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The map label for this gene is pncB2 [H]

Identifier: 83719586

GI number: 83719586

Start: 716912

End: 718273

Strand: Direct

Name: pncB2 [H]

Synonym: BTH_I0625

Alternate gene names: 83719586

Gene position: 716912-718273 (Clockwise)

Preceding gene: 83719604

Following gene: 83718680

Centisome position: 18.82

GC content: 69.9

Gene sequence:

>1362_bases
ATGACGAAGCCCGTGCGCGACGGCGCGCTGCTCGCCGACCTGTACGAATTCACGATGCTGCAGTCGTATTTCGATTGCGG
GATGAACGACACGGCGACGTTCGAGCTCTTCGTGCGCAAGCTGCCCGCGCATCGAAACTTCCTGATGGCGGCGGGGCTCG
AGCAGGCGCTCGATTATCTGGCGGCGCTTGCGCTCGAGCCCGACGAGATCGAGGCGCTCGCGAGCACGGGGCTCTTCAGC
GACGGCTTTCTCGCATCGCTCGAATCGCTGCGCTTCACGGGCTCGGTGCGCGCGATGCGCGAAGGCACGGTGTTCTTCGC
CGACGAGCCGATCCTGCAAGTCACCGCGCCGATGCGCGAGGCGCAACTGATCGAGAGCCGCGTGATGAACCTGCTGCATT
ACGAATCGATCGTCGCGAGCAAGGCCGCGCGCGCGGTGCTCGCGGCGCCCGGCAGGACGCTCGTCGATTTCGGGCTGCGC
CGCGCGCACGGCGCCGAGGCCGCGCTGCTGTCGGCGCGAGCGAGCTACGTCGCGGGCTTCGCGGGCACGGCGACGCTGCT
CGCCGGCTTGCGCTACGGGATTCCGACGTACGGCACGATGGCGCATTCGTATGTGCAGGCGCACGACGACGAATCGCTCG
CGTTCGAGCATTTCGCACGCTCGTTCCCGCGCAACGCGATGCTGCTCGTCGACACATACGACACCGAGGCCGCCGTGGGC
AAGGTCATCGACGTGGCGAGGAAGCTCGCGCGCGAAGGCGTCGAAGTGAAGGGCGTGCGGCTCGACAGCGGCGATCTCGC
GCAGCACGCGATGCGCGTGCGCGCGATGTTCGATCGCGCGGGGCTCGACCGGGTGACGATCTTCGCGAGCGGCAATCTCG
ACGAGTACAGGCTCGCCGAGTTGATCGGCAAGGGCGCACCGATCGACGGCTTCGGCGTGGGCACGCGAATGAACACGTCG
GCGGACGCGCCGTATGCGGACTGCGCGTACAAGCTGACCGAATACGCGGGCGTGCCGCGCCGCAAGCGCTCGGAGGGCAA
GGCAACGTGGCCCGGGCGCAAGCAGGTGTACCGCCGCTATCGCGACGACGGCCTGCTCGACGGCGATTGTCTCGCGCTGC
ATGACGATGTGCGCCCGGGCGTCGCGCTGCTCGCGCCGGTGATGATCGCCGGCGAGCGCGTCGCGCCCTCGCCGAGCCTT
GCCGACGTCCGCGCGCACGCGCGCGCGCAGCTCGACGCGCTGCCCGCGGCGTTGCGCGATCTCGCGCGCGCGGCCGAGTA
TCCGGTCGCCGTGACCGGCACGTTGACGGCGCTCGCGCAACGGCTCGACTCGCCGGCGGCGGGCGATGCGTCGCGCGCGT
AG

Upstream 100 bases:

>100_bases
TCGAGGAGCCGGGCACGCTCGACGAAGTCGCGCGCGTCGCGGCCGACTGGTTCGTCGCGCATCTCGGCGACGGCCGGCGG
CCGCCCGAAGGGACGCGAAG

Downstream 100 bases:

>100_bases
CGCGGCGCGCGCGGGCCGCGCTACGCGCATTGGCGCGAATCGTCGCCGGTCGCCGCATGCATCGGTATGCAGTCGAACGG
GCCGCAGGGGCGAGACCGTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTKPVRDGALLADLYEFTMLQSYFDCGMNDTATFELFVRKLPAHRNFLMAAGLEQALDYLAALALEPDEIEALASTGLFS
DGFLASLESLRFTGSVRAMREGTVFFADEPILQVTAPMREAQLIESRVMNLLHYESIVASKAARAVLAAPGRTLVDFGLR
RAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDESLAFEHFARSFPRNAMLLVDTYDTEAAVG
KVIDVARKLAREGVEVKGVRLDSGDLAQHAMRVRAMFDRAGLDRVTIFASGNLDEYRLAELIGKGAPIDGFGVGTRMNTS
ADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVYRRYRDDGLLDGDCLALHDDVRPGVALLAPVMIAGERVAPSPSL
ADVRAHARAQLDALPAALRDLARAAEYPVAVTGTLTALAQRLDSPAAGDASRA

Sequences:

>Translated_453_residues
MTKPVRDGALLADLYEFTMLQSYFDCGMNDTATFELFVRKLPAHRNFLMAAGLEQALDYLAALALEPDEIEALASTGLFS
DGFLASLESLRFTGSVRAMREGTVFFADEPILQVTAPMREAQLIESRVMNLLHYESIVASKAARAVLAAPGRTLVDFGLR
RAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDESLAFEHFARSFPRNAMLLVDTYDTEAAVG
KVIDVARKLAREGVEVKGVRLDSGDLAQHAMRVRAMFDRAGLDRVTIFASGNLDEYRLAELIGKGAPIDGFGVGTRMNTS
ADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVYRRYRDDGLLDGDCLALHDDVRPGVALLAPVMIAGERVAPSPSL
ADVRAHARAQLDALPAALRDLARAAEYPVAVTGTLTALAQRLDSPAAGDASRA
>Mature_452_residues
TKPVRDGALLADLYEFTMLQSYFDCGMNDTATFELFVRKLPAHRNFLMAAGLEQALDYLAALALEPDEIEALASTGLFSD
GFLASLESLRFTGSVRAMREGTVFFADEPILQVTAPMREAQLIESRVMNLLHYESIVASKAARAVLAAPGRTLVDFGLRR
AHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDESLAFEHFARSFPRNAMLLVDTYDTEAAVGK
VIDVARKLAREGVEVKGVRLDSGDLAQHAMRVRAMFDRAGLDRVTIFASGNLDEYRLAELIGKGAPIDGFGVGTRMNTSA
DAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVYRRYRDDGLLDGDCLALHDDVRPGVALLAPVMIAGERVAPSPSLA
DVRAHARAQLDALPAALRDLARAAEYPVAVTGTLTALAQRLDSPAAGDASRA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=33.011583011583, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71997952, Length=524, Percent_Identity=27.4809160305344, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997947, Length=524, Percent_Identity=27.4809160305344, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997955, Length=203, Percent_Identity=35.9605911330049, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=30.4431599229287, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI161076680, Length=205, Percent_Identity=38.0487804878049, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24581595, Length=205, Percent_Identity=38.0487804878049, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574709, Length=205, Percent_Identity=38.0487804878049, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24581593, Length=205, Percent_Identity=38.0487804878049, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24581591, Length=205, Percent_Identity=38.0487804878049, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48878; Mature: 48747

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPVRDGALLADLYEFTMLQSYFDCGMNDTATFELFVRKLPAHRNFLMAAGLEQALDYL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AALALEPDEIEALASTGLFSDGFLASLESLRFTGSVRAMREGTVFFADEPILQVTAPMRE
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHCCEEEEECCCCEEECCCHHH
AQLIESRVMNLLHYESIVASKAARAVLAAPGRTLVDFGLRRAHGAEAALLSARASYVAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGTATLLAGLRYGIPTYGTMAHSYVQAHDDESLAFEHFARSFPRNAMLLVDTYDTEAAVG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHH
KVIDVARKLAREGVEVKGVRLDSGDLAQHAMRVRAMFDRAGLDRVTIFASGNLDEYRLAE
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIGKGAPIDGFGVGTRMNTSADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVYRRY
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
RDDGLLDGDCLALHDDVRPGVALLAPVMIAGERVAPSPSLADVRAHARAQLDALPAALRD
HCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LARAAEYPVAVTGTLTALAQRLDSPAAGDASRA
HHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKPVRDGALLADLYEFTMLQSYFDCGMNDTATFELFVRKLPAHRNFLMAAGLEQALDYL
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AALALEPDEIEALASTGLFSDGFLASLESLRFTGSVRAMREGTVFFADEPILQVTAPMRE
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHCCEEEEECCCCEEECCCHHH
AQLIESRVMNLLHYESIVASKAARAVLAAPGRTLVDFGLRRAHGAEAALLSARASYVAGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGTATLLAGLRYGIPTYGTMAHSYVQAHDDESLAFEHFARSFPRNAMLLVDTYDTEAAVG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHH
KVIDVARKLAREGVEVKGVRLDSGDLAQHAMRVRAMFDRAGLDRVTIFASGNLDEYRLAE
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIGKGAPIDGFGVGTRMNTSADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVYRRY
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
RDDGLLDGDCLALHDDVRPGVALLAPVMIAGERVAPSPSLADVRAHARAQLDALPAALRD
HCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LARAAEYPVAVTGTLTALAQRLDSPAAGDASRA
HHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]