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The map label for this gene is glmS

Identifier: 84489988

GI number: 84489988

Start: 1363078

End: 1364850

Strand: Direct

Name: glmS

Synonym: Msp_1196

Alternate gene names: 84489988

Gene position: 1363078-1364850 (Clockwise)

Preceding gene: 84489979

Following gene: 84489989

Centisome position: 77.12

GC content: 29.95

Gene sequence:

>1773_bases
ATGTGTGGAATAGTTGGATGTGTTTTAGATAAAAAAGCTGCTCCTATTATTATTGATTCAATTAAAAAACTTGAATATAG
AGGATATGATTCTGTAGGAATTGCTACAGTAACTGATTCAATAAATGTTAAAAAAGGCAGTGGAAAAATTAAAGAAGTTG
ATGATGAAATCAAACTTAAGGATATTGATGGAAACATAGGTATTGCTCATGTCAGATGGGCTACACATGGAAATCCTACA
AAAGAAAATGCACATCCACACTGTGATTGTAAAAATAAGATAAGTATTGTACATAATGGTATAATTGAAAACTACAAAGA
ATTACGTCAAGAACTACTTAATGAAGGACATGTATTTAAATCAGAAACAGATACTGAAGTTATACCTCATTTAATTGAAA
AATATATGGATGAAGGTCTAGACTTATTAAAATCAGTACAAAAAACTGTTAAAAGATTAATAGGATCTTATGCTTTAGCA
GTACTTTCATCAGATGAACCTGATAGAATTATTGGAGCAAGAAATGAAAGTCCTTTGATTGTAGGAGTATCAGATCATGG
AAACTACCTTGCATCTGATGTTCCTGCTATTTTAAATGAAACTAAGAAAGTAATTTATCTTGAAGATAAAGAAATTATTG
TTCTTAAAAAAGATGATGTTACAATAATGGATCTTGACTTAAATGTTCTTGAAAAGAAAATCACCACCATAACATGGGAT
CCTGAAATGGCAGAAAAAGGTGGATATGAACACTTTATGATAAAAGAAATATATGAAGAACCACAAGTAATTAAGGACAC
ATTATCTGAAGCAGAAAAGATAAAGGAAATCGTTAGTAAATTCAAGAATTTCAATAGAATCTGCTTTGTTGCATGTGGAA
CATCGTATCATGCTTCACTTATTGGAGAATATCTTATTGAATCCCAGATAGGAATTCCAACAGAAGTAATACTTGCTTCA
GAATTTGAATACTTCCAAAAAACATTAGATAAACACACATTAGTAATATTCATAACACAATCAGGAGAAACTGCAGACAC
AATAAAAGCTCTGAAAATAGCTAAAAAGAAATCAGAGACTTTAGCTATTGTTAATGTAGTTGGAAGTTCCATTACACGTG
AAGCAGATCATGTTATATATACAAGAGCAGGACCTGAAATTAGTGTAGCTGCTACTAAAACATACATTAGTCAATTAATA
TGTATTTACTTACTTGTAGCATATCTTGGTGAAAATGAAAAACTACTTGATAATTTATATAAAATATCAAGATTATCTGA
GAAAATACTAAGTAGAGAAGAACAAATAAGAGAAATTGCTAAGAAATATAAGTTTGCACGCGACTTCTTCTATATTGGAA
GAGGATTTAACTATCCCACAGCACTTGAAGGAGCATTAAAACTTAAAGAAATAACATATATTCATGGTGAAGGTTATCCT
GCAGGTGAATTAAAACATGGCCCACTTGCATTAATAGAAGATAATATACCAGTAGTTGGAATATTACCTCCTGGACCTAG
CTATAGAAAAACATACAATAATTTACAGGAAATTAAAGCTAGAGGAGCAGATATGATCATATTAGGTGCTAATAATGACA
CTCATCTTGATGATATTGAGGATAAATTATTATTTGATCCTGAAATTGATGAAGTATTATCACCATTATTATATATCATT
GACTTGCAACTATTAGCATATTATATTAGTATTGAAAAGGGTATAGATCCTGATAAACCAAAAAATCTAGCTAAATCTGT
AACAGTAGAATAA

Upstream 100 bases:

