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The map label for this gene is hdaH [H]

Identifier: 83719797

GI number: 83719797

Start: 2382845

End: 2383867

Strand: Reverse

Name: hdaH [H]

Synonym: BTH_I2111

Alternate gene names: 83719797

Gene position: 2383867-2382845 (Counterclockwise)

Preceding gene: 83718829

Following gene: 83720638

Centisome position: 62.58

GC content: 69.01

Gene sequence:

>1023_bases
GTGCAGCCGCCGTCGAGCGCGGGCTACGCGGAATCGCCCGACTCGAAACGACGCCTGCTGTCGCTCGTGTACGCATCGGG
GCTCGCCGCGAGGCTCGACATGTCGAGCGCGCCCGCCGCGACCGACGACGATCTGCTGCGCATCCATCCCGCGCATTACC
TCGAAGCGTTCAAGCGCGCAAGCGACACGGGCGGCGGCGACCTCGGCGAACTCGCGCCGTTCGGCCGGGGCAGCTATGAG
ATCGCGGCGCTGTCGGCGGGGCTCGCGCTGGCCGCCGTCGACGCGGTGCTCGCCGAGCGCGCAGCGAACGCGTTCTCGCT
GTCGCGCCCGCCCGGCCATCACTGCCTGCGCGACAAGCCGATGGGCTTTTGCCTGCTCGCGAACATTCCGATCGCGATCG
AGGCCGCGCGCGCGAAGCATCGCGTCGAGCGCGTCGCGGTGATCGACTGGGACGTGCATCACGGCAACGGCACGCAGGCG
ATCTACTACGACGACGCCGACACGCTGACGATCTCGCTGCATCAGGACCGCTGCTTTCCGCCCGGCTACAGCGGCGCCGA
CGAGCGCGGCGCGGGCGCGGGCATCGGTGCGAACATCAACGTTCCGCTCCTCGCGGGCGCGGGCGACGATGCATATCGAT
ATGCATTCGAGCGGATCGTGCTGCCCGCGCTCGACGCGTTCAGGCCGGAGCTCGTCGTCGTCGCGAGCGGACTCGACGCG
AATGCGGTCGACCCGCTCGCGCGGATGCAACTGCACAGCGACAGCTATCGATTCATGACGCACGCGCTGAAAGCAGCCGC
GCAGCGGCACTGCGCGGGGCGGCTCGTCGTCGTGCACGAAGGCGGTTATTCGGAGGCCTACGTACCGTTTTGCGGACAGG
CGATCGTCGAGGCGCTGTCCGGCATGCGCACCGACGTCGTCGACCCGATGCTCGAACTCGCGATCGCGCAGCAGCCCGGC
GAGCGATTCAACGCGTTCCAGCGGCAGTTGATCGACGAAATGGCGACGGGCTTCGGCTATTGA

Upstream 100 bases:

>100_bases
TTGGCACATTGCAATGACGAAAACCGCTTTCTTCACCGACGAACGCACTTTCTGGCACACGGGCGGCGCGCACGCGCTGT
TCTTTCCGGTCGGCGGATGG

Downstream 100 bases:

>100_bases
TTGATCGAGCAACCGAGGGTCGGGCGACGCGAGAAGCAGGTCGGCACGGCGCGCGCGGCGCCGTTCGCCGGCGCGTGTGA
CGGGGGCGACGGACAATAAC

Product: histone deacetylase family protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQPPSSAGYAESPDSKRRLLSLVYASGLAARLDMSSAPAATDDDLLRIHPAHYLEAFKRASDTGGGDLGELAPFGRGSYE
IAALSAGLALAAVDAVLAERAANAFSLSRPPGHHCLRDKPMGFCLLANIPIAIEAARAKHRVERVAVIDWDVHHGNGTQA
IYYDDADTLTISLHQDRCFPPGYSGADERGAGAGIGANINVPLLAGAGDDAYRYAFERIVLPALDAFRPELVVVASGLDA
NAVDPLARMQLHSDSYRFMTHALKAAAQRHCAGRLVVVHEGGYSEAYVPFCGQAIVEALSGMRTDVVDPMLELAIAQQPG
ERFNAFQRQLIDEMATGFGY

Sequences:

>Translated_340_residues
MQPPSSAGYAESPDSKRRLLSLVYASGLAARLDMSSAPAATDDDLLRIHPAHYLEAFKRASDTGGGDLGELAPFGRGSYE
IAALSAGLALAAVDAVLAERAANAFSLSRPPGHHCLRDKPMGFCLLANIPIAIEAARAKHRVERVAVIDWDVHHGNGTQA
IYYDDADTLTISLHQDRCFPPGYSGADERGAGAGIGANINVPLLAGAGDDAYRYAFERIVLPALDAFRPELVVVASGLDA
NAVDPLARMQLHSDSYRFMTHALKAAAQRHCAGRLVVVHEGGYSEAYVPFCGQAIVEALSGMRTDVVDPMLELAIAQQPG
ERFNAFQRQLIDEMATGFGY
>Mature_340_residues
MQPPSSAGYAESPDSKRRLLSLVYASGLAARLDMSSAPAATDDDLLRIHPAHYLEAFKRASDTGGGDLGELAPFGRGSYE
IAALSAGLALAAVDAVLAERAANAFSLSRPPGHHCLRDKPMGFCLLANIPIAIEAARAKHRVERVAVIDWDVHHGNGTQA
IYYDDADTLTISLHQDRCFPPGYSGADERGAGAGIGANINVPLLAGAGDDAYRYAFERIVLPALDAFRPELVVVASGLDA
NAVDPLARMQLHSDSYRFMTHALKAAAQRHCAGRLVVVHEGGYSEAYVPFCGQAIVEALSGMRTDVVDPMLELAIAQQPG
ERFNAFQRQLIDEMATGFGY

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=35.2112676056338, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI13128864, Length=288, Percent_Identity=34.375, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI153085395, Length=247, Percent_Identity=35.2226720647773, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI148539870, Length=258, Percent_Identity=35.6589147286822, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI169234807, Length=258, Percent_Identity=35.6589147286822, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI17158039, Length=247, Percent_Identity=32.7935222672065, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI30795204, Length=246, Percent_Identity=32.9268292682927, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI30795202, Length=246, Percent_Identity=32.9268292682927, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI226529806, Length=284, Percent_Identity=32.3943661971831, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI62750347, Length=244, Percent_Identity=33.6065573770492, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62750349, Length=244, Percent_Identity=33.6065573770492, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI8923769, Length=319, Percent_Identity=25.3918495297806, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI293336691, Length=254, Percent_Identity=25.9842519685039, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13128862, Length=256, Percent_Identity=27.34375, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13128860, Length=254, Percent_Identity=25.5905511811024, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=26.9058295964126, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262073088, Length=250, Percent_Identity=26.8, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=313, Percent_Identity=31.9488817891374, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI193206283, Length=310, Percent_Identity=31.6129032258064, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17540332, Length=310, Percent_Identity=31.6129032258064, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193209491, Length=240, Percent_Identity=32.9166666666667, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=294, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561978, Length=297, Percent_Identity=28.6195286195286, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17534739, Length=240, Percent_Identity=28.75, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=192, Percent_Identity=34.375, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25154020, Length=286, Percent_Identity=25.5244755244755, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=286, Percent_Identity=25.1748251748252, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=315, Percent_Identity=33.015873015873, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323999, Length=351, Percent_Identity=26.4957264957265, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=242, Percent_Identity=29.7520661157025, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325141, Length=274, Percent_Identity=31.021897810219, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=22.1105527638191, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281360899, Length=326, Percent_Identity=34.3558282208589, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24642142, Length=326, Percent_Identity=34.3558282208589, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642146, Length=326, Percent_Identity=34.3558282208589, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642144, Length=326, Percent_Identity=34.3558282208589, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24641720, Length=239, Percent_Identity=36.8200836820084, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281360799, Length=238, Percent_Identity=36.5546218487395, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI281360801, Length=238, Percent_Identity=36.5546218487395, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24657891, Length=254, Percent_Identity=29.1338582677165, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644244, Length=271, Percent_Identity=27.3062730627306, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36288; Mature: 36288

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPSSAGYAESPDSKRRLLSLVYASGLAARLDMSSAPAATDDDLLRIHPAHYLEAFKRA
CCCCCCCCCCCCCHHHHHHHHHHHHHCHHHEECCCCCCCCCCCCEEEECHHHHHHHHHHC
SDTGGGDLGELAPFGRGSYEIAALSAGLALAAVDAVLAERAANAFSLSRPPGHHCLRDKP
CCCCCCCCHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
MGFCLLANIPIAIEAARAKHRVERVAVIDWDVHHGNGTQAIYYDDADTLTISLHQDRCFP
CCEEEEECCCEEEEHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCCC
PGYSGADERGAGAGIGANINVPLLAGAGDDAYRYAFERIVLPALDAFRPELVVVASGLDA
CCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NAVDPLARMQLHSDSYRFMTHALKAAAQRHCAGRLVVVHEGGYSEAYVPFCGQAIVEALS
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GMRTDVVDPMLELAIAQQPGERFNAFQRQLIDEMATGFGY
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQPPSSAGYAESPDSKRRLLSLVYASGLAARLDMSSAPAATDDDLLRIHPAHYLEAFKRA
CCCCCCCCCCCCCHHHHHHHHHHHHHCHHHEECCCCCCCCCCCCEEEECHHHHHHHHHHC
SDTGGGDLGELAPFGRGSYEIAALSAGLALAAVDAVLAERAANAFSLSRPPGHHCLRDKP
CCCCCCCCHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
MGFCLLANIPIAIEAARAKHRVERVAVIDWDVHHGNGTQAIYYDDADTLTISLHQDRCFP
CCEEEEECCCEEEEHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCCC
PGYSGADERGAGAGIGANINVPLLAGAGDDAYRYAFERIVLPALDAFRPELVVVASGLDA
CCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NAVDPLARMQLHSDSYRFMTHALKAAAQRHCAGRLVVVHEGGYSEAYVPFCGQAIVEALS
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GMRTDVVDPMLELAIAQQPGERFNAFQRQLIDEMATGFGY
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA