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The map label for this gene is mdtD [H]

Identifier: 83721242

GI number: 83721242

Start: 1004516

End: 1006102

Strand: Reverse

Name: mdtD [H]

Synonym: BTH_I0880

Alternate gene names: 83721242

Gene position: 1006102-1004516 (Counterclockwise)

Preceding gene: 83721218

Following gene: 83720245

Centisome position: 26.41

GC content: 69.57

Gene sequence:

>1587_bases
GTGCGCGCGCCGAGCGGCCCGCGCAGCGGAAGCCGCTCCGGCCCCAGACCTGCCGCTCGCCGCGCGCTTCGGCACGCGCG
CCCACTGACCAACGCCCCCGACGACCTCGGGCCAGCGCTGCGCGCCGCCCGAGGCGGCGGGGCTTGCGCCGCGCGCCAGC
CGCGACGCACCCAATCTCATCGGGCCGCACTCATGCTCAATGCCTCTTCCCGAACGACACTGCTGTGGATCGTCGCCACC
GCTTTCTTCATGCAGTCCGTCGACACGACCATCGTCAACACGGCGCTGCCGTCGATCGCCCGCGCGCTCGACCAGGACGC
CCTCTCGATGCACGGCGTCGTCACCGCCTACACCCTGACGATGGCCACGCTCACGCCCGCGTCCGGCTGGCTCGCGGATC
GCTTCGGCACGCGTCGCGTATTCTTCGCCGCGATTGTCGTGTTCGCGCTCGGCTCGCTGTGCTGCGCGGCCGCGGCGAGC
GCGACGCAGCTCATCTTCGCGCGGGTGCTGCAAGGCGTCGGCGGCTCGATGCTGCTGCCGATCGGCCGGCTCGCGGTGCT
GCGCGGCGTCCCCGGCGACGAATACGTGGCCGCCCTCGCGTTCGTGTCGACCTTCGGCCAGATCGGGCCGATCCTCGGCC
CAACGCTCGGCGGCTGGCTCACGCAATCGATGTCGTGGTACTGGGTGTTCCTCGTCAACCTGCCGATCTGCGCGGTCGGA
CTCGCCACCGTCCACCGCTACATGCCGCGCGACAAGCCGACCGATCCCCCGCCGTTCGACTACACCGGCTACACGCTGCT
GTCGATCGCGATGATCGCCGGCTCGCTTGCGATCGACGCGCTGTCCGACGGCGGCTATGCCGACTGGACCGCCGGCATGA
TCGCGATCGCCGCGGCCGCGGCGATCACGTATGTCGCCTACGCGCACTGGCGCCCGAACCCGATCTTCCGGCTCAAGCTC
TTTCGCGAACCGAACTTCGCGGTCGGCCTCGCCGGCAACCTGGTCTCGCGGATCGGCATCGGCGCGACGCCCTTCCTGCT
GCCGCTGATGATGCAGCTCGAATTCGGCTATTCTCCGTTGCGCTCGGGGCTGATGCTCGTTCCAGCCGCCATCGCGGGCG
TGATCGCAAAGCCGTGGATCGCGCCGCTCGTTCGCCGCTACGGCTATCGCACGTTCCTGTTCGTCAACACGTTGATCGTC
GGCGCCGTGATCGCGCTGTTCGCGGCGATCGGCCCCGATACGCCGCTCGTCGTCGAACTGGCGCTGATCGCGATCTTCGG
CGCGATCAACTCGATTCAGATCGCGGCGATGAACAGCGTGACGCTGAAAAGCCTGCCGCACCGAGACGCGGCGAGCGGCA
ACAGCCTGTATTCGATGGTGCAGATGCTGTCGATGGGGCTCGGCGCGTCGGTGGGAAGCGGGCTCACGAGCCTGTTCGGC
GCGCAGACCGGCTCGTCGCTGCTCGGCTTCAAGCTGAGCTTCGTCTGCGTCGGCGCGGTGACGCTCGCGTCCGCGGCGAT
CTTTCGGCGGGTCCAGGACCCGCGCGTGACGCGCACGCAATCCGGCCACGCGGTCGCGCAGCGTTAG

