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The map label for this gene is hemB [H]

Identifier: 83720596

GI number: 83720596

Start: 3483703

End: 3484791

Strand: Direct

Name: hemB [H]

Synonym: BTH_I3038

Alternate gene names: 83720596

Gene position: 3483703-3484791 (Clockwise)

Preceding gene: 83721256

Following gene: 83719447

Centisome position: 91.45

GC content: 64.19

Gene sequence:

>1089_bases
TTGCTCGATCGCTATCATATACCATTGTCTCAAAAGTTTACCGAAGGGAACTGTAAGGTTTCATCGGACACCCATCCCAG
CCATTTCGCCATGAGCATCCATCCCCTGCACCGCCCGCGCCGCATGCGTCGCGACGATTTCTCGCGCCGCCTGATGCGCG
AAAACATTCTCACCACGAACGACCTGATCTATCCCGTGTTCGTCGTCGAAGGCACGAACGTGCGCCAGCCGGTGCCGTCG
ATGCCGGGCGTCGAGCGAGTGTCCGTCGATCTGCTGATGGGCGTCGCCGAGCAGTGCGTCGAACTCGGCGTGCCGGTCCT
GTCGCTCTTTCCCGCGATCGAGCCGTCGCTTAAGACGCCAGATGGCCGCGAGGCGACCAATCCCGAGGGCCTGATCCCGC
GCGCGGTGCGCGAATTGAAGCAACGCTTCCCCGAGCTCGGGGTGCTGACCGACGTCGCGCTCGATCCGTACACGAGCCAC
GGCCAGGACGGCGTGCTCGACGAAGCCGGCTACGTGCTCAACGACGAGACAGTCGAGATCCTCGTCGAGCAGGCGCGCGC
GCAGGCGGAAGCGGGCGTCGACATCGTCGCTCCGTCCGACATGATGGACGGGCGCATCGGCGCGGTGCGCGAGATGCTGG
AGAGCGAAGGCCACATCTATACGCGGATCATGGCGTACTCGGCGAAGTACGCGTCAGCGTTCTACGGCCCGTTCCGCGAC
GCGGTCGGCTCCGCGTCGAATCTCGGCAAGGGCAACAAGATGACCTACCAGATGGATCCAGCGAACAGCGACGAGGCGCT
GCGCGAAGTGCGCCTCGACATCGACGAAGGCGCGGACATGGTGATGGTGAAGCCCGGCATGCCGTATCTCGACATCGTGC
GCCGCGTGAAGGACGCATTCCGTTTTCCGACCTACGTCTACCAGGTGAGCGGCGAATACGCGATGCTGAAGGCCGCTGCG
CAGAACGGCTGGCTCGATCACGACAAGGTCGTGCTCGAATCGCTGCTCGCGTTCAAGCGGGCGGGCGCGGACGGCATTCT
CACGTACTTCGCGCTCGACGCGGCGCGGCTGCTGCGCGCGCAGAAGTAA

Upstream 100 bases:

>100_bases
ATAAAAAAACCCGCCGTTCAACGGCGGGTTAAACAGCCTAATCGAAAAACGACAGGCACCCGCTCAGGGAGGAGAAGCGG
GGAGCATTGCGCAGTGCGCT

Downstream 100 bases:

>100_bases
TCACGCGACACGCGCGCCGCATGCATCGCGGCGCGCGCCGGAAGTGAAAATGAAAACGGCGGGGCTTCAAGCCTCGCCGT
TCTTACTTGTGCCCAAACGA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLDRYHIPLSQKFTEGNCKVSSDTHPSHFAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSVDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREATNPEGLIPRAVRELKQRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETVEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLESEGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDAFRFPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK

Sequences:

>Translated_362_residues
MLDRYHIPLSQKFTEGNCKVSSDTHPSHFAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSVDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREATNPEGLIPRAVRELKQRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETVEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLESEGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDAFRFPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK
>Mature_362_residues
MLDRYHIPLSQKFTEGNCKVSSDTHPSHFAMSIHPLHRPRRMRRDDFSRRLMRENILTTNDLIYPVFVVEGTNVRQPVPS
MPGVERVSVDLLMGVAEQCVELGVPVLSLFPAIEPSLKTPDGREATNPEGLIPRAVRELKQRFPELGVLTDVALDPYTSH
GQDGVLDEAGYVLNDETVEILVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLESEGHIYTRIMAYSAKYASAFYGPFRD
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDAFRFPTYVYQVSGEYAMLKAAA
QNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRAQK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=298, Percent_Identity=46.3087248322148, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI87081728, Length=326, Percent_Identity=46.319018404908, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=38.7622149837134, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=42.3728813559322, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 40294; Mature: 40294

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRYHIPLSQKFTEGNCKVSSDTHPSHFAMSIHPLHRPRRMRRDDFSRRLMRENILTTN
CCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DLIYPVFVVEGTNVRQPVPSMPGVERVSVDLLMGVAEQCVELGVPVLSLFPAIEPSLKTP
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
DGREATNPEGLIPRAVRELKQRFPELGVLTDVALDPYTSHGQDGVLDEAGYVLNDETVEI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHCCCCEECCHHHHH
LVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLESEGHIYTRIMAYSAKYASAFYGPFRD
HHHHHHHHHHCCEEEECCCHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDAF
HHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
RFPTYVYQVSGEYAMLKAAAQNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRA
HCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
QK
CC
>Mature Secondary Structure
MLDRYHIPLSQKFTEGNCKVSSDTHPSHFAMSIHPLHRPRRMRRDDFSRRLMRENILTTN
CCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
DLIYPVFVVEGTNVRQPVPSMPGVERVSVDLLMGVAEQCVELGVPVLSLFPAIEPSLKTP
CCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
DGREATNPEGLIPRAVRELKQRFPELGVLTDVALDPYTSHGQDGVLDEAGYVLNDETVEI
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHCCCCEECCHHHHH
LVEQARAQAEAGVDIVAPSDMMDGRIGAVREMLESEGHIYTRIMAYSAKYASAFYGPFRD
HHHHHHHHHHCCEEEECCCHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
AVGSASNLGKGNKMTYQMDPANSDEALREVRLDIDEGADMVMVKPGMPYLDIVRRVKDAF
HHCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
RFPTYVYQVSGEYAMLKAAAQNGWLDHDKVVLESLLAFKRAGADGILTYFALDAARLLRA
HCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
QK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]