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The map label for this gene is adk [H]

Identifier: 83719561

GI number: 83719561

Start: 849118

End: 849780

Strand: Reverse

Name: adk [H]

Synonym: BTH_I0739

Alternate gene names: 83719561

Gene position: 849780-849118 (Counterclockwise)

Preceding gene: 83719573

Following gene: 83721117

Centisome position: 22.31

GC content: 65.16

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCGCCCGGCGCGGGAAAGGGCACCCAGGCAAACTTCATCAAGGAAAAGTTCGGCATTCC
GCAAATCTCGACGGGCGACATGCTGCGCGCCGCCGTGAAGGCCGGCACGCCGCTCGGCGTCGAAGCGAAGGCGTACATGG
ATGAAGGCAAGCTCGTGCCGGATTCGCTGATCATCGGCCTCGTCAAGGAGCGCCTGAAGGAAGCGGACTGCGCGAACGGC
TACCTGTTCGACGGCTTCCCGCGCACGATCGCGCAGGCCGACGCGATGAAGGAAGCGGGCGTCGCGATCGACTACGTGCT
CGAGATCGACGTGCCGTTCTCGGAAATCATCGAGCGGATGAGCGGCCGCCGCACGCACCCGGCGTCGGGACGCACGTACC
ACGTGAAGTTCAACCCGCCGAAGGTCGAGGGCAAGGACGACGTGACGGGCGAGCCGCTGATTCAGCGCGACGACGACAAG
GAAGAAACGGTGAAGAAGCGCCTCGACGTGTACGAAGCGCAGACGAAGCCGCTCATCACGTATTACGGCGACTGGGCGAC
GCGCGGCGAGGAGAACGGCCTGAAGGCGCCCGCGTACCGGAAGATCTCCGGCCTCGGCGCCGTCGACGAAATCCGCGCGC
GCGTGTTCGACGCGCTGAAGTGA

Upstream 100 bases:

>100_bases
CAGTCAGACCGGCCGATCGCGCTTGCTGCAGAACCGCCGAGCCGCGCAGCGGGTCCCGTAGCGTCTCGCACCAGAGCATT
CACATACCGGAGATATCACC

Downstream 100 bases:

>100_bases
ATCGCGCCCGGCGCGCGCCGCGCATCCCGCGCCACGATGACGAAAGAACCGCCCTCTCCGGGCGGTTTTTTTTCGTCCGG
TCGTTCGCTTCGCGCCGGGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKAYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWATRGEENGLKAPAYRKISGLGAVDEIRARVFDALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKAYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWATRGEENGLKAPAYRKISGLGAVDEIRARVFDALK
>Mature_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKAYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWATRGEENGLKAPAYRKISGLGAVDEIRARVFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=51.6129032258064, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=51.6129032258064, Blast_Score=198, Evalue=2e-51,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=50.5494505494505, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI22749187, Length=190, Percent_Identity=31.0526315789474, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=29.2792792792793, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI7706497, Length=226, Percent_Identity=30.0884955752212, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=27.3381294964029, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=26.3888888888889, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=26.3888888888889, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=65.2582159624413, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=46.2365591397849, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=38.9189189189189, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=219, Percent_Identity=31.9634703196347, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=29.3478260869565, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=47.9381443298969, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=46.195652173913, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.0869565217391, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=48.3516483516484, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=48.3516483516484, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=27.9329608938547, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=27.9329608938547, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24143; Mature: 24143

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKAYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLDVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWATRGEENGLKAPAYRKISGLGAVDEIRARVFDALK
EECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKAYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLDVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWATRGEENGLKAPAYRKISGLGAVDEIRARVFDALK
EECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA