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The map label for this gene is ahcY

Identifier: 84489879

GI number: 84489879

Start: 1226950

End: 1228203

Strand: Direct

Name: ahcY

Synonym: Msp_1085

Alternate gene names: 84489879

Gene position: 1226950-1228203 (Clockwise)

Preceding gene: 84489878

Following gene: 84489883

Centisome position: 69.42

GC content: 33.33

Gene sequence:

>1254_bases
ATGACATATGATATTAAGGATATTAATTTAGCTCCAGAAGGAGAAAAGAAAATAAAATGGGTACAAAAACATATGCCTGT
TTTAGAAACTATTAAAAAACAATTTGAAGAAGAACAACCATTCAAAGGAATTACAATTGGTTCTTGTCTTCATCTTGAAC
CTAAAACAATTAATTTAGGATTAACTCTACAAGCAGGTGGGGCAGAAGTTGTAATGACAGGTTGTAATCCATTATCTACC
CAAGATGATGCTACAGCAGCTGGTGCAAAACTAGGATTAAATATGTATGGTTGGACTGGTGAAACTAATGAGGAATACTA
TGAACAACTCAACAAAGTACTAGATTATGAACCAGATATTGTTATAGATGATGGTGCAGATTTAATATTTTTAATCCATA
AAGAAAGACCCGAACTTCTTGAAAAACTAAGAGGAGGTTGTGAAGAAACAACAACAGGTATTCATAGATTAAAAGCAATG
TATGAAGATAATGCTTTGAAAATGCCTATTATGGCTGTGAATGATTCATACATGAAATACCTCTTTGATAACAGATATGG
TACTGGACAATCTACCTTTGATTCAATAATGGGAACAACAAACTCAGTAATTGCAGGACAAACTGTTGTTGTATGTGGTT
ATGGATGGTGTGGAAGAGGTATTGCCATGAGAGCAGATGGACTTGGAGCAAATGTTATTGTTACAGAAGTTGATCCTATC
AGAGCACTTGAAGCTAAAATGGATGGATACAGAGTAATGACAGTTCAAAAAGCACTTGAAGAAGCAGATATTGTTATAAC
AGCTACTGGTAACAGAGATATCATATCTGGTGATGATTTTAAACATGTGAAAGATGGTTGTATGCTTGCAAATTCTGGAC
ATTTCAATGTGGAAATTAATGAAAATGATCTTGCTAGCCAAGCAATAGGTAGAAATATGTTAAAACCAGATATTGAAGAA
TTTGTAATGGCTGATGGACGTAGTATTTATTTACTAGCTGGTGGTAGATTAGTTAACCTTGCAGGACAATATGGACAGGG
ACATCCAGCTGAAATTATGGATTTAAGTTTTGCTATGCAAGCATTATCTGCAAAACGTCTTTTAAATGAAGATATGAAAC
CAGGTGTTTATAAAACAAGAGATGAAGTAGATATAGAAATAGCTAAATTAAAACTTAAAACAATGGGTGTGGAAATAGAT
ACACTTAGTGATGAACAAGAAAAATATATGAATAGTTGGGATGTTGGTACATAA

Upstream 100 bases:

>100_bases
TTAATAATTTAATACAACTTCCTTTATAATCTAAATTAATAATAAGAAATAAGAAGATATAATAATATATTGAATAATAT
TTTAAAGAGAGATGAAATTA

Downstream 100 bases:

>100_bases
ATATAACATCCTTCACTTTACTTTTTTTAAAACCAATCTTCAAGACTTGACTGTGCTGTTTTTGCTTGTAATTTTTTAAT
TGCACTTATTGTTCGTCTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTYDIKDINLAPEGEKKIKWVQKHMPVLETIKKQFEEEQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVVMTGCNPLST
QDDATAAGAKLGLNMYGWTGETNEEYYEQLNKVLDYEPDIVIDDGADLIFLIHKERPELLEKLRGGCEETTTGIHRLKAM
YEDNALKMPIMAVNDSYMKYLFDNRYGTGQSTFDSIMGTTNSVIAGQTVVVCGYGWCGRGIAMRADGLGANVIVTEVDPI
RALEAKMDGYRVMTVQKALEEADIVITATGNRDIISGDDFKHVKDGCMLANSGHFNVEINENDLASQAIGRNMLKPDIEE
FVMADGRSIYLLAGGRLVNLAGQYGQGHPAEIMDLSFAMQALSAKRLLNEDMKPGVYKTRDEVDIEIAKLKLKTMGVEID
TLSDEQEKYMNSWDVGT

Sequences:

