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The map label for this gene is lysA [H]

Identifier: 84622974

GI number: 84622974

Start: 1436184

End: 1438793

Strand: Direct

Name: lysA [H]

Synonym: XOO_1317

Alternate gene names: 84622974

Gene position: 1436184-1438793 (Clockwise)

Preceding gene: 84622970

Following gene: 84622975

Centisome position: 29.07

GC content: 65.52

Gene sequence:

>2610_bases
ATGTCAGCTCCCCACTCTACCGATCGTTGGATCGTCCTCAAGTTCGGCGGCACTTCGGTGTCGCGTCGTCATCGCTGGGA
CACGATTGGACAACTGGCGAGCAAACGGGCCAGCGAAACCGGCGGCCGCGTGCTGGTGGTGGTGTCCGCATTGTCGGGCG
TGACCAACGCGCTCACCGCCATTGCCGATGGCGCTGCGGACAGCGCACAGCGCGTGGCGGCACTGGACCAACGCCATCGT
GAGTTTCTGGCCGAGCTCGAACTGGACGCCGACGCGGTGCTGGGTGAGCGGCTGGCCGCACTGCATGCATTGCTGAGCGA
CGCGCGCGCCGCAACGCGCACGCTGGAATGGCAGGCCGAGGTGTTGGGGCAGGGCGAGTTGCTATCGTCCACCATTGGTG
CGGCGTATCTGCATGCCAGCGGCCTGGACATGGGCTGGCTGGACGCGCGCCAGTGGTTGTCGGCGCTGCCGCCGCAGCCC
AATCAGAGCGAATGGTCCAAGCGGCTGTCGGTGTCGTGCCAATGGCAGTCCGATGCAGATTGGCGTGCGCGTTTCGCCGC
CCAGCCCACGCGTCTGTTGATCACCCAGGGCTTCATTGCGCGGCACGCCGATGGCGGCACCGCGATTCTGGGCCGTGGCG
GTTCGGACACTTCGGCGGCGTACTTCGGCGCGCTGCTCGGCGCCAGCCGGGTGGAAATCTGGACCGACGTGCCCGGCATG
TTCAGCGCCAACCCGAAAGAGGTACCGGATGCGCGCCTGCTGACCCGGCTGGACTATTACGAAGCACAGGAAATCGCCAC
CACCGGCGCCAAGGTGCTGCATCCGCGTTCGATCAAACCGTGCCGCGATTCCGGCGTGCCGATGGCGATTCTGGACACCG
AGCGCCCCGATCTGCCGGGCACCAGCATCGATGGCAATGCCGAGCCGGTGCTGGGCGTCAAGGCGATCAGCCGCCGCAAC
GGCATCGTGCTGGTGTCGATGGAAGGCATCGGCATGTGGCAACAGGTGGGCTTCCTGGCCGACGTGTTCACGCTGTTCAA
AAAGCATGGGCTGTCGGTGGACTTGATCGGTTCGGCCGAGACCAACGTCACTGTGTCGCTGGATCCTTCGGAAAACCTGG
