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The map label for this gene is purR [H]

Identifier: 83720525

GI number: 83720525

Start: 2829237

End: 2830268

Strand: Reverse

Name: purR [H]

Synonym: BTH_I2472

Alternate gene names: 83720525

Gene position: 2830268-2829237 (Counterclockwise)

Preceding gene: 83721448

Following gene: 83720258

Centisome position: 74.3

GC content: 69.77

Gene sequence:

>1032_bases
ATGGCGACGATCAAGGATGTGGCGGCCATCGCCGGCGTATCGTTCACGACGGTATCGCACGTGGTCAACAACTCGCGGCC
CGTGTCGGCTGACGTGCGTGCCAAGGTGGAGCGGGCGATCCGCGAGCTCAACTACGTGCCGTCGGCCGTCGCGCGCTCGC
TGAAGGCGCGCTCGACGGCCACCATCGGCCTCGTGGTGCCGAACAGCACGAACCCGTACTTCGCCGAGCTCGCGCGCGGC
ATCGAAGACCAGTGCGCGCTGTCCGGCTACTGCGTGTTCCTGTGCAACTCGGACGACGATCCCGAGAAGCAGCGCAACTA
CCTGCGCGTGCTGCAGGAAAAGCGCATCGACGGGCTCATCATCGCGTCCGCGGGCGACGACGCGGTGCTCGCGCAGACGC
TCGCCGACACGCGCGAGCCGCTCGTCGTGGTCGACCGGAACATCGAGGGGCTCGCGGCCGATCTCGTGCAGATCGACCAT
GAGCGCGGCGCGTATCTGGCCACGCGCCATCTGCTCGAACTCGGCCACGCGAAGATCGGCTGCATCACGGGCGCGGTGTC
GACCGCCGTGAGCGCGATGCGCGTGCACGGCTTCATTCGCGCGATGGCCGAGCGCGGGATCGACATCGTGCCGGGCGCGA
TCGCCGAAAGCGACTTCTCGTGCATGGGCGGCTATCACGCGGCCGTGCGCCTGTTCGATAGCGTGCGCCCGAGCGCGATC
TTCGCCGGCAACGATCTGATGGGGCTCGGCGCGCTGCGCGCGGCCGCCGAGCGCGGCATCCGCGTGCCCGCCGACTGCTC
GATCATCGGCTTCGACGACATCGAGCTGTCGCGCTACACGTATCCGGCGCTGTCGACGGTCGGCCAATCGGTGCGCGCGC
TGGGCGAGATGGCCGCGCAGACGCTGATCGAGCGGATCGGCGGCGGTGCGTCGGGCGCGCCGCAGCGGCGGCGCGTCGTG
TCGCCGCGCCTCGTGCTGCGCGAATCGACGACCGTCTATGTGGAGCCGGCCGACGCCGGATATCGCGGATGA

Upstream 100 bases:

>100_bases
TCATCACCGGCGCCGTGATCGTCGTGGCCGTCGTGCTCGACACGTATCGCAGCCGGCGCGCGCGGGGATAGCAAAGAACA
ACGAACCAGAGAGAAACGGA

Downstream 100 bases:

>100_bases
CGGCCGCCGTCGAACGCGCCGCCGGGCGGGCCGCGCCCGTGCGCACCGGCAAGGTGATGGTGGTCGGCAGCCTGAACATG
GACCTCGTCGTGCGCTCGCC

Product: ribose operon repressor RbsR

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLAADLVQIDH
ERGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVV
SPRLVLRESTTVYVEPADAGYRG

Sequences:

>Translated_343_residues
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLAADLVQIDH
ERGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVV
SPRLVLRESTTVYVEPADAGYRG
>Mature_342_residues
ATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARGI
EDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLIIASAGDDAVLAQTLADTREPLVVVDRNIEGLAADLVQIDHE
RGAYLATRHLLELGHAKIGCITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAIF
AGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGASGAPQRRRVVS
PRLVLRESTTVYVEPADAGYRG

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=338, Percent_Identity=40.5325443786982, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=42.4698795180723, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=34.0361445783133, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1788474, Length=333, Percent_Identity=37.2372372372372, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=34.4311377245509, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1789068, Length=338, Percent_Identity=31.9526627218935, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=32.6283987915408, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787580, Length=328, Percent_Identity=31.4024390243902, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI48994940, Length=310, Percent_Identity=27.0967741935484, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790715, Length=316, Percent_Identity=25, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787906, Length=323, Percent_Identity=26.9349845201238, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1786268, Length=324, Percent_Identity=26.8518518518519, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.8125, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=25.0793650793651, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790192, Length=248, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36539; Mature: 36408

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTA
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGDDAVLAQTLADTREPLVVVDRNIEGLAADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
CITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCHHHHHHHHHHHCCCCEE
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGASGAPQRRRVVSPRLVLRESTTVYVEPADAGYRG
HHHHHHCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCC
>Mature Secondary Structure 
ATIKDVAAIAGVSFTTVSHVVNNSRPVSADVRAKVERAIRELNYVPSAVARSLKARSTA
CCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCALSGYCVFLCNSDDDPEKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
IASAGDDAVLAQTLADTREPLVVVDRNIEGLAADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
CITGAVSTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCMGGYHAAVRLFDSVRPSAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCHHHHHHHHHHHCCCCEE
FAGNDLMGLGALRAAAERGIRVPADCSIIGFDDIELSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGASGAPQRRRVVSPRLVLRESTTVYVEPADAGYRG
HHHHHHCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA