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The map label for this gene is lysA [H]

Identifier: 83721058

GI number: 83721058

Start: 3475136

End: 3476407

Strand: Direct

Name: lysA [H]

Synonym: BTH_I3031

Alternate gene names: 83721058

Gene position: 3475136-3476407 (Clockwise)

Preceding gene: 83719498

Following gene: 83721256

Centisome position: 91.23

GC content: 68.32

Gene sequence:

>1272_bases
ATGACTCAAGCTGCATTCGACTACGTCGACGGCACGCTCCACGCCGAGCGCGTCTGCACCGCCGACCTCGCCGAGCGTTT
CGGCACCCCGCTCTTCGTCTATTCGCGCGCCGCGCTCACCGCGGCCTACGAGGCCTACGCGAAGGCCTGCGCGGGCCGCC
GCGCGTCGATTCACGTCGCCGTGAAGGCGAACAGCAACCTCGGCGTGCTGAACGTGTTCGCGCGTCTCGGCGCGGGCTTC
GACATCGTGTCGGGCGGCGAGCTCGCACGCGTGCTCGCGGCGGGCGGCCGCGCGCAAAATGTCGTGTTCTCGGGCGTCGG
CAAGAGCGCCGACGAAATGCGCATCGCGCTCGAAGCGGGCGTCAAGTGCTTCAACGTCGAATCGATCCCGGAGCTCGACC
GGCTGAACGCCGTCGCGGCGTCGCTCGGCAAGCGCGCGCCCGTGTCGCTGCGCGTGAATCCGGACGTCGACCCGAAGACG
CATCCGTACATCTCGACGGGGCTGAAGGCGAACAAGTTCGGCATCGCGTTCGATGACGCGCGCGCGACGTACCGCGCGGC
AGCCGCGCTGCCGAACCTCGAAGTCGTCGGCATCGATTGCCACATCGGCTCGCAAATCACCGAGCTGAGCCCGTACCTCG
ACGCGATCGACAAGCTGCTCGATCTCGTCGAGCAGATCGAGGCGGACGGCGTGAAGATCCATCACGTCGACGTCGGCGGC
GGGCTCGGCATCACGTACGACGACGAAACGCCGCCCGACATCGGCGCGTACGTGCGCGCGGTACTCGAGCGCATCGACGC
GCGCGGCCACGGCCATCGCGAAATCTGGTTCGAGCCGGGCCGCTCGCTGACGGGCAATGCCGGCATCTTGCTCACGCGCG
TCGAATTCCTGAAACAGGGCGAAGAGAAGAACTTCGCGATCGTCGACGCGGCGATGAACGACCTTGCGCGCCCGGCGATG
TACCAGGCGTTTCACGCGATCGAGCCGGTGACCCCGCGCACGGACGTTGCAGCCGCCGTGTACGACGTCGTCGGCCCGGT
CTGCGAAAGCGGCGACTGGCTCGGGCGCGATCGCTCGCTCGCGATCGCGCCGGGCGATCTGCTCGCGATCCGCTCGGCGG
GCGCGTACGGCTTCACGATGAGCTCGAACTACAACGCGCGGCCGCGTGCGGCCGAGGTGATCGTCGACGGTGCGAGCGCG
TATCTGGTGCGGCCGCGCGAGACGGTCGAAAGCCTGTTCGAGCGCGAAGCGGTTCTGCCCGACGGCAAGTAA

Upstream 100 bases:

>100_bases
GCCGACGCGCCGCTCACGCTGTCGCCCGACCTGTCGACGCAACGCACGCCGAAGGCGGCGTCCGCGTCCGGCGCTTCCTC
CGCCCAATGATCGATCCTGC

Downstream 100 bases:

>100_bases
TCGCAGGCAAACGGCGCGCTTGCGCGGCGAGCCGGCAAGCCCTCGTCAAGAAAGAAGGCGATGTCCATTCGGGCATCGCC
TTTTTGTTTGCCCACGCGCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQAAFDYVDGTLHAERVCTADLAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRAQNVVFSGVGKSADEMRIALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVEQIEADGVKIHHVDVGG
GLGITYDDETPPDIGAYVRAVLERIDARGHGHREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIEPVTPRTDVAAAVYDVVGPVCESGDWLGRDRSLAIAPGDLLAIRSAGAYGFTMSSNYNARPRAAEVIVDGASA
YLVRPRETVESLFEREAVLPDGK

Sequences:

>Translated_423_residues
MTQAAFDYVDGTLHAERVCTADLAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRAQNVVFSGVGKSADEMRIALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVEQIEADGVKIHHVDVGG
GLGITYDDETPPDIGAYVRAVLERIDARGHGHREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIEPVTPRTDVAAAVYDVVGPVCESGDWLGRDRSLAIAPGDLLAIRSAGAYGFTMSSNYNARPRAAEVIVDGASA
YLVRPRETVESLFEREAVLPDGK
>Mature_422_residues
TQAAFDYVDGTLHAERVCTADLAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGFD
IVSGGELARVLAAGGRAQNVVFSGVGKSADEMRIALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTH
PYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVEQIEADGVKIHHVDVGGG
LGITYDDETPPDIGAYVRAVLERIDARGHGHREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAMY
QAFHAIEPVTPRTDVAAAVYDVVGPVCESGDWLGRDRSLAIAPGDLLAIRSAGAYGFTMSSNYNARPRAAEVIVDGASAY
LVRPRETVESLFEREAVLPDGK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=23.4463276836158, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789203, Length=414, Percent_Identity=34.0579710144928, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=354, Percent_Identity=25.1412429378531, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=365, Percent_Identity=22.7397260273973, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586474, Length=389, Percent_Identity=28.2776349614396, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24586472, Length=343, Percent_Identity=26.8221574344023, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45154; Mature: 45022

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAAFDYVDGTLHAERVCTADLAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRAQNVVFSGVGKSADEMRIALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHEEEHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCH
RATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVEQIEADGVKIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLERIDARGHGHREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIEPVTPRTDVAAAVYDVVGPVCESGDWLGRDRSL
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNARPRAAEVIVDGASAYLVRPRETVESLFEREAVLP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCCC
DGK
CCC
>Mature Secondary Structure 
TQAAFDYVDGTLHAERVCTADLAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRAQNVVFSGVGKSADEMRIALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHEEEHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCH
RATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVEQIEADGVKIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLERIDARGHGHREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIEPVTPRTDVAAAVYDVVGPVCESGDWLGRDRSL
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNARPRAAEVIVDGASAYLVRPRETVESLFEREAVLP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHHCCCC
DGK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]