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The map label for this gene is mro [H]

Identifier: 83719705

GI number: 83719705

Start: 2630294

End: 2631424

Strand: Reverse

Name: mro [H]

Synonym: BTH_I2336

Alternate gene names: 83719705

Gene position: 2631424-2630294 (Counterclockwise)

Preceding gene: 83718979

Following gene: 83719351

Centisome position: 69.08

GC content: 70.38

Gene sequence:

>1131_bases
GTGAAGACGACCGTCCACGAACCGATTCTCCCCATGCACATCGACCCCGACACTCGCACTTCTCGCCTTGCTCCCGGCCC
TGCCCGCGTGCCGTCCGAGCCGTGGGGCACGCTGCCCGGCGGCGATCCGGTGCGCCGCTACACGCTGCGCAATGCCGACG
GCGTGCGCGTCGTCGTCAGCGATCTCGGCGCGACGGTCGTGTCGTGGCTCGCGCCCGACCGCACCGGCAGCTTCGCCGAC
ATCGTGCTCGCGCACGACGCGCCGGCCGATTACGTCGAATCGGCGGCCTACCTCGGCGCGACGATCGGCCGCTGGGCGAA
CCGCATCGCGGGCGCGCGCTTCACGCTCGACGGCGTCGAACACGCGCTGGATCGCAACGAGAACGGCAATCTGCTGCACG
GCGGCGCGAGCGGCTTTCACCGCGCGCGCTGGGAAGTCATCGACGACTGCGGCGGCCTTGTGCTGCGGCTCGAGTCGCCC
GAAGGCGACGCGGGCTTCCCCGGCAACGTGACGGTGCAGGTGCGCTACACGCTCGACGACGACGGCACGCTGACGATCGA
TTACACCGGCGCGACCGACGCGCCCACGCCGCTCAACCTGACGAATCACAGTTATTTCAACCTGAGCGGACGCCCGGGCG
GCGACATACGCGGCCATCTGTTGACGATCGACGCCGACGCGTTCCTCGAGGTCGACGATGCGCTGATCCCGACGGGCGCC
GCCGGCGTGACCGGCACCGCCTTCGATTTTCGGCACTGCGCGCCGCTTGGCGCGCGGCTCGACTGGCCGCACGCGCAGCT
CGCGCGGGCGGGCGGCTTCGACCACTGTTACGTGCTGAGCGGCGCCGGGATGCGAGGCGTTCGGCCCGTCGCGTGTGTGT
ACGATCCCGAGAGCGGGCGCGAATTGACGGTATCGACCGACCAGCCGGGGCTGCAATGCTACACGGGCAATCATCTGCAC
GGGCTGCGCGTGCGCGACGGCGCGCGCTGCGTGCGCCACGCGGCGCTGTGCCTCGAGGCCGGCGGGTTTCCGAATCAGAT
CAACATGGCCGGCCTGAGCGATGGCGTCGTGTTGCGGCCCGGGGGCACGTATCGGCAGACGACGAAGTATCGGGTCGGCG
TGCGTGCGTAA

Upstream 100 bases:

>100_bases
TCCGCTGCGGGTTCACGTCGCTGCAGTACATGCACGCGGTGTTCCGCCGCGAACTCGGCTGCACGCCGCGCGAATATCAG
GAACGCGCCGCGTCCGCGCG

Downstream 100 bases:

>100_bases
CTTCCGCCCTGTCACGCCCAGCGAATGCTGCCCCGTGCTCGCGTCGCCCGCCCCCCCGGCGCGCGCTACGGCGTGACGAT
CGCGCTCACATCGCCGCCGC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKTTVHEPILPMHIDPDTRTSRLAPGPARVPSEPWGTLPGGDPVRRYTLRNADGVRVVVSDLGATVVSWLAPDRTGSFAD
IVLAHDAPADYVESAAYLGATIGRWANRIAGARFTLDGVEHALDRNENGNLLHGGASGFHRARWEVIDDCGGLVLRLESP
EGDAGFPGNVTVQVRYTLDDDGTLTIDYTGATDAPTPLNLTNHSYFNLSGRPGGDIRGHLLTIDADAFLEVDDALIPTGA
AGVTGTAFDFRHCAPLGARLDWPHAQLARAGGFDHCYVLSGAGMRGVRPVACVYDPESGRELTVSTDQPGLQCYTGNHLH
GLRVRDGARCVRHAALCLEAGGFPNQINMAGLSDGVVLRPGGTYRQTTKYRVGVRA

Sequences:

>Translated_376_residues
MKTTVHEPILPMHIDPDTRTSRLAPGPARVPSEPWGTLPGGDPVRRYTLRNADGVRVVVSDLGATVVSWLAPDRTGSFAD
IVLAHDAPADYVESAAYLGATIGRWANRIAGARFTLDGVEHALDRNENGNLLHGGASGFHRARWEVIDDCGGLVLRLESP
EGDAGFPGNVTVQVRYTLDDDGTLTIDYTGATDAPTPLNLTNHSYFNLSGRPGGDIRGHLLTIDADAFLEVDDALIPTGA
AGVTGTAFDFRHCAPLGARLDWPHAQLARAGGFDHCYVLSGAGMRGVRPVACVYDPESGRELTVSTDQPGLQCYTGNHLH
GLRVRDGARCVRHAALCLEAGGFPNQINMAGLSDGVVLRPGGTYRQTTKYRVGVRA
>Mature_376_residues
MKTTVHEPILPMHIDPDTRTSRLAPGPARVPSEPWGTLPGGDPVRRYTLRNADGVRVVVSDLGATVVSWLAPDRTGSFAD
IVLAHDAPADYVESAAYLGATIGRWANRIAGARFTLDGVEHALDRNENGNLLHGGASGFHRARWEVIDDCGGLVLRLESP
EGDAGFPGNVTVQVRYTLDDDGTLTIDYTGATDAPTPLNLTNHSYFNLSGRPGGDIRGHLLTIDADAFLEVDDALIPTGA
AGVTGTAFDFRHCAPLGARLDWPHAQLARAGGFDHCYVLSGAGMRGVRPVACVYDPESGRELTVSTDQPGLQCYTGNHLH
GLRVRDGARCVRHAALCLEAGGFPNQINMAGLSDGVVLRPGGTYRQTTKYRVGVRA

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=350, Percent_Identity=40.8571428571429, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1786971, Length=337, Percent_Identity=38.8724035608309, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17557428, Length=325, Percent_Identity=31.0769230769231, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI115533334, Length=325, Percent_Identity=31.0769230769231, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319493, Length=335, Percent_Identity=29.5522388059701, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322004, Length=350, Percent_Identity=29.7142857142857, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324399, Length=351, Percent_Identity=28.4900284900285, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=40.117994100295, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24659048, Length=346, Percent_Identity=38.150289017341, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24668278, Length=382, Percent_Identity=32.4607329842932, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24668282, Length=345, Percent_Identity=36.5217391304348, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24641876, Length=349, Percent_Identity=29.2263610315186, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40090; Mature: 40090

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTVHEPILPMHIDPDTRTSRLAPGPARVPSEPWGTLPGGDPVRRYTLRNADGVRVVVS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEH
DLGATVVSWLAPDRTGSFADIVLAHDAPADYVESAAYLGATIGRWANRIAGARFTLDGVE
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
HALDRNENGNLLHGGASGFHRARWEVIDDCGGLVLRLESPEGDAGFPGNVTVQVRYTLDD
HHHCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECC
DGTLTIDYTGATDAPTPLNLTNHSYFNLSGRPGGDIRGHLLTIDADAFLEVDDALIPTGA
CCEEEEEECCCCCCCCCCEECCCCEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCCC
AGVTGTAFDFRHCAPLGARLDWPHAQLARAGGFDHCYVLSGAGMRGVRPVACVYDPESGR
CCCCCCCCCCHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCCCC
ELTVSTDQPGLQCYTGNHLHGLRVRDGARCVRHAALCLEAGGFPNQINMAGLSDGVVLRP
EEEEECCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECC
GGTYRQTTKYRVGVRA
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MKTTVHEPILPMHIDPDTRTSRLAPGPARVPSEPWGTLPGGDPVRRYTLRNADGVRVVVS
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEECCCCCCEEEEH
DLGATVVSWLAPDRTGSFADIVLAHDAPADYVESAAYLGATIGRWANRIAGARFTLDGVE
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
HALDRNENGNLLHGGASGFHRARWEVIDDCGGLVLRLESPEGDAGFPGNVTVQVRYTLDD
HHHCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECC
DGTLTIDYTGATDAPTPLNLTNHSYFNLSGRPGGDIRGHLLTIDADAFLEVDDALIPTGA
CCEEEEEECCCCCCCCCCEECCCCEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCCC
AGVTGTAFDFRHCAPLGARLDWPHAQLARAGGFDHCYVLSGAGMRGVRPVACVYDPESGR
CCCCCCCCCCHHCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEEEEECCCCCC
ELTVSTDQPGLQCYTGNHLHGLRVRDGARCVRHAALCLEAGGFPNQINMAGLSDGVVLRP
EEEEECCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECC
GGTYRQTTKYRVGVRA
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]