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The map label for this gene is metC [H]

Identifier: 83721560

GI number: 83721560

Start: 2546405

End: 2547589

Strand: Direct

Name: metC [H]

Synonym: BTH_I2263

Alternate gene names: 83721560

Gene position: 2546405-2547589 (Clockwise)

Preceding gene: 83720860

Following gene: 83720487

Centisome position: 66.85

GC content: 67.93

Gene sequence:

>1185_bases
ATGACCGCATCCATTCCCAAGCGCGCGCTGCAGACGCGCGTCGTCCAGCCGGACGATCGCATTCCCGCCGGTTTCGAATC
GTTCGTCGTGCCGGTTGCGCGAGCGTCGACGGTCGTGTTCCCCGATCTCGCGACGATGCGCAACCTCGACTGGCGCCAGG
ACGGCCAATGGCGCTACGGGCTGCACGCGACGCCGACGTCGCTCGCGCTCGCGCAGCGGCTCGCCGAGATCGAGGGCGGC
ACGCACGCGCTGTTGCAGCCGTCGGGGCTTTCGGCGATCACGAACGTGTACTTCGGCCTCGTCAAGGCAGGCGACGACGT
GCTGATTCCGGACAACGCGTACGGGCCGAACGGCGATCTCGGCAAATGGCTCGCGAAGGATTTCGGCATTGCCGCGCGCT
TCTACGATCCGATGATCGGCGCGGGCATCGCGGATCTGATCCAGCCGAACACGCGCGTCATCTGGCTCGAGGCGCCCGGC
TCGGTGACGATGGAAGTGCCGGACGTGCGGGCGATCACGGCGGTCGCGCGCTCGCGCGGGATCGTCACGGCAATCGACAA
TACGTATTCGGCGGGCCTCGCGTTCAAGCCGTTCGAGCACGGCGTCGACATCTCGGTGCAGGCGCTGACGAAATATCAAT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACGATCACCGCCGACGACGAGTTGCACGCGAAGCTGAAGCTCGCGCGGATG
CGGCTTGGCATCGGTGTGTCGGCCGACGACTGTTCGCTCGTGCTGCGCGGTCTGCCGAGCATGCGGGCGCGCTTCGACGC
GCACGGCCGCAGCGCGCTGTCGCTTGCGCGCTGGCTGAAGACGCGTGCGGAGATCGCGACGGTGCTGCATCCGCAGTTGC
CCGATTGCCCCGGCCACGAGACCTTCATGCGCGATTTCACGGGGGCGGGCGGCCTGTTCTCGGTCGTGTTCGACGAGCGC
TACGATGCCGCGCAGGTCGATCGCTTCGTCGAGGCGCTCGAACTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCGTGCAG
CCTCGCGATGCCGTACGACGTGCAGTCGATGCGCACGGGCAAGTGGCCGCATCGCGGCACGCTGGTGCGCTTCTATGTCG
GCCTCGAAGATGAAGCCGACCTGCGCGCGGACATCGAGCGTGCATTCGCCGCGGCGCTTGCCTGA

Upstream 100 bases:

>100_bases
CGCGGGCGCGCCGATTGTACCGGGCCAAACGCCCGGAATCGGGCTAAGCTAGCCGGGTTCCAATCTTTTTCGGCTCGTTT
TGCGCCGAGCCTTCCCAGTC

Downstream 100 bases:

>100_bases
CGTGCGATACCGGGCGACATCGGGCCACGGCGGCGCGTCGGCGGGCGGTGTGCGGGCCGTGAGGCGCGTCGCGCGCGGGC
CGGCAGGCGCGCGGTAGCCT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLSAITNVYFGLVKAGDDVLIPDNAYGPNGDLGKWLAKDFGIAARFYDPMIGAGIADLIQPNTRVIWLEAPG
SVTMEVPDVRAITAVARSRGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADDELHAKLKLARM
RLGIGVSADDCSLVLRGLPSMRARFDAHGRSALSLARWLKTRAEIATVLHPQLPDCPGHETFMRDFTGAGGLFSVVFDER
YDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERAFAAALA

Sequences:

>Translated_394_residues
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLSAITNVYFGLVKAGDDVLIPDNAYGPNGDLGKWLAKDFGIAARFYDPMIGAGIADLIQPNTRVIWLEAPG
SVTMEVPDVRAITAVARSRGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADDELHAKLKLARM
RLGIGVSADDCSLVLRGLPSMRARFDAHGRSALSLARWLKTRAEIATVLHPQLPDCPGHETFMRDFTGAGGLFSVVFDER
YDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERAFAAALA
>Mature_393_residues
TASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGGT
HALLQPSGLSAITNVYFGLVKAGDDVLIPDNAYGPNGDLGKWLAKDFGIAARFYDPMIGAGIADLIQPNTRVIWLEAPGS
VTMEVPDVRAITAVARSRGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADDELHAKLKLARMR
LGIGVSADDCSLVLRGLPSMRARFDAHGRSALSLARWLKTRAEIATVLHPQLPDCPGHETFMRDFTGAGGLFSVVFDERY
DAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERAFAAALA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=298, Percent_Identity=30.5369127516779, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI299473759, Length=298, Percent_Identity=27.5167785234899, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI25453487, Length=297, Percent_Identity=27.9461279461279, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789383, Length=366, Percent_Identity=37.431693989071, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=30.1333333333333, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=340, Percent_Identity=31.7647058823529, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=307, Percent_Identity=32.2475570032573, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=395, Percent_Identity=28.3544303797468, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=329, Percent_Identity=38.9057750759878, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319307, Length=351, Percent_Identity=26.4957264957265, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321254, Length=387, Percent_Identity=26.0981912144703, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321904, Length=353, Percent_Identity=25.4957507082153, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=31.3624678663239, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42746; Mature: 42615

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYG
CCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLALAQRLAEIEGGTHALLQPSGLSAITNVYFGLVKAGDDVLIPDNAYGPNGDL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCH
GKWLAKDFGIAARFYDPMIGAGIADLIQPNTRVIWLEAPGSVTMEVPDVRAITAVARSRG
HHHHHHHHCCHHHHHCHHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADDELHAKLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHH
RLGIGVSADDCSLVLRGLPSMRARFDAHGRSALSLARWLKTRAEIATVLHPQLPDCPGHE
HHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
TFMRDFTGAGGLFSVVFDERYDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTG
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHCCC
KWPHRGTLVRFYVGLEDEADLRADIERAFAAALA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYG
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLALAQRLAEIEGGTHALLQPSGLSAITNVYFGLVKAGDDVLIPDNAYGPNGDL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCH
GKWLAKDFGIAARFYDPMIGAGIADLIQPNTRVIWLEAPGSVTMEVPDVRAITAVARSRG
HHHHHHHHCCHHHHHCHHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADDELHAKLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHH
RLGIGVSADDCSLVLRGLPSMRARFDAHGRSALSLARWLKTRAEIATVLHPQLPDCPGHE
HHCCCCCCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
TFMRDFTGAGGLFSVVFDERYDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTG
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHCCC
KWPHRGTLVRFYVGLEDEADLRADIERAFAAALA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]