>100_bases
ATAATATATGAATTAAATAAATTATATTATAATAATTTAATATAAATTAGTTTAATAACTTAATAAGTTAATGAAATAAT
AAGTTCCAGGTGATTAAATA

Downstream 100 bases:

>100_bases
AAAAAATAATTACTATGAGAAGGTGATTCTGTGAATGACACTACAAAAGGTGAACTTGTTATAGTATTACTCATATCTCT
TCTTGCAATAGGTTGTGGAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MCGIVGCVLDKKAAPIIIDSIKKLEYRGYDSVGIATVTDSINVKKGSGKIKEVDDEIKLKDIDGNIGIAHVRWATHGNPT
KENAHPHCDCKNKISIVHNGIIENYKELRQELLNEGHVFKSETDTEVIPHLIEKYMDEGLDLLKSVQKTVKRLIGSYALA
VLSSDEPDRIIGARNESPLIVGVSDHGNYLASDVPAILNETKKVIYLEDKEIIVLKKDDVTIMDLDLNVLEKKITTITWD
PEMAEKGGYEHFMIKEIYEEPQVIKDTLSEAEKIKEIVSKFKNFNRICFVACGTSYHASLIGEYLIESQIGIPTEVILAS
EFEYFQKTLDKHTLVIFITQSGETADTIKALKIAKKKSETLAIVNVVGSSITREADHVIYTRAGPEISVAATKTYISQLI
CIYLLVAYLGENEKLLDNLYKISRLSEKILSREEQIREIAKKYKFARDFFYIGRGFNYPTALEGALKLKEITYIHGEGYP
AGELKHGPLALIEDNIPVVGILPPGPSYRKTYNNLQEIKARGADMIILGANNDTHLDDIEDKLLFDPEIDEVLSPLLYII
DLQLLAYYISIEKGIDPDKPKNLAKSVTVE

Sequences:

>Translated_590_residues
MCGIVGCVLDKKAAPIIIDSIKKLEYRGYDSVGIATVTDSINVKKGSGKIKEVDDEIKLKDIDGNIGIAHVRWATHGNPT
KENAHPHCDCKNKISIVHNGIIENYKELRQELLNEGHVFKSETDTEVIPHLIEKYMDEGLDLLKSVQKTVKRLIGSYALA
VLSSDEPDRIIGARNESPLIVGVSDHGNYLASDVPAILNETKKVIYLEDKEIIVLKKDDVTIMDLDLNVLEKKITTITWD
PEMAEKGGYEHFMIKEIYEEPQVIKDTLSEAEKIKEIVSKFKNFNRICFVACGTSYHASLIGEYLIESQIGIPTEVILAS
EFEYFQKTLDKHTLVIFITQSGETADTIKALKIAKKKSETLAIVNVVGSSITREADHVIYTRAGPEISVAATKTYISQLI
CIYLLVAYLGENEKLLDNLYKISRLSEKILSREEQIREIAKKYKFARDFFYIGRGFNYPTALEGALKLKEITYIHGEGYP
AGELKHGPLALIEDNIPVVGILPPGPSYRKTYNNLQEIKARGADMIILGANNDTHLDDIEDKLLFDPEIDEVLSPLLYII
DLQLLAYYISIEKGIDPDKPKNLAKSVTVE
>Mature_590_residues
MCGIVGCVLDKKAAPIIIDSIKKLEYRGYDSVGIATVTDSINVKKGSGKIKEVDDEIKLKDIDGNIGIAHVRWATHGNPT
KENAHPHCDCKNKISIVHNGIIENYKELRQELLNEGHVFKSETDTEVIPHLIEKYMDEGLDLLKSVQKTVKRLIGSYALA
VLSSDEPDRIIGARNESPLIVGVSDHGNYLASDVPAILNETKKVIYLEDKEIIVLKKDDVTIMDLDLNVLEKKITTITWD
PEMAEKGGYEHFMIKEIYEEPQVIKDTLSEAEKIKEIVSKFKNFNRICFVACGTSYHASLIGEYLIESQIGIPTEVILAS
EFEYFQKTLDKHTLVIFITQSGETADTIKALKIAKKKSETLAIVNVVGSSITREADHVIYTRAGPEISVAATKTYISQLI
CIYLLVAYLGENEKLLDNLYKISRLSEKILSREEQIREIAKKYKFARDFFYIGRGFNYPTALEGALKLKEITYIHGEGYP
AGELKHGPLALIEDNIPVVGILPPGPSYRKTYNNLQEIKARGADMIILGANNDTHLDDIEDKLLFDPEIDEVLSPLLYII
DLQLLAYYISIEKGIDPDKPKNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=34.7507331378299, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=32.9912023460411, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=39.2508143322476, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI87082251, Length=312, Percent_Identity=24.0384615384615, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=427, Percent_Identity=34.8946135831382, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17532897, Length=427, Percent_Identity=35.5971896955504, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17532899, Length=427, Percent_Identity=35.5971896955504, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17554892, Length=214, Percent_Identity=28.0373831775701, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=429, Percent_Identity=35.1981351981352, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6323731, Length=434, Percent_Identity=30.6451612903226, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40.9756097560976, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323958, Length=176, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357745, Length=683, Percent_Identity=34.8462664714495, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI28573187, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66112; Mature: 66112

