Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 83719503

GI number: 83719503

Start: 172303

End: 174711

Strand: Reverse

Name: mrdA [H]

Synonym: BTH_I0143

Alternate gene names: 83719503

Gene position: 174711-172303 (Counterclockwise)

Preceding gene: 83720077

Following gene: 83718660

Centisome position: 4.59

GC content: 69.45

Gene sequence:

>2409_bases
ATGACCGAATTCAAGGACACACAACAGCAGCTGTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGCGTGTTCGTGTTCGT
CTGCTTCGGCCTGCTCGCCACGCGGTTCTTCTACCTTCAGGTCTGGCAGCACGGCAAGTACGCGCTGCAGGCCGAGGAGA
ACCGGATCTCGGTCGCGCCGATCGTCCCGAACCGCGGGATCATCACCGATCGCAACGGCGTCGTCCTCGCGAAGAACTAC
TCCGCGTACACGCTCGAGATCACGCCGTCGAAGCTGACCGACACGCTCGAAAGCACGATCAACGCGCTCTCCGAGATCGT
GCAGATCGACGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAGGACTCGAAGAACTTCGAGAGCCTGCCGATCCGCA
CGCGCCTCACCGACGGCGAAGTCGCGCGCTTCACCGCGCAGCGCTGGCGCTTCCCGGGCGTCGACGTGCGCGCGCGCCTG
TTCCGCCAATATCCGCTCGGCCCGACGGCCGCGCACGTGATCGGCTACATCGGCCGGATCTCGAAGCGCGACCAGGACAG
GATCGACGCGATGAGCGACGACAACGACAGCGATCCGGAAAGCTACGATCCGCGCCGCGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGGTCGGCGTCGAACAGAGCTACGAGACCGAGCTGCACGGAATCACGGGCTTCGAGGAAGTCGAG
GTGACGGCGGGCGGGCGGCCCGTGCGCACGCTGTCGCGCACGCAGGCGACGCCCGGCAGCAACCTCGTGCTGTCGCTCGA
CATCGGGCTGCAGCAGGTCGCCGAGCAGGCGTTCGCCGGCAAGCGCGGCGCGCTCGTCGCGATCGAGCCGAAAACGGGCG
ACGTGCTCGCGTTCGTGTCGTCGCCGAGCTTCGATCCGAATTCGTTCGTCGACGGCATCGACCAGCAGACCTGGGACGAG
TTGAACAACTCGCCCGACAAGCCGCTCCTGAACCGGCCGCTGCACGGCACCTATCCGCCCGGCTCGACGTACAAGCCGTT
CATGGCGCTCGCGGGCCTCACGCTCGGCAAGCGCACGCCCGGCTGGGGCTTCCAGGACCCCGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGCTCGGGCCAGGGCTGGGTCGACATGAACAAGGCGATCATGGTGTCGAACGATACG
TACTTCTACATGCTCGCGCGCGACCTCGGCGTGACCGCGATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGCTCAC
GGGCATCGACATCCAGGGCGAGGCGCGCGGGGTCCTGCCGTCGCCCGAATGGAAGAAGAAGACGTTCAAGAAGGCCGCGC
AGCAGAAATGGTTCGACGGTGAAACGATCAGCCTCGGGATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCCACGGCGACGCTCGCGAACGATGGCGTGGTGATGAAGCCGCACCTGGTGAAGGAGGTCGAGAACCCGATTTCGCG
CGAGCGGCACCTGACGGTGCCGAAGGAAAGCGGCGTGATCCCGCTCAAGCAGAGCGACCTCGACGTCGTGAAGCGCGGAA
TGGAGAACGTCGTCGAGAACCCGTCGGGCACCGCGTTCAAGGTGTTCCGCGGCGCGCCGTACCTCGCGGCGGGCAAGACC
GGCACCGCGCAGGTGTTCTCGCTGCAGGGCGGCAACTACCGCGGCCACCTGCTTGCCGAGCATCTGCGCGATCACGCGCT
CTTCATCGCGTACGCGCCTGTCGACCATCCGCAGATCGCGCTCGCGCTGATCGTCGAGAACGGCGGCTGGGGCGCGCAAT
CGGCGGGCCCGATCGCGCGGCGCGTGCTCGATTTCTACCTGCTCGACCGCAAGAATCCGGCGACGGAGGCGGCAGCCGTC
GCGGCGGCCGCGTCGGCGACGGAGCCGATCAACGCGCCCGTGATCGGCGATGCGACGAAGCCCGTCGGCGTTGCGGCCGG
GTTCAAGGCGCTGCCGCAGCCGACGCCGCCCACGCCGGCGAGCGGCGCGGCCGGCGCATCGGGCGCGAGCGGAACGGAGA
CGGGGCAAGCAAGCGCGGGCGCCGGCTCGCCGGGCGGCGACGCCGCGACCGGCGGCGCCGCCGGCGTCTCGGCGAGCGTG
ACGGGCGGCGCGGCCAACGGGTCGAGCGCCACGCCGACGGCGGGCGCCGCCGCGAGCGCGCCGCCTGCGCTGCGCCGCCT
GCCGTCGCGCAAGCCGCGGCGCACGCCGGCGAGCGGCGCGGCGATCACGGCCGCGGCCCCGCTCGACGACCAGCGGAAGT
CCCCGTCGGGAGACCGGAAAAAGTCCCCGCAGGACGACAACCCTGCCGTCTCCGCCGCCAAGCCGGCGGCGGGCGGCATC
GACGAGTAA

Upstream 100 bases:

>100_bases
CCGGCGAGTCGCGGCAACCGCACGGCGGCCGGCGCACCGCGCCGGCGCGGTCCTGCATGCCGTCGCGGCGGCAAAAGCGC
GCCCCTTCATCCGTAATCGC

Downstream 100 bases:

>100_bases
CGGAGACAGGCATGCAATTCGACAAGCGCGCCTCGCTCGACAAGATCAAGCAGATGTTCGCGGGCTTCGACCGGCCGCTC
GCGCTCATCGTGTTCCTGCT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLTDTLESTINALSEIVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDGEVARFTAQRWRFPGVDVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDDNDSDPESYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGVLPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANDGVVMKPHLVKEVENPISRERHLTVPKESGVIPLKQSDLDVVKRGMENVVENPSGTAFKVFRGAPYLAAGKT
GTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLDRKNPATEAAAV
AAAASATEPINAPVIGDATKPVGVAAGFKALPQPTPPTPASGAAGASGASGTETGQASAGAGSPGGDAATGGAAGVSASV
TGGAANGSSATPTAGAAASAPPALRRLPSRKPRRTPASGAAITAAAPLDDQRKSPSGDRKKSPQDDNPAVSAAKPAAGGI
DE

Sequences:

>Translated_802_residues
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLTDTLESTINALSEIVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDGEVARFTAQRWRFPGVDVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDDNDSDPESYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGVLPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANDGVVMKPHLVKEVENPISRERHLTVPKESGVIPLKQSDLDVVKRGMENVVENPSGTAFKVFRGAPYLAAGKT
GTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLDRKNPATEAAAV
AAAASATEPINAPVIGDATKPVGVAAGFKALPQPTPPTPASGAAGASGASGTETGQASAGAGSPGGDAATGGAAGVSASV
TGGAANGSSATPTAGAAASAPPALRRLPSRKPRRTPASGAAITAAAPLDDQRKSPSGDRKKSPQDDNPAVSAAKPAAGGI
DE
>Mature_801_residues
TEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNYS
AYTLEITPSKLTDTLESTINALSEIVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDGEVARFTAQRWRFPGVDVRARLF
RQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDDNDSDPESYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVEV
TAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTY
FYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGVLPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLAH
ATATLANDGVVMKPHLVKEVENPISRERHLTVPKESGVIPLKQSDLDVVKRGMENVVENPSGTAFKVFRGAPYLAAGKTG
TAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLDRKNPATEAAAVA
AAASATEPINAPVIGDATKPVGVAAGFKALPQPTPPTPASGAAGASGASGTETGQASAGAGSPGGDAATGGAAGVSASVT
GGAANGSSATPTAGAAASAPPALRRLPSRKPRRTPASGAAITAAAPLDDQRKSPSGDRKKSPQDDNPAVSAAKPAAGGID
E

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=646, Percent_Identity=40.2476780185758, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=639, Percent_Identity=23.3176838810642, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 85559; Mature: 85428

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLTDTLESTINALSEIVQIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDGEVARFTAQRWRFPGVDVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDPESYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHHCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVTAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHHC
FGFGQLTGIDIQGEARGVLPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANDGVVMKPHLVKEVENPISRERHLTVPKESGVIPLKQSDLDVVKRGMENVVEN
HHHHHHCCCCEEECHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCHHHHHHHHHHHHCC
PSGTAFKVFRGAPYLAAGKTGTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLLDRKNPATEAAAVAAAASATEPINAPVIGDATK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCC
PVGVAAGFKALPQPTPPTPASGAAGASGASGTETGQASAGAGSPGGDAATGGAAGVSASV
CCCHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TGGAANGSSATPTAGAAASAPPALRRLPSRKPRRTPASGAAITAAAPLDDQRKSPSGDRK
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
KSPQDDNPAVSAAKPAAGGIDE
CCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLTDTLESTINALSEIVQIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDGEVARFTAQRWRFPGVDVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDPESYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHHCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVTAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHHC
FGFGQLTGIDIQGEARGVLPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANDGVVMKPHLVKEVENPISRERHLTVPKESGVIPLKQSDLDVVKRGMENVVEN
HHHHHHCCCCEEECHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCHHHHHHHHHHHHCC
PSGTAFKVFRGAPYLAAGKTGTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLLDRKNPATEAAAVAAAASATEPINAPVIGDATK
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCC
PVGVAAGFKALPQPTPPTPASGAAGASGASGTETGQASAGAGSPGGDAATGGAAGVSASV
CCCHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TGGAANGSSATPTAGAAASAPPALRRLPSRKPRRTPASGAAITAAAPLDDQRKSPSGDRK
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
KSPQDDNPAVSAAKPAAGGIDE
CCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]