TCAACACCGATGTGCTGGCGGCGTTGTCGGCCGATCTGTCGCAGATCTGCAAGGTCAAGATCATCGTTCCGTGCGCGGCC
ATCACCCTGGTCGGGCGCGGCATGCGCTCGCTGCTGCACAAGCTCTCCGACGTGTGGGCCACGTTCGGGAAAGAACGCGT
GCACATGATTTCGCAGTCGTCCAACGACTTGAACCTGACCTTCGTCATCGACGAATCCGATGCCGACGGCTTGCTGCCGA
TCCTGCACGCGGAACTGATCGACAGCGGTGCGATGCCGGTCAGCGAGGGCGACGTGTTCGGCCCGCGCTGGCGCGAGATC
ACCGGCTCGGTGCGTCCGCGCCCCACGCCGTGGTGGCACGCCGAGCGCGCGCATCTGCTGTCGCTGTCCAAGGCCGGCAC
GCCGCGCTACGCGTACCATTTGCCCACCGTGCGTGCGCGTGCGCATGCGCTGGCGCAGGTCGCCGCGGTGGATCAACGCT
ACTACGCGATCAAAGCCAACGCGCATCCGGCCATTTTAATGGCGCTGGAACAGGCCGGCTTCGGGCTGGAATGCGTCTCG
CATGGCGAAGTGCGCCGTGTGTTTCAGGCGTTGCCCGAACTGTCGCCGCGGCGCGTGCTGTTCACGCCGAGCTTTGCGCC
CAAGGCCGAATACGCAGCGGCCTTCGCGCTGGGCGTGACCGTCACCGTGGATAACGTCGAAGCGCTGCGCAACTGGCCGG
AGGTCTTTCGTGGCCGCAATATCTGGCTGCGCATCGATCTGGGGCACGGCGACGGCCATCATGAGAAGGTCAACACCGGG
GGCAAGGCCTCCAAGTTCGGGTTGTCGTCCACGCGCGTGGATGAATTTGTCGACGTGGCGCGCACGCTCGAAGTCACCAT
CACCGGCGTGCATGCGCACCTGGGCAGCGGTGTGGAGACCGGCGAGCATTGGCGGATGATGTACGACGAACTGGCCGGGT
TCGCGCGCCGCATCGGCACGGTGGAGACCATCGACATCGGTGGCGGCTTGCCGATTCCGTACAGCGCCGAAGACGAGCCG
TTCGATCTCGATGTGTGGGCCAAGGGCCTGGCCGAGGTCAAGGCCGTGCATCCTGGCTACCGCCTGGCGATCGAGCCGGG
CCGCTATCTGGTGGCCGAAGCCGGCGTATTGCTGGCCAGCGTCACCCAGGTGATCGAAAAGGACGGCGTGCAGCGCGTGG
GCCTGGATGCGGGCATGAACACCTTGATTCGCCCAGCGTTGTACGATGCCTGGCACGACATCGAAAACCTCAGCCAGCTG
GATGCGCCCGCCGATAGCACGTTCGATGTCGTCGGACCGATCTGCGAATCGTCGGATGTATTCGGCAAGCGTCGCCGCCT
GCCCGCGGCCACCATGCCGGGCGATGTGGTGCTGGTGGCCGACACAGGCGCCTACGGCTACTCGATGGCCAGTACCTACA
ATCAGCGCGAATTACCGCGCGAAGAGGTGATCGATGCGCCCGCTGGCTGA

