Click here to switch to the map view.

The map label for this gene is folP-A [H]

Identifier: 83719692

GI number: 83719692

Start: 3187552

End: 3188550

Strand: Reverse

Name: folP-A [H]

Synonym: BTH_I2775

Alternate gene names: 83719692

Gene position: 3188550-3187552 (Counterclockwise)

Preceding gene: 83718920

Following gene: 83720419

Centisome position: 83.71

GC content: 68.87

Gene sequence:

>999_bases
TTGCGGCTTTCGTTCACGGGCTGGTGTGGCTGTCACACCGGCCCGTTTTGCTTTCTTGTCAGACGCTTTTCATCGCTTCC
CATCGCGTTCGATCCGACGCTTCAGCTCGTGTCCAGTCCCGATCCCGTTTTTTCCATTCCCGAACCGCTGCAGTGCGGCC
GCTTCACGCTGACCTTCGAGCGGCCCCTCGTGATGGGCATCCTCAACGTCACCCCCGATTCGTTTTCGGACGGCGGACGT
TACGTCGCCCGAGACGCCGCGCTCGCGCAGGCGGAGCGGATGCTTGCCGAGGGCGCCGACATCATCGACATCGGCGGCGA
ATCGACGCGTCCCGGCGCGCCGCCCGTGCCGCTCGACGAGGAACTCGAGCGGGTGATTCCGCTCGTCGAAGCGCTGCGCG
GCATGAGCGTGCCGCTGTCGATCGACACGTACAAGCCCGCCGTGATGCGCGCGTCGCTCGCGGCCGGCGCCGATCTGATC
AACGACATCTGGGGCCTGCGGCAGCCGGGCGCGATCGACGCGGTGCGCGACAGCGCGTGCGGCCTCTGCGTGATGCACAT
GCTCGGCGAGCCGCGGACGATGCAGGTGCACGAGCCCGACTATCGCGACGTGGTCGCCGACGTGCGCGCGTTTCTCGCCG
AGCGCGTCGACGCGCTCGTGCAGGCCGGCATCGATGCCCGGCGTATCAGCGTCGATCCGGGGTTCGGTTTCGGCAAGGCG
GTGATAGAACACAACTATGCGCTGCTCGCTCATTTGCCACGGACGGCGCCCGCGCGGCCCGGCGGACGGGCGTATCCGAT
TCTCGCCGGCATGTCGCGCAAGTCGATGCTGGGCGCGCTGATCGGCAAGCCCGCGCCCGAGCGCGTCGCGGCGAGCGTCG
CCGCGGCGGTTTGCGCGCTCGAGCGGGGCGCGGCGATCGTGCGCGTGCATGACGTCGCCGCGACCGTCGACGCACTGAAA
GTATGGAGCGCCGTGCGCGATGCCGCGCGGCGAGCATAA

Upstream 100 bases:

>100_bases
CGTTCGCCGAAGAGCGCGCCGCCGGCCGGCGATCCTTCGTCGGGCGGTTCGTCCGGCGCCGAAGTCAAGCCGGGCAACGC
CACCGCGCCGGCATAAACGA

Downstream 100 bases:

>100_bases
GTCGAAACCAGGAGGAAGGTTCTACATGGGACGTCGTTATTTCGGCACGGACGGCATTCGCGGCAAGGTCGGCGACGCGC
CGATCACCCCCGATTTCGTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRLSFTGWCGCHTGPFCFLVRRFSSLPIAFDPTLQLVSSPDPVFSIPEPLQCGRFTLTFERPLVMGILNVTPDSFSDGGR
YVARDAALAQAERMLAEGADIIDIGGESTRPGAPPVPLDEELERVIPLVEALRGMSVPLSIDTYKPAVMRASLAAGADLI
NDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVHEPDYRDVVADVRAFLAERVDALVQAGIDARRISVDPGFGFGKA
VIEHNYALLAHLPRTAPARPGGRAYPILAGMSRKSMLGALIGKPAPERVAASVAAAVCALERGAAIVRVHDVAATVDALK
VWSAVRDAARRA

Sequences:

>Translated_332_residues
MRLSFTGWCGCHTGPFCFLVRRFSSLPIAFDPTLQLVSSPDPVFSIPEPLQCGRFTLTFERPLVMGILNVTPDSFSDGGR
YVARDAALAQAERMLAEGADIIDIGGESTRPGAPPVPLDEELERVIPLVEALRGMSVPLSIDTYKPAVMRASLAAGADLI
NDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVHEPDYRDVVADVRAFLAERVDALVQAGIDARRISVDPGFGFGKA
VIEHNYALLAHLPRTAPARPGGRAYPILAGMSRKSMLGALIGKPAPERVAASVAAAVCALERGAAIVRVHDVAATVDALK
VWSAVRDAARRA
>Mature_332_residues
MRLSFTGWCGCHTGPFCFLVRRFSSLPIAFDPTLQLVSSPDPVFSIPEPLQCGRFTLTFERPLVMGILNVTPDSFSDGGR
YVARDAALAQAERMLAEGADIIDIGGESTRPGAPPVPLDEELERVIPLVEALRGMSVPLSIDTYKPAVMRASLAAGADLI
NDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVHEPDYRDVVADVRAFLAERVDALVQAGIDARRISVDPGFGFGKA
VIEHNYALLAHLPRTAPARPGGRAYPILAGMSRKSMLGALIGKPAPERVAASVAAAVCALERGAAIVRVHDVAATVDALK
VWSAVRDAARRA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=277, Percent_Identity=48.3754512635379, Blast_Score=244, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=28.8888888888889, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 35484; Mature: 35484

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSFTGWCGCHTGPFCFLVRRFSSLPIAFDPTLQLVSSPDPVFSIPEPLQCGRFTLTFE
CCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCCCCCCCCCCCCCCCEEEEEC
RPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLAEGADIIDIGGESTRPGAPPVPLDE
CCCEEHEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHH
ELERVIPLVEALRGMSVPLSIDTYKPAVMRASLAAGADLINDIWGLRQPGAIDAVRDSAC
HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLCVMHMLGEPRTMQVHEPDYRDVVADVRAFLAERVDALVQAGIDARRISVDPGFGFGKA
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
VIEHNYALLAHLPRTAPARPGGRAYPILAGMSRKSMLGALIGKPAPERVAASVAAAVCAL
HHHCCHHEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ERGAAIVRVHDVAATVDALKVWSAVRDAARRA
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLSFTGWCGCHTGPFCFLVRRFSSLPIAFDPTLQLVSSPDPVFSIPEPLQCGRFTLTFE
CCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCCCCCCCCCCCCCCCEEEEEC
RPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLAEGADIIDIGGESTRPGAPPVPLDE
CCCEEHEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHH
ELERVIPLVEALRGMSVPLSIDTYKPAVMRASLAAGADLINDIWGLRQPGAIDAVRDSAC
HHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLCVMHMLGEPRTMQVHEPDYRDVVADVRAFLAERVDALVQAGIDARRISVDPGFGFGKA
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
VIEHNYALLAHLPRTAPARPGGRAYPILAGMSRKSMLGALIGKPAPERVAASVAAAVCAL
HHHCCHHEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ERGAAIVRVHDVAATVDALKVWSAVRDAARRA
HCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]