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The map label for this gene is guaB [H]

Identifier: 83718847

GI number: 83718847

Start: 2329617

End: 2331077

Strand: Direct

Name: guaB [H]

Synonym: BTH_I2056

Alternate gene names: 83718847

Gene position: 2329617-2331077 (Clockwise)

Preceding gene: 83720135

Following gene: 83719758

Centisome position: 61.16

GC content: 67.9

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAAAAGCACTCACGTTCGATGACGTGCTCCTCGTCCCGGCGTTCTCCGACGTTCTGCCGCGCGACAC
CAGCCTCAAGACCCAGCTGACCCGCCACATCTCCCTGAACATGCCGCTCGTGTCCGCCGCGATGGACACGGTCACCGAAG
GCCGCCTCGCGATCGCGATGGCGCAGCAAGGCGGCGTCGGCATCGTCCACAAGAATCTCACCCCCGTCGAGCAGGCGCGC
GAGGTCGCGAAGGTCAAGCGCTTCGAATCGGGCGTCGTGCGCGATCCGATCACCGTCCCGCCGAGCATGAAGGTGCGCGA
CGTGATCGCGCTGTCGCGCCAGCATGGCATCTCGGGTTTCCCGGTCCTCGAAGGCCCGAAGCTCGTCGGCATCGTGACGA
ACCGCGACCTGCGCTTCGAAACCCGCCTCGACGAGCCGGTCAAGTCGATCATGACGCCGCGCGAGCGCCTCGTGACGGTT
GCCGAAGGCACGCCGCTCGCCGAGGCGAAGGCGCTGATGCACAGCCACCGCCTCGAGCGCGTGCTCGTCGTCAACGATGC
GTTCGAGCTGCGCGGCCTGATGACGGTCAAGGACATCACGAAGCAGACCGAGCATCCGGAAGCGTGCAAGGACGAGCACG
GCAAGCTGCGCGTCGGCGCCGCGGTCGGCGTGGGGGCGGACAACGAGGAGCGCGTCGAGCTGCTCGTGCAGGCGGGCGTC
GACGTGATCGTCGTCGACACCGCGCACGGCCACAGCAAGGGCGTGCTCGAGCGCGTGCGCTGGGTCAAGCAGAACTTCCC
GAAGGTCGAGGTGATCGGCGGCAACATCGCGACCGCGGCCGCCGCGAAGGCGCTCGTCGAATACGGCGCGGACGCGGTGA
AGGTCGGCATCGGCCCGGGCTCGATCTGCACGACGCGGATCGTCGCGGGCGTCGGCGTGCCGCAGATCAGCGCGATCGCG
AACGTGTCGGACGCGTTGCGCGGCACCGGCGTGCCGTGCATCGCCGACGGCGGCATCCGCTTCTCGGGCGACGTGTCGAA
GGCGCTCGCCGCCGGCGCGAACGCGGTGATGATGGGCAGCATGTTCGCGGGCACCGAAGAGGCGCCGGGCGACGTGTTCC
TGTACCAGGGCCGCCAGTACAAGTCGTATCGCGGCATGGGCTCGGTCGGCGCGATGAAGGACGGCGCGGCGGACCGCTAC
TTCCAGGACAACTCCGCGAACATCGACAAGCTCGTGCCGGAAGGCATCGAAGGCCGCGTCGCGTACAAGGGCTCGGTCAA
CGCGATCATCTTCCAGCTGATCGGCGGCGTGCGGGCGAGCATGGGCTACTGCGGCTGCAAGACGATCGCCGAGATGCACG
AGAAGGCCGAGTTCGTCGAGATCACCGCGGCCGGCATGCGCGAGTCGCACGTGCACGACGTGCAGATCACGAAGGAAGCC
CCCAACTATCACGTGGACTGA

Upstream 100 bases:

>100_bases
AACGGCGAGAAACGGCTCGAAAACGGCTAAGCCGTTGTTCGTGTTGTGAAAATTAACCGGGCATCGCGTATAATTCGCTT
TTGCGCCTATAGGATTTGCC

Downstream 100 bases:

>100_bases
TCGCCGATGAAACCGTTGCTGCGCGCCGTTCTCCTGATCGATGCCGTGCTGCTCGCCGCGTTCGGCGTGCTGTTCGTGCT
GACCCCGTGGAAAGCGCTGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRHISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVLEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCIADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAEMHEKAEFVEITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRHISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVLEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCIADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAEMHEKAEFVEITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRHISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVLEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCIADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAEMHEKAEFVEITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=43.9024390243902, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=43.9024390243902, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=43.9024390243902, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=451, Percent_Identity=43.9024390243902, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.6639004149378, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=43.8478747203579, Blast_Score=358, Evalue=7e-99,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=43.0155210643016, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=40.7982261640798, Blast_Score=325, Evalue=8e-89,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=36.2595419847328, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.8421052631579, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.8421052631579, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.8421052631579, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.6283367556468, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=33.4728033472803, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=37.8661087866109, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=39.0588235294118, Blast_Score=284, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=36.4016736401674, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.2561983471074, Blast_Score=350, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.3196721311475, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=38.8429752066116, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.3040935672515, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=35.2112676056338, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.6185567010309, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.6185567010309, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.3092550790068, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51970; Mature: 51970

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRHISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHEECCCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPVEQAREVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVLEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVAEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHCCCCCCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSDALRGTGVPCIADGGIRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEEEH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAIIFQLIGGVRASMGYCGCKTIAEMHEKAEFVEITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRHISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHEECCCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPVEQAREVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVLEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVAEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHCCCCCCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSDALRGTGVPCIADGGIRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEEEH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAIIFQLIGGVRASMGYCGCKTIAEMHEKAEFVEITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA