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The map label for this gene is mdtD [H]

Identifier: 83720903

GI number: 83720903

Start: 863771

End: 865297

Strand: Reverse

Name: mdtD [H]

Synonym: BTH_I0752

Alternate gene names: 83720903

Gene position: 865297-863771 (Counterclockwise)

Preceding gene: 83718775

Following gene: 83718540

Centisome position: 22.72

GC content: 67.98

Gene sequence:

>1527_bases
ATGCGCGCGCCCGCCCGCTGCACGCATCGCGGGCTTTCCCTACAATGTCGGCTGCACGCCCGAACGCGCCCGCCGCGCCC
CGCTTTCATGCTTCAAGCCCCGCCCGCCGCCGCCCCGAGCGAGAAGTCGCTGACCGTGATGCTGTGGCTCGTCGCCACCG
GCTTCTTCATGCAGACGCTCGATGCGACGATCGTCAACACCGCGCTGCCGTCGATGGCCGCGAGCCTCGGCGAATCGCCG
CTCCGGATGCAGTCGGTCGTGATCGCGTACTCGCTGACGATGGCCGTGATGATCCCCGTGTCCGGCTGGCTCGCCGACAC
GCTCGGCACGCGCCGCGTGTTCTTCTGCGCGATCCTGATCTTCACGCTCGGCTCGCTCTTGTGCGCGAACGCGCATACGC
TGCCGCTCCTCGTCGCGTTCCGCGTGATCCAGGGCGTGGGCGGCGCGATGCTGCTGCCCGTCGGGCGGCTCGCCGTGCTG
CGCACGTTCCCCGCCGAGCGCTATCTGCCCGCGCTGTCGTTCGTCGCGATTCCGGGCCTGATCGGCCCGCTGATCGGGCC
GACGCTCGGCGGCTGGCTCGTGAAGATCGCTTCGTGGCACTGGATCTTCCTGATCAACGTGCCGGTCGGCGTCGCGGGCT
GCATCGCGACGTTCTATTCGATGCCCGACGCGCGCAACCCGGCCGCGGGCCGCTTCGACCTGAAAGGCTACCTGCTGCTG
ACGATCGGAATGATCTCGATCTCGCTGTCGCTCGACGGCCTCTCCGATCTCGGCATGCAGCACGCGATGGTGCTCGTGCT
GCTGATCCTGAGCCTCGCGTGCTTCGTCGCGTACGGCTTGTACGCGGTGCGCGCGCCGCAGCCGATCTTCTCGCTCGAGC
TCTTCAAGATCCACGCGTTCAGCGTCGGCCTGCTCGGCAACCTGTTCGCGCGCATCGGCAGCGGCGCGATGCCGTATCTG
ATTCCGCTGCTGCTGCAGGTGAGCCTCGGCTACGACGCGTTCGAAGCGGGCCTGATGATGCTGCCCGTCGCGGCCGCGGG
AATGTTCTCGAAGCGGATCATCACGGTGCTCATCACGCGCCACGGCTACCGCAAGGTGCTGCTCGCGAACACGATCATGG
TCGGGCTGATGATGGCGAGCTTCGCGCTGATCAGCGACGCGATGCCGGCATGGCTCAAGATCGCGCAGCTCGCCCTCTTC
GGCGGCTTCAACTCGATGCAGTTCACCGCGATGAACACGCTCACGCTGAAGGACCTCGGCACGGGCGGCGCGAGCAGCGG
CAACAGCCTGTTCTCGCTCGTGCAGATGCTGTCGATGAGTCTCGGCGTGACGATCGCGGGCGCGCTCCTCGCGACCTTCA
CCGGCATGATGCGAAGCGTCACGCCAACGCACACGCTGCCCGCGTTCCATGCGACGTTCGTGTGCGTCGGCCTCATCACC
GCCGCGTCCGCGTGGATCTTCGCGCAGCTGTCGCCGGACGTGCGCGGCGCCGCGCGCCGCAAGACCGATCCGTCCGAGCG
CGCGTGA

Upstream 100 bases:

>100_bases
ACGGCCCGGCCGCCTGGCCGGAACAGGCGCGGCAGACACGGATGACGCACGACACGCCCGCCCACGCGAGGCGAAAACGC
AATCGGCCGCGCCGCGCGGG

Downstream 100 bases:

>100_bases
CGCGGTGGCGCGCTCGCCGCGCGACGGGCTGCCGCGCGGCCGGCGCGGCGGCGGCAATGCGTTCGAGATGGCTGACGGGC
GCGCGGGATTTCGCATCGAC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRAPARCTHRGLSLQCRLHARTRPPRPAFMLQAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESP
LRMQSVVIAYSLTMAVMIPVSGWLADTLGTRRVFFCAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVL
RTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDARNPAAGRFDLKGYLLL
TIGMISISLSLDGLSDLGMQHAMVLVLLILSLACFVAYGLYAVRAPQPIFSLELFKIHAFSVGLLGNLFARIGSGAMPYL
IPLLLQVSLGYDAFEAGLMMLPVAAAGMFSKRIITVLITRHGYRKVLLANTIMVGLMMASFALISDAMPAWLKIAQLALF
GGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTIAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLIT
AASAWIFAQLSPDVRGAARRKTDPSERA

Sequences:

>Translated_508_residues
MRAPARCTHRGLSLQCRLHARTRPPRPAFMLQAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESP
LRMQSVVIAYSLTMAVMIPVSGWLADTLGTRRVFFCAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVL
RTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDARNPAAGRFDLKGYLLL
TIGMISISLSLDGLSDLGMQHAMVLVLLILSLACFVAYGLYAVRAPQPIFSLELFKIHAFSVGLLGNLFARIGSGAMPYL
IPLLLQVSLGYDAFEAGLMMLPVAAAGMFSKRIITVLITRHGYRKVLLANTIMVGLMMASFALISDAMPAWLKIAQLALF
GGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTIAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLIT
AASAWIFAQLSPDVRGAARRKTDPSERA
>Mature_508_residues
MRAPARCTHRGLSLQCRLHARTRPPRPAFMLQAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESP
LRMQSVVIAYSLTMAVMIPVSGWLADTLGTRRVFFCAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVL
RTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDARNPAAGRFDLKGYLLL
TIGMISISLSLDGLSDLGMQHAMVLVLLILSLACFVAYGLYAVRAPQPIFSLELFKIHAFSVGLLGNLFARIGSGAMPYL
IPLLLQVSLGYDAFEAGLMMLPVAAAGMFSKRIITVLITRHGYRKVLLANTIMVGLMMASFALISDAMPAWLKIAQLALF
GGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTIAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLIT
AASAWIFAQLSPDVRGAARRKTDPSERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=470, Percent_Identity=47.4468085106383, Blast_Score=427, Evalue=1e-120,
Organism=Escherichia coli, GI1788392, Length=459, Percent_Identity=49.6732026143791, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1788710, Length=313, Percent_Identity=32.2683706070287, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789042, Length=455, Percent_Identity=28.3516483516484, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87081983, Length=318, Percent_Identity=30.8176100628931, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322958, Length=439, Percent_Identity=24.1457858769932, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=29.6, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=151, Percent_Identity=30.4635761589404, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54179; Mature: 54179

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPARCTHRGLSLQCRLHARTRPPRPAFMLQAPPAAAPSEKSLTVMLWLVATGFFMQTL
CCCCCCHHHCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
DATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGTRRVFFCAILI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHH
FTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDARNPAAGRFDLKGYLLL
HHHHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEE
TIGMISISLSLDGLSDLGMQHAMVLVLLILSLACFVAYGLYAVRAPQPIFSLELFKIHAF
EEEHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHH
SVGLLGNLFARIGSGAMPYLIPLLLQVSLGYDAFEAGLMMLPVAAAGMFSKRIITVLITR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHEEC
HGYRKVLLANTIMVGLMMASFALISDAMPAWLKIAQLALFGGFNSMQFTAMNTLTLKDLG
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECC
TGGASSGNSLFSLVQMLSMSLGVTIAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AASAWIFAQLSPDVRGAARRKTDPSERA
HHHHHEEEECCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRAPARCTHRGLSLQCRLHARTRPPRPAFMLQAPPAAAPSEKSLTVMLWLVATGFFMQTL
CCCCCCHHHCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
DATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGTRRVFFCAILI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHH
FTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDARNPAAGRFDLKGYLLL
HHHHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHEE
TIGMISISLSLDGLSDLGMQHAMVLVLLILSLACFVAYGLYAVRAPQPIFSLELFKIHAF
EEEHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHH
SVGLLGNLFARIGSGAMPYLIPLLLQVSLGYDAFEAGLMMLPVAAAGMFSKRIITVLITR
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHEEC
HGYRKVLLANTIMVGLMMASFALISDAMPAWLKIAQLALFGGFNSMQFTAMNTLTLKDLG
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECC
TGGASSGNSLFSLVQMLSMSLGVTIAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AASAWIFAQLSPDVRGAARRKTDPSERA
HHHHHEEEECCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA