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The map label for this gene is ilvD [H]

Identifier: 83719513

GI number: 83719513

Start: 940859

End: 942532

Strand: Reverse

Name: ilvD [H]

Synonym: BTH_I0827

Alternate gene names: 83719513

Gene position: 942532-940859 (Counterclockwise)

Preceding gene: 83719017

Following gene: 83719532

Centisome position: 24.74

GC content: 67.03

Gene sequence:

>1674_bases
ATGTCGTACAACCGCCGCTCGAAGAACATCACGCAAGGCGTGGCCCGTTCGCCGAACCGCTCGATGTATTACGCGCTCGG
CTATCAGAAGGACGATTTCGACAAACCGATGATCGGCGTCGCGAACGGCCACTCGACGATCACGCCGTGCAACGCGGGCC
TGCAGCGCCTCGTCGACGCGGCCGTTTCCGCGGTCAAGCAGGCGGACGCGAATCCGCAGACGTTCGGCACGCCGACGATC
TCCGACGGCATGTCGATGGGCACCGAAGGGATGAAGTACTCGCTCGTGTCGCGCGAGGTGATCGCCGATTGCATCGAGAC
CTGCGTGCAGGGCCAATGGATGGACGGCGTCGTCGTCGTGGGCGGCTGCGACAAGAACATGCCGGGCGGCATGATCGCGC
TCGCGCGCATCAACGTGCCGGGCATCTACGTGTACGGCGGCACGATTCGCCCGGGTCACTGGAAAGGCAAGGATCTGACG
ATCGTGTCGGCGTTCGAGGCGGTCGGCGAGTTCACCGCGGGGCGCATGTCGCAGGAGGATTTCGAAGGGGTCGAAAAGAA
CGCGTGCCCGACGACGGGCTCATGCGGCGGCATGTACACCGCGAACACGATGAGCTCGTCGTTCGAGGCGCTCGGCATGT
CGCTGCTGTACTCGTCGACGATGGCCAATCCCGATCAGGAGAAGGTCGATTCGGCGGCCGAGTCGGCGCGCGTGCTCGTG
GAGGCGGTGAAGAAGGATCTGAAGCCGCGCGACATCATCACGAAGCAGGCAATCGAGAACGCGGTGTCGGTGATCATGGC
CACGGGCGGCTCGACGAACGCGGTGCTCCACTATCTGGCGATCGCGCACGCGGCCGAGATCGACTGGTCGATCGAAGACT
TCGAGCGCATCCGCAAACGCGTGCCGGTGATCTGCGACCTGAAACCCTCGGGCCAGTACGTCGCCACCGACCTGCACGCG
GCGGGCGGCATTCCGCAAGTGATGAAGCTGCTGCTCGACGCGGGCCTGCTGCACGGCGATTGCATGACGATCACGGGCCG
CACGATCGCCGAGGAGCTGAAGGACGTGCCGAGCGTGCCGCGCGCCGACCAGAAGGTGATCTACCCGATCGACCAGGCGC
TGTACAAGGAAGGCCACCTCGCGATCCTGAAGGGCAACCTCGCCGAGGACGGCGCGGTCGCGAAGATCACCGGCCTGAAG
AACCCGGTCATCACCGGCCCGGCGCGCGTGTTCGACGACGAGCAGAGCGCGCTCGCCGCGATCCTCGACGACAAGATCCG
TGCGGGCGACGTCGTCGTGCTGCGCTACCTCGGCCCGCAGGGCGGCCCGGGTATGCCGGAGATGCTCGCACCGACGTCGG
CGATCATCGGCAAGGGCCTCGGCGAATCGGTCGGCCTCATCACGGACGGCCGCTTCTCGGGCGGCACGTGGGGGATGGTG
GTCGGCCACGTCGCGCCGGAAGCGTTCGTCGGCGGCACGATCGCGCTCGTGCAGGAAGGCGATTCAATCACGATCGACGC
GCACAAGCTGCTGCTGCAGCTGAACGTCGACGACGCCGAGCTGGCGCGCCGCCGCGCCGCGTGGAAGCAGCCGGCGCCGC
GCTACACGCGCGGGGTGCTCGCGAAATATGCGGCGCTCGCCCGCCCGGCGAACAAGGGCGCGGTGACGGGCTGA

Upstream 100 bases:

>100_bases
TTCTCTAACAGAAACTGCATTCTTGCCCACCTGAGCCGGATCGCGCCGATGCAGCGCGCCGCGCCGCCCCACAGTCAACC
AGTCGATGATGGAGTCCCCC

Downstream 100 bases:

>100_bases
CGCACGGCAGCGCGCCGGCCCCGAAGCCGGCGCGCGCTGCGTGCGCGCATCGCAACGCGACGGCGGCGCCACGATGGCGC
CACGGCGGGACGACAAAAAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDAAVSAVKQADANPQTFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLT
IVSAFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVPRADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANKGAVTG

Sequences:

>Translated_557_residues
MSYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDAAVSAVKQADANPQTFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLT
IVSAFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHA
AGGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVPRADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLK
NPVITGPARVFDDEQSALAAILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANKGAVTG
>Mature_556_residues
SYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDAAVSAVKQADANPQTFGTPTIS
DGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLTI
VSAFEAVGEFTAGRMSQEDFEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVE
AVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKRVPVICDLKPSGQYVATDLHAA
GGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVPRADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLKN
PVITGPARVFDDEQSALAAILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMVV
GHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANKGAVTG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=604, Percent_Identity=37.5827814569536, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI2367371, Length=544, Percent_Identity=32.9044117647059, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786464, Length=469, Percent_Identity=35.181236673774, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788157, Length=482, Percent_Identity=31.3278008298755, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=46.25, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59055; Mature: 58924

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDA
CCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
AVSAVKQADANPQTFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLTIVSAFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEHHHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVP
CCEEEECCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHHE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANKGAVTG
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SYNRRSKNITQGVARSPNRSMYYALGYQKDDFDKPMIGVANGHSTITPCNAGLQRLVDA
CCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
AVSAVKQADANPQTFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARINVPGIYVYGGTIRPGHWKGKDLTIVSAFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEHHHHHHHHHHHCCCCHHH
FEGVEKNACPTTGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKKDLKPRDIITKQAIENAVSVIMATGGSTNAVLHYLAIAHAAEIDWSIEDFERIRKR
HHHHHCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VPVICDLKPSGQYVATDLHAAGGIPQVMKLLLDAGLLHGDCMTITGRTIAEELKDVPSVP
CCEEEECCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIYPIDQALYKEGHLAILKGNLAEDGAVAKITGLKNPVITGPARVFDDEQSALAA
CCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILDDKIRAGDVVVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGLITDGRFSGGTWGMV
HHHCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHHE
VGHVAPEAFVGGTIALVQEGDSITIDAHKLLLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANKGAVTG
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA