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The map label for this gene is cbh [H]

Identifier: 84489564

GI number: 84489564

Start: 872918

End: 873898

Strand: Direct

Name: cbh [H]

Synonym: Msp_0760

Alternate gene names: 84489564

Gene position: 872918-873898 (Clockwise)

Preceding gene: 84489562

Following gene: 84489567

Centisome position: 49.39

GC content: 26.81

Gene sequence:

>981_bases
ATGTGTTCTGCTGCAAATTACACAACAAAAAATCATTATTTTGGTCGTAACTTTGACTATGAAATATCATATAATGAACA
AGTTATGATAACTCCACGAAATTATCCTCTAAAATTTAGAAAGATAAATGATATAACAACAACACACTATGCTATTATTG
GTATAAGTGCAGGTATTAATGAATATCCATTGTATTATGATGCAACGAATGAAAAAGGATTAAGTATGGCTGGATTAAAT
TTCGCTGGATATACAAAGTATCATGAATATGATTCTAATAAATTAAATATCACTCCATTTGAATTTATACCATATATTCT
TAGTAAATATGAATCTGTGGATGATGTTAAAGAAGCTTTGGAAAATATTAACCTTGTTAATATAAATTATAGTGATAAAC
TTCCCCTTTCACCACTTCATTGGATTATATCAGATAGTGAAAGTTCAATTACTGTTGAATGTTTAAAGGATGAATTAAAA
GTATATGATAATCCACTAGGAATACTAACAAATAATCCACCATTTGATTTGCAAATGTTTAATTTAAATAATTATAGAAG
AGTATCTAATAAAACACCAAGTAATGATTTTCTAAAAGATTATAATCTTGATGTGTATAGTAGGGGTATGGGGGGTATGG
GTATTCCTGGTGATTTATCCTCTATGTCACGTTTTGTTAAATTAGCATTTACACTTACAAATTCATTATCTGATGATTCA
GAGGAAAGTAGTGTTAATCAATTTTTCCATATTCTAGCAAGTGTTGAACAACAAAATGGATGTACATTTATAGAAAGTCC
TGATAAATATGAATATACAATATATTCCTCTTGTGTTAATACAAGTTGTGGAATATATTATTATAGAACATATGGAAACT
CTCAGATAAATGCTGTTAATATGCACAATGAAAATTTAGATACTGATAAGTTAATTACATATCCACTTGTAAATAAGGAA
AAATTTAATTTTCAAAATTAA

Upstream 100 bases:

>100_bases
GGAATTTGTATTTTAAATGTTCTAAATGTATTTAACCCTATTTTTTCATATGTAGATAAATAATAGTTTTTAAAGTAAAA
ATAGTATGTAGGTGATTATT

Downstream 100 bases:

>100_bases
TTATTCCTTTCTTTTTTTAATTTTTGTTCTTTCATTATATTTTATTGGAGCATAATTATCATTCAATATTAGTTCTTTTC
TAAGTAATATTCATTTCTTG

Product: putative bile salt acid hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MCSAANYTTKNHYFGRNFDYEISYNEQVMITPRNYPLKFRKINDITTTHYAIIGISAGINEYPLYYDATNEKGLSMAGLN
FAGYTKYHEYDSNKLNITPFEFIPYILSKYESVDDVKEALENINLVNINYSDKLPLSPLHWIISDSESSITVECLKDELK
VYDNPLGILTNNPPFDLQMFNLNNYRRVSNKTPSNDFLKDYNLDVYSRGMGGMGIPGDLSSMSRFVKLAFTLTNSLSDDS
EESSVNQFFHILASVEQQNGCTFIESPDKYEYTIYSSCVNTSCGIYYYRTYGNSQINAVNMHNENLDTDKLITYPLVNKE
KFNFQN

Sequences:

>Translated_326_residues
MCSAANYTTKNHYFGRNFDYEISYNEQVMITPRNYPLKFRKINDITTTHYAIIGISAGINEYPLYYDATNEKGLSMAGLN
FAGYTKYHEYDSNKLNITPFEFIPYILSKYESVDDVKEALENINLVNINYSDKLPLSPLHWIISDSESSITVECLKDELK
VYDNPLGILTNNPPFDLQMFNLNNYRRVSNKTPSNDFLKDYNLDVYSRGMGGMGIPGDLSSMSRFVKLAFTLTNSLSDDS
EESSVNQFFHILASVEQQNGCTFIESPDKYEYTIYSSCVNTSCGIYYYRTYGNSQINAVNMHNENLDTDKLITYPLVNKE
KFNFQN
>Mature_326_residues
MCSAANYTTKNHYFGRNFDYEISYNEQVMITPRNYPLKFRKINDITTTHYAIIGISAGINEYPLYYDATNEKGLSMAGLN
FAGYTKYHEYDSNKLNITPFEFIPYILSKYESVDDVKEALENINLVNINYSDKLPLSPLHWIISDSESSITVECLKDELK
VYDNPLGILTNNPPFDLQMFNLNNYRRVSNKTPSNDFLKDYNLDVYSRGMGGMGIPGDLSSMSRFVKLAFTLTNSLSDDS
EESSVNQFFHILASVEQQNGCTFIESPDKYEYTIYSSCVNTSCGIYYYRTYGNSQINAVNMHNENLDTDKLITYPLVNKE
KFNFQN

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37460; Mature: 37460

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSAANYTTKNHYFGRNFDYEISYNEQVMITPRNYPLKFRKINDITTTHYAIIGISAGIN
CCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCEEEEEECCCCEEEEEEEEEECCCC
EYPLYYDATNEKGLSMAGLNFAGYTKYHEYDSNKLNITPFEFIPYILSKYESVDDVKEAL
CCCEEEECCCCCCCEEECCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHCCHHHHHHHH
ENINLVNINYSDKLPLSPLHWIISDSESSITVECLKDELKVYDNPLGILTNNPPFDLQMF
HCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHCCCEEEEECCCCCEEEEE
NLNNYRRVSNKTPSNDFLKDYNLDVYSRGMGGMGIPGDLSSMSRFVKLAFTLTNSLSDDS
CCCCEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
EESSVNQFFHILASVEQQNGCTFIESPDKYEYTIYSSCVNTSCGIYYYRTYGNSQINAVN
HHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEHHHCCCCCEEEEEEECCCEEEEEE
MHNENLDTDKLITYPLVNKEKFNFQN
ECCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCSAANYTTKNHYFGRNFDYEISYNEQVMITPRNYPLKFRKINDITTTHYAIIGISAGIN
CCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCEEEEEECCCCEEEEEEEEEECCCC
EYPLYYDATNEKGLSMAGLNFAGYTKYHEYDSNKLNITPFEFIPYILSKYESVDDVKEAL
CCCEEEECCCCCCCEEECCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHCCHHHHHHHH
ENINLVNINYSDKLPLSPLHWIISDSESSITVECLKDELKVYDNPLGILTNNPPFDLQMF
HCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHCCCEEEEECCCCCEEEEE
NLNNYRRVSNKTPSNDFLKDYNLDVYSRGMGGMGIPGDLSSMSRFVKLAFTLTNSLSDDS
CCCCEEECCCCCCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
EESSVNQFFHILASVEQQNGCTFIESPDKYEYTIYSSCVNTSCGIYYYRTYGNSQINAVN
HHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEHHHCCCCCEEEEEEECCCEEEEEE
MHNENLDTDKLITYPLVNKEKFNFQN
ECCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]