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The map label for this gene is accC [H]

Identifier: 83721099

GI number: 83721099

Start: 1308631

End: 1309998

Strand: Reverse

Name: accC [H]

Synonym: BTH_I1162

Alternate gene names: 83721099

Gene position: 1309998-1308631 (Counterclockwise)

Preceding gene: 83720081

Following gene: 83719303

Centisome position: 34.39

GC content: 63.96

Gene sequence:

>1368_bases
ATGTTTGAAAAAATCCTCATTGCCAACCGCGGGGAAATCGCGCTGCGCATTCAGCGCGCGTGCCGTGAGCTCGGCGTCAA
GACGGTGGTCGTCTATTCCGAGGCCGACAAGGAAGCCAAGTACGTGAAGTTAGCCGACGAAGCGGTCTGTATCGGCCCCG
CTCCGTCGAATCTGAGCTATCTAAACATGCCGGCCCTGATCAGCGCGGCCGAAGTCACCGACGCCGAGGCGATCCACCCG
GGCTACGGCTTCCTGTCGGAAAACGCCGATTTCGCCGAGCGTGTCGAGCAGTCGGGCTTCACGTTCATCGGTCCGCGCCC
GGACACGATCCGCATGATGGGCGACAAAGTCACCGCGAAGCAGACGATGATCCGCACCGGCGTGCCCTGCGTGCCGGGCT
CGGACGGCGCGTTGCCGGATGATCCGAAGGAGATCGTGAAAATTGCGCGCTCGGTCGGCTATCCGGTGATCATCAAGGCG
GCGGGCGGCGGCGGCGGACGCGGGATGCGCGTCGTCCACACCGAAGCGGCGCTCGTGAACGCGGTCAACATGACGCGCGA
GGAAGCGGGCCGCGCGTTCGGCAATCCGCAGGTCTATATGGAGAAGTTCCTCGAAAATCCGCGCCACATCGAGATCCAGG
TGCTCTCCGATTCGCACAAGAACGCGGTCTGGCTCGGCGAGCGCGACTGCTCGATGCAGCGCCGTCACCAGAAGGTGATC
GAGGAAGCGCCCGCGCCCGGCATCGCACGCCGCCTGATCGACCGGATCGGCGACCGCTGCGCGGACGCGTGCAAGAAGAT
GGGCTACCTCGGCGCGGGCACGTTCGAGTTCCTGTACGAGAACAACGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCATCCGGTGACGGAGCTGATCACGGGCGTCGACATCGTCCAGGAACAGATCAAGATCGCCGCGGGCGAGAAG
CTGTCGTTCCGCCAGCGCGACATCCAGTTCCGCGGCCACGCGATCGAATGCCGGATCAACGCCGAAGATCCGTTCAAGTT
CACGCCGTCGCCGGGCCGGATCACGTCTTGGCACACGCCGGGCGGCCCGGGCATCCGCGTCGATTCGCACGCGTACAATG
GCTACTTCGTCCCGCCCAACTACGATTCGATGATCGGCAAGCTGATCGCCTACGGCGCGACGCGCGAGCAGGCGATCAAC
CGGATGCGCATCGCGCTGTCGGAAATGGTGGTCGAAGGCATCCTGACCAACATCCCGCTGCATCGCGAGCTGATGCTCGA
CTCGAAGTTCGTCGAAGGCGGCCCGAGCATCCACTATCTCGAGAACCGGCTCGCGCAGAAGCTGCAGGCCGCGCCGGAAG
AAGCGTAA

Upstream 100 bases:

>100_bases
TTCGTGATCGGCTAAGACCCGCCGCGCGGCGCGCCCGCCAGCGACGCCGCTCCTCTCAAGGCGCGCGCTCGCGCGCCCAT
CGAAGAGACGAATACTCGCT

Downstream 100 bases:

