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The map label for this gene is trpE [H]

Identifier: 83719019

GI number: 83719019

Start: 3344346

End: 3345914

Strand: Direct

Name: trpE [H]

Synonym: BTH_I2909

Alternate gene names: 83719019

Gene position: 3344346-3345914 (Clockwise)

Preceding gene: 83720491

Following gene: 83720076

Centisome position: 87.8

GC content: 66.09

Gene sequence:

>1569_bases
GTGCTCCGGGCGCGAGCGCAGCGCCACGCGATCCCCGGCGCGCCGCGCCGATCGTCCCGACGACAGGACCGGAACATGAC
TGAACTCGAATTCCAATCGCTCGCCAACGAGGGCTACAACCGCATTCCGCTCATCGCCGAAGCGCTGGCCGACCTCGAAA
CGCCGCTTTCGCTGTATCTGAAGCTCGCGCAGCCCGAACGCGGCGGCGCCAACTCGTTCCTGCTCGAATCGGTGGTGGGC
GGCGAGCGCTTCGGGCGCTACTCGTTCATCGGCCTGCCCGCGCACACGCTCGTGCGCACGAAGAACGGCGTGTCGGAAGT
CGTGACGGACGGCCGGGTCGTCGAAACCCACGACGGCGATCCGTTCGCGTTCATCGCGAAATTCCAGAGCCGCTTCAAGG
TCGCGCAGCGTCCCGGCCTGCCGCGCTTCTGCGGCGGCCTCGCCGGCTACTTCGGCTACGACGCGGTGCGCTACATCGAG
AAAAAGCTCGCGCACACCGCGCCGCGCGACGATCTCGGCCTGCCCGACATCCAGTTGCTGCTCACCGAGGAAGTCGCCGT
CATCGACAATCTCGCCGGCAAGCTCTACCTGATCGTCTACGCCGATCCGACGAAGCCCGAGGCGTACACGAAAGCCAAGC
AGCGGCTGCGCGAGCTGAAGCACCGGCTGCGCGCGAGCGTCGTGCCGCCCGTCACGTCGGCGAGCGTGCGCACCGAAATC
TATCGCGAGTTCAAGAAGGAAGACTATCTGGCCGCCGTGCGCCAGGCGAAGGAATACATCGCGGCGGGCGAGCTGATGCA
GATCCAGGTCGGCCAGCGCCTCGCGAAGCCGTATCGCGACAATCCGCTGTCGCTGTACCGCGCGCTGCGTTCGCTGAATC
CGTCGCCGTATATGTATTACTACAACTTCGGCGAATTCCATGTCGTCGGCGCATCGCCGGAGATTCTCGTGCGCCAGGAG
AAGCGCGGCGACGACCAGATCGTGACAATCCGCCCGCTCGCCGGCACGCGTGCGCGCGGCAACACGCCCGAGCGCGATGC
CGAGCTCGCGACCGAGCTGCTCAACGATCCGAAGGAGATCGCCGAGCACGTGATGCTGATCGACCTCGCGCGCAACGACG
TCGGCCGCATCGCGCAGATCGGCTCGGTTCAAGTGACCGACAAGATGGTGATCGAGAAATACTCGCACGTGCAGCATATC
GTGAGCTCGGTCGAAGGCAAGCTGAAGCCCGGCATGACGAATTACGACGTGCTGCGCGCGACGTTCCCGGCCGGCACGCT
CTCCGGCGCGCCGAAGGTCCGCGCGATGGAGCTGATCGACGAGCTCGAGCCGGTGAAGCGCGGGCTCTACGGCGGCGCGG
TCGGCTACCTGTCGTTCTCGGGCGAGATGGATCTCGCGATCGCGATCCGCACGGGCCTCATCCACAACGGCAATCTGTAC
GTGCAGGCGGCGGCGGGCATCGTCGCCGACTCGGTGCCCGAATCCGAATGGCAGGAAACCGAGAACAAGGCGCGTGCGGT
GCTGCGCGCGGCCGAACAGGTGCAAGACGGCCTCGATTCCGATTTCTGA

Upstream 100 bases:

>100_bases
CCGCTGTCGAACGTTCCGCGTTCGGGCTGCCCGTCGGCGCGCGACGCACGATCGCCAGGCAAAGCATCCGCCGGTTCGTC
CGATCCGCCCCGCGAGGGAC

Downstream 100 bases:

>100_bases
CCGGAGACTGACCATGCTGCTCATGATCGACAACTACGATTCGTTCACCTACAACCTGGTCCAGTACTTCGGCGAGCTCG
GCGAGGACGTGCGCACCTAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MLRARAQRHAIPGAPRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGRVVETHDGDPFAFIAKFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKHRLRASVVPPVTSASVRTEI
YREFKKEDYLAAVRQAKEYIAAGELMQIQVGQRLAKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRARGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAQIGSVQVTDKMVIEKYSHVQHI
VSSVEGKLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF

Sequences:

>Translated_522_residues
MLRARAQRHAIPGAPRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGRVVETHDGDPFAFIAKFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKHRLRASVVPPVTSASVRTEI
YREFKKEDYLAAVRQAKEYIAAGELMQIQVGQRLAKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRARGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAQIGSVQVTDKMVIEKYSHVQHI
VSSVEGKLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
>Mature_522_residues
MLRARAQRHAIPGAPRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGRVVETHDGDPFAFIAKFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKHRLRASVVPPVTSASVRTEI
YREFKKEDYLAAVRQAKEYIAAGELMQIQVGQRLAKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRARGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAQIGSVQVTDKMVIEKYSHVQHI
VSSVEGKLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=409, Percent_Identity=38.3863080684597, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=32.1348314606742, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI87082077, Length=277, Percent_Identity=28.8808664259928, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=30.2222222222222, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=41.0752688172043, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6324361, Length=497, Percent_Identity=25.7545271629779, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57993; Mature: 57993

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRARAQRHAIPGAPRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYL
CCCCCCHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHE
KLAQPERGGANSFLLESVVGGERFGRYSFIGLPAHTLVRTKNGVSEVVTDGRVVETHDGD
EECCCCCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHHCCCCHHHHHCCCEEEEECCCC
PFAFIAKFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLL
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKHRLRASVVPPVTSASVRTEI
HHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YREFKKEDYLAAVRQAKEYIAAGELMQIQVGQRLAKPYRDNPLSLYRALRSLNPSPYMYY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
YNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRARGNTPERDAELATELLNDPKEI
EECCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHH
AEHVMLIDLARNDVGRIAQIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRA
HHHHHHHHHHHCCHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEE
TFPAGTLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEE
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
EEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLRARAQRHAIPGAPRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYL
CCCCCCHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHE
KLAQPERGGANSFLLESVVGGERFGRYSFIGLPAHTLVRTKNGVSEVVTDGRVVETHDGD
EECCCCCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHHCCCCHHHHHCCCEEEEECCCC
PFAFIAKFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLL
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKHRLRASVVPPVTSASVRTEI
HHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YREFKKEDYLAAVRQAKEYIAAGELMQIQVGQRLAKPYRDNPLSLYRALRSLNPSPYMYY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
YNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRARGNTPERDAELATELLNDPKEI
EECCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHH
AEHVMLIDLARNDVGRIAQIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNYDVLRA
HHHHHHHHHHHCCHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEE
TFPAGTLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEE
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
EEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]