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The map label for this gene is iscS

Identifier: 84489801

GI number: 84489801

Start: 1150356

End: 1151606

Strand: Direct

Name: iscS

Synonym: Msp_1002

Alternate gene names: 84489801

Gene position: 1150356-1151606 (Clockwise)

Preceding gene: 84489798

Following gene: 84489802

Centisome position: 65.09

GC content: 33.57

Gene sequence:

>1251_bases
ATGGCACATGAACTAATTTATATGGATAACTCAGCAACTTCACCAGTAGATGAAGAAGTATTAAAAGAAATGCTACCATA
CTTTAATGAAAAATTTGGAAATGCATCAACATTATATCGTCTAGGAGTAGATGCAAAAAAAGCATTAGACAAAGCAAGAC
AACAAGTAGCAGACCTTATCAATGCAGATGTTGATGAAATAACATTTACAAGTGGTGGAACAGAATCAGACAACATGGCA
ATAAAAGGAGTAGCACTAAGTGAAATTCAAAAAGCAACAGACAAAAACCCAAGAAACCATATAATCACAACAACAATAGA
ACACCCAGCAGTACTAGAAACATGTAAATTTCTAGAAAAATTTGGATTTGAAGTAACATACCTACCAGTAGACGAAGATG
GATTAATAAGTCTAGATGACCTTGAAAATGCAATAAAAGAAAGTACCATCCTCATTACAATAATGCACTCAAACAATGAA
ATAGGAACAATACAACCAACAAAAGAAATAGGGGAAATAGCACGCAAACACAACGTATTATTCCACTCTGATGCAGTTCA
AAGTGCAGGAAAAATACCTGTAGATGTAAAAGACCAAAACATCGATATATTATCCTTATCTGGACATAAAATCAACGGAC
CAAAAGGAATAGGAGCAATCTACATTAAAAAAGGTGTAAGATTTGAAGTATTCATGCATGGTGGAGGACAAGAAAAAGGA
TTAAGATCTGGAACAGAAAACATGCCTGGAATTGTAGGATTAGGAAAAGCAGCAGAACTTGCAAGAGAAAATCTAGAAAC
AAGAATGCAACACAACAAAGAAATTAGAGATGCATTAATTGAAAAAGTAACAAGCCAAATTAAAGATGCATATGTAAATG
GAAGTCTTGAAAAAAGATTACCAAACAATGTACACTTTAGATTCTCAGGAATTGAAGGAGAATCCTTAATTTTAAGATTA
GACAATGAAGGAATTGATGGAGCAACAGGATCAGCATGTTCAACCCATGACCTTAAAGGATCACACGTACTTGCAGCTAT
TGGAGTAAAACCAGCACTATCACACGGATCACTAAGATTATCCATAGGTCCAGAAAACTCAATTGATGATGTAGACTACA
TAGTAGCATCAATTAAAAAAGTAGTAGATTACTTAAGAGAACTATCACCATTATGGGATAATGAAACAGATGAATATATT
GGAGATAGATTTGAAAAACCATTAGAAGATGAAGATATAGACAGATACTAA

Upstream 100 bases:

>100_bases
ATACTACTTTTATTAATAAATAACAATGTGAAAAAAAGAATAACATTGTTAAATTTTATATTATAATCAAATAAAAATAA
CACATAGGGAGAAAAAAAAC

Downstream 100 bases:

>100_bases
ATAGGTGATTAAATATGCAATATAGTGATAAAGTAGTAGATCATTACACAAATCCAAGAAATACTGGAGTAATTAAAAAT
CCAGATGGTGAAGGAACTGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAHELIYMDNSATSPVDEEVLKEMLPYFNEKFGNASTLYRLGVDAKKALDKARQQVADLINADVDEITFTSGGTESDNMA
IKGVALSEIQKATDKNPRNHIITTTIEHPAVLETCKFLEKFGFEVTYLPVDEDGLISLDDLENAIKESTILITIMHSNNE
IGTIQPTKEIGEIARKHNVLFHSDAVQSAGKIPVDVKDQNIDILSLSGHKINGPKGIGAIYIKKGVRFEVFMHGGGQEKG
LRSGTENMPGIVGLGKAAELARENLETRMQHNKEIRDALIEKVTSQIKDAYVNGSLEKRLPNNVHFRFSGIEGESLILRL
DNEGIDGATGSACSTHDLKGSHVLAAIGVKPALSHGSLRLSIGPENSIDDVDYIVASIKKVVDYLRELSPLWDNETDEYI
GDRFEKPLEDEDIDRY

Sequences:

>Translated_416_residues
MAHELIYMDNSATSPVDEEVLKEMLPYFNEKFGNASTLYRLGVDAKKALDKARQQVADLINADVDEITFTSGGTESDNMA
IKGVALSEIQKATDKNPRNHIITTTIEHPAVLETCKFLEKFGFEVTYLPVDEDGLISLDDLENAIKESTILITIMHSNNE
IGTIQPTKEIGEIARKHNVLFHSDAVQSAGKIPVDVKDQNIDILSLSGHKINGPKGIGAIYIKKGVRFEVFMHGGGQEKG
LRSGTENMPGIVGLGKAAELARENLETRMQHNKEIRDALIEKVTSQIKDAYVNGSLEKRLPNNVHFRFSGIEGESLILRL
DNEGIDGATGSACSTHDLKGSHVLAAIGVKPALSHGSLRLSIGPENSIDDVDYIVASIKKVVDYLRELSPLWDNETDEYI
GDRFEKPLEDEDIDRY
>Mature_415_residues
AHELIYMDNSATSPVDEEVLKEMLPYFNEKFGNASTLYRLGVDAKKALDKARQQVADLINADVDEITFTSGGTESDNMAI
KGVALSEIQKATDKNPRNHIITTTIEHPAVLETCKFLEKFGFEVTYLPVDEDGLISLDDLENAIKESTILITIMHSNNEI
GTIQPTKEIGEIARKHNVLFHSDAVQSAGKIPVDVKDQNIDILSLSGHKINGPKGIGAIYIKKGVRFEVFMHGGGQEKGL
RSGTENMPGIVGLGKAAELARENLETRMQHNKEIRDALIEKVTSQIKDAYVNGSLEKRLPNNVHFRFSGIEGESLILRLD
NEGIDGATGSACSTHDLKGSHVLAAIGVKPALSHGSLRLSIGPENSIDDVDYIVASIKKVVDYLRELSPLWDNETDEYIG
DRFEKPLEDEDIDRY

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=395, Percent_Identity=45.3164556962025, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI156713448, Length=411, Percent_Identity=34.7931873479319, Blast_Score=224, Evalue=8e-59,
Organism=Escherichia coli, GI48994898, Length=393, Percent_Identity=45.5470737913486, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1787970, Length=398, Percent_Identity=24.8743718592965, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=25.679012345679, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=391, Percent_Identity=42.9667519181586, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=36.5030674846626, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319831, Length=391, Percent_Identity=46.8030690537084, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI20129463, Length=391, Percent_Identity=44.5012787723785, Blast_Score=334, Evalue=8e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45838; Mature: 45707

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHELIYMDNSATSPVDEEVLKEMLPYFNEKFGNASTLYRLGVDAKKALDKARQQVADLI
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHH
NADVDEITFTSGGTESDNMAIKGVALSEIQKATDKNPRNHIITTTIEHPAVLETCKFLEK
CCCHHHEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHH
FGFEVTYLPVDEDGLISLDDLENAIKESTILITIMHSNNEIGTIQPTKEIGEIARKHNVL
HCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEEECCCCEECCCCHHHHHHHHHHCCEE
FHSDAVQSAGKIPVDVKDQNIDILSLSGHKINGPKGIGAIYIKKGVRFEVFMHGGGQEKG
EECHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCC
LRSGTENMPGIVGLGKAAELARENLETRMQHNKEIRDALIEKVTSQIKDAYVNGSLEKRL
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PNNVHFRFSGIEGESLILRLDNEGIDGATGSACSTHDLKGSHVLAAIGVKPALSHGSLRL
CCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
SIGPENSIDDVDYIVASIKKVVDYLRELSPLWDNETDEYIGDRFEKPLEDEDIDRY
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AHELIYMDNSATSPVDEEVLKEMLPYFNEKFGNASTLYRLGVDAKKALDKARQQVADLI
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHH
NADVDEITFTSGGTESDNMAIKGVALSEIQKATDKNPRNHIITTTIEHPAVLETCKFLEK
CCCHHHEEECCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHH
FGFEVTYLPVDEDGLISLDDLENAIKESTILITIMHSNNEIGTIQPTKEIGEIARKHNVL
HCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEEECCCCEECCCCHHHHHHHHHHCCEE
FHSDAVQSAGKIPVDVKDQNIDILSLSGHKINGPKGIGAIYIKKGVRFEVFMHGGGQEKG
EECHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCC
LRSGTENMPGIVGLGKAAELARENLETRMQHNKEIRDALIEKVTSQIKDAYVNGSLEKRL
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PNNVHFRFSGIEGESLILRLDNEGIDGATGSACSTHDLKGSHVLAAIGVKPALSHGSLRL
CCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
SIGPENSIDDVDYIVASIKKVVDYLRELSPLWDNETDEYIGDRFEKPLEDEDIDRY
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA