Click here to switch to the map view.

The map label for this gene is alkA [H]

Identifier: 83719392

GI number: 83719392

Start: 2187894

End: 2188832

Strand: Direct

Name: alkA [H]

Synonym: BTH_I1942

Alternate gene names: 83719392

Gene position: 2187894-2188832 (Clockwise)

Preceding gene: 83719803

Following gene: 83718423

Centisome position: 57.44

GC content: 69.01

Gene sequence:

>939_bases
ATGGCAACGGCCAGAAAAGCGCCGGCTAAGCGCGCGGCGACGCAGCCGCCGATTGCGGCCAAGCGGGCCGGCGCGCGTGC
GCCGGCGGTGCACAAGGCGGGCGCGAAGCGCGCGGCGCCGAACGGCGCGGCCAATGGCGCCGCGCACAAGCCGAGCTTGC
GCACGGCCGCCGCGAAGTCGGCGCGTGCGAAGGTCGATGGCGAGCACGTCGCCGACGCGTTGCCGCGCGAGGCCGGCGTT
GCCGCGGCGGAGCCCGCCGCGCGCAAGGCGCGCGTATCGGAGGCCGCCGTGCCGGTGCAGCTCTCCGACGCCGAGACGGT
CGCGCGTCCGCCGTACTGGGACAAGGCGTGCGCCGATCTCGTCAAGCGCGACCGGATTCTCAAGAAGCTGATCCCGAAAT
TCGGCCCGGCGCATCTCGTCAAGCGCGGCGACTCGTTCGTCACGCTCGCGCGCTCGGTGGTCGGCCAGCAGATCTCGGTC
GCCGCCGCGCAGTCGGTTTGGGTCAAGATCGAGACCGCGTGCCCGAAGCTCGCGCCGCCGCAGATCATCAAGCTCGGTCA
GGAAAAACTGATCGCGTGCGGCCTGTCGAAGCGCAAGTCCGAATATATCCTCGACCTCGCCCAGCACTTCGTGTCGGGCG
CGCTGCACGTCGACAAATGGGCGTCGATGGACGACGAGGACGTGATCGCCGAGCTCACGCAGATTCGCGGGATCGGACGC
TGGACGGCCGAGATGTTCCTGATCTTCAATCTGTCGCGCCCGGACGTGCTGCCGCTCGACGATCTGGGGCTCATTCGCGC
GATCAGCGTCAATTATTTCAGCGGCGAGCCCGTCACACGCAGCGAGGCGCGTGAGGTGGCGGCGAACTGGGAGCCGTGGC
GAACGGTCGCCACCTGGTACATGTGGCGCAGTCTCGATCCGCTGACCGCCAATAACTGA

Upstream 100 bases:

>100_bases
GGATCGCACTTGAAGACAAACCGGGCGGATCGACCGAGTGGCGTCGCGTATGAGCGCGCATCGTCTGTCCCGCTGATCGA
TTCGCCAGGTAGGAGGCTAG

Downstream 100 bases:

>100_bases
CCGAGGCTATTGCTTTCGCCGATCGATAGTTGCGACCTGGTTTTGCGTCCGGCGGGCGCGGTTAGAATACGCGCTGCCGC
AAGATTCAAGGATTTCAGAC

Product: DNA-3-methyladenine glycosylase

Products: NA

Alternate protein names: 3-methyladenine-DNA glycosidase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MATARKAPAKRAATQPPIAAKRAGARAPAVHKAGAKRAAPNGAANGAAHKPSLRTAAAKSARAKVDGEHVADALPREAGV
AAAEPAARKARVSEAAVPVQLSDAETVARPPYWDKACADLVKRDRILKKLIPKFGPAHLVKRGDSFVTLARSVVGQQISV
AAAQSVWVKIETACPKLAPPQIIKLGQEKLIACGLSKRKSEYILDLAQHFVSGALHVDKWASMDDEDVIAELTQIRGIGR
WTAEMFLIFNLSRPDVLPLDDLGLIRAISVNYFSGEPVTRSEAREVAANWEPWRTVATWYMWRSLDPLTANN

Sequences:

>Translated_312_residues
MATARKAPAKRAATQPPIAAKRAGARAPAVHKAGAKRAAPNGAANGAAHKPSLRTAAAKSARAKVDGEHVADALPREAGV
AAAEPAARKARVSEAAVPVQLSDAETVARPPYWDKACADLVKRDRILKKLIPKFGPAHLVKRGDSFVTLARSVVGQQISV
AAAQSVWVKIETACPKLAPPQIIKLGQEKLIACGLSKRKSEYILDLAQHFVSGALHVDKWASMDDEDVIAELTQIRGIGR
WTAEMFLIFNLSRPDVLPLDDLGLIRAISVNYFSGEPVTRSEAREVAANWEPWRTVATWYMWRSLDPLTANN
>Mature_311_residues
ATARKAPAKRAATQPPIAAKRAGARAPAVHKAGAKRAAPNGAANGAAHKPSLRTAAAKSARAKVDGEHVADALPREAGVA
AAEPAARKARVSEAAVPVQLSDAETVARPPYWDKACADLVKRDRILKKLIPKFGPAHLVKRGDSFVTLARSVVGQQISVA
AAQSVWVKIETACPKLAPPQIIKLGQEKLIACGLSKRKSEYILDLAQHFVSGALHVDKWASMDDEDVIAELTQIRGIGRW
TAEMFLIFNLSRPDVLPLDDLGLIRAISVNYFSGEPVTRSEAREVAANWEPWRTVATWYMWRSLDPLTANN

Specific function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkylbase DNA glycosidase alkA family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320990, Length=197, Percent_Identity=31.9796954314721, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010316
- InterPro:   IPR000035
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =3.2.2.21 [H]

Molecular weight: Translated: 33631; Mature: 33500

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATARKAPAKRAATQPPIAAKRAGARAPAVHKAGAKRAAPNGAANGAAHKPSLRTAAAKS
CCCCCCCCHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ARAKVDGEHVADALPREAGVAAAEPAARKARVSEAAVPVQLSDAETVARPPYWDKACADL
HHHHCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHCCCCEEECCCHHHCCCCCHHHHHHHH
VKRDRILKKLIPKFGPAHLVKRGDSFVTLARSVVGQQISVAAAQSVWVKIETACPKLAPP
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
QIIKLGQEKLIACGLSKRKSEYILDLAQHFVSGALHVDKWASMDDEDVIAELTQIRGIGR
HHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCHH
WTAEMFLIFNLSRPDVLPLDDLGLIRAISVNYFSGEPVTRSEAREVAANWEPWRTVATWY
HHEEEEEEEECCCCCCCCCCCCCHHHEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHH
MWRSLDPLTANN
HHHCCCCCCCCC
>Mature Secondary Structure 
ATARKAPAKRAATQPPIAAKRAGARAPAVHKAGAKRAAPNGAANGAAHKPSLRTAAAKS
CCCCCCCHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
ARAKVDGEHVADALPREAGVAAAEPAARKARVSEAAVPVQLSDAETVARPPYWDKACADL
HHHHCCHHHHHHHCCHHCCCCCCCHHHHHHHHHHCCCCEEECCCHHHCCCCCHHHHHHHH
VKRDRILKKLIPKFGPAHLVKRGDSFVTLARSVVGQQISVAAAQSVWVKIETACPKLAPP
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
QIIKLGQEKLIACGLSKRKSEYILDLAQHFVSGALHVDKWASMDDEDVIAELTQIRGIGR
HHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCHH
WTAEMFLIFNLSRPDVLPLDDLGLIRAISVNYFSGEPVTRSEAREVAANWEPWRTVATWY
HHEEEEEEEECCCCCCCCCCCCCHHHEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHH
MWRSLDPLTANN
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8376346; 9384377 [H]