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The map label for this gene is hemF [H]

Identifier: 83718510

GI number: 83718510

Start: 1149482

End: 1150462

Strand: Reverse

Name: hemF [H]

Synonym: BTH_I1013

Alternate gene names: 83718510

Gene position: 1150462-1149482 (Counterclockwise)

Preceding gene: 83719293

Following gene: 83721082

Centisome position: 30.2

GC content: 68.91

Gene sequence:

>981_bases
ATGCCCGGCAGAAGCATTTTTCGACGGCGTCCGTCACGCGGATGCCGCCCCACATCGATGACCGATTCGACTTACGACGT
CAACCGAGTACGCGCGTACCTGCAAGGGCTGCAGACGCGCATAGCCGACGCGCTCGGCGCCTTCGACGGCACGCCGCTTT
CCGCCGACGCGTGGCAGCGCAGCCCCGGCGAGCGGCTGCGCGGCGGCGGCTGCACGCGCATTCTCGAGGAAGGCGGCTTC
TTCGAGCGCGCGGGCATCGGCTTTTCCGACGTCGCGGGCGACGCGCTGCCGCCTTCGGCGAGCGCGTCGCGCCCGCAGCT
CGCCGGGCGCGGCTTCGAGGCGCTCGGCGTGTCGCTCGTGCTGCACCCGCGCAACCCGTACTGCCCGACCGTCCACATGA
ACGTGCGGATGCTGATCGCGACGAAGCCGGGCGAGGCGCCCGTGTTCTGGTTCGGCGGCGGCATGGATCTGACGCCGATC
TACGGCTTCGAAGAGGATGCGCGGCACTTCCATCGCACGTGCCGCGCGGCGCTCGATCCGTTCGGCGCCGAGCTGTACCC
GCGTTTCAAGAAGTGGTGCGACGATTATTTCTTCCTGAAGCACCGCAACGAAGCGCGCGGCATCGGCGGCATCTTCTTCG
ACGACTTCTCGGAGCTCGGCTTCGAACGCTCGTTCGAAATGCTGCAAAGCGTCGGCGACGCGTTCCTGCCGTCGTACCTG
CCGATCGTCGAGCGCCGCCGCGACATGCCGTACGGCGAGCGCGAGCGCGCGTTCCAGACGCAACGGCGCGGCCGCTACGT
CGAATTCAACCTGGTGTTCGACCGCGGCACGCTGTTCGGGCTGCAAAGCGGCGGCCGCACCGAGTCGATCCTGCTGTCGA
TGCCGCCGACGGCGGGCTGGCGCTACGACTGGCACCCGGCCCCGGACACGCCGGAAGCCCGCCTCTACAGCGATTTCCTC
GTGCCGCGCGACTGGGCATGA

Upstream 100 bases:

>100_bases
TACCGCGCGCTCAATCGCAAGACGGTCTGACGCGCGCGCGCCGCTTCTCGCGCACCGGCTTTCGGCCGGCGCGCCCTCTC
CTCTGCCGGGGTTCGCTAGA

Downstream 100 bases:

>100_bases
GTCGCTCCGCCACCGGCCGAGTGGCCGCTCCGCAAGGCTTTGCGCCAAACGCCGAGCCCGCCGGCCTGCCCGCGCTGCCG
CGCCGCATCGGCATCCTCGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPGRSIFRRRPSRGCRPTSMTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLSADAWQRSPGERLRGGGCTRILEEGGF
FERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPI
YGFEEDARHFHRTCRAALDPFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYL
PIVERRRDMPYGERERAFQTQRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPAPDTPEARLYSDFL
VPRDWA

Sequences:

>Translated_326_residues
MPGRSIFRRRPSRGCRPTSMTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLSADAWQRSPGERLRGGGCTRILEEGGF
FERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPI
YGFEEDARHFHRTCRAALDPFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYL
PIVERRRDMPYGERERAFQTQRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPAPDTPEARLYSDFL
VPRDWA
>Mature_325_residues
PGRSIFRRRPSRGCRPTSMTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLSADAWQRSPGERLRGGGCTRILEEGGFF
ERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIY
GFEEDARHFHRTCRAALDPFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYLP
IVERRRDMPYGERERAFQTQRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPAPDTPEARLYSDFLV
PRDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=45.364238410596, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=61.1295681063123, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=44.1640378548896, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI17864388, Length=313, Percent_Identity=45.6869009584665, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36831; Mature: 36700

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRSIFRRRPSRGCRPTSMTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLSADAWQR
CCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
SPGERLRGGGCTRILEEGGFFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLV
CCCHHHCCCCHHHHHHCCCCEECCCCCHHHHCCCCCCCCCCCCCCCHHCCCHHEECEEEE
LHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALDP
EECCCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCC
FGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYL
CCHHHHHHHHHHHCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIVERRRDMPYGERERAFQTQRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGW
HHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCC
RYDWHPAPDTPEARLYSDFLVPRDWA
CCCCCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
PGRSIFRRRPSRGCRPTSMTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLSADAWQR
CCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
SPGERLRGGGCTRILEEGGFFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLV
CCCHHHCCCCHHHHHHCCCCEECCCCCHHHHCCCCCCCCCCCCCCCHHCCCHHEECEEEE
LHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALDP
EECCCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHCC
FGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGDAFLPSYL
CCHHHHHHHHHHHCHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIVERRRDMPYGERERAFQTQRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGW
HHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCC
RYDWHPAPDTPEARLYSDFLVPRDWA
CCCCCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA