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The map label for this gene is hisG [H]

Identifier: 83719881

GI number: 83719881

Start: 3433976

End: 3434632

Strand: Reverse

Name: hisG [H]

Synonym: BTH_I2994

Alternate gene names: 83719881

Gene position: 3434632-3433976 (Counterclockwise)

Preceding gene: 83719131

Following gene: 83720216

Centisome position: 90.17

GC content: 68.49

Gene sequence:

>657_bases
ATGACCGCACCGCTGACGCTGGCGCTGTCGAAAGGGCGTATCTTCGAGGAAACCGTGCCGCTCCTCGCGGCGGCGGGCGT
GACCGTGGCCGAGGACCCTGAGCGCTCGCGCAAGCTGATCCTGCCGACCACCGATCCGAACCTGCGCGTGATCGTCGTGC
GCGCGACCGACGTGCCGACCTACGTCGAGTACGGCGCGGCCGACTTCGGCGTCGCCGGCAAGGACGTGCTGCTCGAGCAC
GGCGGCGGCGGGCTGTATCAGCCGATCGATTTGAACATCGCGCGCTGCCGGATGTCGGTTGCGGTGCCGGCCGGTTTTGA
TTATGCGAATGCGGTGCGCCAGGGCGCGCGGCTGCGCGTCGCGACGAAGTACGTCGAAACGGCGCGCGAGCACTTCGCGG
CGAAGGGCGTGCACGTCGACCTGATCAAGCTGTACGGCTCGATGGAGCTTGCGCCGCTCGTCGGCCTGGCCGACGCGATC
GTCGACCTCGTCAGCTCGGGCGGCACGCTGAAGGCGAACAATCTGGTCGAGGTGGAGGAGATCATGCCGATCTCGTCGCG
CCTCGTCGTGAACCAGGCCGCGCTGAAACTGAAGCGCGCCGCGCTGAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGC
AGGGCGGCGGTGCCTGA

Upstream 100 bases:

>100_bases
TCGTCGAGCGCATCTATCATTTGGACCGCGGCTACGACCGGATGGAGACGAAGCTGACGGCCGTCGGCGCGAACGTGCGC
CGCATTTCAGGGAGCGAAGC

Downstream 100 bases:

>100_bases
CCTTGCGGCTTTCGGCGCATTACCGGAACGGATGACAGCATGGCTATCAAGATACGCAAACTCGATTCGGCAAGCGCAGG
CTTCGCGGCCGAATTGCGTG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTAPLTLALSKGRIFEETVPLLAAAGVTVAEDPERSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEH
GGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASQGGGA

Sequences:

>Translated_218_residues
MTAPLTLALSKGRIFEETVPLLAAAGVTVAEDPERSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEH
GGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASQGGGA
>Mature_217_residues
TAPLTLALSKGRIFEETVPLLAAAGVTVAEDPERSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEHG
GGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIV
DLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASQGGGA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=186, Percent_Identity=34.4086021505376, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=186, Percent_Identity=31.1827956989247, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23121; Mature: 22990

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLTLALSKGRIFEETVPLLAAAGVTVAEDPERSRKLILPTTDPNLRVIVVRATDVPT
CCCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLLEHGGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEHH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPFLDAFERASQGGGA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAPLTLALSKGRIFEETVPLLAAAGVTVAEDPERSRKLILPTTDPNLRVIVVRATDVPT
CCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLLEHGGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEHH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPFLDAFERASQGGGA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA