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The map label for this gene is pth [H]

Identifier: 83719915

GI number: 83719915

Start: 525882

End: 526487

Strand: Reverse

Name: pth [H]

Synonym: BTH_I0472

Alternate gene names: 83719915

Gene position: 526487-525882 (Counterclockwise)

Preceding gene: 284159402

Following gene: 83719412

Centisome position: 13.82

GC content: 67.49

Gene sequence:

>606_bases
ATGATCAAACTGATCGTCGGCCTCGGCAATCCCGGGGCGGAATACACGGCGACGCGCCACAACGCAGGCTTCTGGCTCGT
CGACCAGCTCGCGCGCGAAGCCGGCGCGACGCTGCGCGACGAGCGGCGCTTCCACGGCTTCTATGCGAAAGCGCGCCTCT
ACGGCGAGGAAGTGCATCTGCTCGAGCCGCAGACGTACATGAACCGCTCCGGCCAATCGGTCGTCGCGCTCGCGCATTTC
TTCAAGATCCTGCCGAACGAAATCCTCGTCGCGCACGACGAGCTCGACCTGCCGCCCGGCGCGGTCAAGCTGAAGCTCGG
CGGCGGCAGCGGCGGCCACAACGGCCTGAAGGACATCTCCGCGCATCTGTCTTCGCAGCAGTACTGGCGGCTGCGGATCG
GCATCGGCCATCCGCGCGACATGATTCCGGAAAGCGCGCGCGCGGGCGCGAAGCCCGACGTCGCGAACTTCGTGCTGAAG
CCGCCGCGCAAGGAAGAGCAGGACGTGATCGACGCCGCGATCGAGCGCGCGCTCGCCGTGATGCCCGCCGTCGTCAAGGG
CGAGACCGAGCGCGCGATGATGCAGCTGCATCGCAACGGCGCGTAA

Upstream 100 bases:

>100_bases
CGTTTCGCACGACGGTCGACGAGACCCGCCGCGGCTTGCCCGGCGGGTTTTTTCATTCTTGCCGCCCGCGAGGGCGAATC
CTGACGGGCAAGCGTTCATC

Downstream 100 bases:

>100_bases
GCGCGCGCCTTCCCGCCCTCGCCGCCGCGCGCATCGGTTAAGCTCATCGTTTTACCGCATCGGGAGCCACGTGGTGAGCC
GTTACTGGAGCGACATCGTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPNEILVAHDELDLPPGAVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDMIPESARAGAKPDVANFVLK
PPRKEEQDVIDAAIERALAVMPAVVKGETERAMMQLHRNGA

Sequences:

>Translated_201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPNEILVAHDELDLPPGAVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDMIPESARAGAKPDVANFVLK
PPRKEEQDVIDAAIERALAVMPAVVKGETERAMMQLHRNGA
>Mature_201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLYGEEVHLLEPQTYMNRSGQSVVALAHF
FKILPNEILVAHDELDLPPGAVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDMIPESARAGAKPDVANFVLK
PPRKEEQDVIDAAIERALAVMPAVVKGETERAMMQLHRNGA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=176, Percent_Identity=36.3636363636364, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=53.8071065989848, Blast_Score=173, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22102; Mature: 22102

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLYGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEE
LEPQTYMNRSGQSVVALAHFFKILPNEILVAHDELDLPPGAVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDMIPESARAGAKPDVANFVLKPPRKEEQDVIDAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
MPAVVKGETERAMMQLHRNGA
HHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLYGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEE
LEPQTYMNRSGQSVVALAHFFKILPNEILVAHDELDLPPGAVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDMIPESARAGAKPDVANFVLKPPRKEEQDVIDAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
MPAVVKGETERAMMQLHRNGA
HHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA