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The map label for this gene is ppsD [H]

Identifier: 83719211

GI number: 83719211

Start: 2752877

End: 2758195

Strand: Reverse

Name: ppsD [H]

Synonym: BTH_I2417

Alternate gene names: 83719211

Gene position: 2758195-2752877 (Counterclockwise)

Preceding gene: 83718562

Following gene: 83721564

Centisome position: 72.41

GC content: 75.28

Gene sequence:

>5319_bases
ATGAGGAGCACGCATGAAGGAGCCCGCATGACCCCCCCCGATCTGCTGTCGCTCGCCGCGCGCTTCGCGCGGCTGCCCGA
CACGCAGCGCAAGCAGTTCCTCGCGAAGCTCGGCGACGCGGGGATCGATTTCCGGATGCTGCCGATTCCGCCGCGCGAGG
ACCGCGCGGCGAGCGTGCCGGCGTCGTTCGCGCAGACGCGCCTCTGGCTGCACGCGCGCCTGCTCGGCGAATCGGCCGCG
TACCACATCACCGAGCGGCTGCGCCTCGACGGCGCGCTCGATGCGAACGCGCTGCGGCTGTCGTGCGACGCGCTGATCGC
ACGCCACGAGGCGCTGCGCACGACGTTCGCCGAAGGCGCCGACGGCGTGCTGCAGACGGTTCACGCGCCGATGCGCTGCC
CGTGGCGCTTCACCGATCTCGCCGGCGTGCCCGCCGCGACGCGCGACGCGCGCGCGGCGGCCGTCGCCGAGCGCGACGAG
GCCGAGCCGTTCGATCTCGCGCACGGCCCGCTCGTGCGCGCGCACCTGATCCGGCTCGACGCCGCCGCGCACTGGCTCGT
GCTGACGACGCACCACATCGTGTCGGACGGCTGGTCGGCCGACGTGATGCTCGCCGAGCTGTCGTCGTTCTACCGCTCGT
ATGCGACGGGCGACGCGGTGTCGCTCGCGCCGCTGCCGGTGCAGTACGCGGATTACGCGCTCTGGCAGCGCCGCTGGCTC
GAAGCGGGCGAGGGCGAGCGGCAGCTCGCGCACTGGCGCGCGACGCTCGACGCGAGCCGCGACGTGCTGCTGCTGCCGGG
CGCCGCGACGCGGCCCGCGCAGCGCGGCGCGAGCGGCGCGCGGCATGCGTTCGACGTGCCCGCCGCGCTCGCGCAACGCG
TGCTTGCGCTCGCGCAGGCGCGCCGCGCGACGCCGTTCGCCGTGTTGCTCGCCGCGCTCGCGACGCTGCTCGCGCGCGCG
AGCGGCGAGCATGAGATCCGGATCGGCGTGCCGTCGGCGAATCGCGAGCGCGCCGAGACCGTCGGGCTGATCGGCTTTTT
CGTCAATACGCTGACGCTCGCGGCGAAAACGCCCGCGACGCTCGCGTTCGACGCGCTCGTCGACGCGACGCAGCGCGGCC
TGATCGACGCGCAGTCGCACCAGGACGTGCCGTTCGACCAGGTGGTGGATGCGCTCGGCGTCGCGCGCAGCGCGAGCCAC
CATCCGCTCTTCCAGGTGATGGCCGCGTACGGCGCGCGGCGCGTGCTGCCGTCGTTCGCGGGCGTGCGCGCGGCCGAGCT
GCCGTCGGGCATGCCGTACGCGAAGTTCGACCTCGCGCTCAGCTTCGACGAGCGCGACGACGGCGGGCTCGACGTGCGCT
TCGTCTATGCGACCGACCTCTTCGACGCCGACGCGATCGAGCGCTTCGCCGCGCGCTACGCCGAGCTGCTCGCGCATGCG
CTCGAAGCGCCCGGCGCGGCGATCGGCGATCTGCAATGGCTGCCCGAGGCGGAGCGCCGCCAGCTCGCCGCGTGGAACGG
GCAGACGCACGATTTCGCCGATTCCGGGCGCGGCCGCGCGCAGTCGGCGCGCGCCGCGGCCGGAACGCCCGGCGAGCGGG
GCGGCCAGCCTGCCGGCACCACCGTTTCCGGCGACCTTGCCGGCGCGCGTGCGGGCGATTCGGTCGAAAAGCCCGTTGAT
GAGCCCGTTGATGAGCTCGTTGGCGAGCCTGTCGGCGAGGATTCGGGCCGGCCTCGCGGCATGCCGTTCGTCTCGGTCCA
CGACCGGATCGCGGAGCATGCGCGCCGCCGCCCGGACGCGCGCGGCGTCGCCGATGTCGAGCGCGCGCTCACGCGCGGCG
AAGTCGAAGCGCGCGCGGCGCGGCTCGCGAAGCGCCTCGTCGCGGCGGGCGTGCGCGCGGAGATGCGCGTGGGCGTCGCG
TTGTCGCGCTCGGTCGATCTGCTCGTCGGGCTGATCGCCGCGCTCAAGTCGGGCGGCGCGTTCGTGCCGCTCGATCCGAG
CCACCCGCGCGAGCGCCTCGCGCAGATGCTCGACGACGCGCAGATCGCGCACGTGATCACCGAGCGCGGCAGCGTTCACG
CGCTGCCGCTTGCGGGCGCGACGCGCGCGTGGCTCGTCGACGACGCGATCGCCGACGCGGCGATCGAAGGCGTCGCGCTG
CCCGACGTGTCGCCGCATCAGGCCGCGTACGTGATCTACACGTCGGGCTCGACCGGCAAGCCGAAGGGCGTCGTCGTCGA
TCACGGCGCGTTCGCGCGCCACTGCGAGGCGATCGCCGCGCGCTACGGCGCGACCGAGCGCGACGTGTTCATGCTGTTCC
AGTCGGTCAATTTCGACGGCGCGCACGAGGGCTGGTTCTCGCAGTACATGTCGGGCGCGGCCGTCGCGGTGACGGCCGAC
ACGCTGTGGCCGCCCGCGCGCACCTGCGCGCTGATCGCGCGCGAACGCGTGACGATGACCTACGTGCCCCCCGGCTGCGC
GACGCAGCTCGCCGAATGGGCGCTCGAGCACGGCGCGCCGCCGTCGCTGCGCTCGATCACGGTGGGCGGCGAGGCGACGT
CGCGCGAGGCGTTCGCGCTGATGCGCCGCGCGTTTCCGAACGCGCGCGTCGTCAACGGCTACGGGCCGACCGAGACGGTG
ATCACGCCGATGCTGTGGATGTTCGCGCCGGGCGACGATCCGGCCAAGCTCGCGGACGCCGCGTATCTGCCGATCGGCAC
GCTGGTCGGCGCGCGCACCGCGCACGTGCTCGACGCGCGCCTGAATCCGCTGCCCGTCGGCGTGATCGGCGAGCTGTATC
TGGGCGGCGAGGGCATCGGGCTCGCGCGCGGCTATCTGGGGCGAGCGGCGCTCACGGCCGAGCGCTTCGTACCCGATCCG
TACGGCGCGCCGGGCGCGCGGCTGTACCGCACGGGCGACCTCGTGCGCCGCCGCGCGGACGGCGTGTTCGATTTCATCGG
CCGCATCGACCACCAGGTGAAGCTGCGCGGGCTGCGGATCGAACTGGGCGAGATCGAGGCGCAGCTCGCCGCGCACGACG
ACGTGCGCGAGGCGGTCGCCGTCGTGTTCGGCAAGGGCGGTGAGGCGCGGCTCGTCGCGTTCGTCGAGCTGACGGGCGAC
GCGCGCGAGCGTGCGCGTCGCGCGGATTCGGCCGAGCTCGACGCGCATCTGCGCCGCACGTTGCCCGACTACATGGTGCC
CGCGCACATCGTCGTGCTCGACGCGCTGCCGCGCAACGCGAACAGCAAGGTCGACCGCGCGGCGCTGCCGGAACCCGCGC
ACGTCGCACGCGCATACGAGGCGCCAGAAGGCGACGTCGAGGCGGCGCTCGCCGAGATCTGGCGCGAAGTGCTCGGGCTC
GAGCGGGTCGGCCGCGGCGATCATTTCTTCGAACTGGGCGGCCATTCGCTCGCGGCGGTGCGCGTGGCCACGCGCGTCGC
CGAGCGGCTCGCGCGCGACGTGCCGGTGCGCGCGCTGTTCGAAGCGCCGATTCTCGCGCCGTACGCGCAGCGCGTCGCCG
CCGCCGCGCGGGCGAGCGCGCCGCACGGCGCGCTCGACGCGAGCGACGCATCGCATGCGCCCGACGCCGACGGCGTGCTG
CCGCTGTCCGCCGCGCAGCGCGGCCTGTGGTTTCTGTGGCGCGCGCAGCCGGAGAGCGCCGCGTACAACATCCCGGTCGC
GCTGCGGCTGCGCGGCGCGCTCGACATCGATGCGCTCGCCGACGCGTTCGCGCGCGCGGCCGCCCGTCATCCGGCGCTGC
GCACGCGGATCGTCGCGCGGGCGGACGGCGCGCCGGGGCAGCGGATCGCGCCCGTGCAGCCCGTCGATCTGCCGATCGTC
GAGCTGCGCGTCGCGGACGACGACGCGCGGCTCGCCGCCGCCGCCGCGCTGACCGACGACGACGCGCTCGCGCCGTTCGA
TCTCGCCGCCGACGCGCCGCTGTGGCGCGCGCGCGTGATCCGGCTCGGCGAGCGGGATCACGTGCTGTCGCTCGTCGTTC
ATCACATCGTGTCGGACGGGCAGTCGATCGATTTGTGGCTCGACGAGGTTCGCGCGGCGTACGTCGCGCGGCGCGCGGGC
GGTGGGGCGCCGCCGGCGGCGTCCGACGCATCGGGCGCGCGGGCCGGAACGCTCGGCGGCCCGGGCGCGGGATTGCCTTC
GCAGACGCTTGCGCAAACGCCCGCGCGGCCCCGTTCGGCCTCGCGCGACGCGCTGGTGCTGCCCGCCGCCGCGCCGCGCG
CGCGCCTCGCGTTCTGGCGCGAAGCGCTCGCCGGCGTGCCGTCGTACGCGTTGCCGCCGCCGCGCGCGGGCCGCGCGGTG
TCGCCGCGCTGGGACGCCGGGCGTCTCGCGTTCGAGCTCGACGGCGCGCTCGTGCGCCGCGCGCGCGCGATGGCGCTCGA
CGCGCACGCGACGCTGCCGATGCTGCTGCACGCGGCGCTGAACGCGGCGTTCTACCGGGCGACGGGCGCGACCGATCAGC
CGGTCGGCGTGCTCGCGTCGACGCGCGAGCTGACGGGCGACGCCGCCGAGCGCGCGCTCGGGCTCTTCATCAACGCGGTC
GTCGTGCGCACGCGGCTTTCGGGCGCCGATACGCCGGCCGCGCTCGTCGCCGCCGTGCGCGACGCCGCGCTCGCCGCGTA
TGCGCACGCGGACGCGCCGTTTGGCGACGTCGTCGCCGCGCTGCGCGCACCGCGCGCGGTCAACGGCAATCCGCTGTTCC
AGGTGATGTTCAACTACCTGCGGCCGACGGGCGCCGCCGCGCGCGACTGGGCGGGGCTCGCGGTCGACGAATTCAACGAC
GTCCGGCACCGCGTCGTGTTCGAACTCGAGCTCGACATCGTCGAGCATCCGGACGGCCGCGTGACGGGCGCGTTCTCGTA
TGCGACCGAGCGCGTCGACGGCGCGTTCGTCGCCGCGCTCGCGGCCGACTATCTCGACGTCGTGCGCGGCTTCGTCGACG
CGCCCGCGCGCGCGCTCGGCGCGTGCGCCGCACGGTTTGCGCTCGACGCGCACGACGTGTGCGCGCCGCTGTCGCCGCCC
GCCGCCGCAGCGAACGCGTCCGCCGCCGCGCACGCCGCGCGCGCGCTCGCCGACGTGTGGCGCGCGGCGCTCGGCCATGC
CGCGCCCGCGCCCGACGACAACGTGTTCGAAGCCGGCGCGACGTCGTTCGACGTCGTGCGCTTCGTCGACGCGGCGCGTT
CGGCCGGCTTCGCGCTCGCGATCGCCGACGTGTTCGCCGCGCCGAGCTTCGCGGCGCTCGGCGAGCGCGCCGCGCACATC
GCCGGCCAGCCCGCCACGCAGGCGCGCGATGCCGATTGA

Upstream 100 bases:

>100_bases
CCGCGCGCGCGAAGCCGGCCGCGACCACGACGCCGCGAGCGCGATCGACGCGCTGCTCGGCGAGCTCGAAGCCCAGTAAG
TCGCCCAATCAGGAACACGC

Downstream 100 bases:

>100_bases
GCGCCGCCCGCCGCAGCCGCGCCTGGAGCGCAGCGGCCGCAATCGCCGCATAGGCGGCCTCGACGATGCGCGCGATCCGC
ATCACGTTTTTGTCCGGCCG

Product: non-ribosomal peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Peptide synthase 4; ATP-dependent proline adenylase; ProA 1; Proline activase 1; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase 2; TyrA 2; Tyrosine activase 2 [H]

Number of amino acids: Translated: 1772; Mature: 1772

Protein sequence:

>1772_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGALDANALRLSCDALIARHEALRTTFAEGADGVLQTVHAPMRCPWRFTDLAGVPAATRDARAAAVAERDE
AEPFDLAHGPLVRAHLIRLDAAAHWLVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
EAGEGERQLAHWRATLDASRDVLLLPGAATRPAQRGASGARHAFDVPAALAQRVLALAQARRATPFAVLLAALATLLARA
SGEHEIRIGVPSANRERAETVGLIGFFVNTLTLAAKTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAGVRAAELPSGMPYAKFDLALSFDERDDGGLDVRFVYATDLFDADAIERFAARYAELLAHA
LEAPGAAIGDLQWLPEAERRQLAAWNGQTHDFADSGRGRAQSARAAAGTPGERGGQPAGTTVSGDLAGARAGDSVEKPVD
EPVDELVGEPVGEDSGRPRGMPFVSVHDRIAEHARRRPDARGVADVERALTRGEVEARAARLAKRLVAAGVRAEMRVGVA
LSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLDDAQIAHVITERGSVHALPLAGATRAWLVDDAIADAAIEGVAL
PDVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTAD
TLWPPARTCALIARERVTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETV
ITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGIGLARGYLGRAALTAERFVPDP
YGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVAVVFGKGGEARLVAFVELTGD
ARERARRADSAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPEGDVEAALAEIWREVLGL
ERVGRGDHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAARASAPHGALDASDASHAPDADGVL
PLSAAQRGLWFLWRAQPESAAYNIPVALRLRGALDIDALADAFARAAARHPALRTRIVARADGAPGQRIAPVQPVDLPIV
ELRVADDDARLAAAAALTDDDALAPFDLAADAPLWRARVIRLGERDHVLSLVVHHIVSDGQSIDLWLDEVRAAYVARRAG
GGAPPAASDASGARAGTLGGPGAGLPSQTLAQTPARPRSASRDALVLPAAAPRARLAFWREALAGVPSYALPPPRAGRAV
SPRWDAGRLAFELDGALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAV
VVRTRLSGADTPAALVAAVRDAALAAYAHADAPFGDVVAALRAPRAVNGNPLFQVMFNYLRPTGAAARDWAGLAVDEFND
VRHRVVFELELDIVEHPDGRVTGAFSYATERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFALDAHDVCAPLSPP
AAAANASAAAHAARALADVWRAALGHAAPAPDDNVFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSFAALGERAAHI
AGQPATQARDAD

Sequences:

>Translated_1772_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGALDANALRLSCDALIARHEALRTTFAEGADGVLQTVHAPMRCPWRFTDLAGVPAATRDARAAAVAERDE
AEPFDLAHGPLVRAHLIRLDAAAHWLVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
EAGEGERQLAHWRATLDASRDVLLLPGAATRPAQRGASGARHAFDVPAALAQRVLALAQARRATPFAVLLAALATLLARA
SGEHEIRIGVPSANRERAETVGLIGFFVNTLTLAAKTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAGVRAAELPSGMPYAKFDLALSFDERDDGGLDVRFVYATDLFDADAIERFAARYAELLAHA
LEAPGAAIGDLQWLPEAERRQLAAWNGQTHDFADSGRGRAQSARAAAGTPGERGGQPAGTTVSGDLAGARAGDSVEKPVD
EPVDELVGEPVGEDSGRPRGMPFVSVHDRIAEHARRRPDARGVADVERALTRGEVEARAARLAKRLVAAGVRAEMRVGVA
LSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLDDAQIAHVITERGSVHALPLAGATRAWLVDDAIADAAIEGVAL
PDVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTAD
TLWPPARTCALIARERVTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETV
ITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGIGLARGYLGRAALTAERFVPDP
YGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVAVVFGKGGEARLVAFVELTGD
ARERARRADSAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPEGDVEAALAEIWREVLGL
ERVGRGDHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAARASAPHGALDASDASHAPDADGVL
PLSAAQRGLWFLWRAQPESAAYNIPVALRLRGALDIDALADAFARAAARHPALRTRIVARADGAPGQRIAPVQPVDLPIV
ELRVADDDARLAAAAALTDDDALAPFDLAADAPLWRARVIRLGERDHVLSLVVHHIVSDGQSIDLWLDEVRAAYVARRAG
GGAPPAASDASGARAGTLGGPGAGLPSQTLAQTPARPRSASRDALVLPAAAPRARLAFWREALAGVPSYALPPPRAGRAV
SPRWDAGRLAFELDGALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAV
VVRTRLSGADTPAALVAAVRDAALAAYAHADAPFGDVVAALRAPRAVNGNPLFQVMFNYLRPTGAAARDWAGLAVDEFND
VRHRVVFELELDIVEHPDGRVTGAFSYATERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFALDAHDVCAPLSPP
AAAANASAAAHAARALADVWRAALGHAAPAPDDNVFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSFAALGERAAHI
AGQPATQARDAD
>Mature_1772_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGALDANALRLSCDALIARHEALRTTFAEGADGVLQTVHAPMRCPWRFTDLAGVPAATRDARAAAVAERDE
AEPFDLAHGPLVRAHLIRLDAAAHWLVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
EAGEGERQLAHWRATLDASRDVLLLPGAATRPAQRGASGARHAFDVPAALAQRVLALAQARRATPFAVLLAALATLLARA
SGEHEIRIGVPSANRERAETVGLIGFFVNTLTLAAKTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAGVRAAELPSGMPYAKFDLALSFDERDDGGLDVRFVYATDLFDADAIERFAARYAELLAHA
LEAPGAAIGDLQWLPEAERRQLAAWNGQTHDFADSGRGRAQSARAAAGTPGERGGQPAGTTVSGDLAGARAGDSVEKPVD
EPVDELVGEPVGEDSGRPRGMPFVSVHDRIAEHARRRPDARGVADVERALTRGEVEARAARLAKRLVAAGVRAEMRVGVA
LSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLDDAQIAHVITERGSVHALPLAGATRAWLVDDAIADAAIEGVAL
PDVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTAD
TLWPPARTCALIARERVTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETV
ITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGIGLARGYLGRAALTAERFVPDP
YGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVAVVFGKGGEARLVAFVELTGD
ARERARRADSAELDAHLRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPEGDVEAALAEIWREVLGL
ERVGRGDHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAARASAPHGALDASDASHAPDADGVL
PLSAAQRGLWFLWRAQPESAAYNIPVALRLRGALDIDALADAFARAAARHPALRTRIVARADGAPGQRIAPVQPVDLPIV
ELRVADDDARLAAAAALTDDDALAPFDLAADAPLWRARVIRLGERDHVLSLVVHHIVSDGQSIDLWLDEVRAAYVARRAG
GGAPPAASDASGARAGTLGGPGAGLPSQTLAQTPARPRSASRDALVLPAAAPRARLAFWREALAGVPSYALPPPRAGRAV
SPRWDAGRLAFELDGALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAV
VVRTRLSGADTPAALVAAVRDAALAAYAHADAPFGDVVAALRAPRAVNGNPLFQVMFNYLRPTGAAARDWAGLAVDEFND
VRHRVVFELELDIVEHPDGRVTGAFSYATERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFALDAHDVCAPLSPP
AAAANASAAAHAARALADVWRAALGHAAPAPDDNVFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSFAALGERAAHI
AGQPATQARDAD

Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Pro, Gln and Tyr as part of the biosynthesis of the lipopeptide antibiotic plipastatin. The Tyr residue is further epimerized to the D-isomer form. The activation si

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 11 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=460, Percent_Identity=25, Blast_Score=106, Evalue=2e-22,
Organism=Escherichia coli, GI1786801, Length=586, Percent_Identity=34.641638225256, Blast_Score=255, Evalue=1e-68,
Organism=Escherichia coli, GI1790505, Length=380, Percent_Identity=28.6842105263158, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI221142682, Length=508, Percent_Identity=22.4409448818898, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17550940, Length=565, Percent_Identity=23.0088495575221, Blast_Score=115, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17556356, Length=324, Percent_Identity=27.1604938271605, Blast_Score=103, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=23.7721021611002, Blast_Score=87, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71982997, Length=397, Percent_Identity=28.7153652392947, Blast_Score=82, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=397, Percent_Identity=28.7153652392947, Blast_Score=81, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319591, Length=777, Percent_Identity=26.3835263835264, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24648676, Length=613, Percent_Identity=28.5481239804241, Blast_Score=169, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581924, Length=390, Percent_Identity=25.1282051282051, Blast_Score=80, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 187745; Mature: 187745

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ASFAQTRLWLHARLLGESAAYHITERLRLDGALDANALRLSCDALIARHEALRTTFAEGA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DGVLQTVHAPMRCPWRFTDLAGVPAATRDARAAAVAERDEAEPFDLAHGPLVRAHLIRLD
HHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AAAHWLVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
HHHEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHH
EAGEGERQLAHWRATLDASRDVLLLPGAATRPAQRGASGARHAFDVPAALAQRVLALAQA
HCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHCCHHHHHHHHHHHHHH
RRATPFAVLLAALATLLARASGEHEIRIGVPSANRERAETVGLIGFFVNTLTLAAKTPAT
HCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GVRAAELPSGMPYAKFDLALSFDERDDGGLDVRFVYATDLFDADAIERFAARYAELLAHA
CCCHHHCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LEAPGAAIGDLQWLPEAERRQLAAWNGQTHDFADSGRGRAQSARAAAGTPGERGGQPAGT
HHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
TVSGDLAGARAGDSVEKPVDEPVDELVGEPVGEDSGRPRGMPFVSVHDRIAEHARRRPDA
EECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
RGVADVERALTRGEVEARAARLAKRLVAAGVRAEMRVGVALSRSVDLLVGLIAALKSGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCE
FVPLDPSHPRERLAQMLDDAQIAHVITERGSVHALPLAGATRAWLVDDAIADAAIEGVAL
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCC
PDVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDG
CCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AHEGWFSQYMSGAAVAVTADTLWPPARTCALIARERVTMTYVPPGCATQLAEWALEHGAP
CCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCC
PSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADA
CCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHEECCCCCHHHHHHH
AYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGIGLARGYLGRAALTAERFVPDP
HHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
YGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVA
CCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
VVFGKGGEARLVAFVELTGDARERARRADSAELDAHLRRTLPDYMVPAHIVVLDALPRNA
HHCCCCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCCC
NSKVDRAALPEPAHVARAYEAPEGDVEAALAEIWREVLGLERVGRGDHFFELGGHSLAAV
CCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHH
RVATRVAERLARDVPVRALFEAPILAPYAQRVAAAARASAPHGALDASDASHAPDADGVL
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
PLSAAQRGLWFLWRAQPESAAYNIPVALRLRGALDIDALADAFARAAARHPALRTRIVAR
EHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHEEE
ADGAPGQRIAPVQPVDLPIVELRVADDDARLAAAAALTDDDALAPFDLAADAPLWRARVI
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHH
RLGERDHVLSLVVHHIVSDGQSIDLWLDEVRAAYVARRAGGGAPPAASDASGARAGTLGG
HCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PGAGLPSQTLAQTPARPRSASRDALVLPAAAPRARLAFWREALAGVPSYALPPPRAGRAV
CCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SPRWDAGRLAFELDGALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLAS
CCCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TRELTGDAAERALGLFINAVVVRTRLSGADTPAALVAAVRDAALAAYAHADAPFGDVVAA
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRAPRAVNGNPLFQVMFNYLRPTGAAARDWAGLAVDEFNDVRHRVVFELELDIVEHPDGR
HHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEEEECCCCC
VTGAFSYATERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFALDAHDVCAPLSPP
EEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCC
AAAANASAAAHAARALADVWRAALGHAAPAPDDNVFEAGATSFDVVRFVDAARSAGFALA
CHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEE
IADVFAAPSFAALGERAAHIAGQPATQARDAD
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ASFAQTRLWLHARLLGESAAYHITERLRLDGALDANALRLSCDALIARHEALRTTFAEGA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DGVLQTVHAPMRCPWRFTDLAGVPAATRDARAAAVAERDEAEPFDLAHGPLVRAHLIRLD
HHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AAAHWLVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
HHHEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHH
EAGEGERQLAHWRATLDASRDVLLLPGAATRPAQRGASGARHAFDVPAALAQRVLALAQA
HCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHCCHHHHHHHHHHHHHH
RRATPFAVLLAALATLLARASGEHEIRIGVPSANRERAETVGLIGFFVNTLTLAAKTPAT
HCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
GVRAAELPSGMPYAKFDLALSFDERDDGGLDVRFVYATDLFDADAIERFAARYAELLAHA
CCCHHHCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LEAPGAAIGDLQWLPEAERRQLAAWNGQTHDFADSGRGRAQSARAAAGTPGERGGQPAGT
HHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
TVSGDLAGARAGDSVEKPVDEPVDELVGEPVGEDSGRPRGMPFVSVHDRIAEHARRRPDA
EECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
RGVADVERALTRGEVEARAARLAKRLVAAGVRAEMRVGVALSRSVDLLVGLIAALKSGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCE
FVPLDPSHPRERLAQMLDDAQIAHVITERGSVHALPLAGATRAWLVDDAIADAAIEGVAL
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCC
PDVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCEAIAARYGATERDVFMLFQSVNFDG
CCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AHEGWFSQYMSGAAVAVTADTLWPPARTCALIARERVTMTYVPPGCATQLAEWALEHGAP
CCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCC
PSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADA
CCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHEECCCCCHHHHHHH
AYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGGEGIGLARGYLGRAALTAERFVPDP
HHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
YGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLRGLRIELGEIEAQLAAHDDVREAVA
CCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
VVFGKGGEARLVAFVELTGDARERARRADSAELDAHLRRTLPDYMVPAHIVVLDALPRNA
HHCCCCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCCC
NSKVDRAALPEPAHVARAYEAPEGDVEAALAEIWREVLGLERVGRGDHFFELGGHSLAAV
CCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHH
RVATRVAERLARDVPVRALFEAPILAPYAQRVAAAARASAPHGALDASDASHAPDADGVL
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
PLSAAQRGLWFLWRAQPESAAYNIPVALRLRGALDIDALADAFARAAARHPALRTRIVAR
EHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHEEE
ADGAPGQRIAPVQPVDLPIVELRVADDDARLAAAAALTDDDALAPFDLAADAPLWRARVI
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHH
RLGERDHVLSLVVHHIVSDGQSIDLWLDEVRAAYVARRAGGGAPPAASDASGARAGTLGG
HCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PGAGLPSQTLAQTPARPRSASRDALVLPAAAPRARLAFWREALAGVPSYALPPPRAGRAV
CCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SPRWDAGRLAFELDGALVRRARAMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLAS
CCCCCCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TRELTGDAAERALGLFINAVVVRTRLSGADTPAALVAAVRDAALAAYAHADAPFGDVVAA
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRAPRAVNGNPLFQVMFNYLRPTGAAARDWAGLAVDEFNDVRHRVVFELELDIVEHPDGR
HHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEEEECCCCC
VTGAFSYATERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFALDAHDVCAPLSPP
EEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCC
AAAANASAAAHAARALADVWRAALGHAAPAPDDNVFEAGATSFDVVRFVDAARSAGFALA
CHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEE
IADVFAAPSFAALGERAAHIAGQPATQARDAD
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7711903; 9384377; 10471562 [H]