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The map label for this gene is gabP [H]

Identifier: 83721315

GI number: 83721315

Start: 3357783

End: 3359174

Strand: Reverse

Name: gabP [H]

Synonym: BTH_I2921

Alternate gene names: 83721315

Gene position: 3359174-3357783 (Counterclockwise)

Preceding gene: 83721470

Following gene: 83718684

Centisome position: 88.19

GC content: 66.31

Gene sequence:

>1392_bases
ATGAAAGGAAGTCAGACAGGCCTCGGAACCGGCCTGAAGCAGCGCCACGTCACGATGCTGTCGATCGCGGGCGTGATCGG
CGCCGGGTTGTTCGTCGGTTCGGGGCATGCGATCGCGGAGGCCGGTCCGGCCGCGCTGATCGCTTACGCAATCGCGGGGC
TGCTCGTCGTGCTCGTGATGCGGATGCTCGGCGAGATGGCGGTTGCGCAGCCGGACAGCGGCTCGTTCTCGACCTATGCC
GATCGCGCGATCGGCCATTGGGCGGGCTTCACGATCGGCTGGCTCTACTGGTGGTTCTGGGTGCTCGTGATTCCGATCGA
GGCCACGGCCGCCGCGACGATTCTCAATGCGTGGTTCCCCGGCGTCGCGACGTGGATCTTCGCACTCGGCATCACGTCGG
TGCTCACCGTCACGAATCTTTTCTCGGTCAAGAACTACGGCGAATTCGAATTCTGGTTCGCGCTCATCAAGGTGGTCGCG
ATCGTCGTATTCCTCGCGATCGGCGGCGCGGCGATCGTCGGCCTGCTGCCGGGCTCGAACGTATCGGGCGCGGCGCGCCT
CGTGAACGCGGGCGGCTTCATGCCGAACGGCATCGGCGCGGTGCTCGCCGCGATGCTGACGACGATGTTCTCGTTCCTCG
GCACCGAGATCGTCACGATCGCCGCGGCCGAATCCGAGCACCCGGAGCGCCAGATCGTCCGCGCGACGAATTCGGTGATC
TGGCGGATCTCGCTGTTCTATCTCGGCTCGATCTTCGTCGTCGCGGCGCTCGTGCCTTGGAACGACGCGCTGCTGCCCGC
GCACGGCTCGTATCAGCGCGCGATGGAGCTGATCGGCGTGCCGCACGCGAAGGCGATCATCGACGTGATCGTGCTGGTGT
CGGTCGCGAGCTGCCTGAATTCGGCGCTCTACACGGCGTCGCGGATGATCTTCTCGCTGTCGAGGCGCGGCGACGCGCCC
GCGCTCTTGCGCCGTACCGATGCAAGCGGCACGCCGCGCGCGGCGGTGCTCGCGTCGACCGCGTTCGGCTTCATCACGGT
GATCGCGAACTACGTGATGCCCGAGCAGGTGTTCGGTTTCCTGCTTGCGACGTCGGGCGCGATCGCGTTGCTCGTGTATC
TCGTGATCGCGATCTCGCAGTTGCGGATGCGCAAGATGCTCGACGCGACGGGCGAGCGTTTGCAACTGCGGATGTGGTGT
TTCCCGTGGATCACGTGGGCGGTGATCCTGTTCATTTGCGGCGTGCTGACGGTGATGCTGGTGAGCGAGGCGCACCGGAT
GGAAGTGGGCGCGACGGCGGTGCTTGCGCTGATCGTGCTGGCGGCGTCGTGGCTGAACAAGCGCGGCCGCGATGCGCAGG
CGAGCGTGGGGCGGCGGGTGTCGGCGACGTAA

Upstream 100 bases:

>100_bases
GCGACGCCCGTCGCGCCTGAACGGTTCGATAACAACAAAGCCCCCGCGCCGCCTTCACGCGATGCCCGGTCACACCGGAA
CCGTTTTTTTGGAGGGAGAC

Downstream 100 bases:

