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The map label for this gene is fadA [H]

Identifier: 83718481

GI number: 83718481

Start: 2423301

End: 2424479

Strand: Direct

Name: fadA [H]

Synonym: BTH_I2144

Alternate gene names: 83718481

Gene position: 2423301-2424479 (Clockwise)

Preceding gene: 83721021

Following gene: 83721498

Centisome position: 63.62

GC content: 70.23

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCGACCGCCCGCACGGGGCTCGCGAAATCCTGGCGCGGCGCGTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCACGTGGTCGCGGCCGCCGTCGCGCGCGCGAAGCTCGATCCCGCGCGCGTCGAGGACGTGCTGA
TCGGCTGCGCGAATCCCGAGGGCGCGACGGGCGCGAACATCGCGCGGCAGATCGCGCTGCGCGCGGGGTTGCCCGTCAGC
GTGCCGGGGATGACCGTCAACCGTTTCTGCTCGTCGGGATTGCAGACGATCGCGCTCGCCGCGCAGCGCGTGATCGCGGG
CGAGGGCGACGTGTTCGTCGCGGGCGGGGTCGAATCGATCTCGTGCGTGCAGAACGAGATGAACCGGCACATGCTGCGCG
AGGGCTGGCTCGACGCGCACAAGCCGGAGATCTACTGGTCGATGCTGCAGACGGCCGAGAACGTCGCGAAGCGCTACGGC
ATCGCGAAGGAGCGCCAGGACGAGTACGGCGTGAATTCGCAGCTTCGCGCGGCGGCCGCGCAGGCCGCGGGGCGATTCGA
CGCGGAGATCGTGCCGATCACCGTGCGCGCGGGCGTCGCCGACAAGGCGACGGGCCGTCTCTACACGAAGGACGTGACGC
TCGCCGCCGACGAGGGCATTCGGCCCGACACGACGCTCGAAGGCGTCGCGAAGATCCGCTCGGCGCTGCCGGGAGGCGTG
ATTACCGCGGGCAACGCGAGCCAGTTCTCGGACGGCGCGGCCGCGTGCGTCGTGATGAACGCGAAGCTCGCCGAGCGCGA
GGGCCTCGCGCCGCTCGGCATTTTCCGCGGTTTCGCGGTGGCCGGCTGCGAGCCGGACGAGATGGGCATCGGGCCCGTCT
ACGCGGTGCCGAAGCTGTTGAAGCAGGCGGGGCTCAAGGTGTCCGACATCGATCTGTGGGAGCTGAACGAGGCGTTCGCG
GTGCAGGTGCTCTATTGCCGCGACACGCTCGGGATTCCCGACGATCGGCTGAACGTGAACGGCGGCGCGATCGCGGTCGG
CCATCCGTACGGCGTGTCGGGCGCGCGGCTCACGGGCCATGCGCTGATCGAGGGCAAGCGGCGCGGCGCGAAATACGTGG
TCGTGACGATGTGCATCGGCGGCGGGCAGGGCGCGGCGGGATTGTTCGAGGTGGTGTGA

Upstream 100 bases:

>100_bases
GTGCGGTCGGCCGACGCCCATCCCGGCGTCGATCCGTGATCATCGCCGTCGTTCATTTCATCGCATATCGATCCACAGAA
TTCAGAATCAGGAGACTCGG

Downstream 100 bases:

>100_bases
CGGCGGCACGCGCCGGGGCCGACCGTGCGCCGTTCGGCGGCATCGCCGCGTCGATCGGACGGGTTCCCGCCGCCGCGCGC
GTATTTTGCCGCGACATCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVARAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWSMLQTAENVAKRYG
IAKERQDEYGVNSQLRAAAAQAAGRFDAEIVPITVRAGVADKATGRLYTKDVTLAADEGIRPDTTLEGVAKIRSALPGGV
ITAGNASQFSDGAAACVVMNAKLAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV

Sequences:

>Translated_392_residues
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVARAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWSMLQTAENVAKRYG
IAKERQDEYGVNSQLRAAAAQAAGRFDAEIVPITVRAGVADKATGRLYTKDVTLAADEGIRPDTTLEGVAKIRSALPGGV
ITAGNASQFSDGAAACVVMNAKLAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFA
VQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
>Mature_391_residues
TEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVARAKLDPARVEDVLIGCANPEGATGANIARQIALRAGLPVSV
PGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISCVQNEMNRHMLREGWLDAHKPEIYWSMLQTAENVAKRYGI
AKERQDEYGVNSQLRAAAAQAAGRFDAEIVPITVRAGVADKATGRLYTKDVTLAADEGIRPDTTLEGVAKIRSALPGGVI
TAGNASQFSDGAAACVVMNAKLAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLLKQAGLKVSDIDLWELNEAFAV
QVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=44.8101265822785, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI167614485, Length=366, Percent_Identity=38.5245901639344, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.1287128712871, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=35.7682619647355, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=393, Percent_Identity=31.5521628498728, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=243, Percent_Identity=35.8024691358025, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=40.4358353510896, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.9497487437186, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=41.871921182266, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=38.0246913580247, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=30.6413301662708, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=37.8109452736318, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=36.2068965517241, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.1670822942643, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=28.9954337899543, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.6445012787724, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=414, Percent_Identity=33.3333333333333, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.25, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI17648125, Length=364, Percent_Identity=39.010989010989, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=33.6633663366337, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=408, Percent_Identity=32.3529411764706, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40847; Mature: 40716

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVARAKLDPARVEDVLIGCANPE
CCCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCEEEEECCCCC
GATGANIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMLREGWLDAHKPEIYWSMLQTAENVAKRYGIAKERQDEYGVNSQLRAAAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHH
QAAGRFDAEIVPITVRAGVADKATGRLYTKDVTLAADEGIRPDTTLEGVAKIRSALPGGV
HHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGAAACVVMNAKLAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLL
EECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVSDIDLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCEEECCCCEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
EEEECCCCCCCEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TEAVIVSTARTGLAKSWRGAFNMTHGATLGGHVVAAAVARAKLDPARVEDVLIGCANPE
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCEEEEECCCCC
GATGANIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNRHMLREGWLDAHKPEIYWSMLQTAENVAKRYGIAKERQDEYGVNSQLRAAAA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHH
QAAGRFDAEIVPITVRAGVADKATGRLYTKDVTLAADEGIRPDTTLEGVAKIRSALPGGV
HHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGAAACVVMNAKLAEREGLAPLGIFRGFAVAGCEPDEMGIGPVYAVPKLL
EECCCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVSDIDLWELNEAFAVQVLYCRDTLGIPDDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCEEECCCCEECCCCCEEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCCEEECC
ALIEGKRRGAKYVVVTMCIGGGQGAAGLFEVV
EEEECCCCCCCEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]