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The map label for this gene is lysC [H]

Identifier: 83720747

GI number: 83720747

Start: 2191775

End: 2193025

Strand: Direct

Name: lysC [H]

Synonym: BTH_I1945

Alternate gene names: 83720747

Gene position: 2191775-2193025 (Clockwise)

Preceding gene: 83720432

Following gene: 83719380

Centisome position: 57.54

GC content: 62.43

Gene sequence:

>1251_bases
ATGGCACTCATCGTACATAAATACGGCGGCACTTCGATGGGCTCGGTCGAGCGCATCAAGAACGTCGCGAAACGCGTCGC
AAAATGGCATCAGGCCGGGCACCAGATGGTGGTCGTGCCGTCCGCGATGTCCGGCGAAACGAACCGCCTGCTCGGTCTCG
CGAAAGAGATCTCGAGCCAGCCGAGCCCGCGCGAGCTCGACATGATCGCGTCGACGGGCGAGCAGGTCAGCGTCGGCCTC
TTGTCGATCGCAATGCAGGAAATCGGCGTCGAGGCGGTGAGCTACGCCGGCTGGCAGGTGCCGATCAAGACCGACAGCGC
GTACACGAAGGCGCGCATTCATTCGATCGACGACGAGCGCGTGCGCCGCGATCTCGACGCGGGCAAGGTCGTCATCATCA
CGGGTTTTCAGGGCGTCGATCCGGACGGCCACATCACGACGCTTGGCCGCGGCGGCTCGGACACGTCGGCGGTCGCGGTC
GCGGCGGCGCTCGAGGCGGACGAATGCCTGATCTACACGGACGTCGACGGCGTGTACACGACCGATCCGCGCGTCGTCGA
AGAGGCGCGCCGGCTCGATAGCGTGACGTTCGAGGAAATGCTGGAAATGGCGAGCCTCGGCTCGAAGGTGTTGCAGATCC
GCTCGGTCGAGTTCGCGGGCAAGTACCGCGTGAAGACGCGCGTGCTGTCGAGCCTCACCGATCCGCAGATTCCGCTCGAC
GAAGAGATGCGCTCGGGTACCCTGATTACTTTTGAAGAAGACGAGACCATGGAAAAGGCAGTCATTTCCGGCATTGCGTT
CCAGCGCGACGAAGCGCGCATTGCGGTGATGGGCGTGCCCGACAAGCCGGGCATCGCATATCAGATCCTCGGCCCTGTCG
CGGATGCGAACATCGACGTCGACATGATCATCCAGAACCAGAGCGTCGAAGGGAAAACCGACTTCACGTTTACGGTCGGC
CGCGGCGATTACCAGAAGGCGATGGACATCCTCACGAACCAGGTGAAGGGCCACGTGAACGCCGAGCAGGTGCTGGGCGA
CCCGAAGGTGTCGAAGGTGTCGGTGGTCGGCGTCGGGATGCGTTCGCACGTCGGCGTCGCGAGCACGATGTTCCGCACGC
TGTCGGAGGAGGGCATCAACATCCAGATGATCTCGACGTCCGAAATCAAGATTTCGGTGCTGATCGACGAGAAATACATG
GAATTGGCGGTCCGCGCACTGCACAAGGCATTCGAACTCGATCAGGCGTGA

Upstream 100 bases:

>100_bases
GTTCTTCCCGTCGTCCGTCCACAGCCACAAGCCGCGTGACCGAACGGCACCGCGGTCTGTCCAGTACGCCCGTGCGGCCC
TTCTCCAGTTCTGAACGACA

Downstream 100 bases:

>100_bases
TGAAATTTCCGTGACGCGCCGAAGAAAATGCGTCGCGGAAATTGACCTTGGCCCCGTAACCCTATAGAATCTTGGTTTCG
TCGCGCTGCCTCCCTGGCGC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGL
LSIAMQEIGVEAVSYAGWQVPIKTDSAYTKARIHSIDDERVRRDLDAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAV
AAALEADECLIYTDVDGVYTTDPRVVEEARRLDSVTFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPQIPLD
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVG
RGDYQKAMDILTNQVKGHVNAEQVLGDPKVSKVSVVGVGMRSHVGVASTMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA

Sequences:

>Translated_416_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGL
LSIAMQEIGVEAVSYAGWQVPIKTDSAYTKARIHSIDDERVRRDLDAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAV
AAALEADECLIYTDVDGVYTTDPRVVEEARRLDSVTFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPQIPLD
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVG
RGDYQKAMDILTNQVKGHVNAEQVLGDPKVSKVSVVGVGMRSHVGVASTMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA
>Mature_415_residues
ALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGLL
SIAMQEIGVEAVSYAGWQVPIKTDSAYTKARIHSIDDERVRRDLDAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVA
AALEADECLIYTDVDGVYTTDPRVVEEARRLDSVTFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPQIPLDE
EMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVGR
GDYQKAMDILTNQVKGHVNAEQVLGDPKVSKVSVVGVGMRSHVGVASTMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKAFELDQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=301, Percent_Identity=32.5581395348837, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790455, Length=383, Percent_Identity=28.9817232375979, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790376, Length=109, Percent_Identity=33.9449541284404, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=402, Percent_Identity=27.6119402985075, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45174; Mature: 45043

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQ
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIASTGEQVSVGLLSIAMQEIGVEAVSYAGWQVPIKTDSAYTKARIHSIDDER
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCHHHEEECCEEEEEECCCCHHHHHEECCCHHH
VRRDLDAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVAAALEADECLIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHEEEEECCCCEEEEECCCCEEE
TDPRVVEEARRLDSVTFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPQIPLD
CCHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCC
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDV
HHHCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVGRGDYQKAMDILTNQVKGHVNAEQVLGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECH
RSHVGVASTMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIASTGEQVSVGLLSIAMQEIGVEAVSYAGWQVPIKTDSAYTKARIHSIDDER
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCHHHEEECCEEEEEECCCCHHHHHEECCCHHH
VRRDLDAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVAAALEADECLIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHEEEEECCCCEEEEECCCCEEE
TDPRVVEEARRLDSVTFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPQIPLD
CCHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCC
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDV
HHHCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVGRGDYQKAMDILTNQVKGHVNAEQVLGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEECH
RSHVGVASTMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]