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The map label for this gene is ytnA [H]

Identifier: 83720864

GI number: 83720864

Start: 3566137

End: 3567543

Strand: Direct

Name: ytnA [H]

Synonym: BTH_I3129

Alternate gene names: 83720864

Gene position: 3566137-3567543 (Clockwise)

Preceding gene: 83718783

Following gene: 83720573

Centisome position: 93.62

GC content: 64.32

Gene sequence:

>1407_bases
ATGCAGAAAGGAAGTGCGGAAACCGACCTACACCGAGGACTCGGGCAACGGCAAATGCGCTTGATCGCGCTCGGCGCGGC
GATCGGCGTCGGCCTATTTCTCGGCTCGGCAAACGCGATCAAAATGGCGGGCCCCGGCATCATCCTGTCGTACATCATCG
GCGGCGCAGTGATCTTCGTGATCATGCGCGCGCTCGGCGAGATGGCCGTGCACGAACCTGTCGCGGGCTCGTTCAGCCGC
TACGCGCGCAACTACCTCGGGCCGCTTGCCGGCTACCTGACGGGCTGGAACTACTGGTTCCTCTGGCTCGTCACCTGCAT
CGCCGAAATCACGGCGGTCGGCATCTACATGGGCATCTGGTTCCCGGACGTGCCGCGCTGGATCTGGGCGCTCGCCGCAC
TGGCCACGATGGGCTCGGTGAACCTGCTGACCGTGAAGGCTTACGGCGAGTTCGAATTCTGGTTCGCGCTGATCAAGGTG
GTGACGATCGTCGTGATGATCGCGGTCGGCATCGCGATGATCGCCTTGGGCATCGGCAATCACGGCGTGCCGATGGGCAT
CTCGAACCTCTGGGCGCACGGCGGCTTCTTCCCGAACGGCGCACAGGGCGTGCTGATGTCGATGCAGATGGTGATGTTCG
CGTATCTCGGCGTCGAAATGATCGGGCTGACGGCGGGCGAAGCGGAGAACCCGCAGAAGACGATTCCGGGCGCGATCAAC
TCGGTGTTCTGGCGCATCCTGCTCTTCTACGGCGGCGCGCTCTTCGTGATTCTGTCGATCTACCCGTGGAACGAGATCGG
CACGCAAGGCAGCCCGTTCGTGATGACGTTCGAGCGGCTCGGCATCAAGACGGCCGCGGGCATCATCAACTTCGTCGTGC
TGACGGCGGCGCTTTCGTCGTGCAACGGCGGCATCTTCAGCACGGGACGCATGCTGTACAACCTCGCGCAGCAAGGCCAC
GCGCCGCGCACGTTCGGCGAGACGACGGCGAGCGGCGTGCCGCGCCGGGCGATCCTGGTTTCGATGGCGGCGCTGCTCGT
CGGCGTGCTGCTCAACTACCTGGTGCCGGAAAAGGTGTTCGTCTGGGTGACGTCGATCTCGACGTTCGGGGCGATCTGGA
CTTGGGGCGTCATTCTCGTTGCGCAGATGAAATTTCGCGCGAGTCTCGCGCCGGCGCAGGAGCGGGCGCTGCGGTTCCGG
ATGCCGTTCTGGCCGTACGGCTCCTGGGTGGCGCTCACGTTTCTCGTGCTCGTGGTCGGATTGATGGCCTATTTTCCGGA
TACGCGAATCGCGCTTTATGTCGGACCGGCCTGGCTCGTGTTGCTCGTAGTGCTGTACTACGCGTTGAAGCTCGAGCCCG
AAGGCGGGAAGGAGGCGGGGCTGGCGCGCGGGTACGAGCGCGGGTGA

Upstream 100 bases:

>100_bases
CATACCTTGCTCGCCGCCCTCTAGGCGAGGCGGGCCACGCGCGCGTCGCACGACGCCGACGCACGCACGCCGATTTCACA
AACCCAAAGGAGACATCCCG

Downstream 100 bases:

>100_bases
TTGATTCGCGAGTGAGCGGCGCGAGGTGAAATCGCGACAGCCCGCTGGGCGGGCTGTCGTGCGGTTCGGTGCGCCGCTCC
GCCGAATGCTACGAGCCGAT

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MQKGSAETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIALGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAENPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVAQMKFRASLAPAQERALRFR
MPFWPYGSWVALTFLVLVVGLMAYFPDTRIALYVGPAWLVLLVVLYYALKLEPEGGKEAGLARGYERG

Sequences:

>Translated_468_residues
MQKGSAETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIALGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAENPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVAQMKFRASLAPAQERALRFR
MPFWPYGSWVALTFLVLVVGLMAYFPDTRIALYVGPAWLVLLVVLYYALKLEPEGGKEAGLARGYERG
>Mature_468_residues
MQKGSAETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIALGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAENPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVAQMKFRASLAPAQERALRFR
MPFWPYGSWVALTFLVLVVGLMAYFPDTRIALYVGPAWLVLLVVLYYALKLEPEGGKEAGLARGYERG

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=342, Percent_Identity=24.8538011695906, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258614005, Length=409, Percent_Identity=22.9828850855746, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI258614003, Length=409, Percent_Identity=22.9828850855746, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI258645169, Length=409, Percent_Identity=22.9828850855746, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786602, Length=440, Percent_Identity=55.9090909090909, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=49.2239467849224, Blast_Score=427, Evalue=1e-120,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=45.067264573991, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1786302, Length=444, Percent_Identity=45.4954954954955, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1790653, Length=444, Percent_Identity=42.5675675675676, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI87081915, Length=447, Percent_Identity=42.2818791946309, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=37.3134328358209, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.6589327146172, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788480, Length=468, Percent_Identity=35.6837606837607, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI87081869, Length=286, Percent_Identity=23.7762237762238, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=22.3756906077348, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=467, Percent_Identity=32.3340471092077, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=32.9545454545455, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=32.7354260089686, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6322892, Length=443, Percent_Identity=32.9571106094808, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=32.0454545454545, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=443, Percent_Identity=30.0225733634311, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321629, Length=443, Percent_Identity=28.2167042889391, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=435, Percent_Identity=28.2758620689655, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=443, Percent_Identity=27.5395033860045, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=403, Percent_Identity=32.0099255583127, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319543, Length=425, Percent_Identity=26.8235294117647, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=408, Percent_Identity=26.9607843137255, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=439, Percent_Identity=25.9681093394077, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=439, Percent_Identity=27.1070615034169, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319608, Length=456, Percent_Identity=26.5350877192982, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=406, Percent_Identity=26.1083743842365, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=402, Percent_Identity=25.8706467661692, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=512, Percent_Identity=26.171875, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667468, Length=368, Percent_Identity=25.8152173913043, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221512776, Length=375, Percent_Identity=20.8, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666159, Length=375, Percent_Identity=20.8, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077963, Length=342, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50780; Mature: 50780

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKGSAETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFV
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IMRALGEMAVHEPVAGSFSRYARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKVVTIVVMIAVGIAMIALGIGN
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAENPQKTIPGAIN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHCCHHHH
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSS
HHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHH
CNGGIFSTGRMLYNLAQQGHAPRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVF
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VWVTSISTFGAIWTWGVILVAQMKFRASLAPAQERALRFRMPFWPYGSWVALTFLVLVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHH
LMAYFPDTRIALYVGPAWLVLLVVLYYALKLEPEGGKEAGLARGYERG
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MQKGSAETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFV
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IMRALGEMAVHEPVAGSFSRYARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKVVTIVVMIAVGIAMIALGIGN
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAENPQKTIPGAIN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHCCHHHH
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSS
HHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHH
CNGGIFSTGRMLYNLAQQGHAPRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVF
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VWVTSISTFGAIWTWGVILVAQMKFRASLAPAQERALRFRMPFWPYGSWVALTFLVLVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHH
LMAYFPDTRIALYVGPAWLVLLVVLYYALKLEPEGGKEAGLARGYERG
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]