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGCVLDKKAAPIIIDSIKKLEYRGYDSVGIATVTDSINVKKGSGKIKEVDDEIKLK
CCCEEEEHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCCCCEECCCCEEEE
DIDGNIGIAHVRWATHGNPTKENAHPHCDCKNKISIVHNGIIENYKELRQELLNEGHVFK
ECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEC
SETDTEVIPHLIEKYMDEGLDLLKSVQKTVKRLIGSYALAVLSSDEPDRIIGARNESPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCEE
VGVSDHGNYLASDVPAILNETKKVIYLEDKEIIVLKKDDVTIMDLDLNVLEKKITTITWD
EEECCCCCCHHHHHHHHHCCCCEEEEEECCEEEEEECCCEEEEECCHHHHHHHHHEEEEC
PEMAEKGGYEHFMIKEIYEEPQVIKDTLSEAEKIKEIVSKFKNFNRICFVACGTSYHASL
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
IGEYLIESQIGIPTEVILASEFEYFQKTLDKHTLVIFITQSGETADTIKALKIAKKKSET
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
LAIVNVVGSSITREADHVIYTRAGPEISVAATKTYISQLICIYLLVAYLGENEKLLDNLY
EEEHHHHCCHHHCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KISRLSEKILSREEQIREIAKKYKFARDFFYIGRGFNYPTALEGALKLKEITYIHGEGYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHEEEEEEEEEECCCCC
AGELKHGPLALIEDNIPVVGILPPGPSYRKTYNNLQEIKARGADMIILGANNDTHLDDIE
CCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
DKLLFDPEIDEVLSPLLYIIDLQLLAYYISIEKGIDPDKPKNLAKSVTVE
HHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MCGIVGCVLDKKAAPIIIDSIKKLEYRGYDSVGIATVTDSINVKKGSGKIKEVDDEIKLK
CCCEEEEHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCCCCEECCCCEEEE
DIDGNIGIAHVRWATHGNPTKENAHPHCDCKNKISIVHNGIIENYKELRQELLNEGHVFK
ECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEC
SETDTEVIPHLIEKYMDEGLDLLKSVQKTVKRLIGSYALAVLSSDEPDRIIGARNESPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCEE
VGVSDHGNYLASDVPAILNETKKVIYLEDKEIIVLKKDDVTIMDLDLNVLEKKITTITWD
EEECCCCCCHHHHHHHHHCCCCEEEEEECCEEEEEECCCEEEEECCHHHHHHHHHEEEEC
PEMAEKGGYEHFMIKEIYEEPQVIKDTLSEAEKIKEIVSKFKNFNRICFVACGTSYHASL
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
IGEYLIESQIGIPTEVILASEFEYFQKTLDKHTLVIFITQSGETADTIKALKIAKKKSET
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
LAIVNVVGSSITREADHVIYTRAGPEISVAATKTYISQLICIYLLVAYLGENEKLLDNLY
EEEHHHHCCHHHCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KISRLSEKILSREEQIREIAKKYKFARDFFYIGRGFNYPTALEGALKLKEITYIHGEGYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHEEEEEEEEEECCCCC
AGELKHGPLALIEDNIPVVGILPPGPSYRKTYNNLQEIKARGADMIILGANNDTHLDDIE
CCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
DKLLFDPEIDEVLSPLLYIIDLQLLAYYISIEKGIDPDKPKNLAKSVTVE
HHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]