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The map label for this gene is proY [H]

Identifier: 83719715

GI number: 83719715

Start: 3280900

End: 3282264

Strand: Direct

Name: proY [H]

Synonym: BTH_I2854

Alternate gene names: 83719715

Gene position: 3280900-3282264 (Clockwise)

Preceding gene: 83718833

Following gene: 83720111

Centisome position: 86.13

GC content: 68.35

Gene sequence:

>1365_bases
ATGAAGAACTTGCAGCGCCATCTGAGCGCGCGGCACATCCGCTTTCTCGCGCTCGGCTCGGCGATCGGCACGGGCCTCTT
CTACGGCTCGGCGTCCGCGATCCGGCTGGCGGGCCCCGCCGTCATCCTCGCGTACATCGTCGGCGGCGCGGCCGTCTACA
TGGTGATGCGCGCGCTCGGCGAAATGGCGGTGCGCGAGCCCGTGCCCGGCTCGTTCGGCCACTACGCGAGCGAAAACCTG
GGCCCGTTCGCGGGCTTCGTCACCGGCTGGACCTACACGCTCGAGATGGTGATCGTCGCGATCGCCGACATCACCGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCGGACGTCCCGCAGTGGATCTGGGTGCTCGCGATCGTCGCGATCATCTGCGGGC
TCAATCTGTGCCACGTGAAGGTGTTCGGCGAGCTGGAGTTCTGGCTGTCGATCGTCAAGGTCGGCGCGATCGTCGCGATG
ATCGGCGGCGGCGCGGCGATCCTGTTCTCCGGCATGAAGCTCGGCAGCGGCGGCGCGCCGGCGCTCGCGAATCTGTGGTC
GCACGGCGGCTTCCTGCCGAACGGCGTGGGCGGGCTCGTCGCGTCGCTGTCGGTCGTGATCTTCGCGTATGGCGGCATCG
AGGTGATCGGCATGAGCGCCGGCGAGGCGAAGGAGCCCGAGCGCGTGATTCCGCGCGCGATCAACGCGGTGCCGATGCGC
ATCCTGCTCTTCTACGTGCTGACGATGGTCGTGCTGATGTCGATCTTTCCGTGGACGGGCGTCGGCGCGAACGGCAGCCC
GTTCGTGCAGATCTTCTCGGCGCTCGGCGTGCGCTCCGCGGCCGAGATCCTGAACCTCGTCGTGATCAGCGCGGCGATCT
CCGCGATCAACAGCGACATCTTCGGCGCGGGCCGGATGATGTACGGGATGGCGCTGCAGGGCCAGGCGCCGCGCGCGCTC
GCCTCGATGTCCGCGCGCGGCGTGCCGTGGGTCACGGTGCTCGTGATGGCGGGCGCCCTGCTCGTGGGCGTCGTGCTCAA
CTACCTGATGCCGAAGGACGTGTTCCTGATGGTCGCCGCGATCGCGACGTTCGCGACGGTCTGGGTCTGGCTGATGATCC
TGCTGTCGCAGGTCGCGATGCGCCGCCGGCTCTCGGCGGCCGAGACCGCCGCGCTGAAGTTCAAGGTGCCGTTCTGGCCG
ATCGGGCCGGCGATCACGATCGCATTCATGGCGTTCGTGATCGCGATGCTCGGCTACTTCGACGATACGCGCATCGCGCT
CTTCGTCGGCGCCGCGTGGCTCGCGTTGCTCACGCTCGTGTTCTACACGCGAGTCCGCCCGCGGCTCGCCGCCGTCGCGC
GCTGA

Upstream 100 bases:

>100_bases
TTGGTATGATCTATCCCGCGCCAAGTTGTCTATACAACTTTTCGAGCGCGAGCGCCGGGCCGCATCGCCCGGCCGACGAC
ACCAATCATTCGGAGACACG

Downstream 100 bases:

>100_bases
CGCCGCGCACGGGCGAGCCCTCCGCCCCGCCAAGCGCTGCAAGCGCCGGCCGGGACCGGCGCGCCGCGGGCGGGCGCCGG
CGCGGCCGCGCCACCCGCTT

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYASENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFSGMKLGSGGAPALANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMVVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYGMALQGQAPRAL
ASMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAETAALKFKVPFWP
IGPAITIAFMAFVIAMLGYFDDTRIALFVGAAWLALLTLVFYTRVRPRLAAVAR

Sequences:

>Translated_454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYASENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFSGMKLGSGGAPALANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMVVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYGMALQGQAPRAL
ASMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAETAALKFKVPFWP
IGPAITIAFMAFVIAMLGYFDDTRIALFVGAAWLALLTLVFYTRVRPRLAAVAR
>Mature_454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYASENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFSGMKLGSGGAPALANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMVVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYGMALQGQAPRAL
ASMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAETAALKFKVPFWP
IGPAITIAFMAFVIAMLGYFDDTRIALFVGAAWLALLTLVFYTRVRPRLAAVAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=357, Percent_Identity=26.3305322128852, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI110347453, Length=371, Percent_Identity=26.9541778975741, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=60.8791208791209, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=44.4444444444444, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=43.8325991189427, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=440, Percent_Identity=39.5454545454545, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI48994972, Length=442, Percent_Identity=42.3076923076923, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87081915, Length=398, Percent_Identity=38.9447236180905, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI87081708, Length=454, Percent_Identity=37.2246696035242, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789017, Length=412, Percent_Identity=35.1941747572816, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=34.1067285382831, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081869, Length=193, Percent_Identity=25.3886010362694, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=371, Percent_Identity=22.6415094339623, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=420, Percent_Identity=25.2380952380952, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540018, Length=417, Percent_Identity=23.9808153477218, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=439, Percent_Identity=31.4350797266515, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=29.9086757990868, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=31.8295739348371, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=450, Percent_Identity=30.8888888888889, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=347, Percent_Identity=31.9884726224784, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=29.8795180722892, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=27.6119402985075, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=454, Percent_Identity=29.0748898678414, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=398, Percent_Identity=27.3869346733668, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=26.3157894736842, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=417, Percent_Identity=26.378896882494, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=26.9521410579345, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=27.2264631043257, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=408, Percent_Identity=26.2254901960784, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=27.0676691729323, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321053, Length=428, Percent_Identity=25.4672897196262, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319608, Length=379, Percent_Identity=26.6490765171504, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=502, Percent_Identity=22.7091633466135, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667468, Length=333, Percent_Identity=26.7267267267267, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48288; Mature: 48288

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVPGSFGHYASENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAMIGGGAAILFSGMKLGSGGAP
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCH
ALANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMVVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
FGAGRMMYGMALQGQAPRALASMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAA
HCCCHHHHHEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAAETAALKFKVPFWPIGPAITIAFMAFVIAMLGYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DDTRIALFVGAAWLALLTLVFYTRVRPRLAAVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVPGSFGHYASENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAMIGGGAAILFSGMKLGSGGAP
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCH
ALANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMVVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
FGAGRMMYGMALQGQAPRALASMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAA
HCCCHHHHHEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IATFATVWVWLMILLSQVAMRRRLSAAETAALKFKVPFWPIGPAITIAFMAFVIAMLGYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DDTRIALFVGAAWLALLTLVFYTRVRPRLAAVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]