
RRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGV
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCH
SEVRRLG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]