Upstream 100 bases:

>100_bases
TGTGATCGCACGCGGGGTCATGCGAGCGGCATTGGCAGTAGAATCGGAAGTTGCGCTCGGTATACCGGGCATCTTCCCCC
CCTCCTAAACATCTATCTCA

Downstream 100 bases:

>100_bases
GTTCGTTTTACTCAGCACGCTTGCCGGTGGCGTGGCGATGGTGTTTTCCACCGCCATCGATATCGCCGGGCAACCGACGC
GATGGACCGACAGCCTGAAG

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 869; Mature: 868

Protein sequence:

>869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGQLASKRASETGGRVLVVVSALSGVTNALTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLSDARAATRTLEWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQP
NQSEWSKRLSVSCQWQSDADWRARFAAQPTRLLITQGFIARHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGKERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGDVFGPRWREI
TGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQVAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGEVRRVFQALPELSPRRVLFTPSFAPKAEYAAAFALGVTVTVDNVEALRNWPEVFRGRNIWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLDVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVQRVGLDAGMNTLIRPALYDAWHDIENLSQL
DAPADSTFDVVGPICESSDVFGKRRRLPAATMPGDVVLVADTGAYGYSMASTYNQRELPREEVIDAPAG

Sequences:

>Translated_869_residues
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGQLASKRASETGGRVLVVVSALSGVTNALTAIADGAADSAQRVAALDQRHR
EFLAELELDADAVLGERLAALHALLSDARAATRTLEWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQP
NQSEWSKRLSVSCQWQSDADWRARFAAQPTRLLITQGFIARHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGKERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGDVFGPRWREI
TGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQVAAVDQRYYAIKANAHPAILMALEQAGFGLECVS
HGEVRRVFQALPELSPRRVLFTPSFAPKAEYAAAFALGVTVTVDNVEALRNWPEVFRGRNIWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLDVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVQRVGLDAGMNTLIRPALYDAWHDIENLSQL
DAPADSTFDVVGPICESSDVFGKRRRLPAATMPGDVVLVADTGAYGYSMASTYNQRELPREEVIDAPAG
>Mature_868_residues
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGQLASKRASETGGRVLVVVSALSGVTNALTAIADGAADSAQRVAALDQRHRE
FLAELELDADAVLGERLAALHALLSDARAATRTLEWQAEVLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPN
QSEWSKRLSVSCQWQSDADWRARFAAQPTRLLITQGFIARHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGMF
SANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGNAEPVLGVKAISRRNG
IVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAI
TLVGRGMRSLLHKLSDVWATFGKERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGDVFGPRWREIT
GSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQVAAVDQRYYAIKANAHPAILMALEQAGFGLECVSH
GEVRRVFQALPELSPRRVLFTPSFAPKAEYAAAFALGVTVTVDNVEALRNWPEVFRGRNIWLRIDLGHGDGHHEKVNTGG
KASKFGLSSTRVDEFVDVARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEPF
DLDVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVQRVGLDAGMNTLIRPALYDAWHDIENLSQLD
APADSTFDVVGPICESSDVFGKRRRLPAATMPGDVVLVADTGAYGYSMASTYNQRELPREEVIDAPAG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=392, Percent_Identity=34.1836734693878, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=30.6345733041575, Blast_Score=179, Evalue=6e-46,
Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=30.6079664570231, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790376, Length=485, Percent_Identity=26.8041237113402, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320893, Length=501, Percent_Identity=26.9461077844311, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322664, Length=356, Percent_Identity=24.1573033707865, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586472, Length=348, Percent_Identity=27.0114942528736, Blast_Score=84, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 93985; Mature: 93853

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHSTDRWIVLKFGGTSVSRRHRWDTIGQLASKRASETGGRVLVVVSALSGVTNALTA
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLSDARAATRTLEWQAE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPNQSEWSKRLSVSCQWQSDAD
HHCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCC
WRARFAAQPTRLLITQGFIARHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHHCCCCEEEEECCHHHEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGKERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGDVFGPRWREI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQVAAVDQRYYAIKAN
CCCCCCCCCCCCCCCHHHHEEHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGEVRRVFQALPELSPRRVLFTPSFAPKAEYAAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHEEEEEEEE
VTVDNVEALRNWPEVFRGRNIWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVDVA
EEECCHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLDVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVQRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEECCHHCHH
TLIRPALYDAWHDIENLSQLDAPADSTFDVVGPICESSDVFGKRRRLPAATMPGDVVLVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DTGAYGYSMASTYNQRELPREEVIDAPAG
CCCCCCCHHHHCCCHHCCCHHHHCCCCCC
>Mature Secondary Structure 
SAPHSTDRWIVLKFGGTSVSRRHRWDTIGQLASKRASETGGRVLVVVSALSGVTNALTA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHH
IADGAADSAQRVAALDQRHREFLAELELDADAVLGERLAALHALLSDARAATRTLEWQAE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGQGELLSSTIGAAYLHASGLDMGWLDARQWLSALPPQPNQSEWSKRLSVSCQWQSDAD
HHCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCC
WRARFAAQPTRLLITQGFIARHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHHHHHCCCCEEEEECCHHHEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGNAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGKERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGDVFGPRWREI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TGSVRPRPTPWWHAERAHLLSLSKAGTPRYAYHLPTVRARAHALAQVAAVDQRYYAIKAN
CCCCCCCCCCCCCCCHHHHEEHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
AHPAILMALEQAGFGLECVSHGEVRRVFQALPELSPRRVLFTPSFAPKAEYAAAFALGVT
CCCEEEEEEHHCCCCCEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHEEEEEEEE
VTVDNVEALRNWPEVFRGRNIWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVDVA
EEECCHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLDVWAKGLAEVKAVHPGYRLAIEPGRYLVAEAGVLLASVTQVIEKDGVQRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEECCHHCHH
TLIRPALYDAWHDIENLSQLDAPADSTFDVVGPICESSDVFGKRRRLPAATMPGDVVLVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DTGAYGYSMASTYNQRELPREEVIDAPAG
CCCCCCCHHHHCCCHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]