>100_bases
CGAACGCGAGCGGCCCGAGGGCGCGGCTGCGCCCGATCTTCGCTGCCCGGGGCAAGCCCGGAACAATCTTGGCCCGACCG
GCATGTGCCGGCCGGGCCAT

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGIGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKAIIDVIVLVSVASCLNSALYTASRMIFSLSRRGDAP
ALLRRTDASGTPRAAVLASTAFGFITVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKMLDATGERLQLRMWC
FPWITWAVILFICGVLTVMLVSEAHRMEVGATAVLALIVLAASWLNKRGRDAQASVGRRVSAT

Sequences:

>Translated_463_residues
MKGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGIGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKAIIDVIVLVSVASCLNSALYTASRMIFSLSRRGDAP
ALLRRTDASGTPRAAVLASTAFGFITVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKMLDATGERLQLRMWC
FPWITWAVILFICGVLTVMLVSEAHRMEVGATAVLALIVLAASWLNKRGRDAQASVGRRVSAT
>Mature_463_residues
MKGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVMRMLGEMAVAQPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLAIGGAAIVGLLPGSNVSGAARLVNAGGFMPNGIGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKAIIDVIVLVSVASCLNSALYTASRMIFSLSRRGDAP
ALLRRTDASGTPRAAVLASTAFGFITVIANYVMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKMLDATGERLQLRMWC
FPWITWAVILFICGVLTVMLVSEAHRMEVGATAVLALIVLAASWLNKRGRDAQASVGRRVSAT

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=376, Percent_Identity=21.8085106382979, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4507047, Length=385, Percent_Identity=25.7142857142857, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=66.9767441860465, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=36.6228070175439, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1786789, Length=427, Percent_Identity=36.768149882904, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI48994972, Length=460, Percent_Identity=35, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI87081708, Length=408, Percent_Identity=36.7647058823529, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1788480, Length=387, Percent_Identity=35.6589147286822, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=33.1154684095861, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1790653, Length=455, Percent_Identity=31.8681318681319, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081869, Length=262, Percent_Identity=27.0992366412214, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=375, Percent_Identity=22.6666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=402, Percent_Identity=34.3283582089552, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6322892, Length=406, Percent_Identity=34.9753694581281, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=33.1719128329298, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324061, Length=455, Percent_Identity=29.8901098901099, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=396, Percent_Identity=31.8181818181818, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=32.4519230769231, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324059, Length=422, Percent_Identity=31.042654028436, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=411, Percent_Identity=32.1167883211679, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=30.8433734939759, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=28.641975308642, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=29.7560975609756, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=29.3532338308458, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320251, Length=419, Percent_Identity=29.8329355608592, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=437, Percent_Identity=28.3752860411899, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=28.894472361809, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=392, Percent_Identity=31.6326530612245, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=24.6411483253589, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=470, Percent_Identity=22.9787234042553, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667468, Length=345, Percent_Identity=24.6376811594203, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49278; Mature: 49278

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
VSGAARLVNAGGFMPNGIGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKAIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSRRGDAPALLRRTDASGTPRAAVLASTAFGFITVIANYVMPEQVFGF
HHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRKMLDATGERLQLRMWCFPWITWAVILFICGVLTVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHH
VSEAHRMEVGATAVLALIVLAASWLNKRGRDAQASVGRRVSAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKGSQTGLGTGLKQRHVTMLSIAGVIGAGLFVGSGHAIAEAGPAALIAYAIAGLLVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAQPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITSVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLAIGGAAIVGLLPGSN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
VSGAARLVNAGGFMPNGIGAVLAAMLTTMFSFLGTEIVTIAAAESEHPERQIVRATNSVI
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
WRISLFYLGSIFVVAALVPWNDALLPAHGSYQRAMELIGVPHAKAIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SALYTASRMIFSLSRRGDAPALLRRTDASGTPRAAVLASTAFGFITVIANYVMPEQVFGF
HHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRKMLDATGERLQLRMWCFPWITWAVILFICGVLTVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHH
VSEAHRMEVGATAVLALIVLAASWLNKRGRDAQASVGRRVSAT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]