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The map label for this gene is maeB [H]

Identifier: 83718704

GI number: 83718704

Start: 3545624

End: 3547894

Strand: Reverse

Name: maeB [H]

Synonym: BTH_I3110

Alternate gene names: 83718704

Gene position: 3547894-3545624 (Counterclockwise)

Preceding gene: 83718748

Following gene: 83718710

Centisome position: 93.14

GC content: 66.49

Gene sequence:

>2271_bases
ATGGACGAACAACTGAAGCAAAGCGCTCTCGCCTATCACCAGAATCCGAAACCCGGCAAGATTTCGGTCACCCCCACGAA
GCCGCTGTCGAACCAGCTCGACCTGTCGCTCGCGTATTCGCCGGGCGTCGCGGCCGCGTGCGAGGCGATCCACGCGGACC
CGCTCGACGCGCAGAAGTACACGTCGCGCGGCAACCTGGTCGGCGTCGTGACGAACGGCACCGCGGTGCTCGGCCTCGGC
AACATCGGCCCGCTCGCCGCGAAGCCCGTGATGGAAGGCAAGGGCTGCCTGTTCAAGAAGTTCGCGGGCATCGACGTGTT
CGACATCGAACTCGCCGAATCCGATCCGGACAAGCTTGTCGAGGCGATCGCGATGCTCGAGCCGACGCTCGGCGGCATCA
ACCTCGAGGACATCAAGGCGCCCGAGTGCTTCTACATCGAGCAGAAGCTGCGCGAGCGGATGAAGATCCCCGTCTTCCAC
GACGACCAGCACGGCACCGCGATCATCGCGTCGGCGGCGATCCTGAACGGCCTGAAGGTGGTCGGCAAGGATCTGTCGAG
CGTGAAACTCGTCTGCTCGGGCGCGGGCGCGGCGGCCATCGCGTGTCTCGACCTGCTCGTGAAGCTCGGCCTGTCCAAAT
CGAACGTGCTCGTCGCCGATTCGAAGGGCGTGATCTACGAAGGCCGCGGCAACCTTGATCCGTCGAAGCAGCGCTACGCG
GCGGTGACCGATGCGCGCACGCTCGCCGACGCGATCCGCGATGCGGACGTGTTCCTCGGCTGCTCGAGCGCGGGCGTGCT
GAAGCAGGACATGGTGAAGACGATGGCGGACAAGCCGCTCATCCTCGCGCTCGCGAACCCGGAGCCGGAAATCCGTCCGG
AAGACGCGAAGGCGGTGCGCCCGGACGCGATCGTCGCGACGGGCCGCTCCGACTATCCGAACCAGGTCAACAACGTCCTG
TGCTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCGACGACGATCACCGAGGAGATGAAGCTCGCGTGCGTGCG
CGCGATCGCCGAGCTCGCGCAGGAAACCGACCAGAGCGAGGAAGTCGCGAAGGCGTATGAAGGCCATTCGCTCGAATTCG
GTCCGGATTACCTGATTCCGAAGCCGTTCGATCCGCGCCTCATCATCAAGATCGCGCCGGCCGTCGCGCAGGCCGCGATG
GATTCGGGCGTGGCCACCCGCCCGATCGCCGACATGGACGCGTACCGCGAGCAGCTCGGCACGACCGTCTATCGCACCGG
CATGGTGATGCGCCCCGTGTTCGCGACCGCGAAGACGAAGGCCGCGCGCATCGTGTTCGCCGAGGGCGAGGACGAGCGCG
TGCTGCGCGCCGCGCAGTTCGTGCTGCAGGAGAGGATCGCGAAGCCGATCATCGTCGGCCGGCCGTCGGTCGTCGAGATG
CGGCTGCAGAAGATCGGCTCGAAGCTGAAGTGCGGCGTCGATTTCGAGATCGTCAATCCGGAAGACGATCCGCGCTATCA
GCAATGCTGGCAGGCGTATCACGAGATGGGCGCGCGCGACGGCGTGACGCCGGAGGTCGCGAAGGCCGCGCTGCGCAAGT
TCAACACGCTGATCGGCGCGATGCTCGTGCATCTCGGCGACGCGGACGGCATGATCTGCGGGATGATCGACACGTATCAC
AGCCACCTGAAGTTCATCGAGCAGGTGCTGGGCCGCGCGAAGGGCGCCGAGCACTTCGCCGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCATGTGCGACACGTACGTGAACGAGCAGCCGAGCGCCGAGCAGCTCGCCGACATGACGATCC
AGGCCGCGGCCGAGATCGAGCGCTTCGGCATCACGCCGAAGGCGGCGCTCTTGTCGAACTCGAACTTCGGCAGCGCGCCG
TCGGCGTCGTCGCGCCGGATGGCGGAGGCGCGCAAACTGATCGTCGAGCGCGCGCCCGAGCTCGAAGTCGACGGCGAAAT
GCACGGCGACGCGGCGCTGTCCGAAGTGGTCCGCAAGGCCGCGTTTCCGGGCACGACGCTCACGGGCGAGGCGAACCTCC
TGATCATGCCGAACGTCGAGGCGGCGAACATCGCGTACAACCTGCTGAAGATGGTCGGCGGCGAAGGCGTGACCGTGGGC
CCGTTCCTGCTGGGTGCGGCGAAGCCCGTGCATATCCTGACGCCGGCCGCGACCGTGCGCCGGATCATCAACATGACGGC
CGTCGCCGCAGCGAACGTTCAGGTGAAGTGA

Upstream 100 bases:

>100_bases
ACGGACGCCGCAGTCGACCATCCCTTCGATTCCCGAATCCGCGGCTCCCGGTGCTCGGTACTGAGTCTTCAAAATTACGC
ATGTCTCTCGCAGGTCAACC

Downstream 100 bases:

>100_bases
CGCGCGAAAACCGTGCGTCGCGCGCCGTTCGGGCAGGCGGCGCGCGGTGACGAAACGAAAAGGAGGGCGGCCGCTCGGCC
GGATCGGATCTCGGAAGCTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
AVTDARTLADAIRDADVFLGCSSAGVLKQDMVKTMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLQKIGSKLKCGVDFEIVNPEDDPRYQQCWQAYHEMGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK

Sequences:

>Translated_756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
AVTDARTLADAIRDADVFLGCSSAGVLKQDMVKTMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLQKIGSKLKCGVDFEIVNPEDDPRYQQCWQAYHEMGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
>Mature_756_residues
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
AVTDARTLADAIRDADVFLGCSSAGVLKQDMVKTMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIADMDAYREQLGTTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
RLQKIGSKLKCGVDFEIVNPEDDPRYQQCWQAYHEMGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVNEQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPELEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=26.9662921348315, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=26.7409470752089, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=27.4447949526814, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=63.8522427440633, Blast_Score=993, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=323, Percent_Identity=33.1269349845201, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI1788635, Length=352, Percent_Identity=28.9772727272727, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=24.0875912408759, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=29.1044776119403, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356279, Length=402, Percent_Identity=26.3681592039801, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362674, Length=402, Percent_Identity=26.3681592039801, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362672, Length=402, Percent_Identity=26.3681592039801, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=29.7142857142857, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=29.7142857142857, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI78707242, Length=409, Percent_Identity=23.2273838630807, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI78707238, Length=409, Percent_Identity=23.2273838630807, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81021; Mature: 81021

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
HCCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCHHHHH
AVTDARTLADAIRDADVFLGCSSAGVLKQDMVKTMADKPLILALANPEPEIRPEDAKAVR
HHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIADMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHC
TTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
CHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHH
RLQKIGSKLKCGVDFEIVNPEDDPRYQQCWQAYHEMGARDGVTPEVAKAALRKFNTLIGA
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEECCCC
EQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEEECCEEC
>Mature Secondary Structure
MDEQLKQSALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELAESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKDLSSVKLVCSGAGAAAIACLDLLVKLGLSKSNVLVADSKGVIYEGRGNLDPSKQRYA
HCCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCHHHHH
AVTDARTLADAIRDADVFLGCSSAGVLKQDMVKTMADKPLILALANPEPEIRPEDAKAVR
HHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIADMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHC
TTVYRTGMVMRPVFATAKTKAARIVFAEGEDERVLRAAQFVLQERIAKPIIVGRPSVVEM
CHHHHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHH
RLQKIGSKLKCGVDFEIVNPEDDPRYQQCWQAYHEMGARDGVTPEVAKAALRKFNTLIGA
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFMCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEECCCC
EQPSAEQLADMTIQAAAEIERFGITPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEVVRKAAFPGTTLTGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVQVK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEEECCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]