Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 83718790

GI number: 83718790

Start: 687422

End: 689326

Strand: Direct

Name: ywrD [H]

Synonym: BTH_I0604

Alternate gene names: 83718790

Gene position: 687422-689326 (Clockwise)

Preceding gene: 83721562

Following gene: 83719367

Centisome position: 18.05

GC content: 69.4

Gene sequence:

>1905_bases
ATGTTCGCGGGTGTCGATTCGGCTCGGTGGGACGGGAAACGGGGGCGGCAAATCCGCATTGTAAGGGCTGTTCGCGCGGA
GTCGCCCGGCACGCGGCGCGCGTCGCCGCGCACGCGCGCCGATCTCGGGCTAGACTCGATTCATGTCGTTCATGCATCGA
TTCATGTGACAAATGAATTTGCCGGGGGGGCGCAATCGCGTTGGAATGTCTGTTTCGATCCTGTTTACCATGTCCCTGCG
ATGACTCTTCATTCGAACATCTCCGGCGTGCCGTTCTCGTGGCGCAATCCGTATCTGACGACGCGCGTGCCGGTATTCGC
GCGCAACGTCGTGTCGACGTCGCATCCGCTCGCCGCGCAGGCGGGGCTCAGGATGCTGTGGAAGGGCGGCAATGCGGTTG
ATGCGGCGATCGCCGCGGCGGCCGCGATCACCGTGGTCGAGCCGGTGTCGTGCGGCCTCGGCGGCGATGCGTTCGCGCTC
GTCTGGGACGGCGCGAAGCTGCACGGCCTGAACGCGTCGGGCGTCGCGCCCGCCGCATGGAGCGTCGACTACTTCCGCCG
CCGGCACGGCGACGCGGGCAACGGCCTCGCGCGACAGCCGACGCGCGGCTGGGACACGGTGACGGTGCCCGGCGTGATCG
CCGGCTGGGAGGCGCTGCACGCGAAGTTCGGATCGCTGCCGTTCGCCGATCTGCTCGAGCCGGCGATCGAGCTCGCGGAG
CGCGGGCATGCGGTGGCCGCCGTCGTCGCGCACAAGTGGGCGGCCGCCGTGCCCGAGCTGAACGGCCAGCCGGGTTTCGC
GGAAACCTTCATGCCGCGCGGCCGCGCGCCCGAGGTGAGCGAACTGGTTCGGCTGCCGGGCCACGCGAAGACGCTGCGCA
CGATCGCCGCCGAAGGCGCGCGCGCGTTCTACGAAGGCAGCATCGCCGAGTCGATCGCCGGGTTCTTCCGCGACGGCGGC
GGCGCGTTGACGGCCGACGACCTGCGCGCGTATCGCCCCGAGTGGGTCGAGCCGATCGGCAAGGACTTTCGCGGCTACAC
GGTGCACGAGATTCCGCCGAACGGGCAGGGGATCGCCGCGCTGATCGCGCTCGGCATCGTCGAGCGCTTCGGTCTCGACG
ACCTGCCGCTCGATTCGGCGGAGGCGCAGCACGTGCAGATCGAGGCGATGAAGCTTGCGTTCGCCGACGTCTATCGCTAC
GTCGCCGATCCTCGCGCGATGGCGCTCACGCCGGCACAGATGCTCGACGACGCGTACCTCGACGCGCGCGCGAAGTTGAT
CGACGTCACGCGCGCGACGCATTTCTCGTTCGGCATGCCGCGCGCGGGCGGCACGATCTACCTGTCGGCGGCTGACGAGC
GCGGCATGATGGTGAGCTTCATCCAGTCGAACTACATGGGCTTCGGCTCGGGCCTCGTCGTGCCGGGCATGGGGATCGCG
CTGCAGAACCGCGGCTGCGGGTTCTCGATGGACCCGACGTCGCCGAACGTCGTCGAGGGCGGCAAGCGGCCGTTCCACAC
GATCATCCCGGCGTTCGTCACGCAGCAGGCAGGCGGCGCGCGGCACGCGGTGATGAGCTTCGGCGTGATGGGCGGCGACA
TGCAGCCGCAAGGCCATCTGCAGACGATCGTGCGGATGCTCGGCTACGGCCAGCAGCCGCAGGCCGCGTGCGATGCGCCG
CGCTGGAAGGTGAGCCGGTCGTTCACGCTCGACGTCGAGGCGGCACTCGGGGCGTCCGTCGTCGATGCGCTTGCCGCGCG
CGGCCATACGATCCAGGCGATCGACGATCCCTACATGGATTTCGGCTCCGGCCAGTTCATCTGGCGGCTCGATCGCGACG
AGCCCGACCGCGGGTATGTCGCGGCGAGCGACAGCCGGCGCGACGGCCTCGCGGCGGGTTTTTGA

Upstream 100 bases:

>100_bases
ATGGGCGGCGAGATCGTCGACAGTGACGAAGCCGTCTCGCTGCACCCATTCGAGCAATTCCTGTTGACGCGCATTGAGGG
TGAGGCGGGGGTCTCGTGTC

Downstream 100 bases:

>100_bases
CGTGCGCCGGCGCGCATGGAATGCGCGCGCGTTTCGTTGCGGGCGAAACGATATCGAAAGGCATTTCAAAAGTGGCTTTC
GATGATGTTCGCCTTTTCGA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MFAGVDSARWDGKRGRQIRIVRAVRAESPGTRRASPRTRADLGLDSIHVVHASIHVTNEFAGGAQSRWNVCFDPVYHVPA
MTLHSNISGVPFSWRNPYLTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAFAL
VWDGAKLHGLNASGVAPAAWSVDYFRRRHGDAGNGLARQPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIELAE
RGHAVAAVVAHKWAAAVPELNGQPGFAETFMPRGRAPEVSELVRLPGHAKTLRTIAAEGARAFYEGSIAESIAGFFRDGG
GALTADDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAEAQHVQIEAMKLAFADVYRY
VADPRAMALTPAQMLDDAYLDARAKLIDVTRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGMGIA
LQNRGCGFSMDPTSPNVVEGGKRPFHTIIPAFVTQQAGGARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACDAP
RWKVSRSFTLDVEAALGASVVDALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF

Sequences:

>Translated_634_residues
MFAGVDSARWDGKRGRQIRIVRAVRAESPGTRRASPRTRADLGLDSIHVVHASIHVTNEFAGGAQSRWNVCFDPVYHVPA
MTLHSNISGVPFSWRNPYLTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAFAL
VWDGAKLHGLNASGVAPAAWSVDYFRRRHGDAGNGLARQPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIELAE
RGHAVAAVVAHKWAAAVPELNGQPGFAETFMPRGRAPEVSELVRLPGHAKTLRTIAAEGARAFYEGSIAESIAGFFRDGG
GALTADDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAEAQHVQIEAMKLAFADVYRY
VADPRAMALTPAQMLDDAYLDARAKLIDVTRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGMGIA
LQNRGCGFSMDPTSPNVVEGGKRPFHTIIPAFVTQQAGGARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACDAP
RWKVSRSFTLDVEAALGASVVDALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF
>Mature_634_residues
MFAGVDSARWDGKRGRQIRIVRAVRAESPGTRRASPRTRADLGLDSIHVVHASIHVTNEFAGGAQSRWNVCFDPVYHVPA
MTLHSNISGVPFSWRNPYLTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAFAL
VWDGAKLHGLNASGVAPAAWSVDYFRRRHGDAGNGLARQPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIELAE
RGHAVAAVVAHKWAAAVPELNGQPGFAETFMPRGRAPEVSELVRLPGHAKTLRTIAAEGARAFYEGSIAESIAGFFRDGG
GALTADDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAEAQHVQIEAMKLAFADVYRY
VADPRAMALTPAQMLDDAYLDARAKLIDVTRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGMGIA
LQNRGCGFSMDPTSPNVVEGGKRPFHTIIPAFVTQQAGGARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACDAP
RWKVSRSFTLDVEAALGASVVDALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=559, Percent_Identity=30.0536672629696, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI73915090, Length=559, Percent_Identity=30.0536672629696, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI73915096, Length=559, Percent_Identity=30.0536672629696, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI73915094, Length=559, Percent_Identity=30.0536672629696, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI113429324, Length=559, Percent_Identity=27.7280858676207, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI113429326, Length=564, Percent_Identity=27.4822695035461, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI109148539, Length=520, Percent_Identity=28.0769230769231, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI153266885, Length=559, Percent_Identity=25.2236135957066, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI153266901, Length=560, Percent_Identity=25.1785714285714, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI153266907, Length=557, Percent_Identity=24.2369838420108, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI1789856, Length=553, Percent_Identity=29.8372513562387, Blast_Score=188, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI212646519, Length=499, Percent_Identity=26.8537074148297, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=26.6533066132265, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17542894, Length=541, Percent_Identity=26.6173752310536, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193208245, Length=497, Percent_Identity=25.3521126760563, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=497, Percent_Identity=25.3521126760563, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=535, Percent_Identity=23.5514018691589, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI161077880, Length=564, Percent_Identity=27.1276595744681, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551474, Length=564, Percent_Identity=27.1276595744681, Blast_Score=154, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642670, Length=564, Percent_Identity=27.1276595744681, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642666, Length=564, Percent_Identity=27.1276595744681, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI161077878, Length=564, Percent_Identity=27.1276595744681, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI18859893, Length=573, Percent_Identity=27.5741710296684, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859741, Length=523, Percent_Identity=26.7686424474187, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161077496, Length=513, Percent_Identity=25.9259259259259, Blast_Score=109, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 67814; Mature: 67814

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGVDSARWDGKRGRQIRIVRAVRAESPGTRRASPRTRADLGLDSIHVVHASIHVTNEF
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEEEEEEECCC
AGGAQSRWNVCFDPVYHVPAMTLHSNISGVPFSWRNPYLTTRVPVFARNVVSTSHPLAAQ
CCCCCCCCCEEECCHHHCCCCEECCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCHHHH
AGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAFALVWDGAKLHGLNASGVAPAAW
HCCCEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCEEECCCCCCCCCCHH
SVDYFRRRHGDAGNGLARQPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIELAE
HHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RGHAVAAVVAHKWAAAVPELNGQPGFAETFMPRGRAPEVSELVRLPGHAKTLRTIAAEGA
CCCCEEHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
RAFYEGSIAESIAGFFRDGGGALTADDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAA
HHHHCCHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCHHHH
LIALGIVERFGLDDLPLDSAEAQHVQIEAMKLAFADVYRYVADPRAMALTPAQMLDDAYL
HHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
DARAKLIDVTRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGMGIA
HHHHHEEEHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCCCCCCCCEE
LQNRGCGFSMDPTSPNVVEGGKRPFHTIIPAFVTQQAGGARHAVMSFGVMGGDMQPQGHL
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
QTIVRMLGYGQQPQAACDAPRWKVSRSFTLDVEAALGASVVDALAARGHTIQAIDDPYMD
HHHHHHHCCCCCCCHHCCCCCEEECCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCC
FGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF
CCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MFAGVDSARWDGKRGRQIRIVRAVRAESPGTRRASPRTRADLGLDSIHVVHASIHVTNEF
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCEEEEEEEEEEEECCC
AGGAQSRWNVCFDPVYHVPAMTLHSNISGVPFSWRNPYLTTRVPVFARNVVSTSHPLAAQ
CCCCCCCCCEEECCHHHCCCCEECCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCHHHH
AGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAFALVWDGAKLHGLNASGVAPAAW
HCCCEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCEEECCCCCCCCCCHH
SVDYFRRRHGDAGNGLARQPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIELAE
HHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RGHAVAAVVAHKWAAAVPELNGQPGFAETFMPRGRAPEVSELVRLPGHAKTLRTIAAEGA
CCCCEEHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHH
RAFYEGSIAESIAGFFRDGGGALTADDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAA
HHHHCCHHHHHHHHHHHCCCCCEEHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCHHHH
LIALGIVERFGLDDLPLDSAEAQHVQIEAMKLAFADVYRYVADPRAMALTPAQMLDDAYL
HHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
DARAKLIDVTRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGMGIA
HHHHHEEEHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCCCCCCCCEE
LQNRGCGFSMDPTSPNVVEGGKRPFHTIIPAFVTQQAGGARHAVMSFGVMGGDMQPQGHL
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
QTIVRMLGYGQQPQAACDAPRWKVSRSFTLDVEAALGASVVDALAARGHTIQAIDDPYMD
HHHHHHHCCCCCCCHHCCCCCEEECCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCC
FGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF
CCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]