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The map label for this gene is ybhO [H]

Identifier: 83719800

GI number: 83719800

Start: 639748

End: 641022

Strand: Direct

Name: ybhO [H]

Synonym: BTH_I0562

Alternate gene names: 83719800

Gene position: 639748-641022 (Clockwise)

Preceding gene: 83721114

Following gene: 83720788

Centisome position: 16.79

GC content: 69.1

Gene sequence:

>1275_bases
ATGAGCGGCAAGGCCCGGCACCGTCTCGCGCAACTGCGGCAGATGTTTCTGCAGGAGCGCGGGTCCGCGTCGCGGCTCGC
GTTCACGTCCGGCAACGCGGTGCGCCTCTGTGACGGCGGCGCGGCGTTTTTTCCCGCGCTGATCGAGCGGATCGACGCCG
CGCGCGAGCGCGTCGCGCTCGAAACCTATATCTTTTGCGACGACGCGGTCGGCCGCGCGGTATCGGACGCGCTCGTCCGC
GCGGCCGCGCGCGGCGTCCACGTGCGCGTCATTACCGACGGGATCGGCACCGAGCGCCTGCTGCTCTTCGGCACATGGCC
GGACGCAGGCGTCGAGCACCGGATCTACAACCCCTATCTGTTCGGCCGCTTCGGCTTCTCGCGCACGCACCGCAAGCTCG
CGGTGATCGACGACGCCTACGCGTTCTGCGGCGGCATCAACATCGTCGACGATTTCGAGCAGAACGGCGAGCGCCTGCCG
TATCCGCGCTGGGATTTCGCGCTCGAGCTGCAAGGGCCCGCCGTTGCCGACGTGCGCGCCGCGTTCGAAGTGCAATGGCA
CCGGATCGCGGCCGGCCATAAGCGCTATGCGGAGTATGTGCCGCACGGCGCGGACGGCACGGCGTTCGCCGGGCGCTTTC
GCCGCTGGATGCGCAGCCACCGCTGGGTGAAGGCGGGCGCGCTGCGCGTCGTGACCGAGCCGAGCGTCGCGTTCGTCGCG
CGCGACAACGTCGTGAATCGCCGCGCGATCGAGAAGGCGTATCTCGCGGCGATCGGCCGCGCGCGCCAGTCGATCCTGCT
CGCCAACCCGTACTTCATGCCGGGGCGCAAGCTGCGGCGCGCGCTCGCCGGCGCGGCGCGGCGCGGCGTCGATGTGCGCA
TACTGCTCGGGCGCAACGAGTTCGCGTCGCTCGATATGGCGGTGCCGTTCCTATATCATGCATTGCTGCGCTCGGGCGTG
CGCGTCGCCGAATACGACAAGACGATACTGCACGGCAAGGTCGCGGTGATCGACGATCACTGGGCGACCGTCGGCTCGTC
GAATCTGGATGCGCTCAGCCTGATGCTGAACAACGAGGCGAACGTCGTGCTCGTGCGCCATCGCGAGGAGACGGCCGCGC
TGCGCGACGCGATCGCCGTCGCGTTCGCCGACGGCCGAGAGATCGACCCCGCGCTCTATGCGGCGCGGCCCGCCGTCGAG
CGGTTTCTGAACTGGTTCGCGTACAACGCGTACCGGGGTGCGATGAAGCTGCTGACGGTCGGCGGATACGACTAA

Upstream 100 bases:

>100_bases
ATCAGTGGCTGCCTTACCGCGAAGCGGCCGCGCGCTGCTACTCGCCGTCGAACGCCGAGGCGATCCTGCAACTGCCCGAG
CGCCTCGCGTCGCGCGCCGC

Downstream 100 bases:

>100_bases
GCATTCGCTTACACATACGGCGCGCCGCGGCCTGCACAGGGCCTCCTCCAGAGGCGCGCGACCCTGCAAAATAGCGGGGA
CGGTTAGAAACCGATTTCTA

Product: cardiolipin synthetase II

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSGKARHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVR
AAARGVHVRVITDGIGTERLLLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDAYAFCGGINIVDDFEQNGERLP
YPRWDFALELQGPAVADVRAAFEVQWHRIAAGHKRYAEYVPHGADGTAFAGRFRRWMRSHRWVKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGV
RVAEYDKTILHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAVAFADGREIDPALYAARPAVE
RFLNWFAYNAYRGAMKLLTVGGYD

Sequences:

>Translated_424_residues
MSGKARHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVR
AAARGVHVRVITDGIGTERLLLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDAYAFCGGINIVDDFEQNGERLP
YPRWDFALELQGPAVADVRAAFEVQWHRIAAGHKRYAEYVPHGADGTAFAGRFRRWMRSHRWVKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGV
RVAEYDKTILHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAVAFADGREIDPALYAARPAVE
RFLNWFAYNAYRGAMKLLTVGGYD
>Mature_423_residues
SGKARHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVRA
AARGVHVRVITDGIGTERLLLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDAYAFCGGINIVDDFEQNGERLPY
PRWDFALELQGPAVADVRAAFEVQWHRIAAGHKRYAEYVPHGADGTAFAGRFRRWMRSHRWVKAGALRVVTEPSVAFVAR
DNVVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGVR
VAEYDKTILHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAVAFADGREIDPALYAARPAVER
FLNWFAYNAYRGAMKLLTVGGYD

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=380, Percent_Identity=38.4210526315789, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787502, Length=425, Percent_Identity=25.6470588235294, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI87081826, Length=416, Percent_Identity=28.125, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 47214; Mature: 47082

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKARHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVAL
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHEE
ETYIFCDDAVGRAVSDALVRAAARGVHVRVITDGIGTERLLLFGTWPDAGVEHRIYNPYL
EEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCEECCCEE
FGRFGFSRTHRKLAVIDDAYAFCGGINIVDDFEQNGERLPYPRWDFALELQGPAVADVRA
EEECCCCCCCCEEEEEEHHHHHHCCCCEEHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
AFEVQWHRIAAGHKRYAEYVPHGADGTAFAGRFRRWMRSHRWVKAGALRVVTEPSVAFVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNE
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FASLDMAVPFLYHALLRSGVRVAEYDKTILHGKVAVIDDHWATVGSSNLDALSLMLNNEA
CCHHHHHHHHHHHHHHHCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRHREETAALRDAIAVAFADGREIDPALYAARPAVERFLNWFAYNAYRGAMKLLTV
CEEEEEECHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
GGYD
CCCC
>Mature Secondary Structure 
SGKARHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVAL
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHEE
ETYIFCDDAVGRAVSDALVRAAARGVHVRVITDGIGTERLLLFGTWPDAGVEHRIYNPYL
EEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCEECCCEE
FGRFGFSRTHRKLAVIDDAYAFCGGINIVDDFEQNGERLPYPRWDFALELQGPAVADVRA
EEECCCCCCCCEEEEEEHHHHHHCCCCEEHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
AFEVQWHRIAAGHKRYAEYVPHGADGTAFAGRFRRWMRSHRWVKAGALRVVTEPSVAFVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNE
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FASLDMAVPFLYHALLRSGVRVAEYDKTILHGKVAVIDDHWATVGSSNLDALSLMLNNEA
CCHHHHHHHHHHHHHHHCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRHREETAALRDAIAVAFADGREIDPALYAARPAVERFLNWFAYNAYRGAMKLLTV
CEEEEEECHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
GGYD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]