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The map label for this gene is uppS

Identifier: 84489974

GI number: 84489974

Start: 1352456

End: 1353223

Strand: Direct

Name: uppS

Synonym: Msp_1182

Alternate gene names: 84489974

Gene position: 1352456-1353223 (Clockwise)

Preceding gene: 84489973

Following gene: 84489975

Centisome position: 76.52

GC content: 29.17

Gene sequence:

>768_bases
ATGATATTATTACAACCCTTATACTCATTATATGAATGGTATATTACAAGAAACCTTGAAGCAGATAAGATGCCAAACCA
TGTTGCAATAATAATGGATGGTAATAGACGTTACTCTAAAATTCAAGGAAATATGGATCCAATAGAAGGTCATAAAAAGG
GAGTGGATACACTAGAAAATGTTATTGAATGGTGTATTGATTTAGGTATTAATATTGTAACAGTCTATGCATTTTCAACT
GAGAACTTCAATAGAGATAAAAAGGAAGTAGAGGGTTTAATGGATTTATTTGTTCAAAGTTTTTTAAATATTAGTACAAA
TAAGAAAATTCATAAAAATAAGATACGATTAAATGCTGTTGGTAAATTAGAATTGTTTCCAAAAAAAGTTAGAGATGCAA
TTGACACTGCAGAAGAATCTACAAAAGATTATAATGAAAGAATGATTAATATTGCAATGGGTTATGATGGAAGAGTAGAA
ATTGTAGATGCATTTAAGAAGATTGCAAGAGAAGTTCAAAAGGGTAATATTGAACCTGATGAAATAAATGAAAAAATGAT
TAATGATAATTTATATACAGCAGGACTTGAAGATCCAAATCTAGTAATACGTACTAGTGGAGAAGAAAGATTAAGTGGAT
TCCTATTATGGCAATCTTCCTACTCCGAATTATATTTTACAGATAGTCTTTGGCCACAACTAAGAAAAGTAGATTTTCTA
CGCGCAATAAGATCATATACACAAAGACAAAGAAGATTTGGAAGATAA

Upstream 100 bases:

>100_bases
ACAAATATTATTAAAACTAAAAATAAGTGAAAAAAGTTATTATTTTATGTAAGAATAAACAAATAAATAGTATAAATAAA
AAATTGAAGAAGAATCTACT

Downstream 100 bases:

>100_bases
CTAGATAAAAGAAGGATAAATATGATAGATACACATTGTCATTTAAGTTTTGAAGAATTTGATAATAAAAGAGAAGAAAT
TATAGAAAATACTAGAAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MILLQPLYSLYEWYITRNLEADKMPNHVAIIMDGNRRYSKIQGNMDPIEGHKKGVDTLENVIEWCIDLGINIVTVYAFST
ENFNRDKKEVEGLMDLFVQSFLNISTNKKIHKNKIRLNAVGKLELFPKKVRDAIDTAEESTKDYNERMINIAMGYDGRVE
IVDAFKKIAREVQKGNIEPDEINEKMINDNLYTAGLEDPNLVIRTSGEERLSGFLLWQSSYSELYFTDSLWPQLRKVDFL
RAIRSYTQRQRRFGR

Sequences:

>Translated_255_residues
MILLQPLYSLYEWYITRNLEADKMPNHVAIIMDGNRRYSKIQGNMDPIEGHKKGVDTLENVIEWCIDLGINIVTVYAFST
ENFNRDKKEVEGLMDLFVQSFLNISTNKKIHKNKIRLNAVGKLELFPKKVRDAIDTAEESTKDYNERMINIAMGYDGRVE
IVDAFKKIAREVQKGNIEPDEINEKMINDNLYTAGLEDPNLVIRTSGEERLSGFLLWQSSYSELYFTDSLWPQLRKVDFL
RAIRSYTQRQRRFGR
>Mature_255_residues
MILLQPLYSLYEWYITRNLEADKMPNHVAIIMDGNRRYSKIQGNMDPIEGHKKGVDTLENVIEWCIDLGINIVTVYAFST
ENFNRDKKEVEGLMDLFVQSFLNISTNKKIHKNKIRLNAVGKLELFPKKVRDAIDTAEESTKDYNERMINIAMGYDGRVE
IVDAFKKIAREVQKGNIEPDEINEKMINDNLYTAGLEDPNLVIRTSGEERLSGFLLWQSSYSELYFTDSLWPQLRKVDFL
RAIRSYTQRQRRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=41.8410041841004, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=41.8410041841004, Blast_Score=201, Evalue=7e-52,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=41.5966386554622, Blast_Score=197, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71993029, Length=238, Percent_Identity=37.8151260504202, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319474, Length=223, Percent_Identity=37.6681614349776, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=262, Percent_Identity=31.2977099236641, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18857969, Length=246, Percent_Identity=39.0243902439024, Blast_Score=183, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29800; Mature: 29800

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLQPLYSLYEWYITRNLEADKMPNHVAIIMDGNRRYSKIQGNMDPIEGHKKGVDTLEN
CEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEHHHCCCCCCCCCHHCCHHHHHH
VIEWCIDLGINIVTVYAFSTENFNRDKKEVEGLMDLFVQSFLNISTNKKIHKNKIRLNAV
HHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEEC
GKLELFPKKVRDAIDTAEESTKDYNERMINIAMGYDGRVEIVDAFKKIAREVQKGNIEPD
CCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHH
EINEKMINDNLYTAGLEDPNLVIRTSGEERLSGFLLWQSSYSELYFTDSLWPQLRKVDFL
HHHHHHHCCCCEECCCCCCCEEEECCCHHHHHEEEEEECCCCCEEECCHHHHHHHHHHHH
RAIRSYTQRQRRFGR
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MILLQPLYSLYEWYITRNLEADKMPNHVAIIMDGNRRYSKIQGNMDPIEGHKKGVDTLEN
CEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEHHHCCCCCCCCCHHCCHHHHHH
VIEWCIDLGINIVTVYAFSTENFNRDKKEVEGLMDLFVQSFLNISTNKKIHKNKIRLNAV
HHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCEEEEEEC
GKLELFPKKVRDAIDTAEESTKDYNERMINIAMGYDGRVEIVDAFKKIAREVQKGNIEPD
CCHHHCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHH
EINEKMINDNLYTAGLEDPNLVIRTSGEERLSGFLLWQSSYSELYFTDSLWPQLRKVDFL
HHHHHHHCCCCEECCCCCCCEEEECCCHHHHHEEEEEECCCCCEEECCHHHHHHHHHHHH
RAIRSYTQRQRRFGR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]