>Translated_417_residues
MTYDIKDINLAPEGEKKIKWVQKHMPVLETIKKQFEEEQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVVMTGCNPLST
QDDATAAGAKLGLNMYGWTGETNEEYYEQLNKVLDYEPDIVIDDGADLIFLIHKERPELLEKLRGGCEETTTGIHRLKAM
YEDNALKMPIMAVNDSYMKYLFDNRYGTGQSTFDSIMGTTNSVIAGQTVVVCGYGWCGRGIAMRADGLGANVIVTEVDPI
RALEAKMDGYRVMTVQKALEEADIVITATGNRDIISGDDFKHVKDGCMLANSGHFNVEINENDLASQAIGRNMLKPDIEE
FVMADGRSIYLLAGGRLVNLAGQYGQGHPAEIMDLSFAMQALSAKRLLNEDMKPGVYKTRDEVDIEIAKLKLKTMGVEID
TLSDEQEKYMNSWDVGT
>Mature_416_residues
TYDIKDINLAPEGEKKIKWVQKHMPVLETIKKQFEEEQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVVMTGCNPLSTQ
DDATAAGAKLGLNMYGWTGETNEEYYEQLNKVLDYEPDIVIDDGADLIFLIHKERPELLEKLRGGCEETTTGIHRLKAMY
EDNALKMPIMAVNDSYMKYLFDNRYGTGQSTFDSIMGTTNSVIAGQTVVVCGYGWCGRGIAMRADGLGANVIVTEVDPIR
ALEAKMDGYRVMTVQKALEEADIVITATGNRDIISGDDFKHVKDGCMLANSGHFNVEINENDLASQAIGRNMLKPDIEEF
VMADGRSIYLLAGGRLVNLAGQYGQGHPAEIMDLSFAMQALSAKRLLNEDMKPGVYKTRDEVDIEIAKLKLKTMGVEIDT
LSDEQEKYMNSWDVGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=415, Percent_Identity=40.7228915662651, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI239937451, Length=391, Percent_Identity=41.4322250639386, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI195539349, Length=414, Percent_Identity=33.8164251207729, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI298286489, Length=414, Percent_Identity=33.8164251207729, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI195539337, Length=414, Percent_Identity=33.8164251207729, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI24308043, Length=414, Percent_Identity=33.8164251207729, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI21361647, Length=414, Percent_Identity=33.0917874396135, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17506425, Length=417, Percent_Identity=41.0071942446043, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6320882, Length=429, Percent_Identity=39.6270396270396, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24642172, Length=415, Percent_Identity=40.4819277108434, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24656245, Length=405, Percent_Identity=36.0493827160494, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI45553387, Length=416, Percent_Identity=35.8173076923077, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI45553385, Length=416, Percent_Identity=35.8173076923077, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46106; Mature: 45975

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYDIKDINLAPEGEKKIKWVQKHMPVLETIKKQFEEEQPFKGITIGSCLHLEPKTINLG
CCEECEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCEEEECCCEEEEE
LTLQAGGAEVVMTGCNPLSTQDDATAAGAKLGLNMYGWTGETNEEYYEQLNKVLDYEPDI
EEEECCCCEEEEECCCCCCCCCCCHHCHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCE
VIDDGADLIFLIHKERPELLEKLRGGCEETTTGIHRLKAMYEDNALKMPIMAVNDSYMKY
EEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECEEEEECHHHHHH
LFDNRYGTGQSTFDSIMGTTNSVIAGQTVVVCGYGWCGRGIAMRADGLGANVIVTEVDPI
HHCCCCCCCHHHHHHHHCCCCCEECCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCH
RALEAKMDGYRVMTVQKALEEADIVITATGNRDIISGDDFKHVKDGCMLANSGHFNVEIN
HHHHHHCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEEEC
ENDLASQAIGRNMLKPDIEEFVMADGRSIYLLAGGRLVNLAGQYGQGHPAEIMDLSFAMQ
CCHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHH
ALSAKRLLNEDMKPGVYKTRDEVDIEIAKLKLKTMGVEIDTLSDEQEKYMNSWDVGT
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEHHCEEEECCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TYDIKDINLAPEGEKKIKWVQKHMPVLETIKKQFEEEQPFKGITIGSCLHLEPKTINLG
CEECEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCEEEECCCEEEEE
LTLQAGGAEVVMTGCNPLSTQDDATAAGAKLGLNMYGWTGETNEEYYEQLNKVLDYEPDI
EEEECCCCEEEEECCCCCCCCCCCHHCHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCE
VIDDGADLIFLIHKERPELLEKLRGGCEETTTGIHRLKAMYEDNALKMPIMAVNDSYMKY
EEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECEEEEECHHHHHH
LFDNRYGTGQSTFDSIMGTTNSVIAGQTVVVCGYGWCGRGIAMRADGLGANVIVTEVDPI
HHCCCCCCCHHHHHHHHCCCCCEECCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCH
RALEAKMDGYRVMTVQKALEEADIVITATGNRDIISGDDFKHVKDGCMLANSGHFNVEIN
HHHHHHCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEEEC
ENDLASQAIGRNMLKPDIEEFVMADGRSIYLLAGGRLVNLAGQYGQGHPAEIMDLSFAMQ
CCHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCHHHHHHHHHHH
ALSAKRLLNEDMKPGVYKTRDEVDIEIAKLKLKTMGVEIDTLSDEQEKYMNSWDVGT
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEHHCEEEECCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]