>100_bases
TCATGAGCTATCGGGAACTCGTCGCCGAGTTGCCCCGCGAGCACGCGGAGGCGCTGTCCGACGCGCTCGTCGAGCTGGGC
GCGCTGTCGGTGTCCGTCGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRMMGDKVTAKQTMIRTGVPCVPGSDGALPDDPKEIVKIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDSHKNAVWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGVDIVQEQIKIAAGEK
LSFRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIN
RMRIALSEMVVEGILTNIPLHRELMLDSKFVEGGPSIHYLENRLAQKLQAAPEEA

Sequences:

>Translated_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRMMGDKVTAKQTMIRTGVPCVPGSDGALPDDPKEIVKIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDSHKNAVWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGVDIVQEQIKIAAGEK
LSFRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIN
RMRIALSEMVVEGILTNIPLHRELMLDSKFVEGGPSIHYLENRLAQKLQAAPEEA
>Mature_455_residues
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSYLNMPALISAAEVTDAEAIHP
GYGFLSENADFAERVEQSGFTFIGPRPDTIRMMGDKVTAKQTMIRTGVPCVPGSDGALPDDPKEIVKIARSVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDSHKNAVWLGERDCSMQRRHQKVI
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVTELITGVDIVQEQIKIAAGEK
LSFRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTPGGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAIN
RMRIALSEMVVEGILTNIPLHRELMLDSKFVEGGPSIHYLENRLAQKLQAAPEEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=48.0898876404494, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=48.0898876404494, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=48.0898876404494, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=458, Percent_Identity=46.943231441048, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=465, Percent_Identity=44.5161290322581, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=465, Percent_Identity=44.5161290322581, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=465, Percent_Identity=44.5161290322581, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI38679960, Length=520, Percent_Identity=31.7307692307692, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI38679977, Length=520, Percent_Identity=31.7307692307692, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679967, Length=520, Percent_Identity=31.7307692307692, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679974, Length=520, Percent_Identity=31.7307692307692, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI38679971, Length=520, Percent_Identity=31.7307692307692, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=31.0940499040307, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=66.4414414414414, Blast_Score=596, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.27539503386, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=434, Percent_Identity=46.0829493087558, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.0715883668904, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.2929292929293, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=27.4661508704062, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=27.4661508704062, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.4494382022472, Blast_Score=346, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.3125, Blast_Score=342, Evalue=5e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.7589285714286, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=29.6577946768061, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=31.1300639658849, Blast_Score=219, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24651757, Length=433, Percent_Identity=45.2655889145497, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.7207207207207, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=396, Percent_Identity=44.1919191919192, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=29.1828793774319, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=29.1828793774319, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=29.1828793774319, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=29.1828793774319, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50372; Mature: 50372

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPDTIRMMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEECCCCHHHH
QTMIRTGVPCVPGSDGALPDDPKEIVKIARSVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDSHKNAVWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGVDIVQEQIKIAAGEKLSFRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCCCCHHHHCCEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAINRMRIALSEMVVEGILTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
HRELMLDSKFVEGGPSIHYLENRLAQKLQAAPEEA
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACRELGVKTVVVYSEADKEAKYVKLADEAVCIGPAPSNLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCEEEECCCCCCCCE
LNMPALISAAEVTDAEAIHPGYGFLSENADFAERVEQSGFTFIGPRPDTIRMMGDKVTAK
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEECCCCHHHH
QTMIRTGVPCVPGSDGALPDDPKEIVKIARSVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPQVYMEKFLENPRHIEIQVLSDSHKNAVWLGERDCSMQRRHQKVI
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIARRLIDRIGDRCADACKKMGYLGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
ELITGVDIVQEQIKIAAGEKLSFRQRDIQFRGHAIECRINAEDPFKFTPSPGRITSWHTP
HHHHHHHHHHHHHHHHCCCCCCHHHHCCEECCEEEEEEECCCCCCEECCCCCCEEECCCC
GGPGIRVDSHAYNGYFVPPNYDSMIGKLIAYGATREQAINRMRIALSEMVVEGILTNIPL
CCCCEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
HRELMLDSKFVEGGPSIHYLENRLAQKLQAAPEEA
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]