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The map label for this gene is hexR [H]

Identifier: 83719424

GI number: 83719424

Start: 1362228

End: 1363232

Strand: Reverse

Name: hexR [H]

Synonym: BTH_I1216

Alternate gene names: 83719424

Gene position: 1363232-1362228 (Counterclockwise)

Preceding gene: 83721185

Following gene: 83719002

Centisome position: 35.79

GC content: 69.75

Gene sequence:

>1005_bases
GTGTTCGCCCTGCCATTTCACGCCCCCTTTCGCACCATGCTCCCCCGTATCGAGGCGATTCGCGCCCAGCTCCGCCCGTC
CGAGCGCAAGCTCGCCGACTTCGTGCTCGCCGTGCCGCGCGAGGTGCTCGATCTGTCGATGACCGAGCTCGCCGCCCGCG
CGGGCGTGAGCCAGCCGACGATCGCGCGCTTTTGCCAGGCGCTCGGCTGCAGCGGCTTTCGCGAGTTCAAGATCCGGCTT
GCGCAAAGCGTCGCGCCGGGCGTCGCGTCGGTGTATCGCAACGTCGAGCCCGACGAGCGCGCGCCGGGCATCATCGGCAA
GGTGTTCGACCGCACGATCGGCGCGCTGATCGAGGTGCGCAACAGCCTGTCGGCAACGAGCGTCGCCGACGCGATCGAAC
TGCTCACGCGCGCGTCGCGCATCGAGTTCTACGGCGCGGGCGGCTCGGGCATCGCCGCGCAGGACATCCAGCACAAGTTC
TTCCGGCTGGGCGTGCCGAGCGTCGCGTATTCGGACCCGCACACGTTCTCGATGTCGGCCGCGCTCCTCGGCGCGAACGA
CGTCGTCGTCGCGATCTCGAACACGGGGCGCACGCGCGACATCGTCGACGCCGCGCGCGCGGCGCTCGCGTGCGGCGCGA
AGGTGATCTCGATCACGCACAGCCATTCGCCGCTCGCGCAACTGTCGACGGTGAGCCTCGCGTCGAACGTCGCCGAGGAA
ACCGACGTGTTCTCGCCGATGACGTCGCGGATGTCGCATCTCGCGATCGGCGACATCCTCGCGGTGGGCGTCGCGCTGCG
GCGCGGCCCCGAACTCGTCGACCGGCTCGGCCGCGCGAAGGAGGCGATCACGCGGCGGCGGATCGGCATCGACGCGAAGG
CGGGGAAGGAAACGGGGAAGGACGTGGCGAAGGATGCGACGGGCGATGCGCCGAAAGCCGCCGGCGGACAGCATCCATCG
GAAAAGACGCGCATCGCGCGCGACGTCGAAGACGTGAGGGATTAG

Upstream 100 bases:

>100_bases
CGGCACAATTATTTAGCGTTAACCCTGACATCCGATAAGCTGCATCGCATCAGTCGCTAGAAAATTCTTGTAGATTTTCT
ACAAAACAATCGCGATACTA

Downstream 100 bases:

>100_bases
ACGGCCGGACGCGCAAGCCGCGTTCGAGCAACGGTTGGAATCACCACGAGCGTGAAGAGCGTGATTCGCGACCAAGACAG
CGATTCCCGATTGCGACGAA

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MFALPFHAPFRTMLPRIEAIRAQLRPSERKLADFVLAVPREVLDLSMTELAARAGVSQPTIARFCQALGCSGFREFKIRL
AQSVAPGVASVYRNVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVADAIELLTRASRIEFYGAGGSGIAAQDIQHKF
FRLGVPSVAYSDPHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEE
TDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGIDAKAGKETGKDVAKDATGDAPKAAGGQHPS
EKTRIARDVEDVRD

Sequences:

>Translated_334_residues
MFALPFHAPFRTMLPRIEAIRAQLRPSERKLADFVLAVPREVLDLSMTELAARAGVSQPTIARFCQALGCSGFREFKIRL
AQSVAPGVASVYRNVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVADAIELLTRASRIEFYGAGGSGIAAQDIQHKF
FRLGVPSVAYSDPHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEE
TDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGIDAKAGKETGKDVAKDATGDAPKAAGGQHPS
EKTRIARDVEDVRD
>Mature_334_residues
MFALPFHAPFRTMLPRIEAIRAQLRPSERKLADFVLAVPREVLDLSMTELAARAGVSQPTIARFCQALGCSGFREFKIRL
AQSVAPGVASVYRNVEPDERAPGIIGKVFDRTIGALIEVRNSLSATSVADAIELLTRASRIEFYGAGGSGIAAQDIQHKF
FRLGVPSVAYSDPHTFSMSAALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEE
TDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGIDAKAGKETGKDVAKDATGDAPKAAGGQHPS
EKTRIARDVEDVRD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=278, Percent_Identity=41.0071942446043, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082369, Length=252, Percent_Identity=30.1587301587302, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788767, Length=281, Percent_Identity=27.7580071174377, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082130, Length=281, Percent_Identity=27.4021352313167, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 35575; Mature: 35575

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALPFHAPFRTMLPRIEAIRAQLRPSERKLADFVLAVPREVLDLSMTELAARAGVSQPT
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IARFCQALGCSGFREFKIRLAQSVAPGVASVYRNVEPDERAPGIIGKVFDRTIGALIEVR
HHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NSLSATSVADAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSDPHTFSMSA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEE
HHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
TDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGIDAKAGKETGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DVAKDATGDAPKAAGGQHPSEKTRIARDVEDVRD
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFALPFHAPFRTMLPRIEAIRAQLRPSERKLADFVLAVPREVLDLSMTELAARAGVSQPT
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IARFCQALGCSGFREFKIRLAQSVAPGVASVYRNVEPDERAPGIIGKVFDRTIGALIEVR
HHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NSLSATSVADAIELLTRASRIEFYGAGGSGIAAQDIQHKFFRLGVPSVAYSDPHTFSMSA
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ALLGANDVVVAISNTGRTRDIVDAARAALACGAKVISITHSHSPLAQLSTVSLASNVAEE
HHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
TDVFSPMTSRMSHLAIGDILAVGVALRRGPELVDRLGRAKEAITRRRIGIDAKAGKETGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DVAKDATGDAPKAAGGQHPSEKTRIARDVEDVRD
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]