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The map label for this gene is ilvA-1 [H]

Identifier: 83720819

GI number: 83720819

Start: 624046

End: 625569

Strand: Reverse

Name: ilvA-1 [H]

Synonym: BTH_I0549

Alternate gene names: 83720819

Gene position: 625569-624046 (Counterclockwise)

Preceding gene: 83719690

Following gene: 83720941

Centisome position: 16.42

GC content: 67.98

Gene sequence:

>1524_bases
ATGGCTTCCCACGATTATCTGAAGAAAATCCTGACCGCCCGGGTATACGACGTCGCGCTCGAAACCGAACTCGAGCGCGC
GCGCAACCTGTCCGCGCGGCTCGACAACGCCGTCTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCGTACAACAAGATGGCGCACATCCCCGCCGACGCGCTCGCGCGCGGCGTGATCACCGCGTCGGCGGGCAACCAC
GCGCAAGGCGTCGCGTTCTCGGCCGCGCGGATGAACGTGAAGGCGGTGATCGTCGTGCCGGTGACGACGCCGCAGCTGAA
GGTGGACGCGGTGCGCGCGCACGGCGGGCCGACCGTCGAGGTGATCCAGGCGGGCGAATCGTACAGCGACGCGTACGCGC
ACGCGGTGAAGGTGCAGGCCGAGCGCGGCCTCACGTTCGTTCATCCGTTCGACGATCCGTACGTGATCGCGGGCCAGGGC
ACGGTCGCGATGGAAATCCTGCGCCAGCATCAGGGGCCGATTCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGC
GGCGGGCGTCGCCGCGTACGTGAAGGCGGTGCGCCCCGAGATCAAGGTGATCGGCGTGCAGACCGACGATTCGTGCGCGA
TGAAGCAATCGCTCGCGGCGGGCAAGCGCGTCGAGCTCGCCGAGGTCGGCCTCTTCTCGGACGGCACGGCGGTCAAGCTC
GTCGGCGAGGAGACGTTCCGCCTCTGCGCGGCGTATCTCGACGACGTCGTGACCGTCGACACCGACGCGCTTTGCGCGGC
GATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTCGAGCCGGCCGGCTCGCTCGCCGTCGCGGGCGCGAAGCGGTATG
CGGAGCGCGCGGGCATCGAGGGCGAGACGCTCGTCGCGATCACGTCCGGCGCGAACATGAACTTCGACCGGATGCGCTTC
GTCGCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAGGCGGTGTTCGCGGTGACGATCCCCGAGGAGCGCGGCAGCTTCAG
GCGCTTCTGCTCGCTCGTCGGCGAGCGCAACGTGACCGAGTTCAACTACCGGATCGCCGATGCGCAATCGGCGCACATCT
TCGTCGGGGTGCAGATCCGGCGGCGCGACGAAACGGACGAAATCGCGCGCAACTTCGCCGCGCACGGCTTCACGACCGTC
GATCTGTCGGGCGACGAGCTGTCGAAGCAGCACATCCGCTACATGGTGGGCGGCCGCTCGCCGCTCGCGCACGACGAGCG
GCTGTTCCGCTTCGAATTTCCCGAGCGGCCGGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCCGACTGGAACATCA
GCCTGTTTCACTACCGGAACCAGGGGGCCGATTACAGCTCGATCCTCGTCGGCCTGCAGGTACCGCAGGCGGACCACGCG
GCGTTCGACCGCTTTCTCGCGGCGCTCGGCTATCCGTTCTGGGAAGAAAGCGTCAATCCGGCGTATCGTCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
CCGTCCGGACGGTCGGTAGCCGTTCGGCCGAGGCCGAAACGGCGAGGGTTGGCGCTATCATTGCCTTTTTCCGCCGCATC
CACGCCCTTCTCGCCCTCTC

Downstream 100 bases:

>100_bases
TCCGTCCATTCCATCCGATATGAACCCCGAACACTCCCCGCTCGGCAAGACGACCGTCTACGCGAACCAGTACGACGCGT
CGCTGCTGTTTCCGATTCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVALETELERARNLSARLDNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMNVKAVIVVPVTTPQLKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQG
TVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGKRVELAEVGLFSDGTAVKL
VGEETFRLCAAYLDDVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAERAGIEGETLVAITSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFRRFCSLVGERNVTEFNYRIADAQSAHIFVGVQIRRRDETDEIARNFAAHGFTTV
DLSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
AFDRFLAALGYPFWEESVNPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVALETELERARNLSARLDNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMNVKAVIVVPVTTPQLKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQG
TVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGKRVELAEVGLFSDGTAVKL
VGEETFRLCAAYLDDVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAERAGIEGETLVAITSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFRRFCSLVGERNVTEFNYRIADAQSAHIFVGVQIRRRDETDEIARNFAAHGFTTV
DLSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
AFDRFLAALGYPFWEESVNPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVALETELERARNLSARLDNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHA
QGVAFSAARMNVKAVIVVPVTTPQLKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGT
VAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGKRVELAEVGLFSDGTAVKLV
GEETFRLCAAYLDDVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAERAGIEGETLVAITSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFRRFCSLVGERNVTEFNYRIADAQSAHIFVGVQIRRRDETDEIARNFAAHGFTTVD
LSGDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHAA
FDRFLAALGYPFWEESVNPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=295, Percent_Identity=32.8813559322034, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=28.125, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790207, Length=505, Percent_Identity=54.2574257425743, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=34.4051446945338, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=385, Percent_Identity=30.1298701298701, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71991565, Length=328, Percent_Identity=28.6585365853659, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=292, Percent_Identity=27.3972602739726, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.5822050290135, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=34.2105263157895, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=26.2962962962963, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=29.4303797468354, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=27.843137254902, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55372; Mature: 55241

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVALETELERARNLSARLDNAVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQLKVDAVRAHGGPTVE
HCCCHHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHEEEEEHHCCEEEEECCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGKRVELAEVGLFSDGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECEECCCCEEEE
VGEETFRLCAAYLDDVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAERAGIE
ECHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCSLVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEE
FNYRIADAQSAHIFVGVQIRRRDETDEIARNFAAHGFTTVDLSGDELSKQHIRYMVGGRS
EEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHEECCCC
PLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCHHH
AFDRFLAALGYPFWEESVNPAYRLFLS
HHHHHHHHHCCCHHHHCCCCCEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVALETELERARNLSARLDNAVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQLKVDAVRAHGGPTVE
HCCCHHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEEECCCCCEEEEEEECCCCCEEE
VIQAGESYSDAYAHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHEEEEEHHCCEEEEECCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSCAMKQSLAAGKRVELAEVGLFSDGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECEECCCCEEEE
VGEETFRLCAAYLDDVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKRYAERAGIE
ECHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
GETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCSLVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCCEE
FNYRIADAQSAHIFVGVQIRRRDETDEIARNFAAHGFTTVDLSGDELSKQHIRYMVGGRS
EEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHEECCCC
PLAHDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCHHH
AFDRFLAALGYPFWEESVNPAYRLFLS
HHHHHHHHHCCCHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA