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The map label for this gene is phr [H]

Identifier: 83718773

GI number: 83718773

Start: 2036995

End: 2038455

Strand: Direct

Name: phr [H]

Synonym: BTH_I1815

Alternate gene names: 83718773

Gene position: 2036995-2038455 (Clockwise)

Preceding gene: 83719029

Following gene: 83719415

Centisome position: 53.48

GC content: 73.03

Gene sequence:

>1461_bases
TTGTCTTCATTCGACTCGACCGCACCCGCCGTCGTTTGGTTTCGCGATGATCTGCGCGTATCCGATCATCCCGCGCTCGC
GCGCGCCGCCGAGTCCGGGCGCCCTGTGATCGGCGTCTATGTGTTCGACGAGCGCGCCGGCGGGCGAGCGTTGGGCGGCG
CGGCGCGCTGGTGGCTGCACGGATCGCTGCGCGCGCTCGATGCGGCGCTCGCCGGGCTGGGCGGCCGGCTCGTGCTGTTG
CGCGGCGACGAGGCCGACACGTTCGTTTCGTTCGTCGCGGCGCTCGGCGCGGGCGCCGTCTACTGGAACCGTCGCTATGC
GTTCGCTCAGCGCGCGCTCGACAATGCGGTGCAGACCGCGCTCGACGCGCGGCGCGTCGCGGTCGAGACGTTCAACGCGA
GCCTGCTGTTCGAGCCGGACGATATCGTCAACGGGGACGGTCGTCCGTATCAGGTGTTCGGGGCGTACTGGCGTGCGGCG
CTGCGCCGCGGCGCGCCGCCGCCGCCGCTCGCCGCGCCGCGGCGCCTGAACGGCGGCGCGCTGCCCGAGGCGCTCGCTCG
ACGGCGAGTCGAGCTCGACGCGCTCGGGCTCGAGCCGACGCGCCCGGACTGGGCGGGCGGCTTGCGCGATGCGTGGCGCT
TCGGCGAGGATGCCGCGCACAGCCTGCTGCGCGCGTTCGTCGACAGCCGGCTCGGCGGCTACGCGACCGAGCGCGACCGG
CCGGGCATCGCGTCGACGAGCCGCCTGTCGCCTTACGTGCGCTTCGGCAACCTGTCGGTGCGGCAGATCTGGCAGGCGGC
CGTCGACGCGCACGCGCACCGCGCGGCGACGCAAGCGGATCTCGACAAGTTTCTGAGCGAGCTCGGCTGGCGGGAGTTTT
GCTGGGCTCAGCTGTACCGCTTCCCGGATCTGCCGCGCCGCAATCTGCGCCATACGCTCGACGGAATGCCCTGGCGCGAC
GATCCCGCCGGGCTCGCCGCGTGGCGGCGCGGCGCGACGGGCTACCCGTTCGTCGATGCCGGCATGCGCGAGCTCTGGGC
GACGGGCTGGATGCACAATCGCGCGCGGATGGTATGCGCGTCATTCCTCGTCAAGCATCTGCTGATCGACTGGCGGGAGG
GCGAGGCGTGGTTCTGGGACACGCTCGTCGACGCTGACGCCGCGTCGAACGCGGCGAACTGGCAGTGGGTCGCGGGCTGC
GGCGCGGACGCCGCGCCGTACTTCCGGATTTTCAATCCGGTCGCGCAGGGCAAGAAGTTCGATCCGGACGGTGCCTACGT
GCGGCGCTGGGTGCCCGAGCTGGCCGGCTTGCCGCCGGCCGCGATCCACGAGCCGTGGGCCGCGCCGCCCGCGCAGCTTG
CCGCGGCGGGCGTGCGGCTCGGCGACACCTACCCGGTGCCGGTCGTCGCGCACGACGCCGCGCGCCGGCGCGCACTCGAC
GCATTCGCGACAGCAGGATGA

Upstream 100 bases:

>100_bases
TCGCCAGCGTATTCGGCCGGCCGATGCCGCCCGGCGCTGCCTTCGATGCAGCCGGTGCGCGTCGGCCCTGTTACGGTTGT
CTTTCATCGGAGCCCATCCA

Downstream 100 bases:

>100_bases
ATCTGACGCTGGAGGATTGAATCTTTTGTAATTGATTGGGCTGACATAGTCCTGGAAGACCGCATTTTTTTATCGCTTCC
AGTGGTTAAACTCTCACCTC

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSSFDSTAPAVVWFRDDLRVSDHPALARAAESGRPVIGVYVFDERAGGRALGGAARWWLHGSLRALDAALAGLGGRLVLL
RGDEADTFVSFVAALGAGAVYWNRRYAFAQRALDNAVQTALDARRVAVETFNASLLFEPDDIVNGDGRPYQVFGAYWRAA
LRRGAPPPPLAAPRRLNGGALPEALARRRVELDALGLEPTRPDWAGGLRDAWRFGEDAAHSLLRAFVDSRLGGYATERDR
PGIASTSRLSPYVRFGNLSVRQIWQAAVDAHAHRAATQADLDKFLSELGWREFCWAQLYRFPDLPRRNLRHTLDGMPWRD
DPAGLAAWRRGATGYPFVDAGMRELWATGWMHNRARMVCASFLVKHLLIDWREGEAWFWDTLVDADAASNAANWQWVAGC
GADAAPYFRIFNPVAQGKKFDPDGAYVRRWVPELAGLPPAAIHEPWAAPPAQLAAAGVRLGDTYPVPVVAHDAARRRALD
AFATAG

Sequences:

>Translated_486_residues
MSSFDSTAPAVVWFRDDLRVSDHPALARAAESGRPVIGVYVFDERAGGRALGGAARWWLHGSLRALDAALAGLGGRLVLL
RGDEADTFVSFVAALGAGAVYWNRRYAFAQRALDNAVQTALDARRVAVETFNASLLFEPDDIVNGDGRPYQVFGAYWRAA
LRRGAPPPPLAAPRRLNGGALPEALARRRVELDALGLEPTRPDWAGGLRDAWRFGEDAAHSLLRAFVDSRLGGYATERDR
PGIASTSRLSPYVRFGNLSVRQIWQAAVDAHAHRAATQADLDKFLSELGWREFCWAQLYRFPDLPRRNLRHTLDGMPWRD
DPAGLAAWRRGATGYPFVDAGMRELWATGWMHNRARMVCASFLVKHLLIDWREGEAWFWDTLVDADAASNAANWQWVAGC
GADAAPYFRIFNPVAQGKKFDPDGAYVRRWVPELAGLPPAAIHEPWAAPPAQLAAAGVRLGDTYPVPVVAHDAARRRALD
AFATAG
>Mature_485_residues
SSFDSTAPAVVWFRDDLRVSDHPALARAAESGRPVIGVYVFDERAGGRALGGAARWWLHGSLRALDAALAGLGGRLVLLR
GDEADTFVSFVAALGAGAVYWNRRYAFAQRALDNAVQTALDARRVAVETFNASLLFEPDDIVNGDGRPYQVFGAYWRAAL
RRGAPPPPLAAPRRLNGGALPEALARRRVELDALGLEPTRPDWAGGLRDAWRFGEDAAHSLLRAFVDSRLGGYATERDRP
GIASTSRLSPYVRFGNLSVRQIWQAAVDAHAHRAATQADLDKFLSELGWREFCWAQLYRFPDLPRRNLRHTLDGMPWRDD
PAGLAAWRRGATGYPFVDAGMRELWATGWMHNRARMVCASFLVKHLLIDWREGEAWFWDTLVDADAASNAANWQWVAGCG
ADAAPYFRIFNPVAQGKKFDPDGAYVRRWVPELAGLPPAAIHEPWAAPPAQLAAAGVRLGDTYPVPVVAHDAARRRALDA
FATAG

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=494, Percent_Identity=30.5668016194332, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI4758072, Length=482, Percent_Identity=29.045643153527, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI188536103, Length=448, Percent_Identity=29.6875, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1786926, Length=487, Percent_Identity=37.9876796714579, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324962, Length=533, Percent_Identity=28.8930581613508, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137248, Length=510, Percent_Identity=30.1960784313725, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24585455, Length=510, Percent_Identity=30.1960784313725, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24648152, Length=509, Percent_Identity=27.3084479371316, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53409; Mature: 53277

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFDSTAPAVVWFRDDLRVSDHPALARAAESGRPVIGVYVFDERAGGRALGGAARWWLH
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
GSLRALDAALAGLGGRLVLLRGDEADTFVSFVAALGAGAVYWNRRYAFAQRALDNAVQTA
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LDARRVAVETFNASLLFEPDDIVNGDGRPYQVFGAYWRAALRRGAPPPPLAAPRRLNGGA
HHHHHHHHEECCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LPEALARRRVELDALGLEPTRPDWAGGLRDAWRFGEDAAHSLLRAFVDSRLGGYATERDR
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
PGIASTSRLSPYVRFGNLSVRQIWQAAVDAHAHRAATQADLDKFLSELGWREFCWAQLYR
CCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FPDLPRRNLRHTLDGMPWRDDPAGLAAWRRGATGYPFVDAGMRELWATGWMHNRARMVCA
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SFLVKHLLIDWREGEAWFWDTLVDADAASNAANWQWVAGCGADAAPYFRIFNPVAQGKKF
HHHHHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCC
DPDGAYVRRWVPELAGLPPAAIHEPWAAPPAQLAAAGVRLGDTYPVPVVAHDAARRRALD
CCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEECHHHHHHHHH
AFATAG
HHHCCC
>Mature Secondary Structure 
SSFDSTAPAVVWFRDDLRVSDHPALARAAESGRPVIGVYVFDERAGGRALGGAARWWLH
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHH
GSLRALDAALAGLGGRLVLLRGDEADTFVSFVAALGAGAVYWNRRYAFAQRALDNAVQTA
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LDARRVAVETFNASLLFEPDDIVNGDGRPYQVFGAYWRAALRRGAPPPPLAAPRRLNGGA
HHHHHHHHEECCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LPEALARRRVELDALGLEPTRPDWAGGLRDAWRFGEDAAHSLLRAFVDSRLGGYATERDR
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
PGIASTSRLSPYVRFGNLSVRQIWQAAVDAHAHRAATQADLDKFLSELGWREFCWAQLYR
CCCCCCHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FPDLPRRNLRHTLDGMPWRDDPAGLAAWRRGATGYPFVDAGMRELWATGWMHNRARMVCA
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SFLVKHLLIDWREGEAWFWDTLVDADAASNAANWQWVAGCGADAAPYFRIFNPVAQGKKF
HHHHHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCC
DPDGAYVRRWVPELAGLPPAAIHEPWAAPPAQLAAAGVRLGDTYPVPVVAHDAARRRALD
CCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEECHHHHHHHHH
AFATAG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]