Upstream 100 bases:

>100_bases
GCCATCCATTCTTATCGCCCGACATCAGCCCCGATACGCCGCTTGAAATGGCGGCTCCGAAACCGGCGCGAACGCGCAAG
CCATCGGACCGTCCGCCCGC

Downstream 100 bases:

>100_bases
CGGCGTCGCGACGGCCTGCGCCGACGAGCCGGCAGGCGAATCGCGCGCGCCGCCCGTTTTCTGCGAAACTGGCGGCTTCG
CATCACGCCACCTTTCATGT

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRAPSGPRSGSRSGPRPAARRALRHARPLTNAPDDLGPALRAARGGGACAARQPRRTQSHRAALMLNASSRTTLLWIVAT
AFFMQSVDTTIVNTALPSIARALDQDALSMHGVVTAYTLTMATLTPASGWLADRFGTRRVFFAAIVVFALGSLCCAAAAS
ATQLIFARVLQGVGGSMLLPIGRLAVLRGVPGDEYVAALAFVSTFGQIGPILGPTLGGWLTQSMSWYWVFLVNLPICAVG
LATVHRYMPRDKPTDPPPFDYTGYTLLSIAMIAGSLAIDALSDGGYADWTAGMIAIAAAAAITYVAYAHWRPNPIFRLKL
FREPNFAVGLAGNLVSRIGIGATPFLLPLMMQLEFGYSPLRSGLMLVPAAIAGVIAKPWIAPLVRRYGYRTFLFVNTLIV
GAVIALFAAIGPDTPLVVELALIAIFGAINSIQIAAMNSVTLKSLPHRDAASGNSLYSMVQMLSMGLGASVGSGLTSLFG
AQTGSSLLGFKLSFVCVGAVTLASAAIFRRVQDPRVTRTQSGHAVAQR

Sequences:

>Translated_528_residues
MRAPSGPRSGSRSGPRPAARRALRHARPLTNAPDDLGPALRAARGGGACAARQPRRTQSHRAALMLNASSRTTLLWIVAT
AFFMQSVDTTIVNTALPSIARALDQDALSMHGVVTAYTLTMATLTPASGWLADRFGTRRVFFAAIVVFALGSLCCAAAAS
ATQLIFARVLQGVGGSMLLPIGRLAVLRGVPGDEYVAALAFVSTFGQIGPILGPTLGGWLTQSMSWYWVFLVNLPICAVG
LATVHRYMPRDKPTDPPPFDYTGYTLLSIAMIAGSLAIDALSDGGYADWTAGMIAIAAAAAITYVAYAHWRPNPIFRLKL
FREPNFAVGLAGNLVSRIGIGATPFLLPLMMQLEFGYSPLRSGLMLVPAAIAGVIAKPWIAPLVRRYGYRTFLFVNTLIV
GAVIALFAAIGPDTPLVVELALIAIFGAINSIQIAAMNSVTLKSLPHRDAASGNSLYSMVQMLSMGLGASVGSGLTSLFG
AQTGSSLLGFKLSFVCVGAVTLASAAIFRRVQDPRVTRTQSGHAVAQR
>Mature_528_residues
MRAPSGPRSGSRSGPRPAARRALRHARPLTNAPDDLGPALRAARGGGACAARQPRRTQSHRAALMLNASSRTTLLWIVAT
AFFMQSVDTTIVNTALPSIARALDQDALSMHGVVTAYTLTMATLTPASGWLADRFGTRRVFFAAIVVFALGSLCCAAAAS
ATQLIFARVLQGVGGSMLLPIGRLAVLRGVPGDEYVAALAFVSTFGQIGPILGPTLGGWLTQSMSWYWVFLVNLPICAVG
LATVHRYMPRDKPTDPPPFDYTGYTLLSIAMIAGSLAIDALSDGGYADWTAGMIAIAAAAAITYVAYAHWRPNPIFRLKL
FREPNFAVGLAGNLVSRIGIGATPFLLPLMMQLEFGYSPLRSGLMLVPAAIAGVIAKPWIAPLVRRYGYRTFLFVNTLIV
GAVIALFAAIGPDTPLVVELALIAIFGAINSIQIAAMNSVTLKSLPHRDAASGNSLYSMVQMLSMGLGASVGSGLTSLFG
AQTGSSLLGFKLSFVCVGAVTLASAAIFRRVQDPRVTRTQSGHAVAQR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=455, Percent_Identity=40.2197802197802, Blast_Score=348, Evalue=7e-97,
Organism=Escherichia coli, GI1788392, Length=460, Percent_Identity=41.0869565217391, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1789042, Length=470, Percent_Identity=28.936170212766, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1788710, Length=326, Percent_Identity=31.9018404907975, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081983, Length=305, Percent_Identity=26.8852459016393, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321663, Length=153, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=155, Percent_Identity=33.5483870967742, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=154, Percent_Identity=31.8181818181818, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55661; Mature: 55661

Theoretical pI: Translated: 11.15; Mature: 11.15

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPSGPRSGSRSGPRPAARRALRHARPLTNAPDDLGPALRAARGGGACAARQPRRTQSH
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCC
RAALMLNASSRTTLLWIVATAFFMQSVDTTIVNTALPSIARALDQDALSMHGVVTAYTLT
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MATLTPASGWLADRFGTRRVFFAAIVVFALGSLCCAAAASATQLIFARVLQGVGGSMLLP
HHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGRLAVLRGVPGDEYVAALAFVSTFGQIGPILGPTLGGWLTQSMSWYWVFLVNLPICAVG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LATVHRYMPRDKPTDPPPFDYTGYTLLSIAMIAGSLAIDALSDGGYADWTAGMIAIAAAA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AITYVAYAHWRPNPIFRLKLFREPNFAVGLAGNLVSRIGIGATPFLLPLMMQLEFGYSPL
HHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
RSGLMLVPAAIAGVIAKPWIAPLVRRYGYRTFLFVNTLIVGAVIALFAAIGPDTPLVVEL
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALIAIFGAINSIQIAAMNSVTLKSLPHRDAASGNSLYSMVQMLSMGLGASVGSGLTSLFG
HHHHHHHHHCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
AQTGSSLLGFKLSFVCVGAVTLASAAIFRRVQDPRVTRTQSGHAVAQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MRAPSGPRSGSRSGPRPAARRALRHARPLTNAPDDLGPALRAARGGGACAARQPRRTQSH
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCC
RAALMLNASSRTTLLWIVATAFFMQSVDTTIVNTALPSIARALDQDALSMHGVVTAYTLT
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MATLTPASGWLADRFGTRRVFFAAIVVFALGSLCCAAAASATQLIFARVLQGVGGSMLLP
HHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGRLAVLRGVPGDEYVAALAFVSTFGQIGPILGPTLGGWLTQSMSWYWVFLVNLPICAVG
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LATVHRYMPRDKPTDPPPFDYTGYTLLSIAMIAGSLAIDALSDGGYADWTAGMIAIAAAA
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AITYVAYAHWRPNPIFRLKLFREPNFAVGLAGNLVSRIGIGATPFLLPLMMQLEFGYSPL
HHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
RSGLMLVPAAIAGVIAKPWIAPLVRRYGYRTFLFVNTLIVGAVIALFAAIGPDTPLVVEL
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALIAIFGAINSIQIAAMNSVTLKSLPHRDAASGNSLYSMVQMLSMGLGASVGSGLTSLFG
HHHHHHHHHCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
AQTGSSLLGFKLSFVCVGAVTLASAAIFRRVQDPRVTRTQSGHAVAQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA